Effect of 3-bromopyruvic acid on human erythrocyte antioxidant defense system

Cell Biology International

Volumn 37, Issue 12, 2013, Pages 1285-1290

  Sadowska Bartosz, Izabela ^a   Bartosz, Grzegorz ^a,b  

^a UNIVERSITY OF RZESZÓW   (Poland)

^b UNIVERSITY OF LODZ   (Poland)

Author keywords

3 bromopyruvate; Antioxidant enzymes; Erythrocyte; Glutathione; Oxidative stress

Indexed keywords

BROMOPYRUVIC ACID; CINNAMIC ACID; FERRICYANIDE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; PYRUVIC ACID DERIVATIVE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; BROMOPYRUVATE; ENZYME INHIBITOR; THIOL DERIVATIVE;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL FUNCTION; COLORIMETRY; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; ERYTHROCYTE; ERYTHROCYTE MEMBRANE; GLYCOLYSIS; HEMOLYSIS; HUMAN; HUMAN CELL; IMMUNITY; OSMOTIC FRAGILITY; OXIDATIVE STRESS; PROTEIN DEPLETION; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; FLUOROMETRY; METABOLISM; OXIDATION REDUCTION REACTION; TEMPERATURE;

ENZYME ACTIVATION; ENZYME INHIBITORS; ERYTHROCYTES; FLUOROMETRY; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PYRUVATES; SULFHYDRYL COMPOUNDS; SUPEROXIDE DISMUTASE; TEMPERATURE;

EID: 84888405086     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10160     Document Type: Article

References (26)

1. Avron M, Shavit N (1963) A sensitive and simple method for determination of ferrocyanide. Anal Biochem 6: 549-54.
2. Cimen MY (2008) Free radical metabolism in human erythrocytes. Clin Chim Acta 390: 1-11.
3. Drabkin DL, Austin JM (1932) Spectrophotometric studies, spectrometric constants for common hemoglobin derivatives in human, dog and rabbit blood. J Biol Chem 98: 719-33.
4. Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82: 70-7.
5. El-Sayed SM, El-Magd RM, Shishido Y, Yorita K, Chung SP, Tran DH, Sakai T, Watanabe H, Kagami S, Fukui K (2012) D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects. J Bioenerg Biomembr 44: 513-23.
6. Fiorani M, De Sanctis R, De Bellis R, DachàM(2002) Intracellular flavonoids as electron donors for extracellular ferricyanide reduction in human erythrocytes. Free Radic Biol Med 32:64-72.
7. Geschwind JH, Ko YH, Torbenson MS, Magee C, Pedersen PL (2002) Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production. Cancer Res 62: 3909-13.
8. Habig WH, Pabst MJ, Jacoby WB (1974) Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130-9.
9. Jones AR, Porter KE, Dobbie MS (1996) Renal and spermatozoal toxicity of alpha-bromohydrin, 3-bromolactate and 3-bromopyruvate. J Appl Toxicol 16: 57-63.
10. Kim JS, Ahn KJ, Kim JA, Kim HM, Lee JD, Lee JM, Kim SJ, Park JH (2008) Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells. ROS-mediated cell death by 3-BP. J Bioenerg Biomembr 40: 607-18.
11. Ko YH, Pedersen PL, Geschwind JF (2001) Glucose metabolism in the rabbit VX tumor model for liver cancer: characterization and targeting hexokinase. Cancer Lett 173: 83-91.
12. Ko YH, Smith BL, Wang L, Pamper MG, Rini DA, Torbenson MS, Hullihen J, Pedersen P (2004) Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP. Biochem Biophys Res Commun 324: 269-75.
13. Lane DJ, Lawen A (2008) Transplasma membrane electron transport comes in two flavors. Biofactors; 34: 191-200.
14. Lang F, Qadri SM (2012)Mechanisms and significance of eryptosis, the suicidal death of erythrocytes. Blood Purif 33: 125-30.
15. Marklund SL, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pirogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47: 469-74.
16. Pandey KB, Rizvi SI (2010) Markers of oxidative stress in erythrocytes and plasma during aging in humans. Oxid Med Cell Longev 3: 2-12.
17. Patent application Number 20100203110. (2010) Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of ATP production 2010-08-12.
18. Polhuijs M, Tergau AC, Mulder GJ (1992) Chiral inversion and stereoselective glutathione conjugation of the four 2-bromo-3-methylvaleric acid stereoisomers in the rat in vivo and in vitro. J Pharmacol Exp Ther 260: 1349-54.
19. Qin J.-Z, Xin H, Nickoloff BJ (2010) 3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines. Biochem Biophys Res Commun 396: 495-500.
20. Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C (1999) Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26:1231-7.
21. Sadowska-Woda I, Bartosz G (2013) How do erythrocytes contribute to the ABTS* scavenging capacity of blood? Free Radic Res 47: 35-43.
22. Schaefer NG, Geschwind JF, Engles J, Buchanan JW, Wahl RL (2012) Systemic administration of 3-bromopyruvate in treating disseminated aggressive lymphoma. Translat Res 159: 51-7.
23. Senft A, Dalton T, Shertzer H (2000) Determining glutathione and glutathione disulfide using the fluorescence probe o-phthalaldehyde. Anal Biochem 280: 80-6.
24. Simmonds MJ, Meiselman HJ, Marshall-Gradisnik SM, Pyne M, Kakanis M, Keane J, Brenu E, Christy R, Baskurt OK (2011) Assessment of oxidant susceptibility of red blood cells in various species based on cell deformability. Biorheology 48:293-304.
25. Snel CA, Mahadevan S, Polhuijs M, Mulder GJ (1992) Glutathione conjugation and pharmacokinetics of 2-bromo-3-phenylpropionic acid in vitro and in the rat in vivo. Chirality 4: 407-14.
26. Tsuchihashi M (1923) Zur Kenntnis der Blutkatalase. Biochem Zeitschr 140: 65-74.