Urinary metabolites of organophosphate and pyrethroid pesticides and behavioral problems in Canadian children

Environmental Health Perspectives

Volumn 121, Issue 11-12, 2013, Pages 1378-1384

  Oulhote, Youssef ^a,b   Bouchard, Maryse F ^a,b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANEDIOL DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CIPERMETHRIN; CREATININE; CYFLUTHRIN; DIETHYL ALKYLPHOSPHATE; DIMETHYL ALKYLPHOSPHATE; DRUG METABOLITE; ORGANOPHOSPHATE PESTICIDE; PERMETHRIN; PYRETHROID; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; ATTENTION DEFICIT DISORDER; BEHAVIOR DISORDER; CANADA; CHILD; CONDUCT DISORDER; DRUG EXPOSURE; EDUCATION; EMOTIONAL DISORDER; ENVIRONMENTAL EXPOSURE; ETHNICITY; FEMALE; GENDER; HEALTH SURVEY; HUMAN; HYPERACTIVITY; LEAD BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MATERNAL SMOKING; METABOLITE; PRESCHOOL CHILD; PRIORITY JOURNAL; QUESTIONNAIRE; SCHOOL CHILD; SENSITIVITY ANALYSIS; URINALYSIS;

ADULT; AGE FACTORS; BEHAVIORAL SYMPTOMS; CANADA; CHILD; EDUCATIONAL STATUS; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; LEAD; LOGISTIC MODELS; ODDS RATIO; ORGANOPHOSPHATES; PESTICIDES; PREGNANCY; PYRETHRINS; QUESTIONNAIRES; SEX FACTORS; SMOKING; SOCIOECONOMIC FACTORS;

EID: 84888402921     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1306667     Document Type: Article

References (47)

