Liver resection for colorectal metastases in older adults: A paired matched analysis

Journal of the American Geriatrics Society

Volumn 59, Issue 12, 2011, Pages 2282-2290

  Di Benedetto, Fabrizio ^a   Berretta, Massimiliano ^d   D'Amico, Giuseppe ^a   Montalti, Roberto ^a   De Ruvo, Nicola ^a   Cautero, Nicola ^a   Guerrini, Gian Piero ^a   Ballarin, Roberto ^a   Spaggiari, Mario ^a   Tarantino, Giuseppe ^a   Di Sandro, Stefano ^a   Pecchi, Anna ^b   Luppi, Gabriele ^c   Gerunda, Giorgio Enrico ^a  

^a Liver and Multivisceral Transplant Center   (Italy)

^b Department of Radiology ^*  (Italy)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^d CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

colorectal liver metastases; liver resection; older adults

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLORECTAL LIVER METASTASIS; CONTROLLED STUDY; FEMALE; FOLLOW UP; GROUPS BY AGE; HUMAN; LIVER METASTASIS; LIVER RESECTION; MALE; POSTOPERATIVE COMPLICATION; PRIMARY TUMOR; SURVIVAL RATE; TUMOR VOLUME;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; FEMALE; HEPATECTOMY; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES; SURVIVAL RATE; TIME FACTORS;

EID: 84055177195     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2011.03734.x     Document Type: Article

References (58)

