-
1
-
-
62449282062
-
Total chemical synthesis of proteins
-
Kent, S.B.H. Total chemical synthesis of proteins. Chem. Soc. Rev. 38, 338-351 (2009).
-
(2009)
Chem. Soc. Rev.
, vol.38
, pp. 338-351
-
-
Kent, S.B.H.1
-
2
-
-
20544471186
-
Chemical synthesis of proteins
-
Nilsson, B.L., Soellner, M.B. & Raines, R.T. Chemical synthesis of proteins. Annu. Rev. Biophys. Biomol. Struct. 34, 91-118 (2005).
-
(2005)
Annu. Rev. Biophys. Biomol. Struct.
, vol.34
, pp. 91-118
-
-
Nilsson, B.L.1
Soellner, M.B.2
Raines, R.T.3
-
4
-
-
0027944205
-
Synthesis of proteins by native chemical ligation
-
Dawson, P.E., Muir, T.W., Clark-Lewis, I. & Kent, S.B.H. Synthesis of proteins by native chemical ligation. Science 266, 776-779 (1994).
-
(1994)
Science
, vol.266
, pp. 776-779
-
-
Dawson, P.E.1
Muir, T.W.2
Clark-Lewis, I.3
Kent, S.B.H.4
-
5
-
-
33646728877
-
Insights into the mechanism and catalysis of the native chemical ligation reaction
-
Johnson, E.C.B. & Kent, S.B.H. Insights into the mechanism and catalysis of the native chemical ligation reaction. J. Am. Chem. Soc. 128, 6640-6646 (2006).
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 6640-6646
-
-
Johnson, E.C.B.1
Kent, S.B.H.2
-
6
-
-
34250008546
-
In situ neutralization in Boc-chemistry solid phase peptide synthesis
-
Schnolzer, M., Alewood, P., Jones, A., Alewood, D. & Kent, S.B.H. In situ neutralization in Boc-chemistry solid phase peptide synthesis. Int. J. Pept. Res. Ther. 13, 31-44 (2007).
-
(2007)
Int. J. Pept. Res. Ther.
, vol.13
, pp. 31-44
-
-
Schnolzer, M.1
Alewood, P.2
Jones, A.3
Alewood, D.4
Kent, S.B.H.5
-
7
-
-
0033596308
-
Fmoc-based synthesis of peptide-thioesters: Application to the total chemical synthesis of a glycoprotein by native chemical ligation
-
Shin, Y. et al. Fmoc-based synthesis of peptide-thioesters: application to the total chemical synthesis of a glycoprotein by native chemical ligation. J. Am. Chem. Soc. 121, 11684-11689 (1999).
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 11684-11689
-
-
Shin, Y.1
-
8
-
-
0034734354
-
Semisynthesis of hyperphosphorylated type i TGF-β receptor: Addressing the mechanism of kinase activation
-
Huse, M., Holford, M.N., Kuriyan, J. & Muir, T.W. Semisynthesis of hyperphosphorylated type I TGF-β receptor: addressing the mechanism of kinase activation. J. Am. Chem. Soc. 122, 8337-8338 (2000).
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 8337-8338
-
-
Huse, M.1
Holford, M.N.2
Kuriyan, J.3
Muir, T.W.4
-
9
-
-
0039927314
-
Intein-mediated synthesis of proteins containing carbohydrates and other molecular probes
-
Tolbert, T.J. & Wong, C.-H. Intein-mediated synthesis of proteins containing carbohydrates and other molecular probes. J. Am. Chem. Soc. 122, 5421-5428 (2000).
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 5421-5428
-
-
Tolbert, T.J.1
Wong, C.-H.2
-
10
-
-
0033572729
-
Solid phase synthesis of peptide C-terminal thioesters by Fmoc/t-Bu chemistry
-
Ingenito, R., Bianchi, E., Fattori, D. & Pessi, A. Solid phase synthesis of peptide C-terminal thioesters by Fmoc/t-Bu chemistry. J. Am. Chem. Soc. 121, 11369-11374 (1999).
