The mannoprotein cig1 supports iron acquisition from heme and virulence in the pathogenic fungus cryptococcus neoformans

Journal of Infectious Diseases

Volumn 207, Issue 8, 2013, Pages 1339-1347

  Cadieux, Brigitte ^a,b   Lian, Tianshun ^a   Hu, Guanggan ^a   Wang, Joyce ^a   Biondo, Carmelo ^c   Teti, Giuseppe ^c   Liu, Victor ^a   Murphy, Michael E P ^b   Creagh, A Louise ^a   Kronstad, James W ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

Cryptococcus neoformans; extracellular mannoprotein; fungal hemophore; fungal pathogenesis; heme uptake; pH; Rim101

Indexed keywords

HEMOPROTEIN; MANNOPROTEIN; MANNOPROTEIN CIG1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RIM101; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL DENSITY; CELL SURFACE; CONTROLLED STUDY; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; FEMALE; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS GROWTH; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; IRON METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT;

ANIMALS; COLONY COUNT, MICROBIAL; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; FEMALE; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HEME; HYDROGEN-ION CONCENTRATION; IRON; MICE; PROTEIN BINDING; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY; TITRIMETRY; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; VIRULENCE FACTORS;

EID: 84875581774     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit029     Document Type: Article

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