Sensory input pathways and mechanisms in swallowing: A review

Dysphagia

Volumn 25, Issue 4, 2010, Pages 323-333

  Steele, Catriona M ^a,b,c   Miller, Arthur J ^d  

^a HOLLAND BLOORVIEW KIDS REHABILITATION HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Deglutition; Deglutition disorders; Physiology; Sensation; Sensory pathways

Indexed keywords

BRAIN CORTEX; DYSPHAGIA; ESOPHAGUS MOTILITY; FACIAL NERVE; GLOSSOPHARYNGEAL NERVE; HUMAN; MOTOR CONTROL; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SALIVATION; SENSORY NERVE; SENSORY STIMULATION; STIMULUS RESPONSE; SWALLOWING; TACTILE STIMULATION; THERMAL STIMULATION; TRIGEMINAL NERVE; VAGUS NERVE;

DEGLUTITION; DEGLUTITION DISORDERS; ESOPHAGUS; HUMANS; MOTOR CORTEX; OLFACTORY PATHWAYS; PHARYNX; PHOTIC STIMULATION; SALIVATION; SENSATION; SMELL;

EID: 79951722378     PISSN: 0179051X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00455-010-9301-5     Document Type: Review

References (150)

1. Martin RE. Neuroplasticity and swallowing. Dysphagia. 2009;24:218-29.
2. Martin-Harris B, Brodsky MB, Michel Y, Castell DO, Schleicher M, Sandidge J, Maxwell R, Blair J. MBS measurement tool for swallow impairment-MBSImp: establishing a standard. Dysphagia. 2008;23:392-405.
3. Takahashi T, Miyamoto T, Terao A, Yokoyama A. Cerebral activation related to the control of mastication during changes in food hardness. Neuroscience. 2007;145:791-4. (Pubitemid 46441645)
4. Minato A, Ono T, Miyamoto JJ, Honda E, Kurabayashi T, Moriyama K. Preferred chewing side-dependent two-point discrimination and cortical activation pattern of tactile tongue sensation. Behav Brain Res. 2009;203:118-26.
5. Doty R. Influence of stimulus pattern on reflex deglutition. Am J Physiol. 1951;166:142-55.
6. Doty R, Bosma JF. An electromyographic analysis of reflex deglutition. J Neurophysiol. 1956;19:44-60.
7. Dong H, Loomis CW, Bieger D. Vagal afferent input determines the volume dependence of rat esophageal motility patterns. Am J Physiol Gastrointest Liver Physiol. 2001;281: G44-53.
8. Lowell SY, Poletto CJ, Knorr-Chung BR, Reynolds RC, Simonyan K, Ludlow CL. Sensory stimulation activates both motor and sensory components of the swallowing system. Neuroimage. 2008;42:285-95.
9. Martin RE, Goodyear BG, Gati JS, Menon RS. Cerebral cortical representation of automatic and volitional swallowing in humans. J Neurophysiol. 2001;85:938-50. (Pubitemid 32147791)
10. Martin RE, MacIntosh BJ, Smith RC, Barr AM, Stevens TK, Gati JS, Menon RS. Cerebral areas processing swallowing and tongue movement are overlapping but distinct: a functional magnetic resonance imaging study. J Neurophysiol. 2004;92:2428-43. (Pubitemid 39298694)
11. Martin RE, Sessle BJ. The role of the cerebral cortex in swallowing. Dysphagia. 1993;8:195-202. (Pubitemid 23231185)
12. Hamdy S, Rothwell JC, Aziz Q, Thompson DG. Organization and reorganization of human swallowing motor cortex: implications for recovery after stroke. Clin Sci (Lond). 2000;99:151-7. (Pubitemid 30614384)
13. Hamdy S, Aziz Q, Thompson DG, Rothwell JC. Physiology and pathophysiology of the swallowing area of human motor cortex. Neural Plast. 2001;8:91-7. (Pubitemid 32798690)
14. Hamdy S, Rothwell JC, Brooks DJ, Bailey D, Aziz Q, Thompson DG. Identification of the cerebral loci processing human swallowing with H2 (15) O PET activation. J Neurophysiol. 1999;81:1917-26. (Pubitemid 29262522)
15. Hamdy S, Mikulis DJ, Crawley A, Xue S, Lau H, Henry S, Diamant NE. Cortical activation during human volitional swallowing: an event-related fMRI study. Am J Physiol. 1999;277:G219-25. (Pubitemid 29352664)
16. Hamdy S, Aziz Q, Rothwell JC, Crone R, Hughes D, Tallis RC, Thompson DG. Explaining oropharyngeal dysphagia after unilateral hemispheric stroke. Lancet. 1997;350:686-92. (Pubitemid 27371166)
17. Daniels SK, Corey DM, Barnes CL, Faucheaux NM, Priestly DH, Foundas AL. Cortical representation of swallowing: a modified dual task paradigm. Percept Mot Skills. 2002;94:1029-40.
