Chronic treatment with coenzyme Q10 reverses restraint stress-induced anhedonia and enhances brain mitochondrial respiratory chain and creatine kinase activities in rats

Behavioural Pharmacology

Volumn 24, Issue 7, 2013, Pages 552-560

  Aboul Fotouh, Sawsan ^a  

^a Ain Shams University   (Egypt)

Author keywords

Coenzyme Q10; Depression; Frontal cortex; Hippocampus; Mitochondrial dysfunction; Rat, sucrose preference test

Indexed keywords

CREATINE KINASE; CYTOCHROME C OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIDECARENONE; UBIQUINOL CYTOCHROME C REDUCTASE; ANTIOXIDANT; SUCROSE; UBIQUINONE;

ADRENAL GLAND; ANHEDONIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN HOMOGENATE; BRAIN MITOCHONDRION; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENERGY; ENZYME ACTIVITY; FLUID INTAKE; FOOD INTAKE; FOOD PREFERENCE; FRONTAL CORTEX; HIPPOCAMPUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILIZATION STRESS; MAJOR DEPRESSION; MALE; NONHUMAN; ORGAN WEIGHT; RAT; RESPIRATORY CHAIN; SUGAR INTAKE; WEIGHT REDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; DEPRESSION; DISEASE MODEL; DRUG EFFECTS; ELECTRON TRANSPORT; EXERCISE; MENTAL STRESS; METABOLISM; MITOCHONDRION; WISTAR RAT;

ANHEDONIA; ANIMALS; ANTIOXIDANTS; BRAIN; CREATINE KINASE; DEPRESSION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT; MALE; MITOCHONDRIA; RATS; RATS, WISTAR; RESTRAINT, PHYSICAL; STRESS, PSYCHOLOGICAL; SUCROSE; UBIQUINONE;

EID: 84888300387     PISSN: 09558810     EISSN: 14735849     Source Type: Journal    
DOI: 10.1097/FBP.0b013e3283654029     Document Type: Article

References (62)