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 11369-11374
-
-
Ingenito, R.1
Bianchi, E.2
Fattori, D.3
Pessi, A.4
-
11
-
-
33846935794
-
Peptide ligation using a building block having a cysteinyl prolyl ester (CPE) autoactivating unit at the carboxy terminus
-
Kawakami, T. & Aimoto, S. Peptide ligation using a building block having a cysteinyl prolyl ester (CPE) autoactivating unit at the carboxy terminus. Chem. Lett. 36, 76-77 (2007).
-
(2007)
Chem. Lett.
, vol.36
, pp. 76-77
-
-
Kawakami, T.1
Aimoto, S.2
-
12
-
-
52449107990
-
An efficient Fmoc-SPPS approach for the generation of thioester peptide precursors for use in native chemical ligation
-
Blanco-Canosa, J.B. & Dawson, P.E. An efficient Fmoc-SPPS approach for the generation of thioester peptide precursors for use in native chemical ligation. Angew. Chem. Int. Ed. 47, 6851-6855 (2008).
-
(2008)
Angew. Chem. Int. Ed.
, vol.47
, pp. 6851-6855
-
-
Blanco-Canosa, J.B.1
Dawson, P.E.2
-
13
-
-
70349931080
-
Fmoc solid-phase synthesis of C-terminal peptide thioesters by formation of a backbone pyroglutamyl imide moiety
-
Tofteng, A.P., Sorensen, K.K., Conde-Frieboes, K.W., Hoeg-Jensen, T. & Jensen, K.J. Fmoc solid-phase synthesis of C-terminal peptide thioesters by formation of a backbone pyroglutamyl imide moiety. Angew. Chem. Int. Ed. 48, 7411-7414 (2009).
-
(2009)
Angew. Chem. Int. Ed.
, vol.48
, pp. 7411-7414
-
-
Tofteng, A.P.1
Sorensen, K.K.2
Conde-Frieboes, K.W.3
Hoeg-Jensen, T.4
Jensen, K.J.5
-
14
-
-
58149471991
-
3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters
-
Kang, J., Richardson, J.P. & Macmillan, D. 3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters. Chem. Commun. 2009, 407-409 (2009).
-
(2009)
Chem. Commun.
, vol.2009
, pp. 407-409
-
-
Kang, J.1
Richardson, J.P.2
MacMillan, D.3
-
15
-
-
62749199817
-
N-to-S acyl-transfer-mediated synthesis of peptide thioesters using anilide derivatives
-
Tsuda, S., Shigenaga, A., Bando, K. & Otaka, A. N-to-S acyl-transfer-mediated synthesis of peptide thioesters using anilide derivatives. Org. Lett. 11, 823-826 (2009).
-
(2009)
Org. Lett.
, vol.11
, pp. 823-826
-
-
Tsuda, S.1
Shigenaga, A.2
Bando, K.3
Otaka, A.4
-
16
-
-
77149155649
-
Chemical protein synthesis by kinetically controlled ligation of peptide O-esters
-
Zheng, J.S., Cui, H.K., Fang, G.M., Xi, W.X. & Liu, L. Chemical protein synthesis by kinetically controlled ligation of peptide O-esters. Chem Bio Chem 11, 511-515 (2010).
-
(2010)
Chem Bio Chem
, vol.11
, pp. 511-515
-
-
Zheng, J.S.1
Cui, H.K.2
Fang, G.M.3
Xi, W.X.4
Liu, L.5
-
17
-
-
78449298462
-
Bis(2-sulfanylethyl)amino native peptide ligation
-
Ollivier, N., Dheur, J., Mhidia, R., Blanpain, A. & Melnyk, O. Bis(2-sulfanylethyl)amino native peptide ligation. Org. Lett. 12, 5238-5241 (2010).
-
(2010)
Org. Lett.
