Correlation between obesity, adipokines and the immune system;Correlação entre obesidade, adipocinas e sistema imunológico

Revista Brasileira de Cineantropometria e Desempenho Humano

Volumn 11, Issue 4, 2009, Pages 466-472

  da Silveira, Marcos Regini ^a   Frollini, Anelena Bueno ^a   Verlengia, Rozângela ^a   Cavaglieri, Cláudia Regina ^a  

^a METHODIST UNIVERSITY OF PIRACICABA   (Brazil)

Author keywords

Adipokines; Adiponectin; Immune system; Leptin; Obesity; Resistin

Indexed keywords

EID: 84888191425     PISSN: 14158426     EISSN: 19800037     Source Type: Journal    
DOI: 10.5007/1980-0037.2009v11n4p466     Document Type: Review

References (40)

1. World Helth Organization. Diet, nutrition and prevention of chronic diseases. Geneva; 2003,160.
2. Racette SB, Deusinger SS, Deusinger RH. Obesity: overview of prevalence, etiology, and treatment. Phys Ther 2003;83(3):276-288.
3. Villela NB, Neto OB, Curvello KL, Paneili BE, Seal C, Santos D, et al. Quality of life of obese patients submitted to bariatric surgery. Nutr Hosp 2004;19(6):367-371.
4. Mafra D, Farage NE. O papel do tecido adiposo na doença renal crônica. J Bras Nefrol 2006;28(2):108-113.
5. Fantuzzi G. Adipose tissue, adipokines and inflammation. J Allergy Clin Immunol 2005;115(5):911-919.
6. Benatti FB, Lancha JR, AH. Leptina e exercício físico aeróbio: implicações da adiposidade corporal e insulina. Rev Bras Med Esporte 2007;13(4):263-269.
7. Mota GR, Zanesco A. Leptina, ghrelina e exercício físico. Arq Bras Endocrinol Metab 2007;51(1):25-33.
8. Negrão AB, Licínio J. Leptina: diálogo entre adipócitos e neurônios. Arq Bras Endocrinol Metab 2000;44(3):205-214.
9. Fonseca-Alaniz MH, Takada J, Alonso-Vale MIC, Lima FB. O tecido adiposo como centro regulador do metabolismo. Arq Bras Endocrinol Metab 2006;50(2):216-229.
10. Guimarães DED, Sardinha FLC, Mizurini DM, Tavares do Carmo MG. Adipocitocinas: uma nova visão do tecido adiposo. Rev Nutr 2007;20(5):549-559.
11. Bjorbaek C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 2004;59(1):305-331.
12. El-Haschimi K, Pierroz DD, Hileman SM, Bjorbaek C, Flier J. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 2000;105(12):1827-1832.
13. Margetic S, Gazzola C, Pegg GG, Hill RA. Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord 2002;26(11):1407-1433.
14. La Cava A, Matarese G. The weight of leptin in immunity. Nat Rev Immunol 2004;4(5):371-379.
15. Kleinubing MC. Ações dos níveis plasmáticos de leptina e sua influência no controle do peso corporal. Revista Digital EF Deportes: Buenos Aires. 2003; Disponível em: [2008 jun 04].
16. Heermsdorff HHM, Vieira MAQM, Monteiro JBR. Leptina e sua influência na patofisiologia de distúrbios alimentares. Rev Nutr 2006;19(3):369-379.
17. Alvez MNR. Os efeitos da obesidade na resposta imune. Rev Bras Nutr Clin 2006;21(4):316-319.
18. Costa JV, Duarte JS. Tecido adiposo e adipocinas. Acta Med Port 2006;19(3):251-256.
19. Juge-Aubry CE, Meier CA. Immunomodulatory actions of leptin. Mol Cell Endocrinol 2002;194(1-2):1-7.
20. Shamsuzzaman ASM, Winnicki M, Wolk R, Svatikova A, Phillips BG, Davison DE, et al. Independent association between plasma leptin and c-reactive protein in healthy humans. Circulation 2004;109(18):2181-2185.
21. Bulló M, Lorda PG, Megias I, Salas-Salvado J. Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. Obes Res 2003;11(4):525-531.
22. Reilly MP, Iqbal N, Schutta M, Wolfe ML, Scally M, Localio AR, et al. Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. J Clin Endocrinol Metab 2004;89(8):3872-3878.
23. Carvalho MH, Colaço AL, Fortes ZB. Citocinas, disfunção endotelial e resistência à insulina. Arq Bras Endocrinol Metab 2006;50(2):304-312.
24. Fonseca-Alaniz MH, Takada J, Alonso-Vale MIC, Lima FB. O tecido adiposo como órgão endócrino: da teoria à prática. J Pediatr 2007;83(5):192-203.
25. Greenberg AS, Obin M. Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr 2006;83:461S-465S.
26. Matsuzawa Y, Funahashi T, Kihara S, Shimomura I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol 2004;24(1):29-33.
27. Goldstein BJ, Scalia R. Adiponectin: a novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab 2004;89(6):2563-2568.
28. Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nature 2006;6(10):772-783.
29. Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y, et al. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 1999;100(25):2473-2476.
30. Carvalheira JBC, Zecchin HG, Saad MJA. Bases moleculares e fisiológicas da resistência à insulina. Hipertensão 2002;5(1):33-38.
31. Hermsdorff HHM, Josefina Monteiro JBR. Gordura visceral, subcutânea ou intramuscular: onde está o problema? Arq Bras Endocrinol Metab 2004;48(6):803-811.
32. Janke J, Engeli S, Gorzelniak K, Luft CF, Sharma AM. Resistin gene expression in human adipocytes is not related to insulin resistance. Obes Res 2002;10(1):1-5.
33. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation b activating AMP-activated protein kinase. Nat Med 2002;8(11):1288-1295.
34. Iqbal N, Seshadri P, Stern L, Loh J, Kundu S, Jafar T, et al. Serum resistin is not associated with obesity or insulin resistance in humans. Eur Rev Med Pharmacol Sci 2005;9(3):161-165.
35. Azuma K, Katshkawa F, Oguchi S, Mitsuru, M, Yamazaki H, Shimada A, et al. Correlation between serum resistin level and adiposity in obese individuals. Obes Res 2003;11(8):997-1001.
36. Degawa-Yamauchi M, Bovenkerk JE, Juliar BE, Watson W, Kerr K, Jones R, et al. Serum resistin (FIZZ3) protein is increased in obese humans, J Clin Endocrinol Metab 2003;88(11):5452-5455.
37. Pang S, Le Y. Role of resistin in inflammation and inflammation-related diseases. Cell Mol Immunol 2006;3(1):29-34.
38. Kunnari A, Ukkola O, Paivansalo M, Kesaniemi A. High plasma resistin level is associated with enhanced highly sensitive c-reactive protein and leukocytes. J Clin Endocrinol Metab 2006;91(7):2755-2760.
39. Kaser S, Kaser A, Sandhofer A, Ebenbichler CF, Tilg H, Patsch JR. Resistin messenger-RNA expression is increased by pro-inflammatory cytokines in vitro. Biochem Biophys Res Commun 2003;309(2):286-290.
40. Ohmori R, Momiyama Y, Kato R, Taniguchi H, Ogura M, Ayaori M, et al. Associations between serum resistin levels and insulin resistance. J Am Coll Cardiol 2005;46(2):379-380