Fmoc solid-phase synthesis of C-terminal peptide thioesters by formation of a backbone pyroglutamyl imide moiety

Angewandte Chemie - International Edition

Volumn 48, Issue 40, 2009, Pages 7411-7414

  Tofteng, A Pernille ^b   Sørensen, Kasper K ^b   Conde Frieboes, Kilián W ^a   Hoeg Jensen, Thomas ^a   Jensen, Knud J ^b  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Amide activation; Nucleophilic substitution; Peptides; Solid phase synthesis; Thioesters

Indexed keywords

C-TERMINAL PEPTIDES; GENERAL TOOLS; NEW APPROACHES; NEW CONCEPT; NUCLEOPHILIC SUBSTITUTION; PEPTIDE THIOESTERS; PROTECTING GROUP; SOLID-PHASE SYNTHESIS; SYNTHETIC PEPTIDE; THIOESTERS;

AMIDES; AMINES; CHEMICAL ACTIVATION;

PEPTIDES;

9 FLUORENYLMETHOXYCARBONYL; 9-FLUORENYLMETHOXYCARBONYL; FLUORENE DERIVATIVE; IMIDE; PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SYNTHESIS;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORENES; IMIDES; MASS SPECTROMETRY; PEPTIDES;

EID: 70349931080     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200903710     Document Type: Article

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