Iron influences the abundance of the iron regulatory protein Cir1 in the fungal pathogen Cryptococcus neoformans

FEBS Letters

Volumn 585, Issue 20, 2011, Pages 3342-3347

  Jung, Won Hee ^a   Kronstad, James W ^b  

^a Chung Ang University   (South Korea)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cir1; Cryptococcus neoformans; Iron; Proteasome; Protein stability; Redox

Indexed keywords

IRON; IRON REGULATORY FACTOR; IRON REGULATORY PROTEIN CIR1; PROTEASOME; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; ENZYME ACTIVITY; ENZYME INHIBITION; IRON DEPLETION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN STABILITY;

CRYPTOCOCCUS NEOFORMANS; FUNGAL PROTEINS; IRON; IRON-REGULATORY PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STABILITY; ZINC FINGERS;

FILOBASIDIELLA NEOFORMANS; FUNGI; MAMMALIA;

EID: 80054065895     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.09.025     Document Type: Article

References (36)

1. U.E. Schaible, and S.H. Kaufmann Iron and microbial infection Nat. Rev. Microbiol. 2 2004 946 953 (Pubitemid 39562533)
2. W.H. Jung, and J.W. Kronstad Iron and fungal pathogenesis: a case study with Cryptococcus neoformans doi:10.1111/j.1462-5822.2007.01077.x Cell. Microbiol. 10 2008 277 284
3. R. Barluzzi, S. Saleppico, A. Nocentini, J.R. Boelaert, R. Neglia, F. Bistoni, and E. Blasi Iron overload exacerbates experimental meningoencephalitis by Cryptococcus neoformans J. Neuroimmunol. 132 2002 140 146 (Pubitemid 35333336)
4. W.H. Jung, G. Hu, W. Kuo, and J.W. Kronstad Role of ferroxidases in iron uptake and virulence of Cryptococcus neoformans Eukaryot. Cell 8 2009 1511 1520
5. W.H. Jung, A. Sham, T. Lian, A. Singh, D.J. Kosman, and J.W. Kronstad Iron source preference and regulation of iron uptake in Cryptococcus neoformans PLoS Pathog. 4 2008 e45
6. B.J. Park, K.A. Wannemuehler, B.J. Marston, N. Govender, P.G. Pappas, and T.M. Chiller Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS AIDS 23 2009 525 530
7. W.H. Jung, A. Sham, R. White, and J.W. Kronstad Iron regulation of the major virulence factors in the AIDS-associated pathogen Cryptococcus neoformans PLoS Biol. 4 2006 e410
8. W.H. Jung, S. Saikia, G. Hu, J. Wang, C.K. Fung, C. D'Souza, R. White, and J.W. Kronstad HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans PLoS Pathog. 6 2010 e1001209
9. C. Voisard, J. Wang, J.L. McEvoy, P. Xu, and S.A. Leong Urbs1, a gene regulating siderophore biosynthesis in Ustilago maydis, encodes a protein similar to the erythroid transcription factor GATA-1 Mol. Cell. Biol. 13 1993 7091 7100 (Pubitemid 23321161)
10. Z. An, Q. Zhao, J. McEvoy, W.M. Yuan, J.L. Markley, and S.A. Leong The second finger of Urbs1 is required for iron-mediated repression of sid1 in Ustilago maydis Proc. Natl. Acad. Sci. USA 94 1997 5882 5887
11. L.W. Zhou, H. Haas, and G.A. Marzluf Isolation and characterization of a new gene, sre, which encodes a GATA-type regulatory protein that controls iron transport in Neurospora crassa Mol. Gen. Genet. 259 1998 532 540 (Pubitemid 28472749)
12. H. Haas, I. Zadra, G. Stoffler, and K. Angermayr The Aspergillus nidulans GATA factor SREA is involved in regulation of siderophore biosynthesis and control of iron uptake J. Biol. Chem. 274 1999 4613 4619
13. B. Pelletier, J. Beaudoin, Y. Mukai, and S. Labbe Fep1, an iron sensor regulating iron transporter gene expression in Schizosaccharomyces pombe J. Biol. Chem. 277 2002 22950 22958 (Pubitemid 34967279)
