The mechanism of human tyrosyl-DNA phosphodiesterase 1 in the cleavage of AP site and its synthetic analogs

DNA Repair

Volumn 12, Issue 12, 2013, Pages 1037-1042

  Lebedeva, Natalia A ^a   Rechkunova, Nadejda I ^a,b   Ishchenko, Alexander A ^c   Saparbaev, Murat ^c   Lavrik, Olga I ^a,b  

^a INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

^b NOVOSIBIRSK STATE UNIVERSITY   (Russian Federation)

^c INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Apurinic apyrimidinic site; Cleavage mechanism; Tyrosyl DNA phosphodiesterase 1

Indexed keywords

3 HYDROXY 2(HYDROXYMETHYL) TETRAHYDROFURAN; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA DIRECTED DNA POLYMERASE BETA; PHOSPHODIESTERASE I; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; TYROSYL DNA PHOSPHODIESTERASE 1; UNCLASSIFIED DRUG; XRCC1 PROTEIN;

ARTICLE; DNA CLEAVAGE; DNA HELIX; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME MECHANISM; HUMAN; HYDROLYSIS; PRIORITY JOURNAL;

APURINIC/APYRIMIDINIC SITE; CLEAVAGE MECHANISM; TYROSYL-DNA PHOSPHODIESTERASE 1;

APURINIC ACID; DNA; DNA POLYMERASE BETA; DNA REPAIR; DNA-BINDING PROTEINS; FURANS; HUMANS; HYDROLYSIS; NUCLEIC ACID CONFORMATION; PHOSPHATES; PHOSPHORIC DIESTER HYDROLASES; POLYNUCLEOTIDE 5'-HYDROXYL-KINASE; POLYNUCLEOTIDES; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 84888129073     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2013.09.008     Document Type: Article

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