Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes

Coronary Artery Disease

Volumn 24, Issue 8, 2013, Pages 642-650

  Ito, Shiori ^a   Iwaki, Soichiro ^a   Koike, Keiko ^a   Yuda, Yuichiro ^a   Nagasaki, Ayako ^a   Ohkawa, Ryunosuke ^b   Yatomi, Yutaka ^b   Furumoto, Tomoo ^c   Tsutsui, Hiroyuki ^c   Sobel, Burton E ^d   Fujii, Satoshi ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^c HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

adipocyte; hypoxia; obesity; plasminogen activator inhibitor 1; sphingosine 1 phosphate

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER C1; C REACTIVE PROTEIN; COBALT CHLORIDE; CREATININE; GLUCOSE; HEMOGLOBIN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LYASE; MEMBRANE PROTEIN; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOCYTE; ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BODY MASS; CELL ASSAY; CELL CULTURE; CELL DIFFERENTIATION; CHOLESTEROL BLOOD LEVEL; CREATININE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; DYSLIPIDEMIA; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE COUNT; FEMALE; FIBRINOLYSIS; GLUCOSE BLOOD LEVEL; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPOXIA; IMMUNOBLOTTING; INSULIN BLOOD LEVEL; LEAN BODY WEIGHT; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE COUNT; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING;

3T3-L1 CELLS; ADIPOCYTES; AGED; ALDEHYDE-LYASES; ANIMALS; ATP BINDING CASSETTE TRANSPORTER 1; BODY MASS INDEX; CELL HYPOXIA; CULTURE MEDIA, CONDITIONED; FEMALE; HUMANS; LYSOPHOSPHOLIPIDS; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OBESITY; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTORS, LYSOSPHINGOLIPID; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPHINGOSINE; TIME FACTORS; UP-REGULATION;

EID: 84888115274     PISSN: 09546928     EISSN: 14735830     Source Type: Journal    
DOI: 10.1097/MCA.0000000000000033     Document Type: Article

References (25)

1. Nagai N, Van Hoef B, Lijnen HR. Plasminogen activator inhibitor-1 contributes to the deleterious effect of obesity on the outcome of thrombotic ischemic stroke in mice. J Thromb Haemost 2007; 5:1726-1731.
2. Ye J, Gao Z, Yin J, He Q. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 2007; 293:E1118-E1128.
3. Lucore CL, Sobel BE. Interactions of tissue-type plasminogen activator with plasma inhibitors and their pharmacologic implications. Circulation 1988; 77:660-669.
4. Cox CL, Stanhope KL, Schwarz JM, Graham JL, Hatcher B, Griffen SC, et al. Circulating concentrations of monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, and soluble leukocyte adhesion molecule-in overweight/obese men and women consuming fructose-or glucosesweetened beverages for 10 weeks. J Clin Endocrinol Metab 2011; 96:E2034-E2038.
5. Asakura T, Iwaki S, Okada H, Sobel BE, Fujii S. Posttranscriptional regulation of expression of plasminogen activator inhibitor type-1 by cAMP in HepG2 liver cells. J Biochem 2011; 150:687-694.
6. Iwaki S, Yamamura S, Asai M, Sobel BE, Fujii S. Posttranscriptional regulation of expression of plasminogen activator inhibitor type-1 by sphingosine 1-phosphate in HepG2 liver cells. Biochim Biophys Acta 2012; 1819:1132-1141.
7. Spiegel S, English D, Milstien S. Sphingosine 1-phosphate signaling: providing cells with a sense of direction. Trends Cell Biol 2002; 12: 236-242.
8. Spiegel S, Milstien S. Sphingosine 1-phosphate, a key cell signaling molecule. J Biol Chem 2002; 277:25851-25854.
9. Takuwa Y, Okamoto Y, Yoshioka K, Takuwa N. Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system. Biochim Biophys Acta 2008; 1781:483-488.
10. Sattler KJ, Elbasan S, Keul P, Elter-Schulz M, Bode C, Gräler MH, et al. Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease. Basic Res Cardiol 2010; 105:821-832.
11. Obinata H, Hla T. Sphingosine 1-phosphate in coagulation and inflammation. Semin Immunopathol 2012; 34:73-91.
12. Samad F, Hester KD, Yang G, Hannun YA, Bielawski J. Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes 2006; 55:2579-2587.
13. Leong WI, Saba JD. S1P metabolism in cancer and other pathological conditions. Biochimie 2010; 92:716-723.
14. Cuvillier O, Ader I. Hypoxia-inducible factors and sphingosine 1-phosphate signaling. Anticancer Agents Med Chem 2011; 11:854-862.
15. Yin J, Gao Z, He Q, Zhou D, Guo Z, Ye J. Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue. Am J Physiol Endocrinol Metab 2009; 296:E333-E342.
16. Shin MK, Drager LF, Yao Q, Bevans-Fonti S, Yoo DY, Jun JC, et al. Metabolic consequences of high-fat diet are attenuated by suppression of HIF-1a. PLoS One 2012; 7:e46562.
17. Ohkawa R, Nakamura K, Okubo S, Hosogaya S, Ozaki Y, Tozuka M, et al. Plasma sphingosine-1-phosphate measurement in healthy subjects: close correlation with red blood cell parameters. Ann Clin Biochem 2008; 45:356-363.
18. Olivera A, Kohama T, Tu Z, Milstien S, Spiegel S. Purification and characterization of rat kidney sphingosine kinase. J Biol Chem 1998; 273:12576-12583.
19. Billich A, Bornancin F, Dé vay P, Mechtcheriakova D, Urtz N, Baumruker T. Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. J Biol Chem 2003; 278:47408-47415.
20. Kobayashi N, Yamaguchi A, Nishi T. Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes. J Biol Chem 2009; 284:21192-21200.
21. Hisano Y, Nishi T, Kawahara A. The functional roles of S1P in immunity. J Biochem 2012; 152:305-311.
22. Fyrst H, Saba JD. An update on sphingosine-1-phosphate and other sphingolipid mediators. Nat Chem Biol 2010; 6:489-497.
23. Vykoukal D, Davies MG. Vascular biology of metabolic syndrome. J Vasc Surg 2011; 54:819-831.
24. Nakayama N, Nakamura T, Okada H, Iwaki S, Sobel BE, Fujii S. Modulators of induction of plasminogen activator inhibitor type-1 in HepG2 cells by transforming growth factor-b. Coron Artery Dis 2011; 22:468-478.
25. Sugiura T, Dohi Y, Yamashita S, Ohte N, Ito S, Iwaki S, et al. Analytical evaluation of plasma serotonin and sphingosine 1-phosphate and their clinical assessment in early atherosclerosis. Coron Artery Dis 2012;23:234-238:651-656