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Volumn , Issue 4, 2009, Pages 407-409

3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters

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EID: 58149471991     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b815888f     Document Type: Article
Times cited : (82)

References (30)
  • 19
    • 58149462201 scopus 로고    scopus 로고
    • www.neb.com
  • 27
    • 58149470765 scopus 로고    scopus 로고
    • 3 as part of a two-step thioesterification procedure. The glycine thioester so produced was not isolated or used in ligation reactions due to difficulties encountered as a consequence of the two-step procedure adopted, (the S-peptide spontaneously reverted to the N-peptide upon attempted isolation). Neither the potential selectivity of the thioesterification, nor application to recombinant samples was subsequently explored See ESI for experimental details
    • Although the reaction was not successful, when the CPE peptide was later re-prepared with the cysteine residue adjacent to glycine protected with an S-Acm group the desired CPE ligation product was observed and the Ala-MPA thioester could be isolated (after treatment of the CPE peptide with MPA)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.