18. Doty R, Richmond WH, Storey A. Effect of medullary lesions on coordination of deglutition. Exp Neurol. 1968;17:91-106.
19. Hrycyshyn AW, Basmajian JV. Electromyography of the oral stage of swallowing in man. Am J Anat. 1972;133:333-40.
20. Kitagawa J, Shingai T, Takahashi Y, Yamada Y. Pharyngeal branch of the glossopharyngeal nerve plays a major role in reflex swallowing from the pharynx. Am J Physiol Regul Integr Comp Physiol. 2002;282: R1342-7. (Pubitemid 34664518)
21. Pommerenke W. A study of the sensory areas eliciting the swallowing reflex. Am J Physiol. 1928;84:36-41.
22. Sweazey R, Bradley R. Responses of neurons in the lamb nucleus tractus solitarius to stimulation of the caudal oral cavity and epiglottis with different stimulus modalities. Brain Res. 1989;480:133-50. (Pubitemid 19050206)
23. Sweazey RD, Bradley RM. Response characteristics of lamb pontine neurons to stimulation of the oral cavity and epiglottis with different sensory modalities. J Neurophysiol. 1993;70:1168-80. (Pubitemid 23289789)
24. Thexton AJ. Oral reflexes elicited by mechanical stimulation of palatal mucosa in the cat. Arch Oral Biol. 1973;18(8):977-80.
25. Shingai J. Ionic mechanisms of water receptors in the laryngeal mucosa of the rabbit. Jpn J Physiol. 1977;27:27-42.
26. Shingai T, Shimada K. Reflex swallowing elicited by water and chemical substances. Jpn J Physiol. 1976;26:455-69.
27. Sengupta JN. Electrophysiological recording from neurons controlling sensory and motor functions of the esophagus. Am J Med. 2001;111(Suppl 8A): 169S-73S. (Pubitemid 34032012)
28. Janssens J, De Wever I, Vantrappen G, Hellemans J. Peristalsis in smooth muscle esophagus after transection and bolus deviation. Gastroenterology. 1976;71:1004-9.
29. Janssens J, Valembois P, Hellemans J, Vantrappen G, Pelemans W. Studies on the necessity of a bolus for the progression of secondary peristalsis in the canine esophagus. Gastroenterology. 1974;67:245-51.
30. Janssens J, Valembois P, Vantrappen G, Hellemans J, Pelemans W. Is the primary peristaltic contraction of the canine esophagus bolus-dependent? Gastroenterology. 1973;65:750-6.
31. Janssens J, Vantrappen G, Hellemans J. Neural control of primary esophageal peristalsis. Gastroenterology. 1978;74:801-3.
32. Mansson I, Sandberg N. Effects of surface anesthesia on deglutition in man. Laryngoscope. 1974;84:427-37.
33. Mansson I, Sandberg N. Salivary stimulus and swallowing in man. Acta Otolaryngol. 1975;79:445-50.
34. Rudney JD, Ji Z, Larson CJ. The prediction of saliva swallowing frequency in humans from estimates of salivary flow rate and the volume of saliva swallowed. Arch Oral Biol. 1995;40:507-12.
