Does nature click? Theoretical prediction of an enzyme-catalyzed transannular 1,3-dipolar cycloaddition in the biosynthesis of lycojaponicumins A and B

Journal of the American Chemical Society

Volumn 135, Issue 46, 2013, Pages 17638-17642

  Krenske, Elizabeth H ^a   Patel, Ashay ^b   Houk, K N ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; COMPUTATION THEORY; CYCLOADDITION; ENZYMES; FORECASTING; HYDROGEN BONDS; QUANTUM THEORY;

1 ,3-DIPOLAR CYCLOADDITIONS; 1 ,3-DIPOLARCYCLOADDITION; BIOSYNTHETIC PATHWAY; COMPUTATIONAL APPROACH; DIPOLAR CYCLOADDITIONS; QUANTUM-MECHANICAL CALCULATION; SECONDARY METABOLIC PATHWAYS; UNCATALYZED REACTIONS;

DENSITY FUNCTIONAL THEORY;

ALKALOID; ALKALOID DERIVATIVE; HYDROGEN; LYCOJAPONICUMIN A; LYCOJAPONICUMIN B; UNCLASSIFIED DRUG; WATER;

1,3 DIPOLAR CYCLOADDITION; ARTICLE; BIOSYNTHESIS; CATALYSIS; CYCLOADDITION; DENSITY FUNCTIONAL THEORY; HYDROGEN BOND; PREDICTION;

ALKALOIDS; AZABICYCLO COMPOUNDS; BIOCATALYSIS; CYCLIZATION; ENZYMES; MOLECULAR STRUCTURE; QUANTUM THEORY; THERMODYNAMICS;

EID: 84888343954     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja409928z     Document Type: Article

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