Mechano-regulation of alternative splicing

Current Genomics

Volumn 14, Issue 1, 2013, Pages 49-55

  Liu, Huan ^a   Tang, Liling ^a  

^a CHONGQING UNIVERSITY   (China)

Author keywords

Alternative splicing; Ion channel; Mechanical stress; Regulation mechanism; Signaling pathway; Splicing isoform

Indexed keywords

CD45 ANTIGEN; CYCLINE; CYCLOOXYGENASE 2; FOCAL ADHESION KINASE; HERMES ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MEMBRANE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID; PROTEIN BCL X; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN KINASE C; RHO FACTOR; SOMATOMEDIN C; STRESS ACTIVATED PROTEIN KINASE; TENASCIN; TRANSCRIPTION FACTOR DELTA FOSB; VASCULOTROPIN; VERSICAN;

ALTERNATIVE RNA SPLICING; APOPTOSIS; BIOMECHANICS; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL PROLIFERATION; ENZYME REGULATION; GENE EXPRESSION; GENE REGULATORY NETWORK; HUMAN; MECHANICAL STRESS; MECHANOTRANSDUCTION; METASTASIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; SHEAR STRESS; SIGNAL TRANSDUCTION; SPLICEOSOME;

EID: 84888227210     PISSN: 13892029     EISSN: 18755488     Source Type: Journal    
DOI: 10.2174/138920213804999156     Document Type: Review

References (62)