35. Ebihara T, Ebihara S, Maruyama M, Kobayashi M, Itou A, Arai H, Sasaki H. A randomized trial of olfactory stimulation using black pepper oil in older people with swallowing dysfunction. J Am Geriatr Soc. 2006;54:1401-6. (Pubitemid 44342891)
36. Maeda K, Ono T, Otsuka R, Ishiwata Y, Kuroda T, Ohyama K. Modulation of voluntary swallowing by visual inputs in humans. Dysphagia. 2004;19:1-6. (Pubitemid 38168714)
37. Sweazey R, Bradley R. Response characteristics of lamb trigeminal neurons to stimulation of the oral cavity and epiglottis with different sensory modalities. Brain Res Bull. 1989;22:883-91. (Pubitemid 19196370)
38. Kawagishi S, Kou F, Yoshino K, Tanaka T, Masumi S. Decrease in stereognostic ability of the tongue with age. J Oral Rehabil. 2009;36:872-9.
39. Pouderoux P, Kahrilas PJ. Deglutitive tongue force modulation by volition, volume, and viscosity in humans. Gastroenterology. 1995;108:1418-26.
40. Ali GN, Cook IJ, Laundl TM, Wallace KL, de Carle DJ. Influence of altered tongue contour and position on deglutitive pharyngeal and UES function. Am J Physiol. 1997;273: G1071-6.
41. Bradley RM, Sweazey RD. In vitro intracellular recordings from gustatory neurons in the rat solitary nucleus. Brain Res. 1990;508:160-71.
42. Bradley RM, Sweazey RD. Separation of neuron types in the gustatory zone of the nucleus tractus solitarii on the basis of intrinsic firing discharges. J Neurophyiol. 1992;67:1659-68.
43. Hockman CH, Bieger D, Weerasuriya A. Supranuclear pathways of swallowing. Prog Neurobiol. 1979;12:15-32. (Pubitemid 9141154)
44. Mu L, Sanders I. Sensory nerve supply of the human oro-and laryngopharynx: a preliminary study. Anat Rec. 2000;258:406-20. (Pubitemid 30187466)
45. Bradley RM, Mistretta CM. Swallowing in fetal sheep. Science. 1973;179:1016-7.
46. Bradley RM, Mistretta CM. Fetal sensory receptors. Physiol Rev. 1975;55:352-82.
47. Bradley R. Development of the taste bud and gustatory papillae in human fetuses. In: Bosma JF, editor. Oral sensation and perception. Springfield, IL: Charles C. Thomas; 1972. p. 137-62.
48. Feindel W. The neural pattern of the epiglottis. J Comp Neurol. 1956;105:269-85.
49. Sampson S, Eyzaguirre C. Some functional characteristics of mechanoreceptors in the larynx of the cat. J Neurophysiol. 1964;27:464-80.
50. Ichikawa H, Jacobowitz DM, Sugimoto T. Calretinin-immunoreactivity in the oro-facial and pharyngeal regions of the rat. Neurosci Lett. 1992;146:155-8.
51. Broussard DL, Altschuler SM. Central integration of swallow and airway-protective reflexes. Am J Med. 2000;108(Suppl 4a): 62S-7S.
52. Broussard DL, Altschuler SM. Brainstem viscerotopic organization of afferents and efferents involved in the control of swallowing. Am J Med. 2000;108(Suppl 4a): 79S-86S.
53. Jean A, Amri M, Calas A. Connections between the ventral medullary swallowing area and the trigeminal motor nucleus of the sheep studied by tracing techniques. J Auton Nerv Syst. 1983;7:87-96. (Pubitemid 13132833)
54. Jean A, Car A. Inputs to the swallowing medullary neurons from the peripheral afferent fibers and the swallowing cortical area. Brain Res. 1979;178:567-72. (Pubitemid 10191580)
55. Sumi T. Reticular ascending activation of frontal cortical neurons in rabbits, with special reference to the regulation of deglutition. Brain Res. 1972;46:43-54.
56. Sumi T. Role of the pontine reticular formation in the neural organization of deglutition. Jpn J Physiol. 1972;22:295-314.
