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Volumn 110, Issue 6, 2013, Pages 1250-1258

Co-stimulation with LPS or Poly I:C markedly enhances the anti- platelet immune response and severity of fetal and neonatal alloimmune thrombo cytopenia

Author keywords

3 Integrin; Alloimmune thrombocytopenia; GPIba; Infection; Platelets

Indexed keywords

ANTISERUM; BETA3 INTEGRIN; GLYCOPROTEIN IB ALPHA; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LIPOPOLYSACCHARIDE; LIPOTEICHOIC ACID; POLYINOSINIC POLYCYTIDYLIC ACID; THROMBOCYTE ANTIBODY; THROMBOCYTE ANTIGEN;

EID: 84888393657     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH13-04-0354     Document Type: Article
Times cited : (21)

References (50)
  • 2
    • 38849170472 scopus 로고    scopus 로고
    • Fetal and neonatal alloimmune thrombocytopenia: Progress and ongoing debates
    • Bussel JB, and Primiani A. Fetal and neonatal alloimmune thrombocytopenia: progress and ongoing debates. Blood Rev 2008; 22: 33-52.
    • (2008) Blood Rev , vol.22 , pp. 33-52
    • Bussel, J.B.1    Primiani, A.2
  • 3
    • 34248209254 scopus 로고    scopus 로고
    • Foetal and neonatal alloimmune thrombocytopaenia
    • Kaplan C. Foetal and neonatal alloimmune thrombocytopaenia. Orphanet J Rare Dis 2006; 1: 39.
    • (2006) Orphanet J Rare Dis , vol.1 , pp. 39
    • Kaplan, C.1
  • 4
    • 79953067695 scopus 로고    scopus 로고
    • Prediction of the fetal status in noninvasive management of alloimmune thrombocytopenia
    • Bertrand G, Drame M, Martageix C, et al. Prediction of the fetal status in noninvasive management of alloimmune thrombocytopenia. Blood 2011; 117: 3209-3213.
    • (2011) Blood , vol.117 , pp. 3209-3213
    • Bertrand, G.1    Drame, M.2    Martageix, C.3
  • 5
    • 0024523915 scopus 로고
    • 348 cases of suspected neonatal alloimmune thrombocytopenia
    • Mueller-Eckhardt C, Kiefel V, Grubert A, et al. 348 cases of suspected neonatal alloimmune thrombocytopenia. Lancet 1989; 1: 363-366.
    • (1989) Lancet , vol.1 , pp. 363-366
    • Mueller-Eckhardt, C.1    Kiefel, V.2    Grubert, A.3
  • 6
    • 33644795691 scopus 로고    scopus 로고
    • Prospective epidemiologic study of the outcome and cost-effectiveness of antenatal screening to detect neonatal alloimmune thrombocytopenia due to anti-HPA-1a
    • Turner ML, Bessos H, Fagge T, et al. Prospective epidemiologic study of the outcome and cost-effectiveness of antenatal screening to detect neonatal alloimmune thrombocytopenia due to anti-HPA-1a. Transfusion 2005; 45: 1945-1956.
    • (2005) Transfusion , vol.45 , pp. 1945-1956
    • Turner, M.L.1    Bessos, H.2    Fagge, T.3
  • 7
    • 44949096249 scopus 로고    scopus 로고
    • A prospective study of maternal anti-HPA 1a antibody level as a potential predictor of alloimmune thrombocytopenia in the newborn
    • Killie MK, Husebekk A, Kjeldsen-Kragh J, et al. A prospective study of maternal anti-HPA 1a antibody level as a potential predictor of alloimmune thrombocytopenia in the newborn. Haematologica 2008; 93: 870-877.
    • (2008) Haematologica , vol.93 , pp. 870-877
    • Killie, M.K.1    Husebekk, A.2    Kjeldsen-Kragh, J.3
  • 8
    • 0032190241 scopus 로고    scopus 로고
    • The natural history of fetomaternal alloimmunization to the platelet-specific antigen HPA-1a (PlA1, Zwa) as determined by antenatal screening
    • Williamson LM, Hackett G, Rennie J, et al. The natural history of fetomaternal alloimmunization to the platelet-specific antigen HPA-1a (PlA1, Zwa) as determined by antenatal screening. Blood 1998; 92: 2280-2287.
    • (1998) Blood , vol.92 , pp. 2280-2287
    • Williamson, L.M.1    Hackett, G.2    Rennie, J.3
  • 9
    • 0030457521 scopus 로고    scopus 로고
    • Severe fetomaternal alloimmune thrombocytopenia presenting with fetal hydrocephalus
    • Murphy MF, Hambley H, Nicolaides K, et al. Severe fetomaternal alloimmune thrombocytopenia presenting with fetal hydrocephalus. Prenat Diagn 1996; 16: 1152-1155.
