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Volumn 13, Issue 9, 2013, Pages 1344-1353

Oxaliplapin and capecitabine (XELOX) based chemotherapy in the treatment of metastatic colorectal cancer: The right choice in elderly patients

Author keywords

Chemotherapy; Colorectal cancer; Elderly patients; Oxaliplatin

Indexed keywords

ANTIEMETIC AGENT; CAPECITABINE; CARCINOEMBRYONIC ANTIGEN; FLUOROURACIL; FOLINIC ACID; OXALIPLATIN; ANTINEOPLASTIC AGENT; DEOXYCYTIDINE;

EID: 84888216250     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/18715206113136660347     Document Type: Article
Times cited : (15)

References (52)
  • 1
    • 33847638137 scopus 로고    scopus 로고
    • Estimates of the cancer incidence and mortality in Europe in 2006
    • Ferlay, J.; Autier, P.; Boniol, M.; Heanue, M.; Colombet, M.; Boyle, P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann. Oncol., 2007, 18(3), 581-592.
    • (2007) Ann. Oncol , vol.18 , Issue.3 , pp. 581-592
    • Ferlay, J.1    Autier, P.2    Boniol, M.3    Heanue, M.4    Colombet, M.5    Boyle, P.6
  • 2
    • 0003964361 scopus 로고    scopus 로고
    • American Cancer Society, American Cancer Society; Atlanta, Accessed April 26, 2011
    • American Cancer Society. Cancer facts and figures, 2006. American Cancer Society; Atlanta: 2006. http://www.cancer.org/acs/groups/content/@nho/documents/document/caff2006pwsecuredpdf.pdf (Accessed April 26, 2011).
    • (2006) Cancer Facts and Figures, 2006
  • 3
    • 0032414932 scopus 로고    scopus 로고
    • Survival of colorectal cancer patients in Europe during period 1978-1989: The EUROCARE Working Group
    • (14 Spec. No.)
    • Gatta, G.; Faivre, J.; Capocaccia, R.; Ponz de Leon, M. Survival of colorectal cancer patients in Europe during period 1978-1989: the EUROCARE Working Group. Eur. J. Cancer, 1998, 34 (14 Spec. No.), 2176-2183.
    • (1998) Eur. J. Cancer , vol.34 , pp. 2176-2183
    • Gatta, G.1    Faivre, J.2    Capocaccia, R.3    de Leon, M.P.4
  • 7
  • 8
    • 79956346875 scopus 로고    scopus 로고
    • Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS 2): An open-label; randomised factorial trial
    • FOCUS2 Investigators; National Cancer Research Institute Colorectal Cancer Clinical Studies Group
    • Seymour, M.T.; Thompson, L.C.; Wasan, H.S.; Middleton, G.; Brewster, A.E.; Shepherd, S.F.; O'Mahony, M.S.; Maughan, T.S.; Parmar, M.; Langley, R.E.; FOCUS2 Investigators; National Cancer Research Institute Colorectal Cancer Clinical Studies Group. Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS 2): an open-label; randomised factorial trial. Lancet, 2011, 377 (9779), 1749-1759.
    • (2011) Lancet , vol.377 , Issue.9779 , pp. 1749-1759
    • Seymour, M.T.1    Thompson, L.C.2    Wasan, H.S.3    Middleton, G.4    Brewster, A.E.5    Shepherd, S.F.6    O'Mahony, M.S.7    Maughan, T.S.8    Parmar, M.9    Langley, R.E.10
  • 9
    • 19444366654 scopus 로고    scopus 로고
    • Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials
    • Townsley, C.A.; Selby, R.; Siu, L.L. Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials. J. Clin. Oncol., 2005, 23, 3112-3124.
    • (2005) J. Clin. Oncol , vol.23 , pp. 3112-3124
    • Townsley, C.A.1    Selby, R.2    Siu, L.L.3
