Scn8a voltage-gated sodium channel mutation alters seizure and anxiety responses to acute stress

Psychoneuroendocrinology

Volumn 39, Issue 1, 2014, Pages 225-236

  Sawyer, Nikki T ^a   Papale, Ligia A ^a   Eliason, Jessica ^a   Neigh, Gretchen N ^a,b   Escayg, Andrew ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

Absence; Anxiety; Epilepsy; Scn8a; Seizures; Stress

Indexed keywords

CORTICOSTERONE; SODIUM CHANNEL NAV1.6;

ABSENCE; ACUTE STRESS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY; EXPOSURE; GENE MUTATION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILIZATION STRESS; MALE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SCN8A GENE; SEIZURE; SPIKE WAVE; WILD TYPE; ANXIETY DISORDER;

ABSENCE; ANXIETY; EPILEPSY; SCN8A; SEIZURES; STRESS;

ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; BRAIN; ELECTROENCEPHALOGRAPHY; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MICE; MUTATION; NAV1.6 VOLTAGE-GATED SODIUM CHANNEL; PITUITARY-ADRENAL SYSTEM; RESTRAINT, PHYSICAL; SEIZURES; STRESS, PHYSIOLOGICAL; STRESS, PSYCHOLOGICAL;

EID: 84888073511     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2013.09.018     Document Type: Article

References (54)

