Neurotransmitter receptor and regulatory gene expression in peripheral blood of Brazilian drug-naïve first-episode psychosis patients before and after antipsychotic treatment

Psychiatry Research

Volumn 210, Issue 3, 2013, Pages 1290-1292

  Ota, Vanessa Kiyomi ^a   Noto, Cristiano ^a   Gadelha, Ary ^a   Santoro, Marcos Leite ^a   Silva, Patricia Natalia ^a   Melaragno, Maria Isabel ^a   Smith, Marília De Arruda Cardoso ^a   Cordeiro, Quirino ^b   Bressan, Rodrigo Affonseca ^a   Belangero, Sintia Iole ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b IRMANDADE DA SANTA CASA DE MISERICÓRDIA DE SÃO PAULO   (Brazil)

Author keywords

CHRNA3; GABRR2; Schizophrenia

Indexed keywords

NEUROLEPTIC AGENT; NEUROTRANSMITTER RECEPTOR; RISPERIDONE; 4 AMINOBUTYRIC ACID A RECEPTOR; GABRR2 PROTEIN, HUMAN; MESSENGER RNA; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR SUBUNIT ALPHA3;

ADULT; ARTICLE; BLOOD; BRAIN REGION; BRAZILIAN; CLINICAL ARTICLE; CLINICAL GLOBAL IMPRESSION SCALE; CONTROLLED STUDY; DSM-IV; ETHNIC GROUP; FEMALE; GENE CONTROL; GENE EXPRESSION; HUMAN; LYMPHOCYTE; MALE; POLYMERASE CHAIN REACTION; POSITIVE AND NEGATIVE SYNDROME SCALE; PRIORITY JOURNAL; PSYCHOSIS; REGULATORY MECHANISM; SCHIZOPHRENIA; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; YOUNG ADULT; BRAZIL; DOWN REGULATION; DRUG EFFECTS; GENETICS; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; PSYCHOTIC DISORDERS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT OUTCOME;

ADULT; ANTIPSYCHOTIC AGENTS; BRAZIL; DOWN-REGULATION; FEMALE; GENE EXPRESSION; HUMANS; MALE; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; RECEPTORS, GABA-A; RECEPTORS, NEUROTRANSMITTER; RECEPTORS, NICOTINIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISPERIDONE; RNA, MESSENGER; SCHIZOPHRENIA; TREATMENT OUTCOME;

EID: 84888303969     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2013.09.016     Document Type: Article

References (18)

1. Birchwood M., Todd P., Jackson C. Early intervention in psychosis. The critical period hypothesis. British Journal of Psychiatry Supplement 1998, 172:53-59.
2. Boyadjieva N., Varadinova M. Epigenetics of psychoactive drugs. Journal of Pharmacy and Pharmacology 2012, 64:1349-1358.
3. Breuer R., Hamshere M.L., Strohmaier J., Mattheisen M., Degenhardt F., Meier S., Paul T., O'Donovan M.C., Mühleisen T.W., Schulze T.G., Nöthen M.M., Cichon S., Craddock N., Rietschel M. Independent evidence for the selective influence of GABA(A) receptors on one component of the bipolar disorder phenotype. Molecular Psychiatry 2011, 16:587-589.
4. Fatemi S.H., Folsom T.D., Rooney R.J., Thuras P.D. mRNA and protein expression for novel GABAA receptors θ and ρ2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway. Translational Psychiatry 2013, 3:e271.
5. Gladkevich A., Kauffman H.F., Korf J. Lymphocytes as a neural probe: potential for studying psychiatric disorders. Progress in Neuro-psychopharmacology and Biological Psychiatry 2004, 28:559-576.
6. Ho B.C., Andreasen N.C., Nopoulos P., Arndt S., Magnotta V., Flaum M. Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia. Archives of General Psychiatry 2003, 60:585-594.
7. Kumarasinghe N., Beveridge N.J., Gardiner E., Scott R.J., Yasawardene S., Perera A., Mendis J., Suriyakumara K., Schall U., Tooney P.A. Gene expression profiling in treatment-naive schizophrenia patients identifies abnormalities in biological pathways involving AKT1 that are corrected by antipsychotic medication. International Journal of Neuropsychopharmacology 2013, 16:1483-1503.
8. Kuzman M.R., Medved V., Terzic J., Krainc D. Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia. Journal of Psychiatric Research 2009, 43:1073-1077.
9. Lee J., Goh L.K., Chen G., Verma S., Tan C.H., Lee T.S. Analysis of blood-based gene expression signature in first-episode psychosis. Psychiatry Research 2012, 200:52-54.
10. Lewis C.M., Levinson D.F., Wise L.H., DeLisi L.E., Straub R.E., Hovatta I., Williams N.M., Schwab S.G., Pulver A.E., Faraone S.V., Brzustowicz L.M., Kaufmann C.A., Garver D.L., Gurling H.M., Lindholm E., Coon H., Moises H.W., Byerley W., Shaw S.H., Mesen A., Sherrington R., O'Neill F.A., Walsh D., Kendler K.S., Ekelund J., Paunio T., Lonnqvist J., Peltonen L., O'Donovan M.C., Owen M.J., Wildenauer D.B., Maier W., Nestadt G., Blouin J.L., Antonarakis S.E., Mowry B.J., Silverman J.M., Crowe R.R., Cloninger C.R., Tsuang M.T., Malaspina D., Harkavy-Friedman J.M., Svrakic D.M., Bassett A.S., Holcomb J., Kalsi G., McQuillin A., Brynjolfson J., Sigmundsson T., Petursson H., Jazin E., Zoega T., Helgason T. Genome scan meta-analysis of schizophrenia and bipolar disorder part II: schizophrenia. American Journal of Human Genetics 2003, 73:34-48.
11. Middleton F.A., Pato C.N., Gentile K.L., McGann L., Brown A.M., Trauzzi M., Diab H., Morley C.P., Medeiros H., Macedo A., Azevedo M.H., Pato M.T. Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2005, 136B:12-25.
12. Onwumere J., Bebbington P., Kuipers E. Family interventions in early psychosis: specificity and effectiveness. Epidemiology and Psychiatric Sciences 2011, 20:113-119.
13. Petrovsky N., Quednow B.B., Ettinger U., Schmechtig A., Mossner R., Collier D.A., Kuhn K.U., Maier W., Wagner M., Kumari V. Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers. Neuropsychopharmacology 2010, 35:1429-1439.
14. Polesskaya O.O., Sokolov B.P. Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. Journal of Neuroscience Research 2002, 67:812-822.
15. Sequeira P.A., Martin M.V., Vawter M.P. The first decade and beyond of transcriptional profiling in schizophrenia. Neurobiology of Disease 2012, 45:23-36.
16. Sullivan P.F., Fan C., Perou C.M. Evaluating the comparability of gene expression in blood and brain. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2006, 141B:261-268.
17. Takahashi M., Hayashi H., Watanabe Y., Sawamura K., Fukui N., Watanabe J., Kitajima T., Yamanouchi Y., Iwata N., Mizukami K., Hori T., Shimoda K., Ujike H., Ozaki N., Iijima K., Takemura K., Aoshima H., Someya T. Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures. Schizophrenia Research 2010, 119:210-218.
18. Zhang H.X., Zhao J.P., Lv L.X., Li W.Q., Xu L., Ouyang X., Yuan Z.Q., Huang J.S. Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia. Neuroscience Letters 2008, 438:1-5.