  • 11
    • 0032792959 scopus 로고    scopus 로고
    • Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older
    • Popescu, R.A.; Norman, A.; Ross, P.J.; Parikh, B.; Cunningham, D. Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J. Clin. Oncol., 1999, 17, 2412-2418.
    • (1999) J. Clin. Oncol , vol.17 , pp. 2412-2418
    • Popescu, R.A.1    Norman, A.2    Ross, P.J.3    Parikh, B.4    Cunningham, D.5
  • 15
    • 1842569206 scopus 로고    scopus 로고
    • A randomised controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • Goldberg, R.M.; Sargent, D.J.; Morton, R.F.; Fuchs, C.S.; Ramanathan, R.K.; Williamson, S.K.; Findlay, B.P.; Pitot, H.C.; Alberts, S.R. A randomised controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J. Clin. Oncol., 2004, 22, 23-30.
    • (2004) J. Clin. Oncol , vol.22 , pp. 23-30
    • Goldberg, R.M.1    Sargent, D.J.2    Morton, R.F.3    Fuchs, C.S.4    Ramanathan, R.K.5    Williamson, S.K.6    Findlay, B.P.7    Pitot, H.C.8    Alberts, S.R.9
  • 19
    • 22244477362 scopus 로고    scopus 로고
    • Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal carcinoma: Final results of the Southern Italy Cooperative Oncology Group Trial 0108
    • Comella P.; Natale D.; Farris A.; Gambardella A.; Maiorino L.; Massidda B.; Casaretti R.; Tafuto S.; Lorusso V.; Leo S.; Cannone M. Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal carcinoma: final results of the Southern Italy Cooperative Oncology Group Trial 0108. Cancer, 2005, 104, 282-289.
    • (2005) Cancer , vol.104 , pp. 282-289
    • Comella, P.1    Natale, D.2    Farris, A.3    Gambardella, A.4    Maiorino, L.5    Massidda, B.6    Casaretti, R.7    Tafuto, S.8    Lorusso, V.9    Leo, S.10    Cannone, M.11
  • 23
    • 0032127244 scopus 로고    scopus 로고
    • Design of a novel oral fluoropyrimidine carbamate; capecitabine; which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue
    • Miwa, M.; Ura, M.; Nishida, M.; Sawada, N.; Ishikawa, T.; Mori, K.; Shimma, N.; Umeda, I.; Ishitsuka, H. Design of a novel oral fluoropyrimidine carbamate; capecitabine; which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue. Eur. J. Cancer., 1998, 34, 1274-1281.
    • (1998) Eur. J. Cancer , vol.34 , pp. 1274-1281
    • Miwa, M.1    Ura, M.2    Nishida, M.3    Sawada, N.4    Ishikawa, T.5    Mori, K.6    Shimma, N.7    Umeda, I.8    Ishitsuka, H.9
  • 25
    • 0035871538 scopus 로고    scopus 로고
    • Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized phase III study
    • Hoff, P.M.; Ansari, R.; Batist, G.; Cox, J.; Kocha, W.; Kuperminc, M.; Maroun, J.; Walde, D.; Weaver, C.; Harrison, E.; Burger, H.U.; Osterwalder, B.; Wong, A.O.; Wong, R. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study. J. Clin. Oncol., 2001, 19(8), 2282-2292.
    • (2001) J. Clin. Oncol , vol.19 , Issue.8 , pp. 2282-2292
    • Hoff, P.M.1    Ansari, R.2    Batist, G.3    Cox, J.4    Kocha, W.5    Kuperminc, M.6    Maroun, J.7    Walde, D.8    Weaver, C.9    Harrison, E.10    Burger, H.U.11    Osterwalder, B.12    Wong, A.O.13    Wong, R.14
  • 26
    • 0035987216 scopus 로고    scopus 로고
    • Capecitabine (Xeloda) in combination with oxaliplatin: A phase I dose-escalation study in patients with advancet or metastatic solid tumors
