Iron acquisition in the human fungal pathogen Cryptococcus neoformans

Current Opinion in Microbiology

Volumn 16, Issue 6, 2013, Pages 686-691

  Jung, Won Hee ^a   Do, Eunsoo ^a  

^a Chung Ang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT BINDING FACTOR; CERULOPLASMIN; FERRIC ION; FERRIOXAMINE; FERROUS ION; IRON; IRON REGULATORY FACTOR;

ACIDIFICATION; ACIDITY; ASPERGILLUS NIDULANS; BRUCELLA ABORTUS; CELL MATURATION; CELL SURFACE; CRYPTOCOCCUS NEOFORMANS; ENDOCYTOSIS; ENZYME ACTIVITY; FUNGAL GENOME; FUNGAL VIRULENCE; GLOBAL CHANGE; HISTOPLASMA CAPSULATUM; INTERNALIZATION; IRON TRANSPORT; LEGIONELLA PNEUMOPHILA; LISTERIA MONOCYTOGENES; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE; MICROENVIRONMENT; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATIVE STRESS; PHAGOCYTE; PHAGOLYSOSOME; PHAGOSOME; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN PROCESSING; RESPIRATORY FUNCTION; REVIEW; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SERIAL ANALYSIS OF GENE EXPRESSION; SHIGELLA FLEXNERI;

FILOBASIDIELLA NEOFORMANS; FUNGI; VERTEBRATA;

CRYPTOCOCCUS NEOFORMANS; IRON; MICROBIAL VIABILITY; VIRULENCE;

EID: 84888133477     PISSN: 13695274     EISSN: 18790364     Source Type: Journal    
DOI: 10.1016/j.mib.2013.07.008     Document Type: Review

References (46)