1. Stamm, S.; Ben-Ari, S.; Rafalska, I.; Tang, Y.; Zhang, Z.; Toiber, D.; Thanaraj, T.A.; Soreq, H. Function of alternative splicing. Gene, 2005, 344, 1-20.
2. Wahl, M.C.; Will, C.L.; Lührmann, R. The Spliceosome: Design Principles of a Dynamic RNP Machine. Cell, 2009, 136 (4), 701-718.
3. Staley, J.P.; Woolford, J.J. Assembly of ribosomes and spliceosomes: complex ribonucleoprotein machines. Curr. Opin. Cell. Biol., 2009, 21 (1), 109-118.
4. Gillespie, P.G.; Walker, R.G. Molecular basis of mechanosensory transduction. Nature, 2001, 413 (6852), 194-202.
5. Kravchenko, I.V.; Furalyov, V.A.; Lisitsina, E.S.; Popov, V.O. Stimulation of mechano-growth factor expression by second messengers. Arch. Biochem. Biophys., 2011, 507 (2), 323-331.
6. Goldspink, G. Changes in muscle mass and phenotype and the expression of autocrine and systemic growth factors by muscle in response to stretch and overload. J Anat., 1999, 194 (Pt 3), 323-334.
7. Tang, L.L.; Xian, C.; Wang, Y. The MGF expression of osteoblasts in response to mechanical overload. Arch. Oral. Biol., 2006, 51 (12), 1080-1085.
8. Carro, E.; Trejo, J.L.; Nunez, A.; Torres-Aleman, I. Brain repair and neuroprotection by serum insulin-like growth factor I. Mol. Neurobiol., 2003, 27 (2), 153-162.
9. Skarli, M.; Yang, S.Y.; Bouloux, P.; Yellon, D.M.; Goldspink, G. Up-regulation and alternative splicing of the IGF-1 gene in the rabbit heart following a brief pressure/volume overload. J. Physiol., 1998, 509, 192-193.
10. Heinemeier, K.M.; Olesen, J.L.; Schjerling, P.; Haddad, F.; Langberg, H.; Baldwin, K.M.; Kjaer, M. Short-term strength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon: differential effects of specific contraction types. J. Appl. Physiol., 2007, 102 (2), 573-581.
11. Mantila Roosa, S.M.; Liu, Y.; Turner. C.H. Alternative splicing in bone following mechanical loading. Bone, 2011, 48 (3), 543-551.
12. David, C.J.; Manley, J.L. Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes. Dev., 2010, 24 (21), 2343-2364.
13. Corrionero, A.; Minana, B.; Valcarcel, J. Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A. Genes. Dev., 2011, 25(5), 445-459.
14. Seko, Y.; Takahashi, N.; Shibuya, M.; Yazaki, Y. Pulsatile stretch stimulates vascular endothelial growth factor (VEGF) secretion by cultured rat cardiac myocytes. Biochem. Biophys. Res. Commun., 1999, 254(2), 462-465.
15. Saygili, E.; Pekassa, M.; Saygili, E.; Rackauskas, G.; Hommes, D.; Noor-Ebad, F.; Gemein, C.; Zink, M.D.; Schwinger, R.H.; Weis, J.; Marx, N.; Schauerte, P.; Rana, O.R. Mechanical stretch of sympathetic neurons induces VEGF expression via a NGF and CNTF signaling pathway. Biochem. Biophys. Res. Commun., 2011, 410(1), 62-67.
16. Houck, K.A.; Ferrara, N.; Winer, J.; Cachianes, G.; Li, B.; Leung, D.W. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol. Endocrinol., 1991, 5(12), 1806-1814.
17. Goldspink, G. Research on mechano growth factor: its potential for optimising physical training as well as misuse in doping. Br. J. Sports. Med., 2005, 39(11), 787-788.
18. Jr. Matheny, R.W.; Nindl, B.C.; Adamo, M.L. Minireview: Mechano-Growth Factor: A Putative Product of IGF-I Gene Expression Involved in Tissue Repair and Regeneration. Endocrinology., 2010, 151(3), 865-875.
19. Bannister, A.J.; Schneider, R.; Kouzarides, T. Histone methylation: dynamic or static? Cell, 2002, 109(7), 801-806.
20. Jakkaraju, S.; Zhe, X.; Pan, D.; Choudhury, R.; Schuger, L. TIPs are tension-responsive proteins involved in myogenic versus adipogenic differentiation. Dev. Cell., 2005, 9(1), 39-49.
21. Hsia, H.C.; Schwarzbauer, J.E. Meet the tenascins: multifunctional and mysterious. J. Biol. Chem., 2005, 280(29), 26641-26644.
22. Jones, F.S.; Jones, P.L. The tenascin family of ECM glycoproteins: structure, function, and regulation during embryonic development and tissue remodeling. Dev. Dyn., 2000, 218(2), 235-259.