    • Díaz-Rubio, E.; Evans, T.R.; Tabemero, J.; Cassidy, J.; Sastre, J.; Eatock, M.; Bisset, D.; Regueiro, P.; Baselga, J. Capecitabine (Xeloda) in combination with oxaliplatin: a phase I dose-escalation study in patients with advancet or metastatic solid tumors. Ann. Oncol., 2002, 13(4), 558-565.
    • (2002) Ann. Oncol , vol.13 , Issue.4 , pp. 558-565
    • Díaz-Rubio, E.1    Evans, T.R.2    Tabemero, J.3    Cassidy, J.4    Sastre, J.5    Eatock, M.6    Bisset, D.7    Regueiro, P.8    Baselga, J.9
  • 28
  • 29
    • 0037837645 scopus 로고    scopus 로고
    • Randomized multicenter phase II trial of two different schedules of capecitabine plus oxaliplatin as first-line treatment in advanced colorectal cancer
    • Scheithauer, W.; Kornek, G.V.; Raderer, M.; Schüll, B.; Schmid, K.; Kovats, E.; Schneeweiss, B.; Lang, F.; Lenauer, A.; Depisch, D. Randomized multicenter phase II trial of two different schedules of capecitabine plus oxaliplatin as first-line treatment in advanced colorectal cancer. J. Clin. Oncol., 2003, 21(7), 1307-1312.
    • (2003) J. Clin. Oncol , vol.21 , Issue.7 , pp. 1307-1312
    • Scheithauer, W.1    Kornek, G.V.2    Raderer, M.3    Schüll, B.4    Schmid, K.5    Kovats, E.6    Schneeweiss, B.7    Lang, F.8    Lenauer, A.9    Depisch, D.10
  • 30
    • 34948857445 scopus 로고    scopus 로고
    • Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: A final report of the AIO Colorectal Study Group
    • AIO Colorectal Study Group
    • Porschen, R.; Arkenau, H.T.; Kubicka, S.; Greil, R.; Seufferlein, T.; Freier, W.; Kretzschmar, A.; Graeven, U.; Grothey, A.; Hinke, A.; Schmiegel, W.; Schmoll, H.J.; AIO Colorectal Study Group. Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: a final report of the AIO Colorectal Study Group. J. Clin. Oncol., 2007, 25(27), 4217-4223.
    • (2007) J. Clin. Oncol , vol.25 , Issue.27 , pp. 4217-4223
    • Porschen, R.1    Arkenau, H.T.2    Kubicka, S.3    Greil, R.4    Seufferlein, T.5    Freier, W.6    Kretzschmar, A.7    Graeven, U.8    Grothey, A.9    Hinke, A.10    Schmiegel, W.11    Schmoll, H.J.12
  • 33
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer; National Cancer Institute of the United States; National Cancer Institute of Canada
    • Therasse, P.; Arbuck, S.G.; Eisenhauer, E.A.; Wanders, J.; Kaplan, R.S.; Rubinstein, L.; Verweij, J.; Van Glabbeke, M.; Van Oosterom, A.T.; Christian, M.C.; Gwyther, S.G. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer; National Cancer Institute of the United States; National Cancer Institute of Canada. J. Natl. Cancer. Inst., 2000, 92, 205-216.
    • (2000) J. Natl. Cancer. Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3    Wanders, J.4    Kaplan, R.S.5    Rubinstein, L.6    Verweij, J.7    van Glabbeke, M.8    van Oosterom, A.T.9    Christian, M.C.10    Gwyther, S.G.11
  • 36
    • 33845382806 scopus 로고
    • Non-parametric estimation from incomplete observations
    • Kaplan, E.L.; Meier, P. Non-parametric estimation from incomplete observations. J. Am. Stat. Assoc., 1958, 53, 457-481.
    • (1958) J. Am. Stat. Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 37
    • 0013886333 scopus 로고
