Extracellular generation of adenosine by the ectonucleotidases CD39 and CD73 promotes dermal fibrosis

American Journal of Pathology

Volumn 183, Issue 6, 2013, Pages 1740-1746

  Fernández, Patricia ^a   Perez Aso, Miguel ^a   Smith, Gideon ^b   Wilder, Tuere ^a   Trzaska, Sean ^a   Chiriboga, Luis ^a   Franks Jr , Andrew ^a   Robson, Simon C ^b   Cronstein, Bruce N ^a   Chan, Edwin S L ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5' NUCLEOTIDASE; ADENOSINE; BLEOMYCIN; CD39 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FIBROGENESIS; GENE DELETION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCLERODERMA; SKIN FIBROSIS;

5'-NUCLEOTIDASE; ADENOSINE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIGENS, CD; APYRASE; BLEOMYCIN; DERMIS; FIBROSIS; MICE; MICE, KNOCKOUT; SCLERODERMA, SYSTEMIC; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84888219275     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.08.024     Document Type: Article

References (40)

1. J. Linden Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection Ann Rev Pharmacol Toxicol 41 2001 775 787
2. J.B. Volmer, L.F. Thompson, and M.R. Blackburn Ecto-5′-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury J Immunol 176 2006 4449 4458
3. G. Hasko, and B.N. Cronstein Adenosine: an endogenous regulator of innate immunity Trends Immunol 25 2004 33 39
4. M.R. Blackburn Too much of a good thing: adenosine overload in adenosine-deaminase-deficient mice Trends Pharmacol Sci 24 2003 66 70
5. M. Perez-Aso, A. Mediero, and B.N. Cronstein Adenosine A2A receptor is a fine-tune regulator of the collagen1:collagen3 balance Purinergic Signal 2013 [Epub ahead of print]
6. E.S. Chan, P. Fernandez, A.A. Merchant, M.C. Montesinos, S. Trzaska, A. Desai, C.F. Tung, D.N. Khoa, M.H. Pillinger, A.B. Reiss, M. Tomic-Canic, J.F. Chen, M.A. Schwarzschild, and B.N. Cronstein Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma Arthritis Rheum 54 2006 2632 2642
7. P. Fernandez, S. Trzaska, T. Wilder, L. Chiriboga, M.R. Blackburn, B.N. Cronstein, and E.S. Chan Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine Am J Pathol 172 2008 1675 1682
8. M. Perez-Aso, L. Chiriboga, and B.N. Cronstein Pharmacological blockade of adenosine A2A receptors diminishes scarring FASEB J 26 2012 4254 4263
9. H. Zimmermann Extracellular metabolism of ATP and other nucleotides Naunyn Schmiedebergs Arch Pharmacol 362 2000 299 309
10. B.B. Fredholm Adenosine, an endogenous distress signal, modulates tissue damage and repair Cell Death Differ 14 2007 1315 1323
11. M. Sitkovsky, and D. Lukashev Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors Nat Rev Immunol 5 2005 712 721
12. M.V. Sitkovsky, D. Lukashev, S. Apasov, H. Kojima, M. Koshiba, C. Caldwell, A. Ohta, and M. Thiel Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors Ann Rev Immunol 22 2004 657 682
13. J. Linden Adenosine in tissue protection and tissue regeneration Mol Pharmacol 67 2005 1385 1387
14. J. Reutershan, I. Vollmer, S. Stark, R. Wagner, K.C. Ngamsri, and H.K. Eltzschig Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs FASEB J 23 2009 473 482
15. F. Bonner, N. Borg, S. Burghoff, and J. Schrader Resident cardiac immune cells and expression of the ectonucleotidase enzymes CD39 and CD73 after ischemic injury PLoS One 7 2012 e34730
16. S. Deaglio, K.M. Dwyer, W. Gao, D. Friedman, A. Usheva, A. Erat, J.F. Chen, K. Enjyoji, J. Linden, M. Oukka, V.K. Kuchroo, T.B. Strom, and S.C. Robson Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression J Exp Med 204 2007 1257 1265
17. K.M. Dwyer, S. Deaglio, W. Gao, D. Friedman, T.B. Strom, and S.C. Robson CD39 and control of cellular immune responses Purinergic Signal 3 2007 171 180
18. H.K. Eltzschig, J.C. Ibla, G.T. Furuta, M.O. Leonard, K.A. Jacobson, K. Enjyoji, S.C. Robson, and S.P. Colgan Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors J Exp Med 198 2003 783 796
19. H.K. Eltzschig, L.F. Thompson, J. Karhausen, R.J. Cotta, J.C. Ibla, S.C. Robson, and S.P. Colgan Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism Blood 104 2004 3986 3992