1. Drakesmith H., Prentice A.M. Hepcidin and the iron-infection axis. Science 2012, 338:768-772.
2. Park B.J., Wannemuehler K.A., Marston B.J., Govender N., Pappas P.G., Chiller T.M. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 2009, 23:525-530.
3. Kronstad J., Saikia S., Nielson E.D., Kretschmer M., Jung W., Hu G., Geddes J.M., Griffiths E.J., Choi J., Cadieux B., et al. Adaptation of Cryptococcus neoformans to mammalian hosts: integrated regulation of metabolism and virulence. Eukaryot Cell 2012, 11:109-118.
4. Kronstad J.W., Attarian R., Cadieux B., Choi J., D'Souza C.A., Griffiths E.J., Geddes J.M., Hu G., Jung W.H., Kretschmer M., et al. Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box. Nat Rev Microbiol 2011, 9:193-203.
5. Williams V., Del Poeta M. Role of glucose in the expression of Cryptococcus neoformans antiphagocytic protein 1. App1. Eukaryot Cell 2011, 10:293-301.
6. Griffiths E.J., Hu G., Fries B., Caza M., Wang J., Gsponer J., Gates-Hollingsworth M.A., Kozel T.R., De Repentigny L., Kronstad J.W. A defect in ATP-citrate lyase links acetyl-CoA production, virulence factor elaboration and virulence in Cryptococcus neoformans. Mol Microbiol 2012, 86:1404-1423.
7. Charlier C., Nielsen K., Daou S., Brigitte M., Chretien F., Dromer F. Evidence for a role of monocytes in dissemination and brain invasion by Cryptococcus neoformans. Infect Immun 2009, 77:120-127.
8. Choi J.N., Kim J., Kim J., Jung W.H., Lee C.H. Influence of iron regulation on the metabolome of Cryptococcus neoformans. PLoS One 2012, 7:e41654.
9. Kim J., Cho Y.J., Do E., Choi J., Hu G., Cadieux B., Chun J., Lee Y., Kronstad J.W., Jung W.H. A defect in iron uptake enhances the susceptibility of Cryptococcus neoformans to azole antifungal drugs. Fungal Genet Biol 2012, 49:955-966.
10. Jung W.H., Saikia S., Hu G., Wang J., Fung C.K., D'Souza C., White R., Kronstad J.W. HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans. PLoS Pathog 2010, 6:e1001209.
11. Nyhus K.J., Ozaki L.S., Jacobson E.S. Role of mitochondrial carrier protein Mrs3/4 in iron acquisition and oxidative stress resistance of Cryptococcus neoformans. Med Mycol 2002, 40:581-591.
12. Ingavale S.S., Chang Y.C., Lee H., McClelland C.M., Leong M.L., Kwon-Chung K.J. Importance of mitochondria in survival of Cryptococcus neoformans under low oxygen conditions and tolerance to cobalt chloride. PLoS Pathog 2008, 4:e1000155.
13. Jacobson E.S., Goodner A.P., Nyhus K.J. Ferrous iron uptake in Cryptococcus neoformans. Infect Immun 1998, 66:4169-4175.
14. Nyhus K.J., Wilborn A.T., Jacobson E.S. Ferric iron reduction by Cryptococcus neoformans. Infect Immun 1997, 65:434-438.
15. Jung W.H., Sham A., Lian T., Singh A., Kosman D.J., Kronstad J.W. Iron source preference and regulation of iron uptake in Cryptococcus neoformans. PLoS Pathog 2008, 4:e45.
16. Jung W.H., Hu G., Kuo W., Kronstad J.W. Role of ferroxidases in iron uptake and virulence of Cryptococcus neoformans. Eukaryot Cell 2009, 8:1511-1520.
17. Steen B.R., Zuyderduyn S., Toffaletti D.L., Marra M., Jones S.J., Perfect J.R., Kronstad J. Cryptococcus neoformans gene expression during experimental cryptococcal meningitis. Eukaryot Cell 2003, 2:1336-1349.
18. Hu G., Cheng P.Y., Sham A., Perfect J.R., Kronstad J.W. Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection. Mol Microbiol 2008, 69:1456-1475.
19. Tangen K.L., Jung W.H., Sham A.P., Lian T., Kronstad J.W. The iron- and cAMP-regulated gene SIT1 influences ferrioxamine B utilization, melanization and cell wall structure in Cryptococcus neoformans. Microbiology 2007, 153:29-41.
20. Hu G., Caza M., Cadieux B., Chan V., Liu V., Kronstad J. Cryptococcus neoformans requires the ESCRT protein Vps23 for iron acquisition from heme, for capsule formation, and for virulence. Infect Immun 2013, 81:292-302.
21. Cadieux B., Lian T., Hu G., Wang J., Biondo C., Teti G., Liu V., Murphy M.E., Creagh A.L., Kronstad J.W. The mannoprotein Cig1 supports iron acquisition from heme and virulence in the pathogenic fungus Cryptococcus neoformans. J Infect Dis 2013, 207:1339-1347.
22. Jung W.H., Sham A., White R., Kronstad J.W. Iron regulation of the major virulence factors in the AIDS-associated pathogen Cryptococcus neoformans. PLoS Biol 2006, 4:e410.
23. Jung W.H., Kronstad J.W. Iron influences the abundance of the iron regulatory protein Cir1 in the fungal pathogen Cryptococcus neoformans. FEBS Lett 2011, 585:3342-3347.
24. O'Meara T.R., Norton D., Price M.S., Hay C., Clements M.F., Nichols C.B., Alspaugh J.A. Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule. PLoS Pathog 2010, 6:e1000776.
25. O'Meara T.R., Holmer S.M., Selvig K., Dietrich F., Alspaugh J.A. Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses. mBio 2013, 4. e00522-12.
26. Hsu P.C., Yang C.Y., Lan C.Y. Candida albicans Hap43 is a repressor induced under low-iron conditions and is essential for iron-responsive transcriptional regulation and virulence. Eukaryot Cell 2011, 10:207-225.
27. Znaidi S., Pelletier B., Mukai Y., Labbe S. The Schizosaccharomyces pombe corepressor Tup11 interacts with the iron-responsive transcription factor Fep1. J Biol Chem 2004, 279:9462-9474.
28. Lee H., Chang Y.C., Varma A., Kwon-Chung K.J. Regulatory diversity of TUP1 in Cryptococcus neoformans. Eukaryot Cell 2009, 8:1901-1908.
29. Liu O.W., Chun C.D., Chow E.D., Chen C., Madhani H.D., Noble S.M. Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Cell 2008, 135:174-188.
30. Chun C.D., Brown J.C., Madhani H.D. A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans. Cell Host Microbe 2011, 9:243-251.
31. Feldmesser M., Kress Y., Novikoff P., Casadevall A. Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection. Infect Immun 2000, 68:4225-4237.
32. Rohde K., Yates R.M., Purdy G.E., Russell D.G. Mycobacterium tuberculosis and the environment within the phagosome. Immunol Rev 2007, 219:37-54.
33. Newman S.L., Gootee L., Hilty J., Morris R.E. Human macrophages do not require phagosome acidification to mediate fungistatic/fungicidal activity against Histoplasma capsulatum. J Immunol 2006, 176:1806-1813.
34. Lorenz M.C., Bender J.A., Fink G.R. Transcriptional response of Candida albicans upon internalization by macrophages. Eukaryot Cell 2004, 3:1076-1087.
35. Levitz S.M., Nong S.H., Seetoo K.F., Harrison T.S., Speizer R.A., Simons E.R. Cryptococcus neoformans resides in an acidic phagolysosome of human macrophages. Infect Immun 1999, 67:885-890.
36. Meguro R., Asano Y., Odagiri S., Li C., Iwatsuki H., Shoumura K. The presence of ferric and ferrous iron in the nonheme iron store of resident macrophages in different tissues and organs: histochemical demonstrations by the perfusion-Perls and -Turnbull methods in the rat. Arch Histol Cytol 2005, 68:171-183.
37. Geisow M.J., D'Arcy Hart P., Young M.R. Temporal changes of lysosome and phagosome pH during phagolysosome formation in macrophages: studies by fluorescence spectroscopy. J Cell Biol 1981, 89:645-652.
38. Dautry-Varsat A., Ciechanover A., Lodish H.F. pH and the recycling of transferrin during receptor-mediated endocytosis. Proc Natl Acad Sci U S A 1983, 80:2258-2262.
39. Han K., Do E., Jung W.H. A human fungal pathogen Cryptococcus neoformans expresses three distinct iron permease homologs. J Microbiol Biotechnol 2012, 22:1644-1652.
40. Alvarez M., Casadevall A. Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophages. Curr Biol 2006, 16:2161-2165.
41. Alvarez M., Casadevall A. Cell-to-cell spread and massive vacuole formation after Cryptococcus neoformans infection of murine macrophages. BMC Immunol 2007, 8:16.
42. Ma H., Croudace J.E., Lammas D.A., May R.C. Expulsion of live pathogenic yeast by macrophages. Curr Biol 2006, 16:2156-2160.
43. Ma H., Croudace J.E., Lammas D.A., May R.C. Direct cell-to-cell spread of a pathogenic yeast. BMC Immunol 2007, 8:15.
44. Haley K.P., Skaar E.P. A battle for iron: host sequestration and Staphylococcus aureus acquisition. Microbes Infect 2012, 14:217-227.
45. Skaar E.P. The battle for iron between bacterial pathogens and their vertebrate hosts. PLoS Pathog 2010, 6:e1000949.
46. Chesler M. Regulation and modulation of pH in the brain. Physiol Rev 2003, 83:1183-1221.