DNA vaccines: An evolving approach to the treatment of allergic disorders

Allergy and Asthma Proceedings

Volumn 26, Issue 3, 2005, Pages 195-198

  Broide, David H ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; GLUCOCORTICOID;

AIRWAY OBSTRUCTION; ANIMAL; DISEASE MODEL; HUMAN; MOUSE; RESPIRATORY TRACT ALLERGY; REVIEW;

AIRWAY OBSTRUCTION; ANIMALS; DISEASE MODELS, ANIMAL; GLUCOCORTICOIDS; HUMANS; MICE; RESPIRATORY HYPERSENSITIVITY; VACCINES, DNA;

EID: 24944483715     PISSN: 10885412     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (19)

1. Yamamoto S, Yamamoto T, Kataoka T, et al. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer cell activity. J Immunol 148:4072-4076, 1992.
2. Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 20:709-760, 2002.
3. Spiegelberg HL, Horner AA, Takabayashi K, and Raz E. Allergen- immunostimulatory oligodeoxynucleotide conjugate: A novel allergoid for immunotherapy. Curr Opin Allergy Clin Immunol. 2:547-551, 2002.
4. Broide D, Schwarze J, Tighe H, et al. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. J Immunol 161:7054-7062, 1998.
5. Ikeda RK, Nayar J, Cho JY, et al. Resolution of airway inflammation following OVA inhalation: Comparison of ISS DNA and corticosteroids. Am J Resp Cell Mol Biol 28:655-663, 2003.
6. Cho J, Miller M, Baek K, et al. Immunostimulatory DNA sequences inhibit respiratory syncytial viral load, airway inflammation, and mucus secretion. J Allergy Clin Immunol 108:697-702, 2001.
7. Cho JY, Miller M, Baek KJ, et al. Immunostimulatory DNA inhibits TGF-β expression and airway remodeling. Am J Resp Cell Mol Biol 30:651-661, 2004.
8. Davies DE, Wicks J, Powell RM, et al. Airway remodeling in asthma: New insights. J Allergy Clin Immunol. 111:215-225, 2003.
9. Flood-Page P, Menzies-Gow A, Phipps S, et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest 112: 1029-1036, 2003.
10. Bohle B, Jahn-Schmid B, Maurer D, et al. Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18, and IFN-gamma production in cells from allergic individuals and inhibits IgE synthesis in vitro. Eur J Immunol 29:2344-2353, 1999.
11. Tighe H, Takabayashi K, Schwartz D, et al. Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity. J Allergy Clin Immunol 106:124-134, 2000.
12. Shirota H, Sano K, Hirasawa K, et al. Novel roles of CpG oligodeoxynucleotides as a leader for the sampling and presentation of CpG tagged antigen by dendritic cells. J Immunol 167:66-74, 2001.
13. Santeliz JV, Van Nest G, Traquina P, et al. Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. J Allergy Clin Immunol 109:455-462, 2002.
14. Marshall JD, Abtahi S, Eiden J, et al. Immunostimulatory sequence DNA linked to the Amb a 1 allergen promotes Th1 cytokine expression while downregulating Th2 cytokine expression in PBMC's from human patients with ragweed allergy. J Allergy Clin Immunol 108: 191-197, 2001.
15. Creticos PS, Eiden JJ, Balcer SL, et al. Immunostimulatory oligodeoxynucleotides conjugated to Amb a 1: Safety, skin test reactivity, and basophil histamine release. J Allergy Clin Immunol 105:S70, 2000.
16. Creticos PS, Eiden JJ, Broide DH, et al. Immunotherapy with immunostimulatory oligonucleotides linked to purified ragweed Amb a 1 allergen: Effects on antibody production, nasal allergen provocation, and ragweed seasonal rhinitis. J Allergy Clin Immunol 109:743, 2002.
17. Tulic MK, Fiset PO, Christodoulopoulos P, et al. Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response. J Allergy Clin Immunol 113:235-241, 2004.
18. Raz E, Tighe H, Sato Y, et al. Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc Natl Acad Sci USA 93:5141-5145, 1996.
19. Hsu CH, Chua KY, Tao MH, et al. Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization. Nat Med 2:540-544, 1996.