, vol.12
, pp. 5238-5241
-
-
Ollivier, N.1
Dheur, J.2
Mhidia, R.3
Blanpain, A.4
Melnyk, O.5
-
18
-
-
79960594926
-
Fmoc synthesis of peptide thioesters without post-chain-assembly manipulation
-
Zheng, J.S., Chang, H.N., Wang, F.L. & Liu, L. Fmoc synthesis of peptide thioesters without post-chain-assembly manipulation. J. Am. Chem. Soc. 133, 11080-11083 (2011).
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 11080-11083
-
-
Zheng, J.S.1
Chang, H.N.2
Wang, F.L.3
Liu, L.4
-
19
-
-
79961241515
-
Protein chemical synthesis by ligation of peptide hydrazides
-
Fang, G.M. et al. Protein chemical synthesis by ligation of peptide hydrazides. Angew. Chem. Int. Ed. 50, 7645-7649 (2011).
-
(2011)
Angew. Chem. Int. Ed.
, vol.50
, pp. 7645-7649
-
-
Fang, G.M.1
-
20
-
-
84867057855
-
Convergent chemical synthesis of proteins by ligation of peptide hydrazides
-
Fang, G.M., Wang, J.X. & Liu, L. Convergent chemical synthesis of proteins by ligation of peptide hydrazides. Angew. Chem. Int. Ed. 51, 10347-10350 (2012).
-
(2012)
Angew. Chem. Int. Ed.
, vol.51
, pp. 10347-10350
-
-
Fang, G.M.1
Wang, J.X.2
Liu, L.3
-
21
-
-
84863229328
-
Synthesis of cyclic peptides and cyclic proteins via ligation of peptide hydrazides
-
Zheng, J.S., Tang, S., Guo, Y., Chang, H.N. & Liu, L. Synthesis of cyclic peptides and cyclic proteins via ligation of peptide hydrazides. Chem Bio Chem 13, 542-546 (2012).
-
(2012)
Chem Bio Chem
, vol.13
, pp. 542-546
-
-
Zheng, J.S.1
Tang, S.2
Guo, Y.3
Chang, H.N.4
Liu, L.5
-
22
-
-
84876554020
-
Synthesis of cyclic tetrapeptides via ligation of peptide hydrazides
-
Tang, S., Zheng, J.S., Yang, K. & Liu, L. Synthesis of cyclic tetrapeptides via ligation of peptide hydrazides. Acta Chim. Sinica 70, 1471-1476 (2012).
-
(2012)
Acta Chim. Sinica
, vol.70
, pp. 1471-1476
-
-
Tang, S.1
Zheng, J.S.2
Yang, K.3
Liu, L.4
-
23
-
-
84862563295
-
Ligation of expressed protein α-hydrazides via genetic incorporation of an α-hydroxy acid
-
Li, Y.M. et al. Ligation of expressed protein α-hydrazides via genetic incorporation of an α-hydroxy acid. ACS Chem. Biol. 7, 1015-1022 (2012).
-
(2012)
ACS Chem. Biol.
, vol.7
, pp. 1015-1022
-
-
Li, Y.M.1
-
24
-
-
84880816458
-
Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34
-
Siman, P., Karthikeyan, S.V., Nikolov, M., Fischle, W. & Brik, A. Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34. Angew. Chem. Int. Ed. 52, 8059-8063 (2013).
-
(2013)
Angew. Chem. Int. Ed.
, vol.52
, pp. 8059-8063
-
-
Siman, P.1
Karthikeyan, S.V.2
Nikolov, M.3
Fischle, W.4
Brik, A.5
-
25
-
-
84861563520
-
Direct observation of the interconversion of normal and toxic forms of α-synuclein
-
Cremades, N. et al. Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell 149, 1048-1059 (2012).
-
(2012)
Cell
, vol.149
, pp. 1048-1059
-
-
Cremades, N.1
-
26
-
-
84869109864
-
Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
-
Luk, K.C. et al. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 338, 949-953 (2012).
-
(2012)
Science
, vol.338
, pp. 949-953
-
-
Luk, K.C.1
-
27
-
-
84871414210
-
The many faces of α-synuclein: From structure and toxicity to therapeutic target
-
Lashuel, H.A., Overk, C.R., Oueslati, A. & Masliah, E. The many faces of α-synuclein: from structure and toxicity to therapeutic target. Nat. Rev. Neurosci. 14, 38-48 (2013).