1. An S.J., Park S.K., Hwang I.K., Kim H.S., Seo M.O., Suh J.G., Oh Y.S., Bae J.C., Won M.H., Kang T.C. Altered corticotropin-releasing factor (CRF) receptor immunoreactivity in the gerbil hippocampal complex following spontaneous seizure. Neurochem. Int. 2003, 43:39-45.
2. v1.6 in kindling epileptogenesis. Epilepsia 2009, 50:44-55.
3. Bosnjak J., Vukovic-Bobic M., Mejaski-Bosnjak V. Effect of war on the occurrence of epileptic seizures in children. Epilepsy Behav. 2002, 3:502-509.
4. Burgess D.L., Kohrman D.C., Galt J., Plummer N.W., Jones J.M., Spear B., Meisler M.H. Mutation of a new sodium channel gene, Scn8a, in the mouse mutant 'motor endplate disease'. Nat. Genet. 1995, 10:461-465.
5. Choleris E., Thomas A.W., Kavaliers M., Prato F.S. A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field. Neurosci. Biobehav. Rev. 2001, 25:235-260.
6. Espejo E.F. Effects of weekly or daily exposure to the elevated plus-maze in male mice. Behav. Brain Res. 1997, 87:233-238.
7. Feldman R.G., Paul N.L. Identity of emotional triggers in epilepsy. J. Nerv. Ment. Dis. 1976, 162:345-353.
8. Frankel W.N., Beyer B., Maxwell C.R., Pretel S., Letts V.A., Siegel S.J. Development of a new genetic model for absence epilepsy: spike-wave seizures in C3H/He and backcross mice. J. Neurosci. 2005, 25:3452-3458.
9. Frucht M.M., Quigg M., Schwaner C., Fountain N.B. Distribution of seizure precipitants among epilepsy syndromes. Epilepsia 2000, 41:1534-1539.
10. Garcia-Morales I., de la Pena Mayor P., Kanner A.M. Psychiatric comorbidities in epilepsy: identification and treatment. Neurologist 2008, 14:S15-S25.
11. Gauguier D., van Luijtelaar G., Bihoreau M.T., Wilder S.P., Godfrey R.F., Vossen J., Coenen A., Cox R.D. Chromosomal mapping of genetic loci controlling absence epilepsy phenotypes in the WAG/Rij rat. Epilepsia 2004, 45:908-915.
12. Giorgi F.S., Pizzanelli C., Biagioni F., Murri L., Fornai F. The role of norepinephrine in epilepsy: from the bench to the bedside. Neurosci. Biobehav. Rev. 2004, 28:507-524.
13. Han S., Tai C., Westenbroek R.E., Yu F.H., Cheah C.S., Potter G.B., Rubenstein J.L., Scheuer T., de la Iglesia H.O., Catterall W.A. Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission. Nature 2012, 489:385-390.
14. Haut S.R., Hall C.B., Masur J., Lipton R.B. Seizure occurrence: precipitants and prediction. Neurology 2007, 69:1905-1910.
15. Haut S.R., Vouyiouklis M., Shinnar S. Stress and epilepsy: a patient perception survey. Epilepsy Behav. 2003, 4:511-514.
16. Heinrichs S.C. Neurobehavioral consequences of stressor exposure in rodent models of epilepsy. Prog. Neuropsychopharmacol. Biol. Psychiatry 2010, 34:808-815.
17. Hoehn-Saric R., McLeod D.R. Anxiety and arousal: physiological changes and their perception. J. Affect. Disord. 2000, 61:217-224.
18. Ito S., Ogiwara I., Yamada K., Miyamoto H., Hensch T.K., Osawa M., Yamakawa K. Mouse with Na(v)1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment. Neurobiol. Dis. 2012, 49C:29-40.
19. Joels M. Steroid hormones and excitability in the mammalian brain. Front. Neuroendocrinol. 1997, 18:2-48.
20. Joels M., Baram T.Z. The neuro-symphony of stress. Nat. Rev. Neurosci. 2009, 10:459-466.
21. Jones N.C., Salzberg M.R., Kumar G., Couper A., Morris M.J., O'Brien T.J. Elevated anxiety and depressive-like behavior in a rat model of genetic generalized epilepsy suggesting common causation. Exp. Neurol. 2008, 209:254-260.
22. Krzemien D.M., Schaller K.L., Levinson S.R., Caldwell J.H. Immunolocalization of sodium channel isoform NaCh6 in the nervous system. J. Comp. Neurol. 2000, 420:70-83.
23. Martin M.S., Tang B., Papale L.A., Yu F.H., Catterall W.A., Escayg A. The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy. Hum. Mol. Genet. 2007, 16:2892-2899.
24. v1.6). Genes Brain Behav. 2008, 7:629-638.
25. Midzyanovskaya I.S., Shatskova A.B., Sarkisova K.Y., van Luijtelaar G., Tuomisto L., Kuznetsova G.D. Convulsive and nonconvulsive epilepsy in rats: effects on behavioral response to novelty stress. Epilepsy Behav. 2005, 6:543-551.
26. Mirza N.R., Bright J.L., Stanhope K.J., Wyatt A., Harrington N.R. Lamotrigine has an anxiolytic-like profile in the rat conditioned emotional response test of anxiety: a potential role for sodium channels?. Psychopharmacology (Berl.) 2005, 180:159-168.
27. Nakken K.O., Solaas M.H., Kjeldsen M.J., Friis M.L., Pellock J.M., Corey L.A. Which seizure-precipitating factors do patients with epilepsy most frequently report?. Epilepsy Behav. 2005, 6:85-89.
28. Papale L.A., Beyer B., Jones J.M., Sharkey L.M., Tufik S., Epstein M., Letts V.A., Meisler M.H., Frankel W.N., Escayg A. Heterozygous mutations of the voltage-gated sodium channel SCN8A are associated with spike-wave discharges and absence epilepsy in mice. Hum. Mol. Genet. 2009, 18:1633-1641.
