A noticeable phenomenon: Thiol terminal PEG enhances the immunogenicity of PEGylated emulsions injected intravenously or subcutaneously into rats

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 3 PART A, 2013, Pages 744-751

  Wang, Chunling ^a   Cheng, Xiaobo ^a   Sui, Yue ^a   Luo, Xiang ^a   Jiang, Gongping ^a   Wang, Yu ^a   Huang, Zhenjun ^a   She, Zhennan ^a   Deng, Yihui ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Accelerated blood clearance; Intravenous injection; PEGylated emulsions; Subcutaneous injection; Thiol groups

Indexed keywords

CARBOXYL GROUP; DISTEAROYLPHOSPHATIDY N ( METHOXY POLYOXYETHYLENE SUCCINYL) ETHANOLAMINE; DISTEAROYLPHOSPHATIDYL N (3 CARBOXYPROPIONYL POLY OXYETHYLENE SUCCINYL) ETHANOLAMINE; DISTEAROYLPHOSPHATIDYL N (AMINE POLY OXYETHYLENE SUCCINYL) ETHANOLAMINE; DISTEAROYLPHOSPHATIDYL N (HYDROXY POLY OXYETHYLENE SUCCINYL) ETHANOLAMINE; DISTEAROYLPHOSPHATIDYL N (THIOL POLY OXYETHYLENE SUCCINYL) ETHANOLAMINE; HYDROXYL GROUP; IMMUNOGLOBULIN M ANTIBODY; MACROGOL DERIVATIVE; NANOCARRIER; THIOL GROUP; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY DETECTION; AREA UNDER THE CURVE; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; CIRCULATION TIME; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG RELEASE; DRUG UPTAKE; FOLLICULAR DENDRITIC CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOSTIMULATION; IN VIVO STUDY; MALE; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PLASMA CLEARANCE; WISTAR RAT; ZETA POTENTIAL;

ACCELERATED BLOOD CLEARANCE; INTRAVENOUS INJECTION; PEGYLATED EMULSIONS; SUBCUTANEOUS INJECTION; THIOL GROUPS;

ANIMALS; DRUG ADMINISTRATION SCHEDULE; DRUG CARRIERS; EMULSIONS; HALF-LIFE; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; MALE; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS;

EID: 84888329659     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.10.002     Document Type: Article

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