-
(2013)
Nat. Rev. Neurosci.
, vol.14
, pp. 38-48
-
-
Lashuel, H.A.1
Overk, C.R.2
Oueslati, A.3
Masliah, E.4
-
28
-
-
77749341497
-
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits α-synuclein oligomerization, and influences synuclein-membrane interactions
-
Paleologou, K.E. et al. Phosphorylation at S87 is enhanced in synucleinopathies, inhibits α-synuclein oligomerization, and influences synuclein-membrane interactions. J. Neurosci. 30, 3184-3198 (2010).
-
(2010)
J. Neurosci.
, vol.30
, pp. 3184-3198
-
-
Paleologou, K.E.1
-
29
-
-
84861064848
-
α-synuclein phosphorylation as a therapeutic target in Parkinson's disease
-
Braithwaite, S.P., Stock, J.B. & Mouradian, M.M. α-Synuclein phosphorylation as a therapeutic target in Parkinson's disease. Rev. Neurosci. 23, 191-198 (2012).
-
(2012)
Rev. Neurosci.
, vol.23
, pp. 191-198
-
-
Braithwaite, S.P.1
Stock, J.B.2
Mouradian, M.M.3
-
30
-
-
84863349141
-
Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125
-
Hejjaoui, M. et al. Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125. J. Am. Chem. Soc. 134, 5196-5210 (2012).
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 5196-5210
-
-
Hejjaoui, M.1
-
31
-
-
37349094422
-
Free-radical-based, specific desulfurization of cysteine: A powerful advance in the synthesis of polypeptides and glycopolypeptides
-
Wan, Q. & Danishefsky, S.J. Free-radical-based, specific desulfurization of cysteine: a powerful advance in the synthesis of polypeptides and glycopolypeptides. Angew. Chem. Int. Ed. 46, 9248-9252 (2007).
-
(2007)
Angew. Chem. Int. Ed.
, vol.46
, pp. 9248-9252
-
-
Wan, Q.1
Danishefsky, S.J.2
-
32
-
-
0034609561
-
Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse α-synuclein
-
Rochet, J.C., Conway, K.A. & Lansbury, P.T. Jr. Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse α-synuclein. Biochemistry 39, 10619-10626 (2000).
-
(2000)
Biochemistry
, vol.39
, pp. 10619-10626
-
-
Rochet, J.C.1
Conway, K.A.2
Lansbury Jr., P.T.3
-
33
-
-
0036462499
-
The uronium/guanidinium peptide coupling reagents: Finally the true uronium salts
-
Carpino, L.A. et al. The uronium/guanidinium peptide coupling reagents: finally the true uronium salts. Angew. Chem. Int. Ed. 41, 441-445 (2002).
-
(2002)
Angew. Chem. Int. Ed.
, vol.41
, pp. 441-445
-
-
Carpino, L.A.1
-
34
-
-
84871578763
-
New TFA-free cleavage and final deprotection in Fmoc solid-phase peptide synthesis: Dilute HCl in fluoro alcohol
-
Palladino, P. & Stetsenko, D.A. New TFA-free cleavage and final deprotection in Fmoc solid-phase peptide synthesis: dilute HCl in fluoro alcohol. Org. Lett. 14, 6346-6349 (2012).
-
(2012)
Org. Lett.
, vol.14
, pp. 6346-6349
-
-
Palladino, P.1
Stetsenko, D.A.2
-
35
-
-
0014772602
-
Color test for detection of free terminal amino groups in solid-phase synthesis of peptides
-
Kaiser, E., Colescot, R.L., Bossinge, C.D. & Cook, P.I. Color test for detection of free terminal amino groups in solid-phase synthesis of peptides. Anal. Biochem. 34, 595-598 (1970).
-
(1970)
Anal. Biochem.
, vol.34
, pp. 595-598
-
-
Kaiser, E.1
Colescot, R.L.2
Bossinge, C.D.3
Cook, P.I.4
|