    • (1996) Prenat Diagn , vol.16 , pp. 1152-1155
    • Murphy, M.F.1    Hambley, H.2    Nicolaides, K.3
  • 10
    • 0036851876 scopus 로고    scopus 로고
    • Platelets in atherothrombosis
    • Ruggeri ZM. Platelets in atherothrombosis. Nat Med 2002; 8: 1227-1234.
    • (2002) Nat Med , vol.8 , pp. 1227-1234
    • Ruggeri, Z.M.1
  • 11
    • 84874876447 scopus 로고    scopus 로고
    • Platelets in thrombosis and hemostasis: Old topic with new mechanisms
    • Wang Y, Andrews M, Yang Y, et al. Platelets in thrombosis and hemostasis: old topic with new mechanisms. Cardiovasc Hematol Disord Drug Targets 2012; 12: 126-132.
    • (2012) Cardiovasc Hematol Disord Drug Targets , vol.12 , pp. 126-132
    • Wang, Y.1    Andrews, M.2    Yang, Y.3
  • 12
    • 0025904579 scopus 로고
    • GPIIb-IIIa: The responsive integrin
    • and Scarborough RM
    • Phillips DR, Charo IF and Scarborough RM. GPIIb-IIIa: the responsive integrin. Cell 1991; 65: 359-362.
    • (1991) Cell , vol.65 , pp. 359-362
    • Phillips, D.R.1    Charo, I.F.2
  • 13
    • 0030748125 scopus 로고    scopus 로고
    • Mechanisms initiating platelet thrombus formation
    • Ruggeri ZM. Mechanisms initiating platelet thrombus formation. Thromb Haemost 1997; 78: 611-616.
    • (1997) Thromb Haemost , vol.78 , pp. 611-616
    • Ruggeri, Z.M.1
  • 14
    • 0026580102 scopus 로고
    • Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane
    • Modderman PW, Admiraal LG, Sonnenberg A, et al. Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane. J Biol Chem 1992; 267: 364-369.
    • (1992) J Biol Chem , vol.267 , pp. 364-369
    • Modderman, P.W.1    Admiraal, L.G.2    Sonnenberg, A.3
  • 15
    • 0029763215 scopus 로고    scopus 로고
    • Analysis of GPIIb/IIIa receptor number by quantification of 7E3 binding to human platelets
    • Wagner CL, Mascelli MA, Neblock DS, et al. Analysis of GPIIb/IIIa receptor number by quantification of 7E3 binding to human platelets. Blood 1996; 88: 907-914.
    • (1996) Blood , vol.88 , pp. 907-914
    • Wagner, C.L.1    Mascelli, M.A.2    Neblock, D.S.3
  • 16
    • 80555134759 scopus 로고    scopus 로고
    • The maternal immune response to fetal platelet GPIbalpha causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies
    • Li C, Piran S, Chen P, et al. The maternal immune response to fetal platelet GPIbalpha causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies. J Clin Invest 2011; 121: 4537-4547.
    • (2011) J Clin Invest , vol.121 , pp. 4537-4547
    • Li, C.1    Piran, S.2    Chen, P.3
  • 17
    • 14644389506 scopus 로고    scopus 로고
    • Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice
    • Tong MH, Jiang H, Liu P, et al. Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice. Nat Med 2005; 11: 153-159.
    • (2005) Nat Med , vol.11 , pp. 153-159
    • Tong, M.H.1    Jiang, H.2    Liu, P.3
  • 18
    • 34648836081 scopus 로고    scopus 로고
    • Immune thrombocytopenic purpura in adults
    • Godeau B, Provan D and Bussel J. Immune thrombocytopenic purpura in adults. Curr Opin Hematol 2007; 14: 535-556.
    • (2007) Curr Opin Hematol , vol.14 , pp. 535-556
    • Godeau, B.1    Provan, D.2    Bussel, J.3
  • 19
    • 69249240344 scopus 로고    scopus 로고
    • The ITP syndrome: Pathogenic and clinical diversity
    • Cines DB, Bussel JB, Liebman HA, et al. The ITP syndrome: pathogenic and clinical diversity. Blood 2009; 113: 6511-6521.