1. World Health Organisation. World Health Statistics. Anonymous. WHO Library Cataloguing-in-Publication Data. 2009.
2. Quaglia A, Capocaccia R, Micheli A, et al. A wide difference in cancer survival between middle aged and elderly patients in Europe. Int J Cancer 2007; 120: 2196-2201. (Pubitemid 46555858)
3. Cooper GS, Yuan Z, Landefeld CS, et al. A national population-based study of incidence of colorectal cancer and age. Implications for screening in older Americans. Cancer 1995; 75: 775-781.
4. Bengmark S, Hafstrom L,. The natural history of primary and secondary malignant tumors of the liver. I. The prognosis for patients with hepatic metastases from colonic and rectal carcinoma by laparotomy. Cancer 1969; 23: 198-202.
5. Gilbert HA,. Metastases Incidence, Detection and Evaluation Without Histologic Confirmation. Fundamental Aspects of Metastases. Amsterdam: North-Holland, 1976, pp 385-405.
6. Hutchins LF, Unger JM, Crowley JJ, et al. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 1999; 341: 2061-2067. (Pubitemid 30035956)
7. Fong Y, Fortner J, Sun RL, et al. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: Analysis of 1001 consecutive cases. Ann Surg 1999; 230: 309-318; discussion 318-321.
8. Fortner JG, Silva JS, Golbey RB, et al. Multivariate analysis of a personal series of 247 consecutive patients with liver metastases from colorectal cancer. I. Treatment by hepatic resection. Ann Surg 1984; 199: 306-316. (Pubitemid 14194076)
9. Adson MA,. Resection of liver metastases-When is it worthwhile? World J Surg 1987; 11: 511-520.
10. Fong Y, Cohen AM, Fortner JG, et al. Liver resection for colorectal metastases. J Clin Oncol 1997; 15: 938-946. (Pubitemid 27106275)
11. Kato T, Yasui K, Hirai T, et al. Therapeutic results for hepatic metastasis of colorectal cancer with special reference to effectiveness of hepatectomy: Analysis of prognostic factors for 763 cases recorded at 18 institutions. Dis Colon Rectum 2003; 46: S22-S31. (Pubitemid 37266357)
12. Jaeck D, Bachellier P, Guiguet M, et al. Long-term survival following resection of colorectal hepatic metastases. Association Francaise de Chirurgie. Br J Surg 1997; 84: 977-980. (Pubitemid 27310867)
13. Nordlinger B, Guiguet M, Vaillant JC, et al. Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Francaise de Chirurgie. Cancer 1996; 77: 1254-1262. (Pubitemid 26102322)
14. Scheele J, Stang R, Altendorf-Hofmann A, et al. Resection of colorectal liver metastases. World J Surg 1995; 19: 59-71.
15. Berretta M, Bearz A, Frustaci S, et al. FOLFOX2 in the treatment of advanced colorectal cancer: A comparison between elderly and middle aged patients. J Chemother 2008; 20: 503-508.
16. Berretta M, Cappellani A, Fiorica F, et al. FOLFOX4 in the treatment of metastatic colorectal cancer in elderly patients: A prospective study. Arch Gerontol Geriatr 2011; 52: 89-93.
17. Rosati G, Cordio S, Bordonaro R, et al. Capecitabine in combination with oxaliplatin or irinotecan in elderly patients with advanced colorectal cancer: Results of a randomized phase II study. Ann Oncol 2010; 21: 781-786.
18. Fleisher LA, Beckman JA, Brown KA, et al. ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery): Developed in collaboration with the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. Circulation 2007; 116: e418-e499.
19. Fujii Y, Shimada H, Endo I, et al. Effects of portal vein embolization before major hepatectomy. Hepatogastroenterology 2003; 50: 438-442. (Pubitemid 36390539)
20. Fujii Y, Shimada H, Endo I, et al. Risk factors of posthepatectomy liver failure after portal vein embolization. J Hepatobiliary Pancreat Surg 2003; 10: 226-232. (Pubitemid 37407508)
21. Balzan S, Belghiti J, Farges O, et al. The "50-50 criteria" on postoperative day 5: An accurate predictor of liver failure and death after hepatectomy. Ann Surg 2005; 242: 824-828, discussion 828-829.
22. Pang YY,. The Brisbane 2000 terminology of liver anatomy and resections. HPB 2000;2:333-39. HPB (Oxford) 2002; 4: 99-100. (Pubitemid 34830606)
23. Dice JF,. Cellular theories of aging as related to the liver. Hepatology 1985; 5: 508-513. (Pubitemid 15065963)
24. James OF,. Gastrointestinal and liver function of old age. Clin Gastroenterol 1983; 12: 671-691. (Pubitemid 13006032)
25. Nagano Y, Nojiri K, Matsuo K, et al. The impact of advanced age on hepatic resection of colorectal liver metastases. J Am Coll Surg 2005; 201: 511-516. (Pubitemid 41393071)
26. Zacharias T, Jaeck D, Oussoultzoglou E, et al. First and repeat resection of colorectal liver metastases in elderly patients. Ann Surg 2004; 240: 858-865. (Pubitemid 39425780)
27. Iwatsuki S, Dvorchik I, Madariaga JR, et al. Hepatic resection for metastatic colorectal adenocarcinoma: A proposal of a prognostic scoring system. J Am Coll Surg 1999; 189: 291-299. (Pubitemid 29408866)
