Discovery of Dihydro-Alkyloxy-Benzyl-Oxopyrimidines as Promising Anti-Influenza Virus Agents

Chemical Biology and Drug Design

Volumn 78, Issue 4, 2011, Pages 596-602

  Yu, Mingyan ^a   Liu, Ailin ^b   Du, Guanhua ^b   Naesens, Lieve ^c   Vanderlinden, Evelien ^c   De Clercq, Erik ^c   Liu, Xinyong ^a  

^a SHANDONG UNIVERSITY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Anti influenza agents; Antiviral activity; DABO; Influenza A; Influenza B; Influenza virus

Indexed keywords

2 [( METHOXYPHENYLAMINO)CARBONYLMETHYLTHIO] 6 (2,6 DIFLUOROBENZYL) 5 ETHYLPYRIMIDIN 4(3H)ONE; 2 [(4 BROMOPHENYLAMINO)CARBONYLMETHYLTHIO] 6 (1 NAPHTHYLMETHYL) 5 ETHYLPYRIMIDIN 4(3H)ONE; 2 [(4 BROMOPHENYLAMINO)CARBONYLMETHYLTHIO] 6 (1 NAPHTHYLMETHYL) 5 METHYLPYRIMIDIN 4(3H)ONE; 2 [(4 BROMOPHENYLAMINO)CARBONYLMETHYLTHIO] 6 (2,6 DIFLUOROBENZYL) 5 ETHYLPYRIMIDIN 4(3H)ONE; 2 [(4 BROMOPHENYLAMINO)CARBONYLMETHYLTHIO] 6 (2,6 DIFLUOROBENZYL) 5 METHYLPYRIMIDIN 4(3H)ONE; 2 [(4 CHLOROPHENYLAMINO)CARBONYLMETHYLTHIO] 6 (1 NAPHTHYLMETHYL) 5 ETHYLPYRIMIDIN 4(3H)ONE; 2 [(4 CHLOROPHENYLAMINO)CARBONYLMETHYLTHIO] 6 (1 NAPHTHYLMETHYL) 5 METHYLPYRIMIDIN 4(3H)ONE; 2 [(4 CHLOROPHENYLAMINO)CARBONYLMETHYLTHIO] 6 (2,6 DIFLUOROBENZYL) 5 ETHYLPYRIMIDIN 4(3H)ONE; 2 [(4 CHLOROPHENYLAMINO)CARBONYLMETHYLTHIO] 6 (2,6 DIFLUOROBENZYL) 5 METHYLPYRIMIDIN 4(3H)ONE; 2 [(4 METHOXYPHENYLAMINO)CARBONYLMETHYLTHIO] 6 (1 NAPHTHYLMETHYL) 5 ETHYLPYRIMIDIN 4(3H)ONE; 2 [(4 METHOXYPHENYLAMINO)CARBONYLMETHYLTHIO] 6 (1 NAPHTHYLMETHYL) 5 METHYLPYRIMIDIN 4(3H)ONE; AMANTADINE; ANTIVIRUS AGENT; OSELTAMIVIR; PYRIMIDINE DERIVATIVE; RIBAVIRIN; RIMANTADINE; UNCLASSIFIED DRUG; VIRUS SIALIDASE; ZANAMIVIR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENCY; DRUG TARGETING; INFLUENZA A (H1N1); INFLUENZA A (H3N2); INFLUENZA B; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; INFLUENZA VIRUS B; KIDNEY CELL; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; STRUCTURE ACTIVITY RELATION; TREATMENT OUTCOME;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DOGS; HUMANS; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA B VIRUS; INFLUENZA, HUMAN; ORTHOMYXOVIRIDAE INFECTIONS; PYRIMIDINES;

INFLUENZA B VIRUS; ORTHOMYXOVIRIDAE;

EID: 80052644321     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2011.01180.x     Document Type: Article

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