    • (2009) Blood , vol.113 , pp. 6511-6521
    • Cines, D.B.1    Bussel, J.B.2    Liebman, H.A.3
  • 20
    • 13144254201 scopus 로고    scopus 로고
    • Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori
    • Gasbarrini A, Franceschi F, Tartaglione R, et al. Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori. Lancet 1998; 352: 878.
    • (1998) Lancet , vol.352 , pp. 878
    • Gasbarrini, A.1    Franceschi, F.2    Tartaglione, R.3
  • 21
    • 1642459370 scopus 로고    scopus 로고
    • Does Helicobater pylori initiate or perpetuate immune thrombocytopenic purpura?
    • Michel M, Cooper N, Jean C, et al. Does Helicobater pylori initiate or perpetuate immune thrombocytopenic purpura? Blood 2004; 103: 890-896.
    • (2004) Blood , vol.103 , pp. 890-896
    • Michel, M.1    Cooper, N.2    Jean, C.3
  • 22
    • 78149300934 scopus 로고    scopus 로고
    • Animal model of fetal and neonatal immune thrombocytopenia: Role of neonatal Fc receptor in the pathogenesis and therapy
    • Chen P, Li C, Lang S, et al. Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy. Blood 2010; 116: 3660-3668.
    • (2010) Blood , vol.116 , pp. 3660-3668
    • Chen, P.1    Li, C.2    Lang, S.3
  • 23
    • 0031822072 scopus 로고    scopus 로고
    • Clinical aspects and typing of platelet alloantigens
    • Kroll H, Kiefel V and Santoso S. Clinical aspects and typing of platelet alloantigens. Vox Sang 1998; 74 (Suppl 2): 345-354.
    • (1998) Vox Sang , vol.74 , Issue.SUPPL. 2 , pp. 345-354
    • Kroll, H.1    Kiefel, V.2    Santoso, S.3
  • 24
    • 70449669099 scopus 로고    scopus 로고
    • Antiplatelet antibodies in chronic immune thrombocytopenia and their role in platelet destruction and defective platelet production
    • McMillan R. Antiplatelet antibodies in chronic immune thrombocytopenia and their role in platelet destruction and defective platelet production. Hematol Oncol Clin North Am 2009; 23: 1163-1175.
    • (2009) Hematol Oncol Clin North Am , vol.23 , pp. 1163-1175
    • McMillan, R.1
  • 25
    • 0023936489 scopus 로고
    • Neonatal alloimmune amegakaryocytosis. Case report
    • Bizzaro N and Dianese G. Neonatal alloimmune amegakaryocytosis. Case report. Vox Sang 1988; 54: 112-114.
    • (1988) Vox Sang , vol.54 , pp. 112-114
    • Bizzaro, N.1    Dianese, G.2
  • 26
    • 0037608940 scopus 로고    scopus 로고
    • Neonatal alloimmune thrombocytopenia due to anti-HPA-2b (anti-Koa)
    • Goldman M, Trudel E, Richard L, et al. Neonatal alloimmune thrombocytopenia due to anti-HPA-2b (anti-Koa). Immunohematology 2003; 19: 43-46.
    • (2003) Immunohematology , vol.19 , pp. 43-46
    • Goldman, M.1    Trudel, E.2    Richard, L.3
  • 27
    • 0028793552 scopus 로고
    • Alloimmunization against Iy, a lowfrequency antigen on platelet glycoprotein Ib/IX as a cause of severe neonatal alloimmune thrombocytopenic purpura
    • Kiefel V, Vicariot M, Giovangrandi Y, et al. Alloimmunization against Iy, a lowfrequency antigen on platelet glycoprotein Ib/IX as a cause of severe neonatal alloimmune thrombocytopenic purpura. Vox Sang 1995; 69: 250-254.
    • (1995) Vox Sang , vol.69 , pp. 250-254
    • Kiefel, V.1    Vicariot, M.2    Giovangrandi, Y.3
  • 28
    • 0032590042 scopus 로고    scopus 로고
    • Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
    • Hodivala-Dilke KM, McHugh KP, Tsakiris DA, et al. Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest 1999; 103: 229-238.
    • (1999) J Clin Invest , vol.103 , pp. 229-238
    • Hodivala-Dilke, K.M.1    McHugh, K.P.2    Tsakiris, D.A.3
  • 29
    • 0034646267 scopus 로고    scopus 로고
    • Generation and rescue of a murine model of platelet dysfunction: The Bernard-Soulier syndrome
    • Ware J, Russell S and Ruggeri ZM. Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndrome. Proc Natl Acad Sci USA 2000; 97: 2803-2808.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2803-2808
    • Ware, J.1    Russell, S.2    Ruggeri, Z.M.3
  • 30
    • 67651098995 scopus 로고    scopus 로고
    • Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression
    • Yang H, Lang S, Zhai Z, et al. Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression. Blood 2009; 114: 425-436.