23. Keller, K.E.; Kelley, M.J.; Acott, T.S. Extracellular matrix gene alternative splicing by trabecular meshwork cells in response to mechanical stretching. Invest. Ophthalmol. Vis. Sci., 2007, 48(3), 1164-1172.
24. Wight, T.N. Versican: a versatile extracellular matrix proteoglycan in cell biology. Curr. Opin. Cell. Biol., 2002, 14(5), 617-623.
25. Ponta, H.; Sherman, L.; Herrlich, P.A. CD44: from adhesion molecules to signalling regulators. Nat. Rev. Mol. Cell. Biol., 2003, 4(1), 33-45.
26. Kemp, P.R.; Metcalfe, J.C. Four isoforms of serum response factor that increase or inhibit smooth-muscle-specific promoter activity. Biochem. J., 2000, 345(Pt 3), 445-451.
27. Yang, Y.; Beqaj, S.; Kemp, P.; Ariel, I.; Schuger, L. Stretchinduced alternative splicing of serum response factor promotes bronchial myogenesis and is defective in lung hypoplasia. J. Clin. Invest., 2000, 106(11), 1321-1330.
28. Kondratev, D.; Gallitelli, M.F. Increments in the concentration of sodium and calcium in cell compartments of stretched mouse ventricular myocytes. Cell. Calcium., 2003, 34(2), 193-203.
29. Niggel, J.; Sigurdson, W.; Sachs, F. Mechanically induced calcium movements in astrocytes, bovine aortic endothelial cells and C6 glioma cells. J. Membr. Biol., 2000, 174(2), 121-134.
30. Sgambato, V.; Minassian, R.; Nairn, A.C.; Hyman, S.E. Regulation of ania-6 splice variants by distinct signaling pathways in striatal neurons. J. Neurochem., 2003, 86(1), 153-164.
31. 2+ signals. Biochim. Biophys. Acta., 2008, 1779(8), 438-452.
32. Lee, J.A.; Xing, Y.; Nguyen, D.; Xie, J.; Lee, C.J.; Black, D.L. Depolarization and CaM kinase IV modulate NMDA receptor splicing through two essential RNA elements. PLoS. Biol., 2007, 5(2), e40.
33. Kimura, M.; Obara, K.; Sasase, T.; Ishikawa, T.; anabe, T.Y.; Nakayama, K. Specific inhibition of stretch-induced increase inL-type calcium channel currents by herbimycin A in canine basilar arterial myocytes. Br. J. Pharmacol., 2000, 130(4), 923-931.
34. An, P.; Grabowski, PJ. Exon silencing by UAGG motifs in response to neuronal excitation. PLoS. Biol., 2007, 5(2), e36.
35. Inoue, D.; Kido, S.; Matsumoto, T. Transcriptional Induction of FosB/ FosB Gene by Mechanical Stress in Osteoblasts. J. Biol. Chem., 2004, 279(48), 49795-49803.
36. Ogasawara, A.; Arakawa, T.; Kaneda, T.; Takuma, T.; Sato, T.; Kaneko, H.; Kumegawa, M.; Hakeda, Y. Fluid shear stress-induced cyclooxygenase-2 expression is mediated by C/EBP beta, cAMPresponse element-binding protein, and AP-1 in osteoblastic MC3T3-E1 cells. J. Biol. Chem., 2001, 276(10), 7048-7054.
37. Fukuno, N.; Matsui, H.; Kanda, Y.; Suzuki, O.; Matsumoto, K.; Sasaki, K.; Kobayashi, T.; Tamura, S. TGF-b-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts. Biochem. Biophys. Res. Commun., 2011, 408(2), 202-207.
38. Lynch, K.W.; Weiss, A. A Model System for Activation-Induced Alternative Splicing of CD45 Pre-mRNA in T Cells Implicates Protein Kinase C and Ras. Mol. Cell. Biol., 2000, 20(1), 70-80.
39. Weg-Remers, S.; Ponta, H.; Herrlich, P.; König, H. Regulation of alternative pre-mRNA splicing by the ERK MAP-kinase pathway. EMBO. J., 2001, 20(15), 4194-4203.
40. Plotkin, L, I,; Mathov, I.; Aguirre, J.I.; Parfitt, A.M.; Manolagas, S.C.; Bellido, T. Mechanical stimulation prevents osteocyte apoptosis: Requirement of integrins, Src kinases and ERKs. Am. J. Physiol. Cell. Physiol., 2005, 289(3), C633-C643.
41. Makino, A.; Glogauer, M.; Bokoch, G.M.; Chien, S.; Schmid-Schon-bein, G.W. Control of neutrophil pseudopods by fluid shear: role of Rho family GTPases. Am. J. Physiol. Cell. Physiol., 2005, 288(4), C863-C871.
42. Shi, Y.; Li, H.; Zhang, X.; Fu, Y.; Huang, Y.; Lui, P.P.; Tang, T.; Dai, K. Continuous Cyclic Mechanical Tension Inhibited Runx2 Expression in Mesenchymal Stem Cells Through RhoA-ERK1/2 Pathway. J. Cell. Physiol., 2011, 226(8), 2159-2169.
43. Hong, S.Y.; Jeon, Y.M.; Lee, H.J.; Kim, J.G.; Baek, J.A.; Lee, J.C. Activation of RhoA and FAK induces ERK-mediated osteopontin expression in mechanical force-subjected periodontal ligament flbroblasts. Mol. Cell. Biochem., 2010, 335(1-2), 263-272.