1. Agency for Toxic Substances and Disease Registry. 2003. Toxicological Profile for Pyrethrins and Pyrethroids. Available: http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=787&tid=153 [accessed 6 May 2013].
2. American Psychiatric Association. 2000. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Arlington, VA:American Psychiatric Association.
3. Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL, Pirkle JL. 2005. Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspect 113:192-200; doi:10.1289/ehp.7337.
4. Bellinger DC. 2008. Very low lead exposures and children's neurodevelopment. Curr Opin Pediatr 20:172-177.
5. Bouchard MF, Bellinger DC, Wright RO, Weisskopf MG. 2010. Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides. Pediatrics 125:e1270-e1277.
6. Bouchard MF, Chevrier J, Harley KG, Kogut K, Vedar M, Calderon N, et al. 2011. Prenatal exposure to organophosphate pesticides and IQ in 7-year old children. Environ Health Perspect 119:1189-1195; doi:10.1289/ehp.1003185.
7. Bradman A, Kogut K, Eisen EA, Jewell NP, Quiros-Alcala L, Castorina R, et al. 2013. Variability of organophosphorous pesticide metabolite levels in spot and 24-hr urine samples collected from young children during 1 week. Environ Health Perspect 12:118-124; doi:10.1289/ehp.1104808.
8. Bradman A, Whyatt RM. 2005. Characterizing exposures to nonpersistent pesticides during pregnancy and early childhood in the National Children's Study: a review of monitoring and measurement methodologies. Environ Health Perspect 113:1092-1099; doi:10.1289/ehp.7769.
9. Braun JM, Froehlich TE, Daniels JL, Dietrich KN, Hornung R, Auinger P, et al. 2008. Association of environmental toxicants and conduct disorder in U.S. children: NHANES 2001-2004. Environ Health Perspect 116:956-962; doi:10.1289/ehp.11177.
10. Braun JM, Kahn RS, Froehlich T, Auinger P, Lanphear BP. 2006. Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. Environ Health Perspect 114:1904-1909; doi:10.1289/ehp.9478.
11. Cole TJ, Freeman JV, Preece MA. 1995. Body mass index reference curves for the UK, 1990. Arch Dis Child 73:25-29.
12. Elwan MA, Richardson JR, Guillot TS, Caudle WM, Miller GW. 2006. Pyrethroid pesticide-induced alterations in dopamine transporter function. Toxicol Appl Pharmacol 211:188-197.
13. Eskenazi B, Marks AR, Bradman A, Harley K, Barr DB, Johnson C, et al. 2007. Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environ Health Perspect 115:792-798; doi:10.1289/ ehp.9828.
14. Goodman A, Goodman R. 2009. Strengths and Difficulties Questionnaire as a dimensional measure of child mental health. J Am Acad Child Adolesc Psychiatry 48:400-403.
15. Goodman R. 1997. The Strengths and Difficulties Questionnaire: a research note. J Child Psychol Psychiatry 38:581-586.
16. Goodman R. 2001. Psychometric properties of the Strengths and Difficulties Questionnaire. J Am Acad Child Adolesc Psychiatry 40:1337-1345.
17. Grandjean P, Harari R, Barr DB, Debes F. 2006. Pesticide exposure and stunting as independent predictors of neurobehavioral deficits in Ecuadorian school children. Pediatrics 117:e546-e556.
18. Helsel D. 2005. Nondetects and Data Analysis: Statistics for Censored Environmental Data. Hoboken, NJ:John Wiley and Sons.
19. Horton MK, Rundle A, Camann DE, Boyd Barr D, Rauh VA, Whyatt RM. 2011. Impact of prenatal exposure to piperonyl butoxide and permethrin on 36-month neurodevelopment. Pediatrics 127:e699-e706.
20. Huen K, Harley K, Brooks J, Hubbard A, Bradman A, Eskenazi B, et al. 2009. Developmental changes in PON1 enzyme activity in young children and effects of PON1 polymorphisms. Environ Health Perspect 117:1632-1638; doi:10.1289/ ehp.0900870.
21. Imamura L, Yasuda M, Kuramitsu K, Hara D, Tabuchi A, Tsuda M. 2006. Deltamethrin, a pyrethroid insecticide, is a potent inducer for the activity-dependent gene expression of brain-derived neurotrophic factor in neurons. J Pharmacol Exp Ther 316:136-143.
22. INSPQ (Institut national de santé publique du Québec). 2009a. Analytical method for the determination of bisphenol A and pesticide metabolites in urine by GC-MS-MS (E-454), condensed version for CHMS with GC-MS detection limit values for Cycle 1. Québec, QC:Laboratoire de toxicologie, Institut national de santé publique du Québec.
23. INSPQ (Institut national de santé publique du Québec). 2009b. Analytical method for the determination of pyrethroid metabolites in urine by GC-MS (e-426), condensed version for CHMS. Québec, QC:Institut national de santé publique du Québec.