    • (2009) Blood , vol.114 , pp. 425-436
    • Yang, H.1    Lang, S.2    Zhai, Z.3
  • 31
    • 30444436765 scopus 로고    scopus 로고
    • Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factoralpha production in vivo
    • Aslam R, Speck ER, Kim M, et al. Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factoralpha production in vivo. Blood 2006; 107: 637-641.
    • (2006) Blood , vol.107 , pp. 637-641
    • Aslam, R.1    Speck, E.R.2    Kim, M.3
  • 32
    • 33646539166 scopus 로고    scopus 로고
    • Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver
    • Gustot T, Lemmers A, Moreno C, et al. Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver. Hepatology 2006; 43: 989-1000.
    • (2006) Hepatology , vol.43 , pp. 989-1000
    • Gustot, T.1    Lemmers, A.2    Moreno, C.3
  • 33
    • 80052611973 scopus 로고    scopus 로고
    • Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity
    • Lin AC, Dissanayake D, Dhanji S, et al. Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity. PLoS One 2011; 6: e23940.
    • (2011) PLoS One , vol.6
    • Lin, A.C.1    Dissanayake, D.2    Dhanji, S.3
  • 34
    • 33645531319 scopus 로고    scopus 로고
    • A novel murine model of fetal and neonatal alloimmune thrombocytopenia: Response to intravenous IgG therapy
    • Ni H, Chen P, Spring CM, et al. A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy. Blood 2006; 107: 2976-2983.
    • (2006) Blood , vol.107 , pp. 2976-2983
    • Ni, H.1    Chen, P.2    Spring, C.M.3
  • 35
    • 84863802865 scopus 로고    scopus 로고
    • Toward a prophylaxis against fetal and neonatal alloimmune thrombocytopenia: Induction of antibody-mediated immune suppression and prevention of severe clinical complications in a murine model
    • Tiller H, Killie MK, Chen P, et al. Toward a prophylaxis against fetal and neonatal alloimmune thrombocytopenia: induction of antibody-mediated immune suppression and prevention of severe clinical complications in a murine model. Transfusion 2012; 52: 1446-1457.
    • (2012) Transfusion , vol.52 , pp. 1446-1457
    • Tiller, H.1    Killie, M.K.2    Chen, P.3
  • 36
    • 0029051295 scopus 로고
    • Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development
    • Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, et al. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell 1995; 81: 695-704.
    • (1995) Cell , vol.81 , pp. 695-704
    • Shivdasani, R.A.1    Rosenblatt, M.F.2    Zucker-Franklin, D.3
  • 38
    • 80555136383 scopus 로고    scopus 로고
    • Association between recurrent pregnancy loss and prothrombotic gene polymorphisms
    • Lens D, Brugnini A, Trías N, et al. Association between recurrent pregnancy loss and prothrombotic gene polymorphisms. J Thromb Haemost 2003; 1: P0951.
    • (2003) J Thromb Haemost , vol.1
    • Lens, D.1    Brugnini, A.2    Trías, N.3
  • 39
    • 0032880674 scopus 로고    scopus 로고
    • Antepartum diagnosis of fetal intracranial hemorrhage due to maternal Bernard-Soulier syndrome
    • Fujimori K, Ohto H, Honda S, et al. Antepartum diagnosis of fetal intracranial hemorrhage due to maternal Bernard-Soulier syndrome. Obstet Gynecol 1999; 94: 817-819.
    • (1999) Obstet Gynecol , vol.94 , pp. 817-819
    • Fujimori, K.1    Ohto, H.2    Honda, S.3
  • 40
    • 77954837555 scopus 로고    scopus 로고
    • Bernard Soulier syndrome in pregnancy: A systematic review
    • Peitsidis P, Datta T, Pafilis I, et al. Bernard Soulier syndrome in pregnancy: a systematic review. Haemophilia 2010; 16: 584-591.
    • (2010) Haemophilia , vol.16 , pp. 584-591
    • Peitsidis, P.1    Datta, T.2    Pafilis, I.3
  • 41
    • 0036890393 scopus 로고    scopus 로고
    • Protein A immunoadsorption in a pregnant woman with habitual abortion
    • Hickstein H, Barz D, Kulz T, et al. Protein A immunoadsorption in a pregnant woman with habitual abortion. Transfus Apher Sci 2002; 27: 259-261.