1. Aboul-Fotouh S (2013). Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats. Pharmacol Biochem Behav 104:105-112.
2. Adam-Vizi V (2005). Production of reactive oxygen species in brain mitochondria: contribution by electron transport chain and non-electron transport chain sources. Antioxid Redox Signal 7:1140-1149.
3. Aksenov M, Aksenova M, Butterfield A, Markesbery WR (2000). Oxidative modification of creatine kinase BB in Alzheimers disease brain. J Neurochem 74:2520-2527.
4. Anglin RE, Tarnopolsky MA, Mazurek MF, Rosebush PI (2012a). The psychiatric presentation of mitochondrial disorders in adults. J Neuropsychiatry Clin Neurosci 24:1-16.
5. Anglin RE, Rosebush PI, Noseworthy MD, Tarnopolsky M, Mazurek MF (2012b). Psychiatric symptoms correlate with metabolic indices in the hippocampus and cingulate in patients with mitochondrial disorders. Transl Psychiatry 13:e187.
6. Anglin RE, Garside SL, Tarnopolsky MA, Mazurek MF, Rosebush PI (2012c). The psychiatric manifestations of mitochondrial disorders: A case and review of the literature. J Clin Psychiatry 73:506-512.
7. Armario A, Garća-Marquez C, Giralt M (1988). Previous chronic chlorimipramine treatment did not modify some physiological responses to acute and chronic stress in rats. Psychopharmacology (Berl) 94:217-220.
8. Beal MF (2002). Coenzyme Q10 as a possible treatment for neurodegenerative diseases. Free Radic Res 36:455-460.
9. Blass JP (2001). Brain metabolism and brain disease: Is metabolic deficiency the proximate cause of Alzheimer dementia J Neurosci Res 66:851-856.
10. Boekema EJ, Braun HP (2007). Supramolecular structure of the mitochondrial oxidative phosphorylation system. J Biol Chem 282:1-4.
11. Bravo JA, D́az-Veliz G, Mora S, Ulloa JL, Berthoud VM, Morales P, et al. (2009). Desipramine prevents stress-induced changes in depressive-like behavior and hippocampal markers of neuroprotection. Behav Pharmacol 20: 273-285.
12. Brennan WA, Bird ED, Aprille JR (1985). Regional mitochondrial respiratory activity in Huntingtons disease brain. J Neurochem 44:1948.
13. Burigo M, Roza CA, Bassani C, Feier G, Dal-Pizzol F, Quevedo J, Streck EL (2006). Decreased creatine kinase activity caused by electroconvulsive shock. Neurochem Res 31:877-881.
14. Cataldo AM, McPhie DL, Lange NT, Punzell S, Elmiligy S, Ye NZ (2010). Abnormalities in mitochondrial structure in cells from patients with bipolar disorder. Am J Pathol 177:575-585.
15. Chew G, Watts G (2004). Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the recoupling hypotheses. Int J Med 97:537-548.
16. Chiba S, Numakawa T, Ninomiya M, Richards MC, Wakabayashi C, Kunugi H (2012). Chronic restraint stress causes anxiety-and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry 39:112-119.
17. Crane FL (2001). Biochemical functions of coenzyme Q10. J Am Coll Nutr 20:591-598.
18. Dallner G, Sindelar PJ (2000). Regulation of ubiquinone metabolism. Free Radic Biol Med 29:285-294.
19. El-Sheikh AAK, Morsy MA, Mahmoud MM, Rifaai RA, Abdelrahman AM (2012). Effect of coenzyme-Q10 on doxorubicin-induced nephrotoxicity in rats. Adv Pharmacol Sci 2012:981461.
20. Fischer JC, RuitenbeekW, Berden JA, Trijbels JM, Veerkamp JH, Stadhouders AM (1985). Differential investigation of the capacity of succinate oxidation in human skeletal muscle. Clin Chim Acta 153:23-26.
21. Forester BP, Zuo CS, Ravichandran C, Harper DG, Du F, Kim S (2012). Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression. J Geriatr Psychiatry Neurol 25:43-50.
22. Gardner A, Boles RG (2008a). Symptoms of somatization as a rapid screening tool for mitochondrial dysfunction in depression. Biopsychosoc Med 2:7.
23. Gardner A, Boles RG (2008b). Mitochondrial energy depletion in depression with somatization. Psychother Psychosom 77:127-129.
24. Gardner A, Johansson A, Wibom R, Nennesmo I, Von Dobeln U, Hagenfeldt L, Hallstrom T (2003). Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients. J Affect Disord 76:55-68.
25. Gong Y, Chai Y, Ding JH, Sun XL, Hu G (2011). Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain. Neurosci Lett 488:76-80.
26. Hargreaves IP, Lane A, Sleiman PM (2008). The coenzyme Q10 status of the brain regions of Parkinsons disease patients. Neurosci Lett 447:17-19.
27. Hosoe K, Kitano M, Kishida H, Kubo H, Fujii K, Kitahaara M (2007). Study on safety and bioavailability of ubiquinol (Kaneka QHTM) after single and 4-week multiple oral administrations to healthy volunteers. Regul Toxicol Pharmacol 47:19-28.
28. Kasparová S, Sumbalová Z, Bystrický P, Kucharská J, Liptaj T, Mlyná rik V, Gvozdjáková A (2006). Effect of coenzyme Q10 and vitamin E on brain energy metabolism in the animal model of Huntingtons disease. Neurochem Int 48:93-99.
29. Katz RJ (1981). Animal models and human depressive disorders. Neurosci Biobehav Rev 5:231-246.
30. Katz RJ (1982). Animal model of depression: pharmacological sensitivity of a hedonic deficit. Pharmacol Biochem Behav 16:965-968.
31. Kobayashi N, Machida T, Takahashi T, Takatsu H, Shinkai T, Abe K, Urano S (2009). Elevation by oxidative stress and aging of hypothalamic-pituitary- adrenal activity in rats and its prevention by vitamin E. J Clin Biochem Nutr 45:207-213.
32. Littarru G, Tiano L (2007). Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol 37:31-37.