20. T. Eckle, L. Fullbier, M. Wehrmann, J. Khoury, M. Mittelbronn, J. Ibla, P. Rosenberger, and H.K. Eltzschig Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury J Immunol 178 2007 8127 8137
21. B.M. Kunzli, P. Nuhn, K. Enjyoji, Y. Banz, R.N. Smith, E. Csizmadia, D. Schuppan, P.O. Berberat, H. Friess, and S.C. Robson Disordered pancreatic inflammatory responses and inhibition of fibrosis in CD39-null mice Gastroenterology 134 2008 292 305
22. Z. Peng, P. Fernandez, T. Wilder, H. Yee, L. Chiriboga, E.S. Chan, and B.N. Cronstein Ecto-5′-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis FASEB J 22 2008 2263 2272
23. K. Enjyoji, J. Sevigny, Y. Lin, P.S. Frenette, P.D. Christie, J.S. Esch 2nd, M. Imai, J.M. Edelberg, H. Rayburn, M. Lech, D.L. Beeler, E. Csizmadia, D.D. Wagner, S.C. Robson, and R.D. Rosenberg Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation Nat Med 5 1999 1010 1017
24. L.F. Thompson, H.K. Eltzschig, J.C. Ibla, C.J. Van De Wiele, R. Resta, J.C. Morote-Garcia, and S.P. Colgan Crucial role for ecto-5′-nucleotidase (CD73) in vascular leakage during hypoxia J Exp Med 200 2004 1395 1405
25. C. Goepfert, C. Sundberg, J. Sevigny, K. Enjyoji, T. Hoshi, E. Csizmadia, and S. Robson Disordered cellular migration and angiogenesis in cd39-null mice Circulation 104 2001 3109 3115
26. B.N. Cronstein, D. Naime, and E. Ostad The antiinflammatory mechanism of methotrexate: increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation J Clin Invest 92 1993 2675 2682
27. L.C. Junqueira, G.S. Montes, and R.M. Krisztan The collagen of the vertebrate peripheral nervous system Cell Tissue Res 202 1979 453 460
28. G.S. Montes, R.M. Krisztan, K.M. Shigihara, R. Tokoro, P.A. Mourao, and L.C. Junqueira Histochemical and morphological characterization of reticular fibers Histochemistry 65 1980 131 141
29. E.S. Chan, H. Liu, P. Fernandez, A. Luna, M. Perez-Aso, A.M. Bujor, M. Trojanowska, and B.N. Cronstein Adenosine A2A receptors promote collagen production by a Fli1- and CTGF-mediated mechanism Arthritis Res Ther 15 2013 R58
30. B. Hinz, S.H. Phan, V.J. Thannickal, A. Galli, M.L. Bochaton-Piallat, and G. Gabbiani The myofibroblast: one function, multiple origins Am J Pathol 170 2007 1807 1816
31. J.J. Tomasek, G. Gabbiani, B. Hinz, C. Chaponnier, and R.A. Brown Myofibroblasts and mechano-regulation of connective tissue remodelling Nat Rev Mol Cell Biol 3 2002 349 363
32. P.J. Wipff, and B. Hinz Integrins and the activation of latent transforming growth factor beta1: an intimate relationship Eur J Cell Biol 87 2008 601 615
33. M.D. Valls, B.N. Cronstein, and M.C. Montesinos Adenosine receptor agonists for promotion of dermal wound healing Biochem Pharmacol 77 2009 1117 1124
34. M.C. Montesinos, J.P. Shaw, H. Yee, P. Shamamian, and B.N. Cronstein Adenosine A(2A) receptor activation promotes wound neovascularization by stimulating angiogenesis and vasculogenesis Am J Pathol 164 2004 1887 1892
35. M.C. Montesinos, A. Desai, J.F. Chen, H. Yee, M.A. Schwarzschild, J.S. Fink, and B.N. Cronstein Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors Am J Pathol 160 2002 2009 2018
36. C. Victor-Vega, A. Desai, M.C. Montesinos, and B.N. Cronstein Adenosine A2A receptor agonists promote more rapid wound healing than recombinant human platelet-derived growth factor (Becaplermin gel) Inflammation 26 2002 19 24
37. M.C. Montesinos, P. Gadangi, M. Longaker, J. Sung, J. Levine, D. Nilsen, J. Reibman, M. Li, C.K. Jiang, R. Hirschhorn, P.A. Recht, E. Ostad, R.I. Levin, and B.N. Cronstein Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptors J Exp Med 186 1997 1615 1620
38. J.L. Chunn, J.G. Molina, T. Mi, Y. Xia, R.E. Kellems, and M.R. Blackburn Adenosine-dependent pulmonary fibrosis in adenosine deaminase-deficient mice J Immunol 175 2005 1937 1946
39. M.R. Blackburn, C.G. Lee, H.W. Young, Z. Zhu, J.L. Chunn, M.J. Kang, S.K. Banerjee, and J.A. Elias Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway J Clin Invest 112 2003 332 344
40. M.R. Blackburn, and R.E. Kellems Adenosine deaminase deficiency: metabolic basis of immune deficiency and pulmonary inflammation Adv Immunol 86 2005 1 41