57. Sumi T. Neuronal mechanisms in swallowing. Pflugers Arch Gesamte Physiol Menschen Tiere. 1964;278:467-77.
58. Amri M, Car A, Jean A. Medullary control of the pontine swallowing neurones in sheep. Exp Brain Res. 1984;55:105-10. (Pubitemid 14081836)
59. Amri M, Car A, Roman C. Axonal branching of medullary swallowing neurons projecting on the trigeminal and hypoglossal motor nuclei: demonstration by electrophysiological and fluorescent double labeling techniques. Exp Brain Res. 1990;81:384-90. (Pubitemid 20216616)
60. Sweazey R, Bradley R. Central connections of the lingual-tonsillar branch of the glossopharyngeal nerve and the superior laryngeal nerve in lamb. J Comp Neurol. 1986;245:471-82. (Pubitemid 16128821)
61. Sweazey R, Bradley R. Response of lamb nucleus of the solitary tract neurons to chemical stimulation of the epiglottis. Brain Res. 1988;439:195-210. (Pubitemid 18065705)
62. Sweazey RD. Distribution of aspartate and glutamate in the nucleus of the solitary tract of the lamb. Exp Brain Res. 1995;105:241-53.
63. Travers JB, Smith DV. Gustatory sensitivities in neurons of the hamster nucleus tractus solitarius. Sens Process. 1979;3:1-26. (Pubitemid 10203895)
64. Sweazey RD, Smith DV. Convergence onto hamster medullary taste neurons. Brain Res. 1987;408:173-84. (Pubitemid 17068427)
65. Travers SP, Norgren R. Organization of orosensory responses in the nucleus of the solitary tract of rat. J Neurophysiol. 1995;73:2144-62.
66. Sengupta JN, Kauvar D, Goyal RK. Characteristics of vagal esophageal tension-sensitive afferent fibers in the opossum. J Neurophysiol. 1989;61:1001-10.
67. Sengupta JN, Saha JK, Goyal RK. Stimulus-response function studies of esophageal mechanosensitive nociceptors in sympathetic afferents of opossum. J Neurophysiol. 1990;64:796-812. (Pubitemid 20319444)
68. Sengupta JN, Saha JK, Goyal RK. Differential sensitivity to bradykinin of esophageal distension-sensitive mechanoreceptors in vagal and sympathetic afferents of the opossum. J Neurophysiol. 1992;68:1053-67.
69. Raut VV, McKee GJ, Johnston BT. Effect of bolus consistency on swallowing-does altering consistency help? Eur Arch Otorhinolaryngol. 2001;258:49-53. (Pubitemid 32202046)
70. Palmer JB, Hiiemae KM, Matsuo K, Haishima H. Volitional control of food transport and bolus formation during feeding. Physiol Behav. 2007;91:66-70. (Pubitemid 46616877)
71. Palmer JB, Rudin NJ, Lara G, Crompton AW. Coordination of mastication and swallowing. Dysphagia. 1992;7:187-200.
72. Steele CM, Van Lieshout P. Tongue movements during water swallowing in healthy young and older adults. J Speech Lang Hear Res. 2009;52:1255-67.
73. Daniels SK, Foundas AL. Swallowing physiology of sequential straw drinking. Dysphagia. 2001;16:176-82. (Pubitemid 32579016)
74. Daniels SK, Corey DM, Hadskey LD, Legendre C, Priestly DH, Rosenbek JC, Foundas AL. Mechanism of sequential swallowing during straw drinking in healthy young and older adults. J Speech Lang Hear Res. 2004;47:33-45. (Pubitemid 38338380)
75. Martin-Harris B, Brodsky MB, Michel Y, Lee FS, Walters B. Delayed initiation of the pharyngeal swallow: normal variability in adult swallows. J Speech Lang Hear Res. 2007;50(3):585-94. (Pubitemid 350058585)
76. Daniels SK, Schroeder MF, Degeorge PC, Corey DM, Rosenbek JC. Effects of verbal cue on bolus flow during swallowing. Am J Speech Lang Pathol. 2007;16:140-7.
77. Pouderoux P, Logemann JA, Kahrilas PJ. Pharyngeal swallowing elicited by fluid infusion: role of volition and vallecular containment. Am J Physiol. 1996;270: G347-54.