    • Evaluation of survival data and two new rank order statistics arising in its consideration
    • Mantel, N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer. Chemother. Rep., 1966, 50, 163-170.
    • (1966) Cancer. Chemother. Rep , vol.50 , pp. 163-170
    • Mantel, N.1
  • 40
    • 0038518557 scopus 로고    scopus 로고
    • Enrollment of older patients in cancer treatment trials in Canada: Why is age a barrier
    • Yee, K.W.; Pater, J.L.; Pho, L.; Zee, B.; Siu, L.L. Enrollment of older patients in cancer treatment trials in Canada: Why is age a barrier? J. Clin. Oncol., 2003, 21, 1618-1623.
    • (2003) J. Clin. Oncol , vol.21 , pp. 1618-1623
    • Yee, K.W.1    Pater, J.L.2    Pho, L.3    Zee, B.4    Siu, L.L.5
  • 42
    • 12244298248 scopus 로고    scopus 로고
    • Colorectal cancer in the elderly: Is palliative chemotherapy of value?
    • Honecker, F.; Kohne, C.H.; Bokemeyer, C. Colorectal cancer in the elderly: Is palliative chemotherapy of value? Drugs Aging, 2003, 20, 1-11.
    • (2003) Drugs Aging , vol.20 , pp. 1-11
    • Honecker, F.1    Kohne, C.H.2    Bokemeyer, C.3
  • 43
    • 33644839465 scopus 로고    scopus 로고
    • Outcomes in elderly patients with advanced colorectal cancer treated with capecitabine: A population-based analysis
    • Ho, C.; Ng, K.; O'Reilly, S.; Gill, S. Outcomes in elderly patients with advanced colorectal cancer treated with capecitabine: a population-based analysis. Clin. Colorectal Cancer, 2005, 5, 279-282.
    • (2005) Clin. Colorectal Cancer , vol.5 , pp. 279-282
    • Ho, C.1    Ng, K.2    O'Reilly, S.3    Gill, S.4
  • 45
    • 8944234341 scopus 로고    scopus 로고
    • Toxicity and therapeutic response to chemotherapy in patients aged 70 years or older with advanced cancer
    • Cascinu, S.; Del Ferro, E.; Catalano, G. Toxicity and therapeutic response to chemotherapy in patients aged 70 years or older with advanced cancer. Am. J. Clin. Oncol., 1996, 19, 371-374.
    • (1996) Am. J. Clin. Oncol , vol.19 , pp. 371-374
    • Cascinu, S.1    Del Ferro, E.2    Catalano, G.3
  • 48
    • 84888271838 scopus 로고    scopus 로고
    • Comparative effectiveness of chemotherapy in elderly patients with metastatic colorectal cancer
    • abstract 463
    • Satram-Hoang, S.; Ramanan, D.; Lee, L.F.; Yu, S.; Reyes, C.M.; McKenna E. Comparative effectiveness of chemotherapy in elderly patients with metastatic colorectal cancer. J. Clin. Oncol., 2012, 30 (Suppl. 4), abstract 463.
    • (2012) J. Clin. Oncol , vol.30 , Issue.SUPPL. 4
    • Satram-Hoang, S.1    Ramanan, D.2    Lee, L.F.3    Yu, S.4    Reyes, C.M.5    McKenna, E.6
  • 49
    • 0037087667 scopus 로고    scopus 로고
    • Vive la difference: Sex and fluorouracil toxicity
    • Macdonald, J.S. Vive la difference: sex and fluorouracil toxicity. J. Clin. Oncol., 2002, 20, 1439-1441.
    • (2002) J. Clin. Oncol , vol.20 , pp. 1439-1441
    • Macdonald, J.S.1
  • 52
    • 0033920730 scopus 로고    scopus 로고
    • Management of cancer in the older person: A practical approach
    • Balducci, L.; Extermann, M. Management of cancer in the older person: A practical approach. Oncologist, 2000, 5, 224-237.
    • (2000) Oncologist , vol.5 , pp. 224-237
    • Balducci, L.1    Extermann, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.