HSP70/CD80 DNA vaccine inhibits airway remodeling by regulating the transcription factors T-bet and GATA-3 in a murine model of chronic asthma

Archives of Medical Science

Volumn 9, Issue 5, 2013, Pages 906-915

  Li, Yan ^a   Shi, Xiao Ling ^a   Cheng, Zheng Yan ^b   Li, Guo Ping ^a   Zhong, Sen ^c   Chen, Zhuang ^a  

^a SOUTHWEST MEDICAL UNIVERSITY   (China)

^b SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^c CHENGDU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Airway remodeling; Asthma; DNA vaccine; GATA 3; T bet

Indexed keywords

B7 ANTIGEN; BETA ACTIN; BUPIVACAINE; DNA VACCINE; GAMMA INTERFERON; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 70 B7 ANTIGEN VACCINE; INTERLEUKIN 4; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

AIRWAY REMODELING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA IMMUNIZATION; EXTRACELLULAR MATRIX; FEMALE; HISTOPATHOLOGY; LUNG LAVAGE; MOUSE; MUCUS SECRETION; NONHUMAN; PROTEIN EXPRESSION; RESPIRATORY TRACT ALLERGY;

EID: 84888095365     PISSN: 17341922     EISSN: None     Source Type: Journal    
DOI: 10.5114/aoms.2013.33180     Document Type: Article

References (32)

1. Chetta A, Foresi A, Del-Donno M, et al. Airways remodeling is a distinctive feature of asthma and is related to severity of disease. Chest 1997; 111: 852-7. (Pubitemid 27171451)
2. Majewski S, Cichocki P, Stepnicka-Bindemann M, Górski P. Asthma control, quality of life and successful sputum induction. Arch Med Sci 2011; 7: 840-3.
3. Haahtela T. Lung function decline in asthma and early intervention with inhaled corticosteroids. Chest 2006; 129: 1405-6. (Pubitemid 43894966)
4. Irwin RS, Richardson ND. Side effects with inhaled corticosteroids the physician's perception. Chest 2006; 130: 41-53.
5. Broide DH. DNA vaccines: an evolving approach to the treatment of allergic disorders. Allergy Asthma Proc 2005; 26: 195-8. (Pubitemid 41328127)
6. Cheng ZY, Shi XL, Li Y, et al. The effects of HSP70/CD80 DNA vaccine on airway inflammation and hyperresponsiveness of asthmatic mice. Chin J Microbiol Immunol 2009; 29: 981-6.
7. Li H, Shi XL, Zhong S, Deng CL, Zhang JJ. Construction and identification of the hsp70/CD80 eukaryotic expression plasmid. Chin J Tuber Respir Dis 2002; 25: 244-5.
8. Liu GX, Xu QA, Jin J, et al. Mucosal and systemic immunization with targeted fusion anti-caries DNA plasmid in young rats. Vaccine 2009; 27: 2940-7.
9. McMillan SJ, Xanthou G, Lloyd CM. Manipulation of allergen-induced airway remodeling by treatment with anti- TGF-beta antibody: effect on the Smad signaling pathway. J Immunol 2005; 174: 5774-80. (Pubitemid 40593221)
10. Kearley J, Robinson DS, Lloyd CM. CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling. J Allergy Clin Immunol 2008; 122: 617-24.
11. TRAIL-mediated HepG2 cell death in direct and indirect co-cultures. Anticancer Res 2011; 31: 3705-12.
12. Flood-Page P, Menzies-Gow A, Phipps S, et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthma tics. J Clin Invest 2003; 112: 1029-36. (Pubitemid 38056318)
13. Vignola AM, Mirabella F, Costanzo G, et al. Airway remodeling in asthma. Chest 2003; 123: 417-22.
14. Eden WV, van der Zee R, Prakken B. Heat-shock proteins induce T-cell regulation of chronic inflammation. Nat Rev Immunol 2005; 5: 318-30. (Pubitemid 40516157)
15. Borges TJ, Wieten L, van Herwijnen MJ, et al. The anti-inflammatory mechanisms of Hsp70[J]. Front Immunol 2012; 3: 95.
16. Ugurlucan M, Erer D, Kalko Y, et al. Aortic stiffness in diabetes mellitus: association with glutamine and heat shock protein 70 expression: a pilot study based on an experimental rodent model. Expert Opin Ther Targets 2009; 13: 267-74.
17. Ndejembi MP, Teijaro JR, Patke DS, et al. Control of memory CD4 T cell recall by the CD28/B7 costimulatory pathway. J Immunol 2006; 177: 7698-706. (Pubitemid 44846285)
18. Weiner GJ. The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides. J Leukoc Biol 2000; 68: 455-63.
19. Wu ZQ, Xu YP, Xiang H, Shen HH. Effects of CpG oligo-deoxynucleotide on transcription factors GATA-3 and T-bet mRNA expression in asthmatic mice. Acta Pharmacol Sin 2005; 26: 1117-22. (Pubitemid 41296952)
20. Ashino S, Wakita D, Zhang Y, Chamoto K, Kitamura H, Nishimura T. CpG-ODN inhibits airway inflammation at effector phase through down-regulation of antigen-specific Th2-cell migration into lung. Int Immunol 2008; 20: 259-66. (Pubitemid 351234393)
21. Boyce JA, Austen FK. No audible wheezing: nuggets and conundrums from mouse asthma models. J Exp Med 2005; 201: 1869-73. (Pubitemid 41002921)
22. Henderson WR, Tang LO, Chu SJ, et al. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med 2002; 165: 108-16.
23. Bates JH, Rincon M, Irvin CG. Animal models of asthma. Am J Physiol Lung Cell Mol Physiol 2009; 297: 401-10.
24. Temelkovski JS, Hogan P, Shepherd DP, Foster PS, Kumar RK. An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen. Thorax 1998; 53: 849-56. (Pubitemid 28459541)
25. Larché M. Regulatory T cells in allergy and asthma. Chest 2007; 132: 1007-14.
26. Yeh WI, Harrington LE. Regulation of effector CD4+ T cell functions by Tbet. J Immunol 2009; 182: 48.
27. Cook KD, Miller J. TCR-dependent translational control of GATA-3 enhances Th2 differentiation. J Immunol 2010; 185: 3209-16.
28. Kemp KL, Levin SD, Bryce PJ, Stein PL. Lck mediates Th2 differentiation through effects on T-bet and GATA-3. J Immunol 2010; 184: 4178-84.
29. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100: 655-69.
30. Ouyang W, Lohning M, Gao Z, et al. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 deve lopment and commitment. J Immunity 2000; 12: 27-37. (Pubitemid 30069212)
31. Cen O, Ueda A, Guzman L, et al. The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in Valpha14 Transgenic NKT cells via effects on GATA-3 and T-bet expression. J Immunol 2009; 182: 1370-8.
32. Cohn L, Homer RJ, Niu N, Bottomly K. T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. J Exp Med 1999; 190: 1309-18.