78. Sant'Ambrogio G, Anderson JW, Sant'Ambrogio FB, Mathew OP. Response of laryngeal receptors to water solutions of different osmolality and ionic composition. Respir Med. 1991;85(Suppl A): 57-60.
79. Sant'Ambrogio G, Mathew OP. Laryngeal receptors and their reflex responses. Clin Chest Med. 1986;7:211-22. (Pubitemid 16090977)
80. Sant'Ambrogio G, Mathew OP, Sant'Ambrogio FB. Characteristics of laryngeal cold receptors. Respir Physiol. 1988;71:287-97.
81. Sant'Ambrogio FB, Anderson JW, Kuna ST, Sant'Ambrogio G. Effect of changes in airway surface liquid on laryngeal receptors and muscles. Respir Physiol. 1995;101:31-9.
82. Sinclair W. Initiation of reflex swallowing from the naso-and oropharnyx. Am J Physiol. 1970;221:956-90.
83. Sinclair W. Role of the pharyngeal plexus in initiation of swallowing. Am J Physiol. 1971;221:1260-3.
84. Storey A. A functional analysis of sensory units innervating epiglottis and larynx. Exp Neurol. 1968;20:366-83.
85. Storey A. Laryngeal initiation of swallowing. Exp Neurol. 1968;20:359-65.
86. Jafari S, Prince RA, Kim DY, Paydarfar D. Sensory regulation of swallowing and airway protection: a role for the internal superior laryngeal nerve in humans. J Physiol. 2003;550:287-304. (Pubitemid 36869288)
87. Barkmeier JM, Bielamowicz S, Takeda N, Ludlow CL. Modulation of laryngeal responses to superior laryngeal nerve stimulation by volitional swallowing in awake humans. J Neurophysiol. 2000;83:1264-72. (Pubitemid 30159555)
88. Sulica L, Hembree A, Blitzer A. Swallowing and sensation: evaluation of deglutition in the anesthetized larynx. Ann Otol Rhinol Laryngol. 2002;111:291-4. (Pubitemid 34309773)
89. Kijima H, Shingai T, Takahashi Y, Kajii Y, Fukushima S, Taguchi Y, Noda T, Yamada Y. Nitric oxide modulates elicitation of reflex swallowing from the pharynx in rats. Am J Physiol Regul Integr Comp Physiol. 2006;291: R651-6. (Pubitemid 44352347)
90. Capra N. Mechanisms of oral sensation. Dysphagia. 1995;10:235-47.
91. Miller A. Characteristics of the swallowing reflex induced by peripheral nerve and brain stem stimulation. Exp Neurol. 1972;34:210-22.
92. Miller F, Sherrington C. Some observations on the buccopharyngeal stage of reflex deglutition in the cat. Q J Exp Physiol. 1916;9:147-86.
93. Sumi T. Some properties of cortically-evoked swallowing and chewing in rabbits. Brain Res. 1969;15:107-20.
94. Storey A, Johnson P. Laryngeal water receptors initiating apnea in the lamb. Exp Neurol. 1975;47:42-55.
95. Yahagi R, Okuda-Akabane K, Fukami H, Matsumoto N, Kitada Y. Facilitation of voluntary swallowing by chemical stimulation of the posterior tongue and pharyngeal region in humans. Neurosci Lett. 2008;448:139-42.
