Rescue of a primary myelofibrosis model by retinoid-antagonist therapy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 47, 2013, Pages 18820-18825

  Hong, Suk Hyun ^a   Dvorak Ewell, Melita ^b   Stevens, Hazel Y ^c,e   Barish, Grant D ^a   Castro, Glenda L ^a   Nofsinger, Russell ^a,f   Frangos, John A ^c   Shoback, Dolores ^b   Evans, Ronald M ^a,d  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LA JOLLA BIOENGINEERING INSTITUTE   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^f WaferGen Bio Systems Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED GROWTH FACTOR; RECEPTOR BLOCKING AGENT; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ANTAGONIST; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; THROMBOPOIETIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL PROLIFERATION; DISEASE COURSE; MALE; MEGAKARYOCYTE; MOUSE; MYELOFIBROSIS; NONHUMAN; PRIORITY JOURNAL; RETICULUM CELL; SIGNAL TRANSDUCTION; STROMA CELL; UPREGULATION;

MYELODYSPLASTIC SYNDROME; OSTESCLEROSIS; SPLENOMEGALY;

ALKALINE PHOSPHATASE; ANIMALS; BONE MARROW; CALCIUM; CELL PROLIFERATION; CYTOKINES; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIGENETIC REPRESSION; GENE EXPRESSION PROFILING; GENE KNOCK-IN TECHNIQUES; LUCIFERASES; MEGAKARYOCYTES; MICE; NUCLEAR RECEPTOR CO-REPRESSOR 2; ORGANIC CHEMICALS; PLATELET-DERIVED GROWTH FACTOR; POLYMERASE CHAIN REACTION; PRIMARY MYELOFIBROSIS; SIGNAL TRANSDUCTION; THROMBOPOIETIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84888108757     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1318974110     Document Type: Article

References (29)

1. Karsenty G, Wagner EF (2002) Reaching a genetic and molecular understanding of skeletal development. Dev Cell 2(4-389-406
2. Teitelbaum SL (2000) Bone resorption by osteoclasts. Science 289(5484-1504-1508
3. Wan Y, Chong LW, Evans RM (2007) PPAR-gamma regulates osteoclastogenesis in mice. Nat Med 13(12-1496-1503
4. Purton LE, Scadden DT (2006) Osteoclasts eat stem cells out of house and home. Nat Med 12(6-610-611
5. Perry JM, Li L (2007) Disrupting the stem cell niche: Good seeds in bad soil. Cell 129(6- 1045-1047
6. Dameshek W (1951) Some speculations on the myeloproliferative syndromes. Blood 6(4-372-375
7. Abdel-Wahab OI, Levine RL (2009) Primary myelofibrosis: Update on definition, pathogenesis, and treatment. Annu Rev Med 60:233-245
8. Fleischman AG, Maziarz RT (2013) Hematopoietic stem cell transplantation for myelofibrosis: Where are we now? Curr Opin Hematol 20(2-130-136
9. Tefferi A (2011) How I treat myelofibrosis. Blood 117(13-3494-3504
10. Mascarenhas J, Hoffman R (2013) A comprehensive review and analysis of the effect of ruxolitinib therapy on the survival of patients with myelofibrosis. Blood 121(24- 4832-4837
11. Ostojic A, Vrhovac R, Verstovsek S (2011) Ruxolitinib:A new JAK1/2 inhibitor that offers promising options for treatment of myelofibrosis. Future Oncol 7(9-1035-1043
12. Petrie K, Zelent A, Waxman S (2009) Differentiation therapy of acute myeloid leukemia: Past, present and future. Curr Opin Hematol 16(2-84-91
13. Bland R (2000) Steroid hormone receptor expression and action in bone. Clin Sci (Lond) 98(2-217-240
14. Ordentlich P, et al. (1999) Unique forms of human and mouse nuclear receptor corepressor SMRT. Proc Natl Acad Sci USA 96(6-2639-2644
15. Chen JD, Evans RM (1995) A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377(6548-454-457
16. Hörlein AJ, et al. (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377(6548-397-404
17. Sande S, Privalsky ML (1996) Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. Mol Endocrinol 10(7-813-825
18. Nofsinger RR, et al. (2008) SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc Natl Acad Sci USA 105(50-20021-20026
19. Vannucchi AM, Migliaccio AR, Paoletti F, Chagraoui H, Wendling F (2005) Pathogenesis of myelofibrosis with myeloid metaplasia: Lessons from mouse models of the disease. Semin Oncol 32(4-365-372
20. Mesa RA, Hanson CA, Rajkumar SV, Schroeder G, Tefferi A (2000) Evaluation and clinical correlations of bone marrow angiogenesis in myelofibrosis with myeloid metaplasia. Blood 96(10-3374-3380
21. Chagraoui H, et al. (2002) Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in mice. Blood 100(10-3495-3503
22. Kakumitsu H, et al. (2005) Transgenic mice overexpressing murine thrombopoietin develop myelofibrosis and osteosclerosis. Leuk Res 29(7-761-769
23. Kacena MA, Gundberg CM, Horowitz MC (2006) A reciprocal regulatory interaction between megakaryocytes, bone cells, and hematopoietic stem cells. Bone 39(5- 978-984
24. Kinjo K, et al. (2004) All-trans retinoic acid directly up-regulates thrombopoietin transcription in human bone marrow stromal cells. Exp Hematol 32(1-45-51
25. Wong CW, Privalsky ML (1998) Transcriptional silencing is defined by isoform- and heterodimer-specific interactions between nuclear hormone receptors and corepressors. Mol Cell Biol 18(10-5724-5733
26. Walkley CR, et al. (2007) A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell 129(6-1097-1110
27. Hatake K, et al. (1996) Tretinoin induces bone marrow collagenous fibrosis in acute promyelocytic leukaemia: New adverse, but reversible effect. Br J Haematol 93(3- 646-649
28. Flicek P, et al. (2013) Ensembl 2013. Nucleic Acids Res 41(Database issue-D48-D55
29. Hong SH, Privalsky ML (2000) The SMRT corepressor is regulated by a MEK-1 kinase pathway: Inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export. Mol Cell Biol 20(17-6612-6625.