DNMT3B7 expression related to MENT expression and its promoter methylation in human lymphomas

Leukemia Research

Volumn 37, Issue 12, 2013, Pages 1662-1667

  Alkebsi, Lobna ^a   Handa, Hiroshi ^c   Sasaki, Yoshiko ^a   Osaki, Yohei ^b   Yanagisawa, Kunio ^b   Ogawa, Yoshiaki ^b   Yokohama, Akihiko ^c   Hattori, Hikaru ^a   Koiso, Hiromi ^c   Saitoh, Takayuki ^c   Mitsui, Takeki ^b   Tsukamoto, Norifumi ^c   Nojima, Yoshihisa ^c   Murakami, Hirokazu ^a  

^a GUNMA UNIVERSITY   (Japan)

^b Graduate School of Medicine   (Japan)

^c GUNMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

DNMT3B7; Human lymphoma; MENT

Indexed keywords

DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; DNA METHYLTRANSFERASE 3B7; MESSENGER RNA; METHYLATED IN NORMAL THYMOCYTE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA EXTRACTION; DNA METHYLATION; DNMT3B7 GENE; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN TISSUE; LARGE CELL LYMPHOMA; LYMPHOMA; MAJOR CLINICAL STUDY; MANTLE CELL LYMPHOMA; MENT GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TUMOR GENE; UPREGULATION;

EID: 84888134905     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2013.09.014     Document Type: Article

References (29)

1. McCabe M.T., Brandes J.C., Vertino P.M. Cancer DNA methylation: molecular mechanisms and clinical implications. Clin Cancer Res 2009, 15:3927-3937.
2. Bernstein B.E., Meissner A., Lander E.S. The mammalian epigenome. Cell 2007, 128:669-681.
3. Iacobuzio-Donahue C.A. Epigenetic changes in cancer. Annu Rev Pathol 2009, 4:229-249.
4. Rice K.L., Hormaeche I., Licht J.D. Epigenetic regulation of normal and malignant hematopoiesis. Oncogene 2007, 26:6697-6714.
5. Amara K., Trimeche M., Ziadi S., et al. Presence of simian virus 40 DNA sequences in diffuse large B-cell lymphomas in Tunisia correlates with aberrant promoter hypermethylation of multiple tumor suppressor genes. Int J Cancer 2007, 121:2693-2702.
6. Amara K., Trimeche M., Ziadi S., Laatiri A., Hachana M., Korbi S. Prognostic significance of aberrant promoter hypermethylation of CpG islands in patients with diffuse large B-cell lymphomas. Ann Oncol 2008, 19:1774-1786.
7. Amara K., Ziadi S., Hachana M., Soltani N., Korbi S., Trimeche M. DNA methyltransferase DNMT3b protein overexpression as a prognostic factor in patients with diffuse large B-cell lymphomas. Cancer Sci 2010, 101:1722-1730.
8. Bestor T.H. The DNA methyltransferases of mammals. Hum Mol Genet 2000, 9:2395-2402.
9. Robertson K.D. DNA methylation, methyltransferases, and cancer. Oncogene 2001, 20:3139-3155.
10. Lin R.K., Hsu H.S., Chang J.W., Chen C.Y., Chen J.T., Wang Y.C. Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer. Lung Cancer 2007, 55:205-213.
11. Robertson K.D., Wolffe A.P. DNA methylation in health and disease. Nat Rev Genet 2000, 1:11-19.
12. Li E. Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet 2002, 3:662-673.
13. Cedar H., Bergman Y. Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet 2009, 10:295-304.
14. Hagleitner M.M., Lankester A., Maraschio P., et al. Clinical spectrum of immunodeficiency, centromeric instability and facial dysmorphism (ICF syndrome). J Med Genet 2008, 45:93-99.
15. Fackenthal J.D., Godley L.A. Aberrant RNA splicing and its functional consequences in cancer cells. Dis Model Mech 2008, 1:37-42.
16. Ostler K.R., Davis E.M., Payne S.L., et al. Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins. Oncogene 2007, 26:5553-5563.
17. Shah M.Y., Vasanthakumar A., Barnes N.Y., et al. DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis. Cancer Res 2010, 70:5840-5850.
18. Hlady R.A., Novakova S., Opavska J., et al. Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. J Clin Invest 2012, 122:163-177.
19. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001, 25:402-408.
20. Okano M., Bell D.W., Haber D.A., Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999, 99:247-257.
21. Wang J., Walsh G., Liu D.D., Lee J.J., Mao L. Expression of Delta DNMT3B variants and its association with promoter methylation of p16 and RASSF1A in primary non-small cell lung cancer. Cancer Res 2006, 66:8361-8366.
22. Wang J., Bhutani M., Pathak A.K., et al. Delta DNMT3B variants regulate DNA methylation in a promoter-specific manner. Cancer Res 2007, 67:10647-10652.
23. Gopalakrishnan S., Van Emburgh B.O., Shan J., et al. A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding. Mol Cancer Res 2009, 7:1622-1634.
24. Clark H.F., Gurney A.L., Abaya E., et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res 2003, 13:2265-2270.
25. Hata K., Okano M., Lei H., Li E. Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development 2002, 129:1983-1993.
26. Jia D., Jurkowska R.Z., Zhang X., Jeltsch A., Cheng X. Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature 2007, 449:248-251.
27. Liang G., Chan M.F., Tomigahara Y., et al. Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol 2002, 22:480-491.
28. Kim G.D., Ni J., Kelesoglu N., Roberts R.J., Pradhan S. Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases. EMBO J 2002, 21:4183-4195.
29. Swerdlow S.H., Campo E., Harris N.L., Jaffe E.S., Pileri S.A., Stain H., Thiele J., Vardiman J.W. WHO classification of tumours of haematopoietic and lymphoid tissues 2008, International Agency for Research on Cancer (IARC), Lyon. forth ed.