96. Dua K, Bardan E, Ren J, Sui Z, Shaker R. Effect of chronic and acute cigarette smoking on the pharyngo-upper oesophageal sphincter contractile reflex and reflexive pharyngeal swallow. Gut. 1998;43:537-41. (Pubitemid 28462040)
97. Dua K, Bardan E, Ren J, Sui Z, Shaker R. Effect of chronic and acute cigarette smoking on the pharyngoglottal closure reflex. Gut. 2002;51:771-5. (Pubitemid 35408593)
98. Lazarus CL, Logemann JA, Rademaker AW, Kahrilas PJ, Pajak T, Lazar R, Halper A. Effects of bolus volume, viscosity, and repeated swallows in nonstroke subjects and stroke patients. Arch Phys Med Rehabil. 1993;74:1066-70. (Pubitemid 23310167)
99. Kahrilas PJ, Lin S, Logemann JA, Ergun GA, Facchini F. Deglutitive tongue action: volume accommodation and bolus propulsion. Gastroenterology. 1993;104:152-62. (Pubitemid 23040018)
100. Kahrilas PJ, Logemann JA. Volume accommodation during swallowing. Dysphagia. 1993;8:259-65. (Pubitemid 23231195)
101. Dantas RO, Kern MK, Massey BT, Dodds WJ, Kahrilas PJ, Brasseur JG, Cook IJ, Lang IM. Effect of swallowed bolus variables on oral and pharyngeal phases of swallowing. Am J Physiol. 1990;258: G675-81. (Pubitemid 20180198)
102. Ali GN, Laundl TM, Wallace KL, deCarle DJ, Cook IJ. Influence of cold stimulation on the normal pharyngeal swallow response. Dysphagia. 1996;11:2-8. (Pubitemid 26119306)
103. Christensen CM, Casper LM. Oral and nonoral perception of solution viscosity. J Food Sci. 1987;52:445-7.
104. Dantas RO, Dodds WJ. Effect of bolus volume and consistency on swallow-induced submental and infrahyoid electromyographic activity. Braz J Med Biol Res. 1990;23:37-44.
105. Chi-Fishman G, Sonies BC. Effects of systematic bolus viscosity and volume changes on hyoid movement kinematics. Dysphagia. 2002;17:278-87. (Pubitemid 36919819)
106. Aviv JE. Clinical assessment of pharyngolaryngeal sensitivity. Am J Med. 2000;108(Suppl 4a): 68S-72S.
107. Aviv JE, Murry T, Zschommler A, Cohen M, Gartner C. Flexible endoscopic evaluation of swallowing with sensory testing: patient characteristics and analysis of safety in 1, 340 consecutive examinations. Ann Otol Rhinol Laryngol. 2005;114:173-6. (Pubitemid 40381530)
108. Aviv JE, Martin JH, Keen MS, Debell M, Blitzer A. Air pulse quantification of supraglottic and pharyngeal sensation: a new technique. Ann Otol Rhinol Laryngol. 1993;102:777-80. (Pubitemid 23308987)
109. Aviv JE, Kim T, Thomson JE, Sunshine S, Kaplan S, Close LG. Fiberoptic endoscopic evaluation of swallowing with sensory testing (FEESST) in healthy controls. Dysphagia. 1998;13:87-92. (Pubitemid 28122093)
110. Kawamura O, Easterling C, Aslam M, Rittmann T, Hofmann C, Shaker R. Laryngo-upper esophageal sphincter contractile reflex in humans deteriorates with age. Gastroenterology. 2004;127:57-64. (Pubitemid 38962274)
111. Kawamura O, Easterling C, Rittmann T, Hofmann C, Shaker R. Optimal stimulus intensity and reliability of air stimulation technique for elicitation of laryngo-upper esophageal sphincter contractile reflex. Ann Otol Rhinol Laryngol. 2005;114:223-8. (Pubitemid 40381539)
112. Aviv JE, Martin JH, Jones ME, Wee TA, Diamond B, Keen MS, Blitzer A. Age-related changes in pharyngeal and supraglottic sensation. Ann Otol Rhinol Laryngol. 1994;103:749-52. (Pubitemid 24324770)
113. Theurer JA, Bihari F, Barr AM, Martin RE. Oropharyngeal stimulation with air-pulse trains increases swallowing frequency in healthy adults. Dysphagia. 2005;20:254-60.
114. Theurer JA, Czachorowski KA, Martin LP, Martin RE. Effects of oropharyngeal air-pulse stimulation on swallowing in healthy older adults. Dysphagia. 2009;24:302-13.
115. Chi-Fishman G, Capra NF, McCall GN. Thermomechanical facilitation of swallowing evoked by electrical nerve stimulation in cats. Dysphagia. 1994;9:149-55. (Pubitemid 24218296)
116. Kaatzke-McDonald MN, Post E, Davis PJ. The effects of cold, touch, and chemical stimulation of the anterior faucial pillar on human swallowing. Dysphagia. 1996;11:198-206. (Pubitemid 26258498)
117. Rosenbek JC, Robbins J, Fishback B, Levine RL. Effects of thermal application on dysphagia after stroke. J Speech Hear Res. 1991;34:1257-68.
