Central neural circuits for coordination of swallowing, breathing, and coughing: Predictions from computational modeling and simulation

Otolaryngologic Clinics of North America

Volumn 46, Issue 6, 2013, Pages 957-964

  Bolser, Donald C ^a   Gestreau, Christian ^b   Morris, Kendall F ^c   Davenport, Paul W ^a   Pitts, Teresa E ^a  

^a University of Florida   (United States)

^b University of Mediterranée   (France)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Airway; Brainstem; Breathing; Central pattern generator; Cough; Swallow

Indexed keywords

AIRFLOW; AIRWAY; ASPIRATION PNEUMONIA; BEHAVIORAL CONTROL ASSEMBLY; BRAIN STEM; BREATHING; BREATHING MUSCLE; BREATHING PATTERN; CELL FUNCTION; CELL POPULATION; CENTRAL PATTERN GENERATOR; COMPRESSIVE PHASE; CONNECTOME; CONTROL SYSTEM; COUGHING; ESOPHAGEAL PHASE; EXPULSION PHASE; HYPOGLOSSAL NERVE; HYPOTHESIS; INSPIRATORY PHASE; MATHEMATICAL MODEL; MOTONEURON; MUSCLE CONTRACTION; NERVE CELL; NEUROPHYSIOLOGY; NONHUMAN; ORAL PHASE; OSCILLATOR; PHARYNGEAL PHASE; PHRENIC NERVE; REVIEW; SIMULATION; SWALLOWING;

AIRWAY; BRAINSTEM; BREATHING; CENTRAL PATTERN GENERATOR; COUGH; SWALLOW;

COMPUTER SIMULATION; COUGH; DEGLUTITION; DEGLUTITION DISORDERS; EXHALATION; HUMANS; INHALATION; MODELS, NEUROLOGICAL; RESPIRATORY ASPIRATION; RESPIRATORY SYSTEM;

EID: 84888064231     PISSN: 00306665     EISSN: 15578259     Source Type: Journal    
DOI: 10.1016/j.otc.2013.09.013     Document Type: Review

References (28)

1. Korpas J., Tomori Z. Cough and other respiratory reflexes 1979, S. Karger, Basel (Switzerland), New York.
2. Smith Hammond C.A., Goldstein L.B., Zajac D.J., et al. Assessment of aspiration risk in stroke patients with quantification of voluntary cough. Neurology 2001, 56(4):502-506.
3. Smith Hammond C.A., Goldstein L.B., Horner R.D., et al. Predicting aspiration in patients with ischemic stroke: comparison of clinical signs and aerodynamic measures of voluntary cough. Chest 2009, 135(3):769-777.
4. Pitts T., Troche M., Mann G., et al. Using voluntary cough to detect penetration and aspiration during oropharyngeal swallowing in patients with Parkinson disease. Chest 2010, 138(6):1426-1431.
5. Smith Hammond C.A., Goldstein L.B. Cough and aspiration of food and liquids due to oral-pharyngeal dysphagia: ACCP evidence-based clinical practice guidelines. Chest 2006, 129(Suppl 1):154S-168S.
6. Scannapieco F.A. Role of oral bacteria in respiratory infection. JPeriodontol 1999, 70(7):793-802.
7. Daniels S.K., Schroeder M.F., McClain M., et al. Dysphagia in stroke: development of a standard method to examine swallowing recovery. JRehabil Res Dev 2006, 43(3):347-356.
8. Pitts T., Rose M.J., Mortensen A.N., et al. Coordination of cough and swallow: a meta-behavioral response to aspiration. Respir Physiol Neurobiol 2013, [Epub ahead of print].
9. Martin-Harris B., Brodsky M.B., Price C.C., et al. Temporal coordination of pharyngeal and laryngeal dynamics with breathing during swallowing: single liquid swallows. JAppl Physiol 2003, 94(5):1735.
10. Cvejic L., Harding R., Churchward T., et al. Laryngeal penetration and aspiration in individuals with stable COPD. Respirology 2011, 16(2):269-275.
11. Jean A. Brain stem control of swallowing: neuronal network and cellular mechanisms. Physiol Rev 2001, 81(2):929-969.
12. Steele C.M., Miller A.J. Sensory input pathways and mechanisms in swallowing: a review. Dysphagia 2010, 25(4):323-333.
13. Leith D.E., Butler J.P., Sneddon S.L., et al. Cough. Handbook of physiology. Therespiratory system. Mechanics of breathing, Part I 1986, vol. III:315-336. American Physiological Society, Bethesda (MD). P.T. Macklem, J. Mead (Eds.).
14. van Lunteren E., Daniels R., Deal E.C., et al. Role of costal and crural diaphragm and parasternal intercostals during coughing in cats. JAppl Physiol 1989, 66(1):135-141.
15. Shannon R., Baekey D.M., Morris K.F., et al. Functional connectivity among ventrolateral medullary respiratory neurones and responses during fictive cough in the cat. JPhysiol 2000, 525(Pt 1):207-224.
16. Shannon R., Baekey D.M., Morris K.F., et al. Ventrolateral medullary respiratory network and a model of cough motor pattern generation. JAppl Physiol 1998, 84(6):2020-2035.
17. Gestreau C., Milano S., Bianchi A.L., et al. Activity of dorsal respiratory group inspiratory neurons during laryngeal-induced fictive coughing and swallowing in decerebrate cats. Exp Brain Res 1996, 108(2):247-256.
18. Bolser D.C., Poliacek I., Jakus J., et al. Neurogenesis of cough, other airway defensive behaviors and breathing: a holarchical system?. Respir Physiol Neurobiol 2006, 152(3):255-265.
19. Bolser D.C., Pitts T.E., Morris K.F. The use of multiscale systems biology approaches to facilitate understanding of complex control systems for airway protection. Curr Opin Pharmacol 2011, 11(3):272-277.
20. Bolser D.C., Davenport P.W. Codeine and cough: an ineffective gold standard. Curr Opin Allergy Clin Immunol 2007, 7(1):32-36.
21. Koestler A. The ghost in the machine 1967, The Macmillan Company, New York.
22. Lindsey B.G., Rybak I.A., Smith J.C. Computational models and emergent properties of respiratory neural networks. Compr Physiol 2012, 2(3):1619-1670.
23. Rybak I.A., O'Connor R., Ross A., et al. Reconfiguration of the pontomedullary respiratory network: a computational modeling study with coordinated invivo experiments. JNeurophysiol 2008, 100(4):1770-1799.
24. Gestreau C., Dutschmann M., Obled S., et al. Activation of XII motoneurons and premotor neurons during various oropharyngeal behaviors. Respir Physiol Neurobiol 2005, 147(2-3):159-176.
25. Roda F., Gestreau C., Bianchi A.L. Discharge patterns of hypoglossal motoneurons during fictive breathing, coughing, and swallowing. JNeurophysiol 2002, 87(4):1703-1711.
26. Bolser D.C., Hey J.A., Chapman R.W. Influence of central antitussive drugs on the cough motor pattern. JAppl Physiol 1999, 86(3):1017-1024.
27. Poliacek I., Corrie L.W., Wang C., et al. Microinjection of DLH into the region of the caudal ventral respiratory column in the cat: evidence for an endogenous cough-suppressant mechanism. JAppl Physiol 2007, 102(3):1014-1021.
28. Poliacek I., Wang C., Corrie L.W., et al. Microinjection of codeine into the region of the caudal ventral respiratory column suppresses cough in anesthetized cats. JAppl Physiol 2010, 108(4):858-865.