Knockdown of Lingo1b protein promotes myelination and oligodendrocyte differentiation in zebrafish

Experimental Neurology

Volumn 251, Issue , 2014, Pages 72-83

  Yin, Wu ^a   Hu, Bing ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

Differentiation; Lingo1b; Multiple sclerosis; Myelination; Oligodendrocyte; Zebrafish

Indexed keywords

LINGO1B PROTEIN; MESSENGER RNA; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EXON; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC CODE; LINGO1B GENE; MOLECULAR PHYLOGENY; MYELINATION; NERVE CELL DIFFERENTIATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM; ZEBRA FISH;

EID: 84888224347     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2013.11.012     Document Type: Article

References (49)

1. Almeida R.G., Czopka T., Ffrench-Constant C., Lyons D.A. Individual axons regulate the myelinating potential of single oligodendrocytes in vivo. Development 2011, 138:4443-4450.
2. Beattie C.E. Control of motor axon guidance in the zebrafish embryo. Brain Res. Bull. 2000, 53:489-500.
3. Buckley C.E., Goldsmith P., Franklin R.J. Zebrafish myelination: a transparent model for remyelination?. Dis. Model. Mech. 2008, 1:221-228.
4. Buckley C.E., Marguerie A., Alderton W.K., Franklin R.J. Temporal dynamics of myelination in the zebrafish spinal cord. Glia 2010, 58:802-812.
5. Buckley C.E., Marguerie A., Roach A.G., Goldsmith P., Fleming A., Alderton W.K., Franklin R.J. Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects. Neuropharmacology 2010, 59:149-159.
6. Chang A., Tourtellotte W.W., Rudick R., Trapp B.D. Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N. Engl. J. Med. 2002, 346:165-173.
7. Coles A.J., Compston D.A., Selmaj K.W., Lake S.L., Moran S., Margolin D.H., Norris K., Tandon P.K. Alemtuzumab vs. interferon beta-1a in early multiple sclerosis. N. Engl. J. Med. 2008, 359:1786-1801.
8. Compston A., Coles A. Multiple sclerosis. Lancet 2008, 372:1502-1517.
9. Czopka T., Ffrench-Constant C., Lyons D.A. Individual oligodendrocytes have only a few hours in which to generate new myelin sheaths in vivo. Dev. Cell 2013, 25:599-609.
10. Dubois-Dalcq M., Ffrench-Constant C., Franklin R.J. Enhancing central nervous system remyelination in multiple sclerosis. Neuron 2005, 48:9-12.
11. Dubois-Dalcq M., Williams A., Stadelmann C., Stankoff B., Zalc B., Lubetzki C. From fish to man: understanding endogenous remyelination in central nervous system demyelinating diseases. Brain 2008, 131:1686-1700.
12. Ekker S.C. Nonconventional antisense in zebrafish for functional genomics applications. Methods Cell Biol. 2004, 77:121-136.
13. Emery B. Regulation of oligodendrocyte differentiation and myelination. Science 2010, 330:779-782.
14. Felsenstein J. Comparative methods with sampling error and within-species variation: contrasts revisited and revised. Am. Nat. 2008, 171:713-725.
15. Franklin R.J. Why does remyelination fail in multiple sclerosis?. Nat. Rev. Neurosci. 2002, 3:705-714.
16. Fu Q.L., Hu B., Li X., Shao Z., Shi J.B., Wu W., So K.F., Mi S. LINGO-1 negatively regulates TrkB phosphorylation after ocular hypertension. Eur. J. Neurosci. 2010, 31:1091-1097.
17. Giovannoni G., Comi G., Cook S., Rammohan K., Rieckmann P., Soelberg Sorensen P., Vermersch P., Chang P., Hamlett A., Musch B., Greenberg S.J. A placebo-controlled trial of oral cladribine for relapsing multiple sclerosis. N. Engl. J. Med. 2010, 362:416-426.
18. Haines B.P., Rigby P.W. Expression of the Lingo/LERN gene family during mouse embryogenesis. Gene Expr. Patterns 2008, 8:79-86.
19. Homma S., Shimada T., Hikake T., Yaginuma H. Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Gene Expr. Patterns 2009, 9:1-26.
20. Huang P., Zhu Z., Lin S., Zhang B. Reverse genetic approaches in zebrafish. J. Genet. Genomics 2012, 39:421-433.
21. Jepson S., Vought B., Gross C.H., Gan L., Austen D., Frantz J.D., Zwahlen J., Lowe D., Markland W., Krauss R. LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions. J. Biol. Chem. 2012, 287:22184-22195.
22. Kimmel C.B., Ballard W.W., Kimmel S.R., Ullmann B., Schilling T.F. Stages of embryonic development of the zebrafish. Dev. Dyn. 1995, 203:253-310.
23. Kumar S., Tamura K., Nei M. MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief. Bioinform. 2004, 5:150-163.
24. Lee X., Yang Z., Shao Z., Rosenberg S.S., Levesque M., Pepinsky R.B., Qiu M., Miller R.H., Chan J.R., Mi S. NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination. J. Neurosci. 2007, 27:220-225.
25. Lee J.S., Padmanabhan A., Shin J., Zhu S., Guo F., Kanki J.P., Epstein J.A., Look A.T. Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene. Hum. Mol. Genet. 2010, 19:4643-4653.
26. Letunic I., Doerks T., Bork P. SMART 7: recent updates to the protein domain annotation resource. Nucleic Acids Res. 2012, 40:D302-D305.