33. Liu W, Zhou C (2012). Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning. Psychoneuroendocrinology 37:1057-1070.
34. Madrigal JL, Olivenza R, Moro MA, Lizasoain I, Lorenzo P, Rodrigo J, Leza JC (2001). Glutathione depletion, lipid peroxidation and mitochondrial dysfunction are induced by chronic stress in rat brain. Neuropsychopharmacology 24:420-429.
35. Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E (2009). Lower plasma coenzyme Q10 in depression: A marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness. Neuro Endocrinol Lett 30:462-469.
36. Maes M, Galecki P, Chang YS, Berk M (2011). A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness. Prog Neuropsychopharmacol Biol Psychiatry 35:676-692.
37. Mancuso M, Coppede F, Migliore L, Siciliano G, Murri L (2006). Mitochondrial dysfunction, oxidative stress and neurodegeneration. J Alzheimers Dis 10:59-73.
38. Manji H, Kato T, Di Prospero NA, Ness S, Beal MF, Krams M, Chen G (2012). Impaired mitochondrial function in psychiatric disorders. Nat Rev Neurosci 13:293-307.
39. Marti O, Marti J, Armario A (1994). Effects of chronic stress on food intake in rats: Influence of stressor intensity and duration of daily exposure. Physiol Behav 55:747-753.
40. Moreira PI, Santos MS, Oliveira CR (2007). Alzheimers disease: A lesson from mitochondrial dysfunction. Antioxid Redox Signal 9:1621-1630.
41. Navarro A, Boveris A (2007). The mitochondrial energy transduction the aging process. Am J Physiol Cell Physiol 292:670-686.
42. Ré us GZ, Stringari RB, Gonçalves CL, Scaini G, Carvalho-Silva M, Jeremias GC (2012). Administration of harmine and imipramine kinase and mitochondrial respiratory chain. Depress Res Treat 2012:987397.
43. Rezin GT, Cardoso MR, Gonçalves CL, Scaini G, Fraga DB, Riegel RE (2008). Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression. Neurochem Int 53:395-400.
44. Rezin GT, Gonçalves CL, Daufenbach JF, Fraga DB, Santos PM, Ferreira GK (2009a). Acute administration of ketamine reverses the inhibition of mitochondrial respiratory chain induced by chronic mild stress. Brain Res Bull 79:418-421.
45. Rezin GT, Amboni G, Zugno AI, Quevedo J, Streck EL (2009b). Mitochondrial dysfunction and psychiatric disorders. Neurochem Res 34:1021-1029.
46. Rezin GT, Gonçalves CL, Daufenbach JF, Carvalho-Silva M, Borges LS, Vieira JS (2010). Effect of chronic administration of ketamine on the mitochondrial respiratory chain activity caused by chronic mild stress. Acta Neuropsychiatr 22:292-299.
47. Rustin P, Chretien D, Bourgeron T, Gé rard B, Ro tig A, Saudubray JM, Munnich A (1994). Biochemical and molecular investigations in respiratory chain deficiencies. Clin Chim Acta 228:35-51.
48. Rybkin II, Zhou Y, Volaufova J, Smagin GN, Ryan DH, Harris RB (1997). Effect of restraint stress on food intake and body weight is determined by time of day. Am J Physiol 273:R1612-R1622.
49. Santos PM, Scaini G, Rezin GT, Benedet J, Rochi N, Jeremiasa GC (2009). Brain creatine kinase activity is increased by chronic administration of paroxetine. Brain Res Bull 80:327-330.
50. Scaini G, Maggi DD, De-Nes BT, Goncalves CL, Ferreira GK, Teodorak BP (2011). Activity of mitochondrial respiratory chain is increased by chronic administration of antidepressants. Acta Neuropsychiatr 23:112-118.
51. Schlattner U, Wallimann T (2000). Octamers of mitochondrial creatine kinase isoenzymes differ in stability and membrane binding. J Biol Chem 275: 17314-17320.
52. Schurr A (2002). Energy metabolism, stress hormones and neural recovery from cerebral ischemia/hypoxia. Neurochem Int 41:1-8.
53. Stockmeier CA, Rajkowska G (2004). Cellular abnormalities in depression: evidence from postmortem brain tissue. Dialogues Clin Neurosci 6:185-197.
54. Streck EL, Amboni G, Scaini G, Di-Pietro PB, Rezin GT, Valvassori SS (2008). Brain creatine kinase activity in an animal model of mania. Life Sci 82: 424-429.
55. Strekalova T, Spanagel R, Bartsch D, Henn FA, Gass P (2004). Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration. Neuropsychopharmacology 29:2007-2017.
56. Sunanda BS, Rao S, Raju TR (2000). Chronic restraint stress impairs acquisition and retention of spatial memory task in rats. Curr Sci 79:1581-1584.
57. Tagliari B, Noschang CG, Ferreira AG, Ferrari OA, Feksa LR, Wannmacher CM (2010). Chronic variable stress impairs energy metabolism in prefrontal cortex and hippocampus of rats: prevention by chronic antioxidant treatment. Metab Brain Dis 25:169-176.
58. Tawfik MK (2011). Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoininduced cognitive impairment and oxidative stress. Epilepsy Behav 22: 671-677.
59. Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM (1992). Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the phosphocreatine circuit for cellular energy homeostasis. Biochem J 281:21-40.
60. Willner P, Towell A, Sampson D, Sophokleous S, Muscat R (1987). Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl) 93: 358-364.
61. Willner P, Moreau JL, Nielsen CK, Papp M, Sluzewska A (1996). Decreased hedonic responsiveness following chronic mild stress is not secondary to loss of body weight. Physiol Behav 60:129-134.
62. Zafir A, Ara A, Banu N (2009). In vivo antioxidant status: A putative target of antidepressant action. Prog Neuropsychopharmacol Biol Psychiatry 33:220-228.