29. Papale L.A., Paul K.N., Sawyer N.T., Manns J.R., Tufik S., Escayg A. Dysfunction of the Scn8a voltage-gated sodium channel alters sleep architecture, reduces diurnal corticosterone levels, and enhances spatial memory. J. Biol. Chem. 2010, 285:16553-16561.
30. Racine R.J. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 1972, 32:281-294.
31. Raman I.M., Sprunger L.K., Meisler M.H., Bean B.P. Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice. Neuron 1997, 19:881-891.
32. Rudolf G., Bihoreau M.T., Godfrey R.F., Wilder S.P., Cox R.D., Lathrop M., Marescaux C., Gauguier D. Polygenic control of idiopathic generalized epilepsy phenotypes in the genetic absence rats from Strasbourg (GAERS). Epilepsia 2004, 45:301-308.
33. Sarkisova K., van Luijtelaar G. The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 2011, 35:854-876.
34. Sawyer N.T., Escayg A. Stress and epilepsy: multiple models, multiple outcomes. J. Clin. Neurophysiol. 2010, 27:445-452.
35. Schaller K.L., Krzemien D.M., Yarowsky P.J., Krueger B.K., Caldwell J.H. A novel, abundant sodium channel expressed in neurons and glia. J. Neurosci. 1995, 15:3231-3242.
36. Schridde U., van Luijtelaar G. Corticosterone increases spike-wave discharges in a dose- and time-dependent manner in WAG/Rij rats. Pharmacol. Biochem. Behav. 2004, 78:369-375.
37. Seyfried T.N., Todorova M.T., Poderycki M.J. Experimental models of multifactorial epilepsies: the EL mouse and mice susceptible to audiogenic seizures. Adv. Neurol. 1999, 79:279-290.
38. Smyk M.K., Coenen A.M., Lewandowski M.H., van Luijtelaar G. Endogenous rhythm of absence epilepsy: relationship with general motor activity and sleep-wake states. Epilepsy Res. 2011, 93:120-127.
39. Spatt J., Langbauer G., Mamoli B. Subjective perception of seizure precipitants: results of a questionnaire study. Seizure 1998, 7:391-395.
40. Staufenbiel S.M., Penninx B.W., Spijker A.T., Elzinga B.M., van Rossum E.F. Hair cortisol, stress exposure, and mental health in humans: a systematic review. Psychoneuroendocrinology 2012, 38:1220-1235.
41. Swinkels W.A., Engelsman M., Kasteleijn-Nolst Trenite D.G., Baal M.G., de Haan G.J., Oosting J. Influence of an evacuation in February 1995 in The Netherlands on the seizure frequency in patients with epilepsy: a controlled study. Epilepsia 1998, 39:1203-1207.
42. Temkin N.R., Davis G.R. Stress as a risk factor for seizures among adults with epilepsy. Epilepsia 1984, 25:450-456.
43. Thapar A., Kerr M., Harold G. Stress, anxiety, depression, and epilepsy: investigating the relationship between psychological factors and seizures. Epilepsy Behav. 2009, 14:134-140.
44. Tolmacheva E.A., Oitzl M.S., van Luijtelaar G. Stress, glucocorticoids and absences in a genetic epilepsy model. Horm. Behav. 2012, 61:706-710.
45. Trudeau M.M., Dalton J.C., Day J.W., Ranum L.P., Meisler M.H. Heterozygosity for a protein truncation mutation of sodium channel SCN8A in a patient with cerebellar atrophy, ataxia, and mental retardation. J. Med. Genet. 2006, 43:527-530.
46. Van Wart A., Matthews G. Impaired firing and cell-specific compensation in neurons lacking nav1.6 sodium channels. J. Neurosci. 2006, 26:7172-7180.
47. Veeramah K.R., O'Brien J.E., Meisler M.H., Cheng X., Dib-Hajj S.D., Waxman S.G., Talwar D., Girirajan S., Eichler E.E., Restifo L.L., Erickson R.P., Hammer M.F. De novo pathogenic SCN8A mutation identified by whole-genome sequencing of a family quartet affected by infantile epileptic encephalopathy and SUDEP. Am. J. Hum. Genet. 2012, 90:502-510.
48. Velisek L. Models of chemically-induced acute seizures. Models of Seizures and Epilepsy 2006, 127-152. Elsevier, Amsterdam. A. Pitkanen, P.A. Schwartzkroin, S.L. Moshe (Eds.).
49. Veliskova J. Behavioral characterization of seizures in rats. Models of Seizures and Epilepsy 2006, 601-611. Elsevier, Amsterdam. A. Pitkanen, P.A. Schwartzkroin, S.L. Moshe (Eds.).
50. Vreeburg S.A., Zitman F.G., van Pelt J., Derijk R.H., Verhagen J.C., van Dyck R., Hoogendijk W.J., Smit J.H., Penninx B.W. Salivary cortisol levels in persons with and without different anxiety disorders. Psychosom. Med. 2010, 72:340-347.
51. Wang Y., Zhang J., Li X., Ji J., Yang F., Wan C., Feng G., Wan P., He L., He G. SCN8A as a novel candidate gene associated with bipolar disorder in the Han Chinese population. Prog. Neuropsychopharmacol. Biol. Psychiatry 2008, 32:1902-1904.
52. Wasserman D., Geijer T., Rozanov V., Wasserman J. Suicide attempt and basic mechanisms in neural conduction: relationships to the SCN8A and VAMP4 genes. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005, 133B:116-119.
53. Werkman T.R., Van der Linden S., Joels M. Corticosteroid effects on sodium and calcium currents in acutely dissociated rat CA1 hippocampal neurons. Neuroscience 1997, 78:663-672.
54. Wu J., Ma D.L., Ling E.A., Tang F.R. Corticotropin releasing factor (CRF) in the hippocampus of the mouse pilocarpine model of status epilepticus. Neurosci. Lett. 2012, 512:83-88.