27. Lyons D.A., Pogoda H.M., Voas M.G., Woods I.G., Diamond B., Nix R., Arana N., Jacobs J., Talbot W.S. erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish. Curr. Biol. 2005, 15:513-524.
28. Martino G., Franklin R.J., Baron Van Evercooren A., Kerr D.A. Stem cell transplantation in multiple sclerosis: current status and future prospects. Nat. Rev. Neurol. 2010, 6:247-255.
29. Mei F., Wang H., Liu S., Niu J., Wang L., He Y., Etxeberria A., Chan J.R., Xiao L. Stage-specific deletion of Olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes. J. Neurosci. 2013, 33:8454-8462.
30. Mi S., Lee X., Shao Z., Thill G., Ji B., Relton J., Levesque M., Allaire N., Perrin S., Sands B., Crowell T., Cate R.L., McCoy J.M., Pepinsky R.B. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat. Neurosci. 2004, 7:221-228.
31. Mi S., Miller R.H., Lee X., Scott M.L., Shulag-Morskaya S., Shao Z., Chang J., Thill G., Levesque M., Zhang M., Hession C., Sah D., Trapp B., He Z., Jung V., McCoy J.M., Pepinsky R.B. LINGO-1 negatively regulates myelination by oligodendrocytes. Nat. Neurosci. 2005, 8:745-751.
32. Mi S., Hu B., Hahm K., Luo Y., Kam Hui E.S., Yuan Q., Wong W.M., Wang L., Su H., Chu T.H., Guo J., Zhang W., So K.F., Pepinsky B., Shao Z., Graff C., Garber E., Jung V., Wu E.X., Wu W. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat. Med. 2007, 13:1228-1233.
33. Mi S., Sandrock A., Miller R.H. LINGO-1 and its role in CNS repair. Int. J. Biochem. Cell Biol. 2008, 40:1971-1978.
34. Mi S., Miller R.H., Tang W., Lee X., Hu B., Wu W., Zhang Y., Shields C.B., Miklasz S., Shea D., Mason J., Franklin R.J., Ji B., Shao Z., Chedotal A., Bernard F., Roulois A., Xu J., Jung V., Pepinsky B. Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells. Ann. Neurol. 2009, 65:304-315.
35. Mosyak L., Wood A., Dwyer B., Buddha M., Johnson M., Aulabaugh A., Zhong X., Presman E., Benard S., Kelleher K., Wilhelm J., Stahl M.L., Kriz R., Gao Y., Cao Z., Ling H.P., Pangalos M.N., Walsh F.S., Somers W.S. The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition. J. Biol. Chem. 2006, 281:36378-36390.
36. Nakaya N., Sultana A., Lee H.S., Tomarev S.I. Olfactomedin 1 interacts with the Nogo A receptor complex to regulate axon growth. J. Biol. Chem. 2012, 287:37171-37184.
37. Park H.C., Mehta A., Richardson J.S., Appel B. olig2 is required for zebrafish primary motor neuron and oligodendrocyte development. Dev. Biol. 2002, 248:356-368.
38. Park J.B., Yiu G., Kaneko S., Wang J., Chang J., He X.L., Garcia K.C., He Z. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron 2005, 45:345-351.
39. Postlethwait J.H., Yan Y.L., Gates M.A., Horne S., Amores A., Brownlie A., Donovan A., Egan E.S., Force A., Gong Z., Goutel C., Fritz A., Kelsh R., Knapik E., Liao E., Paw B., Ransom D., Singer A., Thomson M., Abduljabbar T.S., Yelick P., Beier D., Joly J.S., Larhammar D., Rosa F., Westerfield M., Zon L.I., Johnson S.L., Talbot W.S. Vertebrate genome evolution and the zebrafish gene map. Nat. Genet. 1998, 18:345-349.
40. Shao Z., Browning J.L., Lee X., Scott M.L., Shulga-Morskaya S., Allaire N., Thill G., Levesque M., Sah D., McCoy J.M., Murray B., Jung V., Pepinsky R.B., Mi S. TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration. Neuron 2005, 45:353-359.
41. Shin J., Park H.C., Topczewska J.M., Mawdsley D.J., Appel B. Neural cell fate analysis in zebrafish using olig2 BAC transgenics. Methods Cell Sci. 2003, 25:7-14.
42. Shin J., Padmanabhan A., de Groh E.D., Lee J.S., Haidar S., Dahlberg S., Guo F., He S., Wolman M.A., Granato M., Lawson N.D., Wolfe S.A., Kim S.H., Solnica-Krezel L., Kanki J.P., Ligon K.L., Epstein J.A., Look A.T. Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Dis. Model. Mech. 2012, 5:881-894.
43. Sumanas S., Larson J.D. Morpholino phosphorodiamidate oligonucleotides in zebrafish: a recipe for functional genomics?. Brief. Funct. Genomic. Proteomic. 2002, 1:239-256.
44. Thisse C., Thisse B. High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat. Protoc. 2008, 3:59-69.
45. Thisse B., Wright G.J., Thisse C. Embryonic and larval expression patterns from a large scale screening for novel low affinity extracellular protein interactions ZFIN Direct Data Submission: ZDB-PUB-080227-22. http://zfin.org.
46. Westerfield M. The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Danio rerio) 2000, University of Oregon Press, Eugene, OR.
47. Yiu G., He Z. Glial inhibition of CNS axon regeneration. Nat. Rev. Neurosci. 2006, 7:617-627.
48. Zawadzka M., Franklin R.J. Myelin regeneration in demyelinating disorders: new developments in biology and clinical pathology. Curr. Opin. Neurol. 2007, 20:294-298.
49. Zou S.Q., Yin W., Zhang M.J., Hu C.R., Huang Y.B., Hu B. Using the optokinetic response to study visual function of zebrafish. J. Vis. Exp. 2010.