Aortic stiffness in diabetes mellitus - Association with glutamine and heat shock protein 70 expression: A pilot study based on an experimental rodent model

Expert Opinion on Therapeutic Targets

Volumn 13, Issue 3, 2009, Pages 267-274

  Ugurlucan, Murat ^a   Erer, Dilek ^b   Kalko, Yusuf ^a   Gungor, Funda ^c   Haholu, Aptullah ^d   Basaran, Murat ^a   Banach, Maciej ^e   Rysz, Jacek ^e   Mikhailidis, Dimitri P ^f   Tireli, Emin ^a   Dayioglu, Enver ^a   Alpagut, Ufuk ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b GAZI UNIVERSITY FACULTY OF MEDICINE   (Turkey)

^c State Hospital of Dursunbey   (Turkey)

^d GATA HAYDARPASA TRAINING HOSPITAL   (Turkey)

^e MEDICAL UNIVERSITY OF LODZ   (Poland)

^f ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Aorta; Diabetes mellitus; Glutamine; Heat shock protein

Indexed keywords

ELASTIN; GLUCOSE; GLUTAMINE; HEAT SHOCK PROTEIN 70; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERIAL STIFFNESS; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE SEVERITY; EXPERIMENTAL DIABETES MELLITUS; EXPERIMENTAL MODEL; GLUCOSE BLOOD LEVEL; MALE; MORBIDITY; MORTALITY; NONHUMAN; PILOT STUDY; PROTEIN EXPRESSION; RAT; SPRAGUE DAWLEY RAT; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; HOSPITALIZATION; METABOLISM; PATHOPHYSIOLOGY;

ANIMALS; AORTA; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; ELASTIN; GENE EXPRESSION REGULATION; GLUTAMINE; HSP70 HEAT-SHOCK PROTEINS; MALE; PILOT PROJECTS; RATS; RATS, SPRAGUE-DAWLEY; SEVERITY OF ILLNESS INDEX; STREPTOZOCIN;

EID: 65549092757     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728220902735833     Document Type: Article

References (41)