14. L.Y. Chao, M.A. Marletta, and J. Rine Sre1, an iron-modulated GATA DNA-binding protein of iron-uptake genes in the fungal pathogen Histoplasma capsulatum Biochemistry 47 2008 7274 7283 (Pubitemid 351956376)
15. M. Schrettl SreA-mediated iron regulation in Aspergillus fumigatus Mol. Microbiol. 70 2008 27 43
16. G.M. Gauthier SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis PLoS Pathog. 6 2010 e1000846
17. C.Y. Lan, G. Rodarte, L.A. Murillo, T. Jones, R.W. Davis, J. Dungan, G. Newport, and N. Agabian Regulatory networks affected by iron availability in Candida albicans Mol. Microbiol. 53 2004 1451 1469 (Pubitemid 39209117)
18. K.A. Harrison, and G.A. Marzluf Characterization of DNA binding and the cysteine rich region of SRE, a GATA factor in Neurospora crassa involved in siderophore synthesis Biochemistry 41 2002 15288 15295 (Pubitemid 36008138)
19. B. Pelletier, A. Trott, K.A. Morano, and S. Labbe Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe J. Biol. Chem. 280 2005 25146 25161 (Pubitemid 40934607)
20. C.D. Chun, J.C. Brown, and H.D. Madhani A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans Cell Host Microbe 9 2011 243 251
21. K.J. Kwon-Chung Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans Mycologia 68 1976 821 833
22. R.S. Sikorski, and P. Hieter A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae Genetics 122 1989 19 27
23. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
24. J. Sambrook, E.F. Fritch, and T. Maniatis Molecular Cloning, a Laboratory Manual 1989 Cold Spring Harbor Laboratory Press New York
25. M. Jbel, A. Mercier, B. Pelletier, J. Beaudoin, and S. Labbe Iron activates in vivo DNA binding of Schizosaccharomyces pombe transcription factor Fep1 through its amino-terminal region Eukaryot. Cell 8 2009 649 664
26. M.L. Wallander, E.A. Leibold, and R.S. Eisenstein Molecular control of vertebrate iron homeostasis by iron regulatory proteins Biochim. Biophys. Acta 1763 2006 668 689 (Pubitemid 44189547)
27. A.A. Vashisht Control of iron homeostasis by an iron-regulated ubiquitin ligase Science 326 2009 718 721
28. C. Brasse-Lagnel, Z. Karim, P. Letteron, S. Bekri, A. Bado, and C. Beaumont Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation Gastroenterology 140 2011 1261 1271
29. A. Rufini Preventing the ubiquitin-proteasome-dependent degradation of frataxin, the protein defective in Friedreich's ataxia Hum. Mol. Genet. 20 2011 1253 1261
30. Y. Kim, Y. Deng, and C.C. Philpott GGA2- and ubiquitin-dependent trafficking of Arn1, the ferrichrome transporter of Saccharomyces cerevisiae Mol. Biol. Cell 18 2007 1790 1802 (Pubitemid 46717560)
31. X. Shi, K. Chabarek, A. Budai, and Z. Zhu Iron requirement for GAL gene induction in the yeast Saccharomyces cerevisiae J. Biol. Chem. 278 2003 43110 43113 (Pubitemid 37345928)
32. Y. Yamaguchi-Iwai, R. Stearman, A. Dancis, and R.D. Klausner Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast EMBO J. 15 1996 3377 3384 (Pubitemid 26231944)
33. L. Li, and J. Kaplan A mitochondrial-vacuolar signaling pathway in yeast that affects iron and copper metabolism J. Biol. Chem. 279 2004 33653 33661 (Pubitemid 39063015)
34. L. Ojeda, G. Keller, U. Muhlenhoff, J.C. Rutherford, R. Lill, and D.R. Winge Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae J. Biol. Chem. 281 2006 17661 17669 (Pubitemid 44035564)
35. R. Ueta, N. Fujiwara, K. Iwai, and Y. Yamaguchi-Iwai Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae Mol. Biol. Cell 18 2007 2980 2990 (Pubitemid 47235305)
36. M. Jbel, A. Mercier, and S. Labbe Grx4 monothiol glutaredoxin is required for iron limitation-dependent inhibition of Fep1 Eukaryot. Cell 10 2011 629 645