118. Rosenbek JC, Robbins J, Willford WO, Kirk G, Schiltz A, Sowell TW, Deutsch SE, Milanti FJ, Ashford J, Gramigna GD, Fogarty A, Dong K, Rau MT, Prescott TE, Lloyd AM, Sterkel MT, Hansen JE. Comparing treatment intensities of tactilethermal application. Dysphagia. 1998;13:1-9. (Pubitemid 28029964)
119. Rosenbek JC, Roecker EB, Wood JL, Robbins J. Thermal application reduces the duration of stage transition in dysphagia after stroke. Dysphagia. 1996;11:225-33. (Pubitemid 26331839)
120. GdL Lazzara, Lazarus C, Logemann J. Impact of thermal stimulation on the triggering of swallowing reflex. Dysphagia. 1986;1:73-7. (Pubitemid 18026765)
121. Sciortino K, Liss JM, Case JL, Gerritsen KG, Katz RC. Effects of mechanical, cold, gustatory, and combined stimulation to the human anterior faucial pillars. Dysphagia. 2003;18:16-26. (Pubitemid 36918075)
122. Shaker R, Medda BK, Ren J, Jaradeh S, Xie P, Lang IM. Pharyngoglottal closure reflex: identification and characterization in a feline model. Am J Physiol. 1998;275: G521-5.
123. Shaker R, Ren J, Bardan E, Easterling C, Dua K, Xie P, Kern M. Pharyngoglottal closure reflex: characterization in healthy young, elderly and dysphagic patients with predeglutitive aspiration. Gerontology. 2003;49:12-20. (Pubitemid 35398575)
124. Kajii Y, Shingai T, Kitagawa J, Takahashi Y, Taguchi Y, Noda T, Yamada Y. Sour taste stimulation facilitates reflex swallowing from the pharynx and larynx in the rat. Physiol Behav. 2002;77:321-5. (Pubitemid 35373887)
125. Logemann JA, Pauloski BR, Colangelo L, Lazarus C, Fujiu M, Kahrilas PJ. Effects of a sour bolus on oropharyngeal swallowing measures in patients with neurogenic dysphagia. J Speech Hear Res. 1995;38:556-63.
126. Hamdy S, Jilani S, Price V, Parker C, Hall N, Power M. Modulation of human swallowing behaviour by thermal and chemical stimulation in health and after brain injury. Neurogastroenterol Motil. 2003;15:69-77. (Pubitemid 36313137)
127. Pelletier CA, Lawless HT. Effect of citric acid and citric acidsucrose mixtures on swallowing in neurogenic oropharyngeal dysphagia. Dysphagia. 2003;18:231-41. (Pubitemid 37221641)
128. Pelletier CA, Dhanaraj GE. The effect of taste and palatability on lingual swallowing pressure. Dysphagia. 2006;21:121-8. (Pubitemid 44078545)
129. Ali GN, Laundl TM, Wallace KL, Shaw DW, Decarle DJ, Cook IJ. Influence of mucosal receptors on deglutitive regulation of pharyngeal and upper esophageal sphincter function. Am J Physiol. 1994;267: G644-9.
130. Lang IM, Medda BK, Shaker R. Mechanisms of reflexes induced by esophageal distension. Am J Physiol Gastrointest Liver Physiol. 2001;281: G1246-63.
131. Bardan E, Xie P, Ren J, Dua K, Shaker R. Effect of pharyngeal water stimulation on esophageal peristalsis and bolus transport. Am J Physiol. 1997;272: G265-71.
132. Bardan E, Saeian K, Xie P, Ren J, Kern M, Dua K, Shaker R. Effect of pharyngeal stimulation on the motor function of the esophagus and its sphincters. Laryngoscope. 1999;109:437-41. (Pubitemid 29128545)
133. Bardan E, Xie P, Aslam M, Kern M, Shaker R. Disruption of primary and secondary esophageal peristalsis by afferent stimulation. Am J Physiol Gastrointest Liver Physiol. 2000;279: G255-61.