1. Mulvany MJ. A reduced elastic modulus of vascular wall components in hypertension? Hypertension 1992;20:7-9
2. Henry RM, Kostense PJ, Spijkerman AM, et al. Arterial stiffness increases with deteriorating glucose tolerance status: the Hoorn Study. Circulation 2003;29;107:2089-2095 (Pubitemid 36532189)
3. Stefanadis C, Dernellis J, Tsiamis E, et al. Aortic stiffness as a risk factor for recurrent acute coronary events in patients with ischaemic heart disease. Eur Heart J 2000;21:390-396 (Pubitemid 30107556)
4. St John Sutton M. Aortic stiffness: a predictor of acute coronary events? Eur Heart J 2000;21:342-344
5. Schram MT, Kostense PJ, Van Dijk RA, et al. Diabetes, pulse pressure and cardiovascular mortality: the Hoorn Study. J Hypertens 2002;20:1743-1751 (Pubitemid 35041963)
6. Stergiopulos N, Westerhof N. Role of total arterial compliance and peripheral resistance in the determination of systolic and diastolic aortic pressure. Pathol Biol (Paris) 1999;47:641-647 (Pubitemid 30706527)
7. van Popele NM, Grobbee DE, Bots ML, et al. Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke 2001;32:454-460 (Pubitemid 32155234)
8. Giannessi D, Caselli C, Vitale RL, et al. A possible cardioprotective effect of heat shock proteins during cardiac surgery in pediatric patients. Pharmacol Res 2003;48:519-529 (Pubitemid 37101212)
9. Dybdahl B, Wahba A, Lien E, et al. Infl ammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4. Circulation 2002;105:685-690 (Pubitemid 34157370)
10. Binder RJ, Vatner R, Srivastava P. The heat-shock protein receptors: some answers and more questions. Tissue Antigens 2004;64:442-451 (Pubitemid 39312725)
11. Parsell DA, Taulien J, Lindquist S. The role of heat-shock proteins in thermotolerance. Philos Trans R Soc Lond B Biol Sci 1993;339:279-285
12. Mandal K, Torsney E, Poloniecki J, et al. Association of high intracellular, but not serum, heat shock protein 70 with postoperative atrial fi brillation. Ann Thorac Surg 2005;79:865-871 (Pubitemid 40288738)
13. Ugurlucan M, Alpagut U, Tireli E, Dayioglu E. Isolated dissection of the infrarenal abdominal aorta. Chirurgia 2009 . In press
14. Selimoglu O, Ugurlucan M, Basaran M, et al. Effi cacy of remote ischaemic preconditioning for spinal cord protection against ischaemic injury: association with heat shock protein expression. Folia Neuropathol 2008;46 (3): 204-212
15. Lansing AI, Rorenthal TB, Alex M, Dempsey EW. The structure and chemical characterization of elastic fi bers as revealed by elastase and by electron microscopy. Anat Rec 1952;114 (4): 555-575
16. Hayashi K, Washizu T, Tsushima N, et al. Mechanical properties of aortas and pulmonary arteries of calves implanted with cardiac prostheses. J Biomech 1981;14:173-182 (Pubitemid 11090608)
17. Nosaka T, Tanaka H, Watanabe I, et al. Infl uence of regular exercise on age-related changes in arterial elasticity: mechanistic insights from wall compositions in rat aorta. Can J Appl Physiol 2003;28:204-212 (Pubitemid 37033785)
18. Park JH, Omi N, Nosaka T, et al. Estrogen defi ciency and low-calcium diet increased bone loss and urinary calcium excretion but did not alter arterial stiffness in young female rats. J Bone Miner Metab 2008;26:218-225 (Pubitemid 351677842)
19. Laurent S, Boutouyrie P, Asmar R, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001;37:1236-1241 (Pubitemid 34163575)
20. Alpagut U, Ugurlucan M, Dayioglu E. Major arterial involvement and review of Behcet's disease. Ann Vasc Surg 2007;21:232-239 (Pubitemid 46367534)
21. Brownlee M, Cerami A, Vlassara H. Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N Engl J Med 1988;318:1315-1321 (Pubitemid 18126831)
22. Rysz J, Banach M, Stolarek RA, et al. Serum matrix metalloproteinases MMP-2 and MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in diabetic nephropathy. J Nephrol 2007;20:444-452 (Pubitemid 350081499)
23. Lacombe F, Dart A, Dewar E, et al. Arterial elastic properties in man: a comparison of echo-Doppler indices of aortic stiffness. Eur Heart J 1992;13:1040-1045
24. Stefanadis C, Stratos C, Boudoulas H, et al. Distensibility of the ascending aorta: comparison of invasive and non-invasive techniques in healthy men and in men with coronary artery disease. Eur Heart J 1990;11:990-996
25. Stefanadis C, Wooley CF, Bush CA, et al. Aortic distensibility abnormalities in coronary artery disease. Am J Cardiol 1987;59:1300-1304 (Pubitemid 17093809)
26. Sobenin IA, Tertov VV, Koschinsky T, et al. Modifi ed low density lipoprotein from diabetic patients causes cholesterol accumulation in human intimal aortic cells. Atherosclerosis 1993;100:41-54 (Pubitemid 23166007)
27. Dunn FL, Raskin P, Bilheimer DW, Grundy SM. The effect of diabetic control on very low-density lipoprotein - triglyceride metabolism in patients with type II diabetes mellitus and marked hypertriglyceridemia. Metabolism 1984;33:117-123 (Pubitemid 14185404)
28. Feingold KR, Grunfeld C, Pang M, et al. LDL subclass phenotypes and triglyceride metabolism in non-insulin-dependent diabetes. Arterioscler Thromb 1992;12:1496-1502
29. Austin MA, King MC, Vranizan KM, Krauss RM. Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation 1990;82:495-506
30. Inchovska M, Ogneva V, Martinova Y. Fibroblast growth factors promote pancreatic cell proliferation in normal and STZ - treated hamsters. Arch Med Sci 2006;2:90-93 (Pubitemid 44022734)
31. Toutouzas K, Stefanadis C, Tsiamis E, et al. Aortic pressure-diameter relation in patients with non-insulin dependent diabetes mellitus: new insights. Diabetologia 2000;43:1070-1075 (Pubitemid 30655729)
32. Yoshimune K, Yoshimura T, Nakayama T, et al. Hsc62, Hsc56, and GrpE, the third Hsp70 chaperone system of Escherichia coli. Biochem Biophys Res Commun 2002;293:1389-1395 (Pubitemid 34681031)
33. Suzuki K, Murtuza B, Sammut IA, et al. Heat shock protein 72 enhances manganese superoxide dismutase activity during myocardial ischemia-reperfusion injury, associated with mitochondrial protection and apoptosis reduction. Circulation 2002;106 (12 Suppl 1): I270 -6
34. Pockley AG, Georgiades A, Thulin T, et al. Serum heat shock protein 70 levels predict the development of atherosclerosis in subjects with established hypertension. Hypertension 2003;42:235-238 (Pubitemid 37093466)
35. Wang R, Town T, Gokarn V, et al. HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways. J Surg Res 2006;136 (1): 58-69 (Pubitemid 44634564)
36. Hayashi Y, Sawa Y, Fukuyama N, et al. Preoperative glutamine administration induces heat-shock protein 70 expression and attenuates cardiopulmonary bypass-induced infl ammatory response by regulating nitric oxide synthase activity. Circulation 2002;106:2601-2607 (Pubitemid 35340697)
37. Singleton KD, Wischmeyer PE. Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia. Shock 2006;25:295-299 (Pubitemid 43755956)
38. Singleton KD, Serkova N, Beckey VE, Wischmeyer PE. Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression. Crit Care Med 2005;33:1206-1213 (Pubitemid 40827366)
39. Heusch P, Skyschally A, Leineweber K, et al. The interaction of coronary microembolization and ischemic preconditioning: A third window of cardioprotection through TNF-alpha. Arch Med Sci 2007;3:83-92 (Pubitemid 47241094)
40. Reszka E, Jegier B, Wasowicz W, et al. Detection of infectious agents by polymerase chain reaction in human aortic wall. Cardiovasc Pathol 2008;17:297-302
41. Bielecka-Dabrowa A, Barylski M, Mikhailidis DP, et al. HSP 70 and atherosclerosis - protector or activator? Expert Opin Ther Targets 2009; In press