Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity

Journal of Natural Products

Volumn 76, Issue 11, 2013, Pages 2080-2087

  Nguyen, Phi Hung ^a   Yang, Jun Li ^b   Uddin, Mohammad N ^a,b   Park, So Lim ^c   Lim, Seong Il ^c   Jung, Da Woon ^d   Williams, Darren R ^d   Oh, Won Keun ^b  

^a Chosun University   (South Korea)

^b Seoul National University   (South Korea)

^c Korea Food Research Institute   (South Korea)

^d Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHOXY 1' CARBOXY 4 ',7 EPOXY 8,3' OXYNEOLIGNAN 4,9 DIOL; 3,4,3 ',4 'TETRAHYDROXY 9,7' BETA EPOXYLIGNANO 7BETA ,9 LACTONE; 3,4,9 TRIHYDROXY 4 ,7 EPOXY 8,3' OXYNEOLIGNAN 1' AL; 3,4,9 TRIHYDROXY 4' 7 EPOXY 8, 3' OXYNEOLIGNAN 7' EN 8 OIC ACID; ANTIDIABETIC AGENT; INSULIN; LIGNAN DERIVATIVE; NEOLIGNAN; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; ROSIGLITAZONE; TRANS (3)E 3 (3,4 DIHYDROXYBENZYLIDENE) 5 (3,4 DIHYDROXYPHENYL) 4 (HYDROXYMETHYL)DIHYDROFURAN 2(3H) ONE; UNCLASSIFIED DRUG;

ADIPOCYTE; ARTICLE; DRUG ACTIVITY; DRUG DETERMINATION; DRUG PURIFICATION; DRUG STRUCTURE; GLUCOSE TRANSPORT; INSULIN MIMETIC ACTIVITY; MORINDA CITRIFOLIA; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POWDER;

3T3-L1 CELLS; 4-CHLORO-7-NITROBENZOFURAZAN; ADIPOCYTES; ANIMALS; DEOXYGLUCOSE; HYPOGLYCEMIC AGENTS; INHIBITORY CONCENTRATION 50; INSULIN; LIGNANS; MICE; MOLECULAR STRUCTURE; MORINDA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLANTS, MEDICINAL; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; REPUBLIC OF KOREA;

EID: 84888390380     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np400533h     Document Type: Article

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