    • (2002) Transfus Apher Sci , vol.27 , pp. 259-261
    • Hickstein, H.1    Barz, D.2    Kulz, T.3
  • 42
    • 3042637761 scopus 로고    scopus 로고
    • Prospective screening of 205 patients with ITP, including diagnosis, serological markers, and the relationship between platelet counts, endogenous thrombopoietin, and circulating antithrombopoietin antibodies
    • Aledort LM, Hayward CP, Chen MG, et al. Prospective screening of 205 patients with ITP, including diagnosis, serological markers, and the relationship between platelet counts, endogenous thrombopoietin, and circulating antithrombopoietin antibodies. Am J Hematol 2004; 76: 205-213.
    • (2004) Am J Hematol , vol.76 , pp. 205-213
    • Aledort, L.M.1    Hayward, C.P.2    Chen, M.G.3
  • 43
    • 0032864871 scopus 로고    scopus 로고
    • Immunogenicity of tumor peptides: Importance of peptide length and stability of peptide/MHC class II complex
    • Grohmann U, Belladonna ML, Bianchi R, et al. Immunogenicity of tumor peptides: importance of peptide length and stability of peptide/MHC class II complex. Cancer Immunol Immunother 1999; 48: 195-203.
    • (1999) Cancer Immunol Immunother , vol.48 , pp. 195-203
    • Grohmann, U.1    Belladonna, M.L.2    Bianchi, R.3
  • 44
    • 79953155667 scopus 로고    scopus 로고
    • Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses
    • Freire T, Lo-Man R, Bay S, et al. Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses. J Biol Chem 2011; 286: 7797-7811.
    • (2011) J Biol Chem , vol.286 , pp. 7797-7811
    • Freire, T.1    Lo-Man, R.2    Bay, S.3
  • 45
    • 0037144544 scopus 로고    scopus 로고
    • Crystal structure of the platelet glycoprotein Ib(alpha) N-terminal domain reveals an unmasking mechanism for receptor activation
    • Uff S, Clemetson JM, Harrison T, et al. Crystal structure of the platelet glycoprotein Ib(alpha) N-terminal domain reveals an unmasking mechanism for receptor activation. J Biol Chem 2002; 277: 35657-35663.
    • (2002) J Biol Chem , vol.277 , pp. 35657-35663
    • Uff, S.1    Clemetson, J.M.2    Harrison, T.3
  • 46
    • 0032485487 scopus 로고    scopus 로고
    • Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
    • Albert ML, Sauter B, Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 1998; 392: 86-89.
    • (1998) Nature , vol.392 , pp. 86-89
    • Albert, M.L.1    Sauter, B.2    Bhardwaj, N.3
  • 47
    • 48749092592 scopus 로고    scopus 로고
    • The known unknowns of antigen processing and presentation
    • Vyas JM, Van der Veen AG, Ploegh HL. The known unknowns of antigen processing and presentation. Nat Rev Immunol 2008; 8: 607-618.
    • (2008) Nat Rev Immunol , vol.8 , pp. 607-618
    • Vyas, J.M.1    Van der Veen, A.G.2    Ploegh, H.L.3
  • 48
    • 33751195901 scopus 로고    scopus 로고
    • Maturation of murine bone marrow-derived dendritic cells with poly(I: C) produces altered TLR-9 expression and response to CpG DNA
    • Tsujimoto H, Efron PA, Matsumoto T, et al. Maturation of murine bone marrow-derived dendritic cells with poly(I: C) produces altered TLR-9 expression and response to CpG DNA. Immunol Lett 2006; 107: 155-162.
    • (2006) Immunol Lett , vol.107 , pp. 155-162
    • Tsujimoto, H.1    Efron, P.A.2    Matsumoto, T.3
  • 49
    • 0035865232 scopus 로고    scopus 로고
    • Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2
    • Hertz CJ, Kiertscher SM, Godowski PJ, et al. Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2. J Immunol 2001; 166: 2444-2450.
    • (2001) J Immunol , vol.166 , pp. 2444-2450
    • Hertz, C.J.1    Kiertscher, S.M.2    Godowski, P.J.3
  • 50
    • 34547933129 scopus 로고    scopus 로고
    • A screening and intervention program aimed to reduce mortality and serious morbidity associated with severe neonatal alloimmune thrombocytopenia
    • Kjeldsen-Kragh J, Killie MK, Tomter G, et al. A screening and intervention program aimed to reduce mortality and serious morbidity associated with severe neonatal alloimmune thrombocytopenia. Blood 2007; 110: 833-839.
    • (2007) Blood , vol.110 , pp. 833-839
    • Kjeldsen-Kragh, J.1    Killie, M.K.2    Tomter, G.3


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