24. Jurek AM, Greenland S, Maldonado G, Church TR. 2005. Proper interpretation of non-differential misclassification effects: expectations vs observations. Int J Epidemiol 34:680-687.
25. Kaneko H, Miyamoto J. 2001. Pyrethroid chemistry and metabolism. In: Handbook of Pesticide Toxicology, Vol 2: Agents (Krieger R, Doull J, Ecobichon D, eds). San Diego:Academic Press, 1263-1288.
26. Korn EL, Graubard BI. 1991. Epidemiologic studies utilizing surveys: accounting for the sampling design. Am J Public Health 81:1166-1173.
27. Lazarini C, Florio J, Lemonica I, Bernardi M. 2001. Effects of prenatal exposure to deltamethrin on forced swimming behavior, motor activity, and striatal dopamine levels in male and female rats. Neurotoxicol Teratol 23:665-673.
28. Lu C, Barr DB, Pearson MA, Waller LA. 2008. Dietary intake and its contribution to longitudinal organophosphorus pesticide exposure in urban/suburban children. Environ Health Perspect 116:537-542; doi:10.1289/ehp.10912.
29. Marks AR, Harley K, Bradman A, Kogut K, Barr DB, Johnson C, et al. 2010. Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study. Environ Health Perspect 118:1768-1774; doi:10.1289/ehp.1002056.
30. McCrory C, Layte R. 2012. Prenatal exposure to maternal smoking and childhood behavioural problems: a quasi-experimental approach. J Abnorm Child Psychol 40:1277-1288.
31. Moniz AC, Bernardi MM, Spinosa HS. 1994. Effects of a pyrethroid type II pesticide on conditioned behaviors of rats. Vet Hum Toxicol 36:120-124.
32. Morgan MK. 2012. Children's exposures to pyrethroid insecticides at home: a review of data collected in published exposure measurement studies conducted in the United States. Int J Environ Res Publ Health 9:2964-2985.
33. National Research Council. 1993. Pesticides in the Diets of Infants and Children. Washington, DC:National Academy Press.
34. Rauh VA, Garfinkel R, Perera FP, Andrews HF, Hoepner L, Barr DB, et al. 2006. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Pediatrics 118:e1845-e1859.
35. Roberts JR, Karr CJ, Council on Environmental Health. 2012. Pesticide exposure in children. Pediatrics 130:e1765-e1788.
36. Rohlman DS, Arcury TA, Quandt SA, Lasarev M, Rothlein J, Travers R, et al. 2005. Neurobehavioral performance in preschool children from agricultural and non-agricultural communities in Oregon and North Carolina. Neurotoxicology 26:589-598.
37. Ruckart PZ, Kakolewski K, Bove FJ, Kaye WE. 2004. Long-term neurobehavioral health effects of methyl parathion exposure in children in Mississippi and Ohio. Environ Health Perspect 112:46-51; doi:10.1289/ehp.6430.
38. Rust KF, Rao JK. 1996. Variance estimation for complex surveys using replication techniques. Stat Methods Med Res 5:283-310.
39. Shafer T, Meyer D, Crofton K. 2005. Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs. Environ Health Perspect 113:123-136; doi:10.1289/ehp.7254.
40. Shumway RH, Azari RS, Kayhanian M. 2002. Statistical approaches to estimating mean water quality concentrations with detection limits. Environ Sci Technol 36:3345-3353.
41. Statistics Canada. 2011. Canadian Health Measures Survey (CHMS) Data User Guide: Cycle 1. Available: http://www23.statcan.gc.ca/imdb-bmdi/pub/document/5071_D2_T1_V1-eng.htm [accessed 5 May 2013].
42. Stout DM II, Bradham KD, Egeghy PP, Jones PA, Croghan CW, Ashley PA, et al. 2009. American Healthy Homes Survey: a national study of residential pesticides measured from floor wipes. Environ Sci Technol 43:4294-4300.
43. Sudakin DL, Power LE. 2007. Organophosphate exposures in the United States: a longitudinal analysis of incidents reported to poison centers. J Toxicol Environ Health Part A 70:141-147.
44. Tayebati SK, Di Tullio MA, Ricci A, Amenta F. 2009. Influence of dermal exposure to the pyrethroid insecticide deltamethrin on rat brain microanatomy and cholinergic/ dopaminergic neurochemistry. Brain Res 1301:180-188.
45. Walters JK, Boswell LE, Green MK. 2009. Pyrethrin and pyrethroid illnesses in the Pacific Northwest: a five-year review. Public Health Rep 124:149-159.
46. Wessels D, Barr DB, Mendola P. 2003. Use of biomarkers to indicate exposure of children to organophosphate pesticides: implications for a longitudinal study of children's environmental health. Environ Health Perspect 111:1939-1946; doi:10.1289/ehp.6179.
47. Zhang X, Driver JH, Li Y, Ross JH, Krieger RI. 2008. Dialkylphosphates (DAPs) in fruits and vegetables may confound biomonitoring in organophosphorus insecticide exposure and risk assessment. J Agric Food Chem 56:10638-10645.