Innate and adaptive immunity in inflammatory bowel diseases

Digestive Diseases

Volumn 31, Issue 3-4, 2013, Pages 317-320

  Foersch, Sebastian ^a   Waldner, Maximilian J ^a   Neurath, Markus F ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Adaptive immune system; Innate immune system

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 23; INTERLEUKIN 6; LECTIN RECEPTOR; MYELOID DIFFERENTIATION FACTOR 88; STAT1 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; TOLL LIKE RECEPTOR; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR3; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 25; INTERLEUKIN 33; INTERLEUKIN 5; INTERLEUKIN 8; INTERLEUKIN 9; TRANSCRIPTION FACTOR GATA 3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; CONFERENCE PAPER; CROHN DISEASE; HUMAN; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INFLAMMATION; INNATE IMMUNITY; MUCOSAL IMMUNITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ULCERATIVE COLITIS; ANIMAL; BIOLOGICAL MODEL; IMMUNOLOGY; INFLAMMATORY BOWEL DISEASE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DENDRITIC CELL; INTESTINE FLORA; LYMPHOCYTE STRUCTURE; MACROPHAGE; MACROPHAGE FUNCTION; NATURAL KILLER CELL; NEUTROPHIL; PHAGOCYTOSIS; REGULATORY T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL;

ADAPTIVE IMMUNITY; ANIMALS; HUMANS; IMMUNITY, INNATE; INFLAMMATORY BOWEL DISEASES; MODELS, BIOLOGICAL;

EID: 84888212964     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000354685     Document Type: Conference Paper

References (38)

1. Crohn B, Rosenberg H: The sigmoidoscopic picture of chronic ulcerative colitis (non-specific). Am J Med Sci 1925; 220-228.
2. Foersch S, Waldner MJ, Neurath MF: Colitis and colorectal cancer. Dig Dis 2012; 30: 469-476.
3. Schroeder BO, Wu Z, Nuding S, Groscurth S, Marcinowski M, Beisner J, et al: Reduction of disulphide bonds unmasks potent antimicrobial activity of human -defensin 1. Nature 2011; 469: 419-423.
4. Gunther C, Martini E, Wittkopf N, Amann K, Weigmann B, Neumann H, et al: Caspase-8 regulates TNF induced epithelial necroptosis and terminal ileitis. Nature 2011; 477: 335-339.
5. Xavier RJ, Podolsky DK: Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007; 448: 427-434.
6. Rakoff-Nahoum S, Hao L, Medzhitov R: Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity 2006; 25: 319-329.
7. Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, et al: Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 2007; 446: 557-561.
8. Franchimont D: Deficient host-bacteria interactions in inflammatory bowel disease The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis. Gut 2004; 53: 987-992.
9. Szu-Hee L, Starkey P, Gordon S: Quantitative analysis of total macrophage content in adult mouse tissues. J Exp Med 1985; 161: 475-489.
10. Bar-on L, Zigmond E, Jung S: Management of gut inflammation through the manipulation of intestinal dendritic cells and macrophages Semin Immunol 2011; 23: 58-64.
11. Smythies LE, Sellers M, Clements RH, Mosteller-Barnum M, Meng G, Benjamin WH, et al: Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J Clin Invest 2005; 115: 66-75.
12. Smythies LE, Shen R, Bimczok D, Novak L, Clements RH, Eckhoff DE, et al: Inflammation anergy in human intestinal macrophages is due to Smad-induced IB expression and NF-B inactivation. J Biol Chem 2010; 285: 19593-19604.
13. Kamada N, Hisamatsu T: Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN- axis. J Clin Invest 2008; 118: 2269-2280.
14. Denning TL, Wang Y, Patel SR, Williams IR, Pulendran B: Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin-17-producing T-cell responses. Nat Immunol 2007; 8: 1086-1094.
15. Kamada N, Hisamatsu T: Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria. J Immunol 2005; 175: 6900-6908.
16. Rimoldi M, Chieppa M, Salucci V, Avogadri F, Sonzogni A, Sampietro GM, et al: Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol 2005; 6: 507-514.
17. Rescigno M, Di Sabatino A: Dendritic cells in intestinal homeostasis and disease. J Clin Invest 2009; 119: 2441-2450.
18. Chieppa M, Rescigno M, Huang AYC, Germain RN: Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J Exp Med 2006; 203: 2841-2852.
19. Lathrop SK, Santacruz NA, Pham D, Luo J, Hsieh C-S: Antigen-specific peripheral shaping of the natural regulatory T-cell population. J Exp Med 2008; 205: 3105-1317.
20. Powrie F, Leach MW, Mauze S, Menon S, Caddle LB, Coffman RL: Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1994; 1: 553-562.
21. Zhou L, Littman DR: Transcriptional regulatory networks in Th17 cell differentiation. Curr Opin Immunol 2009; 21: 146-152.
22. Murphy K, Ouyang W: Signaling and transcription in T-helper development. Annu Rev Immunol 2000; 451-494.
23. Kamiya S, Owaki T, Morishima N, Fukai F, Mizuguchi J, Yoshimoto T: An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells. J Immunol 2004; 173: 3871-3877.
24. Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, et al: Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J Immunol 2003; 170: 4886-4890.
25. Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, et al: The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature 2009; 460: 405-409.
26. Neurath M: IL-23: a master regulator in Crohn disease. Nat Med 2007; 13: 26-28.
27. Leppkes M, Becker C, Ivanov II, Hirth S, Wirtz S, Neufert C, et al: ROR-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology 2009; 136: 257-267.
28. Ho I-C, Tai T-S, Pai S-Y: GATA3 and the Tcell lineage: essential functions before and after T-helper-2 cell differentiation. Nat Rev Immunol 2009; 9: 125-135.
29. Atreya R, Zimmer M, Bartsch B, Waldner MJ, Atreya I, Neumann H, et al: Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14+ macrophages. Gastroenterology 2011; 141: 2026-2038.
30. Scanlon ST, McKenzie ANJ: Type 2 innate lymphoid cells: new players in asthma and allergy. Curr Opin Immunol 2012; 24: 707-712.
31. Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, et al: Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science 2012; 336: 1321-1325.
32. Sawa S, Lochner M, Satoh-Takayama N, Dulauroy S, Berard M, Kleinschek M, et al: RORt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nat Immunol 2011; 12: 320-326.
33. Brandtzaeg P: Induction of secretory immunity and memory at mucosal surfaces. Vaccine 2007; 25: 5467-5484.
34. Brandtzaeg P, Carlsen HS, Halstensen TS: The B-cell system in inflammatory bowel disease. Adv Exp Med Biol 2006; 579: 149-167.
35. Goetz M, Atreya R, Ghalibafian M, Galle PR, Neurath MF: Exacerbation of ulcerative colitis after rituximab salvage therapy. Inflamm Bowel Dis 2007; 13: 1365-1368.
36. Noronha A, Liang Y: Hyperactivated B cells in human inflammatory bowel disease. J Leukoc Biol 2009; 86: 1007-1016.
37. Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, et al: Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 2012; 491: 119-124.
38. Schurmann S, Foersch S, Atreya R, Neumann H, Friedrich O, Neurath MF, et al: Label-free imaging of inflammatory bowel disease using multiphoton microscopy Gastroenterology 2013, E-pub ahead of print.