28. Minagawa M, Makuuchi M, Torzilli G, et al. Extension of the frontiers of surgical indications in the treatment of liver metastases from colorectal cancer: Long-term results. Ann Surg 2000; 231: 487-499. (Pubitemid 30185854)
29. Adam R, Frilling A, Elias D, et al. Liver resection of colorectal metastases in elderly patients. Br J Surg 2010; 97: 366-376.
30. Huguet C, Gavelli A, Bona S,. Hepatic resection with ischemia of the liver exceeding one hour. J Am Coll Surg 1994; 178: 454-458. (Pubitemid 24141499)
31. Nuzzo G, Giuliante F, Giovannini I, et al. Hepatic resections in normothermic ischemia. Surgery 1996; 120: 852-858. (Pubitemid 26378187)
32. Pringle JH, V. Notes on the arrest of hepatic hemorrhage due to trauma. Ann Surg 1908; 48: 541-549.
33. Wynne HA, Cope LH, Mutch E, et al. The effect of age upon liver volume and apparent liver blood flow in healthy man. Hepatology 1989; 9: 297-301. (Pubitemid 19063317)
34. Brand MI, Saclarides TJ, Dobson HD, et al. Liver resection for colorectal cancer: Liver metastases in the aged. Am Surg 2000; 66: 412-415; discussion 415-416.
35. Fong Y, Blumgart LH, Fortner JG, et al. Pancreatic or liver resection for malignancy is safe and effective for the elderly. Ann Surg 1995; 222: 426-434; discussion 434-427.
36. Mann CD, Neal CP, Pattenden CJ, et al. Major resection of hepatic colorectal liver metastases in elderly patients-An aggressive approach is justified. Eur J Surg Oncol 2008; 34: 428-432. (Pubitemid 351381285)
37. Zieren HU, Muller JM, Zieren J, et al. The impact of patient's age on surgical therapy of colorectal liver metastases. Int Surg 1993; 78: 288-291. (Pubitemid 24038396)
38. de Liguori Carino N, van Leeuwen BL, Ghaneh P, et al. Liver resection for colorectal liver metastases in older patients. Crit Rev Oncol Hematol 2008; 67: 273-278.
39. Zieren HU, Muller JM, Zieren J,. Resection of colorectal liver metastases in old patients. Hepatogastroenterology 1994; 41: 34-37. (Pubitemid 24081729)
40. Goldberg RM, Sargent DJ, Morton RF, et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 2004; 22: 23-30. (Pubitemid 41095110)
41. Tournigand C, Cervantes A, Figer A, et al. OPTIMOX1: A randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-Go fashion in advanced colorectal cancer-A GERCOR study. J Clin Oncol 2006; 24: 394-400. (Pubitemid 46630458)
42. Feliu J, Safont MJ, Salud A, et al. Capecitabine and bevacizumab as first-line treatment in elderly patients with metastatic colorectal cancer. Br J Cancer 2010; 102: 1468-1473.
43. Tournigand C, Andre T, Achille E, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study. J Clin Oncol 2004; 22: 229-237. (Pubitemid 41095086)
44. Falcone A, Ricci S, Brunetti I, et al. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: The Gruppo Oncologico Nord Ovest. J Clin Oncol 2007; 25: 1670-1676. (Pubitemid 46797946)
45. Adam R, Avisar E, Ariche A, et al. Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal. Ann Surg Oncol 2001; 8: 347-353. (Pubitemid 32422861)
46. Adam R, Wicherts DA, de Haas RJ, et al. Patients with initially unresectable colorectal liver metastases: Is there a possibility of cure? J Clin Oncol 2009; 27: 1829-1835.
47. Bismuth H, Adam R, Levi F, et al. Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy. Ann Surg 1996; 224: 509-520; discussion 520-502.
48. Giacchetti S, Itzhaki M, Gruia G, et al. Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery. Ann Oncol 1999; 10: 663-669. (Pubitemid 29342371)
49. Benoist S, Brouquet A, Penna C, et al. Complete response of colorectal liver metastases after chemotherapy: Does it mean cure? J Clin Oncol 2006; 24: 3939-3945. (Pubitemid 46630742)
50. Nasti G, Ottaiano A, Berretta M, et al. Pre-operative chemotherapy for colorectal cancer liver metastases: An update of recent clinical trials. Cancer Chemother Pharmacol 2010; 66: 209-218.
51. Pozzo C, Basso M, Cassano A, et al. Neoadjuvant treatment of unresectable liver disease with irinotecan and 5-fluorouracil plus folinic acid in colorectal cancer patients. Ann Oncol 2004; 15: 933-939. (Pubitemid 39004350)
52. Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007; 25: 1539-1544. (Pubitemid 46733080)
53. Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-2342. (Pubitemid 38702844)
54. Kabbinavar FF, Hambleton J, Mass RD, et al. Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol 2005; 23: 3706-3712.
55. Gruenberger B, Tamandl D, Schueller J, et al. Bevacizumab, capecitabine, and oxaliplatin as neoadjuvant therapy for patients with potentially curable metastatic colorectal cancer. J Clin Oncol 2008; 26: 1830-1835.
56. Folprecht G, Gruenberger T, Bechstein WO, et al. Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: The CELIM randomised phase 2 trial. Lancet Oncol 2010; 11: 38-47.
57. Scheithauer W, Rosen H, Kornek GV, et al. Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer. BMJ 1993; 306: 752-755. (Pubitemid 23080053)
58. Hecht JR, Mitchell E, Chidiac T, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 2009; 27: 672-680.