134. Pouderoux P, Shi G, Tatum RP, Kahrilas PJ. Esophageal solid bolus transit: studies using concurrent videofluoroscopy and manometry. Am J Gastroenterol. 1999;94:1457-63. (Pubitemid 29260429)
135. Pouderoux P, Verdier E, Kahrilas PJ. Patterns of esophageal inhibition during swallowing, pharyngeal stimulation, and transient les relaxation. Lower esophageal sphincter. Am J Physiol Gastrointest Liver Physiol. 2003;284: G242-7. (Pubitemid 36120129)
136. Aslam M, Kern M, Shaker R. Modulation of oesophago-UOS contractile reflex: effect of proximal and distal esophageal distention and swallowing. Neurogastroenterol Motil. 2003;15:323-9. (Pubitemid 36774160)
137. Gawrieh S, Shaker R. Peripheral mechanisms affecting the lower esophageal sphincter tone. Gastroenterol Clin North Am. 2002;31:S21-33. (Pubitemid 35416662)
138. Bartolome G, Neumann S. Swallowing therapy in patients with neurological disorders causing cricopharyngeal dysfunction. Dysphagia. 1993;8:146-9. (Pubitemid 23144077)
139. Medda BK, Sengupta JN, Lang IM, Shaker R. Responseproperties of the brainstem neurons of the cat following intra-esophageal acid-pepsin infusion. Neuroscience. 2005;135:1285-94. (Pubitemid 41416689)
140. Gow D, Hobson AR, Furlong P, Hamdy S. Characterising the central mechanisms of sensory modulation in human swallowing motor cortex. Clin Neurophysiol. 2004;115:2382-90. (Pubitemid 39200804)
141. Gow D, Rothwell J, Hobson A, Thompson D, Hamdy S. Induction of long-term plasticity in human swallowing motor cortex following repetitive cortical stimulation. Clin Neurophysiol. 2004;115:1044-51. (Pubitemid 38453013)
142. Hamdy S, Aziz Q, Rothwell JC, Hobson A, Barlow J, Thompson DG. Cranial nerve modulation of human cortical swallowing motor pathways. Am J Physiol. 1997;272: G802-8.
143. Hamdy S, Rothwell JC, Aziz Q, Singh KD, Thompson DG. Long-term reorganization of human motor cortex driven by short-term sensory stimulation. Nat Neurosci. 1998;1:64-8. (Pubitemid 128652644)
144. Teismann IK, Dziewas R, Steinstraeter O, Pantev C. Timedependent hemispheric shift of the cortical control of volitional swallowing. Hum Brain Mapp. 2009;30:92-100.
145. Fraser C, Rothwell J, Power M, Hobson A, Thompson D, Hamdy S. Differential changes in human pharyngoesophageal motor excitability induced by swallowing, pharyngeal stimulation, and anesthesia. Am J Physiol Gastrointest Liver Physiol. 2003;285: G137-44. (Pubitemid 36736397)
146. Miller AJ, Loizzi RF. Anatomical and functional differentiation of superior laryngeal nerve fibers affecting swallowing and respiration. Exp Neurol. 1974;42:369-87.
147. Jean A, Car A, Roman C. Study by means of microelectrodes of bulbar deglutitory neuron activity. J Physiol (Paris). 1970;62(Suppl 1): 170):170.
148. Kezirian EJ, Boudewyns A, Eisele DW, Schwartz AR, Smith PL, Van de Heyning PH, De Backer WA. Electrical stimulation of the hypoglossal nerve in the treatment of obstructive sleep apnea. Sleep Med Rev. 2010. doi:10.1016/j.smrv. 2009.10.009.
149. Litvak L, Delgutte B, Eddington D. Auditory nerve fiber responses to electric stimulation: modulated and unmodulated pulse trains. J Acoust Soc Am. 2001;110:368-79. (Pubitemid 32642577)
150. Bulow M, Olsson R, Ekberg O. Videoradiographic analysis of how carbonated thin liquids and thickened liquids affect the physiology of swallowing in subjects with aspiration on thin liquids. Acta Radiol. 2003;44:366-72.