Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia

Journal of Psychiatric Research

Volumn 43, Issue 13, 2009, Pages 1073-1077

  Kuzman, Martina Rojnic ^a   Medved, Vesna ^a   Terzic, Janos ^b   Krainc, Dimitri ^c,d  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b UNIVERSITY OF SPLIT   (Croatia)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d Mediterranean Institute for Life Sciences   (Croatia)

Author keywords

Biomarkers; Blood; DAAM2; Gene expression; Schizophrenia

Indexed keywords

ACTIN ASSEMBLY FACTOR; BETA CATENIN; BIOLOGICAL MARKER; GENE PRODUCT; GLUCOSE TRANSPORTER 3; METALLOPROTEINASE; MYOSIN; MYOSIN C; NEUROLEPTIC AGENT; NEUROLYSIN; NEUROLYSIN 1; RING FINGER PROTEIN; UNCLASSIFIED DRUG; ZINC METALLOPROTEINASE;

ADULT; AGE; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE COURSE; EDUCATIONAL STATUS; FAMILY HISTORY; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MOLECULAR PROBE; POSITIVE AND NEGATIVE SYNDROME SCALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSYCHOSIS; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SEX DIFFERENCE; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ANTIPSYCHOTIC AGENTS; BIOLOGICAL MARKERS; CARBOXYPEPTIDASE H; CASE-CONTROL STUDIES; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; GLUCOSE TRANSPORTER TYPE 3; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LONGITUDINAL STUDIES; MALE; METALLOENDOPEPTIDASES; MYOSIN TYPE III; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RETROSPECTIVE STUDIES; SCHIZOPHRENIA; YOUNG ADULT;

EID: 68949213816     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2009.03.005     Document Type: Article

References (30)

1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. (1994), American Psychiatric Association, Washington, DC p. 285-6
2. Andreasen N.C., Carpenter W.T., Kane J.M., Lasser R.A., Marder S.R., and Weinberger D.R. Remission in schizophrenia: proposed criteria and rationale for consensus. American Journal of Psychiatry 162 (2005) 441-449
3. Benes F.M. Emerging principles of altered neural circuitry in schizophrenia. Brain Research Reviews 31 2-3 (2000) 251-269
4. Callicott J.H., Mattay V.S., Bertolino A., Finn K., Coppola R., Frank J.A., et al. Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cerebral Cortex 9 (1999) 20-26
5. Colantuoni C., Hyde T.M., Mitkus S., Joseph A., Sartorius L., Aguirre C., et al. Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex. Brain Structure and Function May 10 (2008) [Epub ahead of print]
6. Farrow T.F., Whitford T.J., Williams L.M., Gomes L., and Harris A.W. Diagnosis-related regional gray matter loss over two years in first episode schizophrenia and bipolar disorder. Biological Psychiatry 58 (2005) 713-723
7. Fenton W.S., Hibbeln J., and Knable M. Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia. Biological Psychiatry 47 (2000) 8-21 [Review]
8. Gentleman R.C., Carey V.J., Bates D.M., Bolstad B., Dettling M., Dudoit S., et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biology 5 (2004) R80
9. Gladkevich A., Kauffman H.F., and Korf J. Lymphocytes as a neural probe: potential for studying psychiatric disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry 28 (2004) 559-576
10. Glatt S.J., Everall I.P., Kremen W.S., Corbeil J., Sásik R., Khanlou N., et al. Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia. PNAS 102 (2005) 15533-15538
11. Kakiuchi C., Ishiwata M., Nanko S., Ozaki N., Iwata N., Umekage T., et al. l. Up-Regulation of ADM and SEPX1 in the lymphoblastoid cells of patients in monozygotic twins discordant for Schizophrenia. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: the Official Publication of the International Society of Psychiatric Genetics 147B (2008) 557-564
12. Kane J.M., Leucht S., Caprenter D., and Docherty J.P. Expert consensus guidelines series: optimizing pharmacologic treatment of psychotic disorders. The Journal of Clinical Psychiatry 64 Suppl 12 (2003) 21-51
13. Kay S.R., Fiszbein A., and Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13 (1987) 261-276
14. Kida Y., Shiraishi T., and Ogura T. Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system. Brain Research. Developmental Brain Research 153 (2004) 143-150
15. Ludwig J.A., and Weinstein J.N. Biomarkers in cancer staging, prognosis and treatment selection. Nature reviews. Cancer 5 (2005) 845-856
16. Middleton F.A., Pato C.N., Gentile K.L., McGann L., Brown A.M., Trauzzi M., et al. l. Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals point of convergence between genetic and functional genomic approaches. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: the Official Publication of the International Society of Psychiatric Genetics 136B (2005) 12-25
17. Mirnics K., Middleton F.A., Lewis D.A., and Levitt P. Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse. Trends in Neurosciences 24 (2001) 479-486
18. Numata S., Ueno S., Iga J., Yamauchi K., Hongwei S., Hashimoto R., et al. Gene expression in the peripheral leukocytes and association analysis of PDLIM5 gene in schizophrenia. Neuroscience Letters 415 (2007) 28-33
19. Numata S., Ueno S., Iga J., Yamauchi K., Hongwei S., Hashimoto R., et al. TGFBR2 gene expression and genetic association with schizophrenia. Journal of Psychiatric Research 42 (2008) 425-432
20. Parikh V., Evans D.R., Khan M.M., and Mahadik S.P. Nerve growth factor in never-medicated first-episode psychotic and medicated chronic schizophrenic patients: possible implications for treatment outcome. Schizophrenia Research 60 (2003) 117-123
21. Pollio G., Hoozemans J.J., Andersen C.A., Roncarati R., Rosi M.C., van Haastert E.S., et al. Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Aβ toxicity. Neurobiology of Disease 31 1 (2008) 145-158
22. Proitsi P., Li T., Hamilton G., Di Forti M., Collier D., Killick R., et al. Positional pathway screen of wnt signaling genes in schizophrenia: association with DKK4. Biological Psychiatry 63 (2008) 13-16
23. Sadock B.J., and Sadock V.A. Kaplan & Sadock's synopsis of psychiatry: behavioral sciences/clinical psychiatry. 9th ed. (2003), Lippincott Williams and Wilkins, Philadelphia p. 471-504
24. Shapiro R.M. Regional neuropathology in schizophrenia: where are we? Where are we going?. Schizophrenia Research 10 (1993) 187-239.9
25. Stahl S.M. Essential psychopharmacology, neuroscientific basis and practical applications. 2nd ed. (2000), Cambridge University Press
26. Suzuki K., Nakamura K., Iwata Y., Sekine Y., Kawai M., Sugihara G., et al. Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients. Schizophrenia Research 98 (2008) 148-156
27. Tsuang M.T., Nossova N., Yager T., Tsuang M.M., Guo S.C., Shyu K.G., et al. Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: a preliminary report. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: the Official Publication of the International Society of Psychiatric Genetics 133B (2005) 1-5
28. Vawter M.P., Ferran E., Galke B., Cooper K., Bunney W.E., and Byerley W. Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigree. Schizophrenia Research 67 (2004) 41-52
29. Zhang H.X., Zhao J.P., Lv L.X., Li W.Q., Xu L., Ouyang X., et al. Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia. Neuroscience Letters 438 (2008) 1-5
30. Zvara A., Szekeres G., Janka Z., Kelemen J.Z., Cimmer C., Sántha M., et al. Over-expression of dopamine D2 receptor and inwardly rectifying potassium channel genes in drug-naive schizophrenic peripheral blood lymphocytes as potential diagnostic markers. Disease Markers 21 (2005) 61-69