44. Fichter, M.; Hinrichs, R.; Eissner, G.; Scheffer, B.; Classen, S.; Ueffing, M. Expression of CD44 isoforms in neuroblastoma cells is regulated by PI 3-kinase and protein kinase C. Oncogene, 1997, 14(23), 2817-2824.
45. Fruman, D.A.; Meyers, R.E.; Cantley, L.C. Phosphoinositide kinases. Annu. Rev. Biochem., 1998, 67, 481-507.
46. Zhang, B.C.; Zhou, Z.W.; Li, X.K.; Xu, Y.W. PI-3K/AKT signal pathway modulates vascular smooth muscle cells migration under cyclic mechanical strain. Vasa, 2011, 40(2), 109-116.
47. Li, Y.S.; Haga, J.H.; Chien, S. Molecular basis of the effects of shear stress on vascular endothelial cells. J. Biomech., 2005, 38(10), 1949-1971.
48. Faure, C.; Linossier, M.T.; Malaval, L.; Lafage-Proust, M.H.; Peyroche, S.; Vico, L.; Guignandon, A. Mechanical signals modulated vascular endothelial growth factor-A (VEGF-A) alternative splicing in osteoblastic cells through actin polymerisation. Bone, 2008, 42(6), 1092-1101.
49. Guignandon, A.; Usson, Y.; Laroche, N.; Lafage-Proust, M.H.; Sabido, O.; Alexandre, C.; Vico, L. Effects of intermittent or continuous gravitational stresses on cell-matrix adhesion: quantitative analysis of focal contacts in osteoblastic ROS 17/2.8 cells. Exp. Cell. Res., 1997, 236(1), 66-75.
50. Jimenez, C.; Portela, R.A.; Mellado, M.; Rodriguez-Frade, J.R.; Collard, J.; Serrano, A.; Martínez-A, C.; Avila, J.; Carrera, A.C. Role of the PI3K regulatory subunit in the control of actin organization and cell migration. J. Cell. Biol., 2000, 151(2), 249-262.
51. Maes, C.; Stockmans, I.; Moermans, K.; Van Looveren, R.; Smets, N.; Carmeliet, P.; Bouillon, R.; Carmeliet, G. Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J. Clin. Invest., 2004, 113(2), 188-199.
52. Yang, Y.; Beqaj, S.; Kemp, P.; Ariel, I.; Schuger, L. Stretchinduced alternative splicing of serum response factor promotes bronchial myogenesis and is defective in lung hypoplasia. J. Clin. Invest., 2000, 106(11), 1321-1330.
53. Goldspink, G.; Goldspink, P. Use of the insulin-like-growth factor I splice variant MGF for the prevention of myocardial damage. United. States. Patent., 2005, US20050048028A1.
54. Tang, L.L.; Wang, Y.L.; Sun, C.X. The stress reaction and itsmolecular events: splicing variants. Biochem. Biophys. Res. Commun., 2004, 320(2), 287-291.
55. Heinemeier, K.M.; Olesen, J.L.; Schjerling, P.; Haddad, F.; Langberg, H.; Baldwin, K.M.; Kjaer, M. Short-termstrength training and the expression of myostatin and IGF-I isoforms in rat muscle and tendon: differential effects of specific contraction types. J. Appl. Physiol., 2007, 102(2), 573-581.
56. Dluzniewska, J.; Sarnowska, A.; Beresewicz, M.; Johnson, I.; Srai, S.K.S.; Ramesh, B.; Goldspink, G.; Górecki, D.C.; Zabłocka, B. A strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia. FASEB. J., 2005, 19(13), 1896-1898.
57. Yang, S.Y.; Goldspink, G. Different roles of the IGF-I Ec peptide (MGF) andmature IGF-I in myoblast proliferation and differentiation. FEBS. Lett., 2002, 522(1-3), 156-160.
58. Hill, M.; Goldspink, G. Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. J. Physiol., 2003, 549(pt2), 409-418.
59. Barrie, E.S.; Smith, R.M.; Sanford, J.C.; Sadee, W. mRNA transcript diversity creates new opportunities for pharmacological intervention. Mol. Pharmacol., 2012, 81(5), 620-630.
60. Urano, E.; Miyauchi, K.; Ichikawa, R.; Futahashi, Y.; Komano, J. Regualtion of cyclin T1 expression and function by an alternative splice variant that skipts exon7 and contains a premature termination codon. Gene, 2012, 505(1), 1-8.
61. Liu, H.; He, L.; Tang, L. Alternative splicing regulation and cell lineage differentiation. Curr. Stem. Cell. Res. Ther., 2012.[Epub ahead of print]
62. Sahoo, A.; Im, S.H. Interleukin and interleukin receptor diversity: role of alternative splicing. Int. Rev. Immunol., 2010, 29(1), 77-109.