Microinjection of codeine into the region of the caudal ventral respiratory column suppresses cough in anesthetized cats

Journal of Applied Physiology

Volumn 108, Issue 4, 2010, Pages 858-865

  Poliacek, Ivan ^a,b   Wang, Cheng ^a   Corrie, Lu Wen Chi ^a   Rose, Melanie J ^a   Bolser, Donald C ^a  

^a University of Florida College of Veterinary Medicine   (United States)

^b University Teaching Hospital in Martin   (Slovakia)

Author keywords

Brain stem; D,L homocysteic acid; Respiratory motor output; Ventral respiratory group

Indexed keywords

ANTITUSSIVE AGENT; CODEINE; NARCOTIC ANALGESIC AGENT;

ABDOMINAL WALL MUSCULATURE; ANESTHESIA; ANIMAL; ARTICLE; BREATHING MUSCLE; CAT; COUGHING; DISEASE MODEL; DRUG EFFECT; ELECTROMYOGRAPHY; FEMALE; MEDULLA OBLONGATA; MICROINJECTION; PATHOPHYSIOLOGY;

ABDOMINAL MUSCLES; ANALGESICS, OPIOID; ANESTHESIA; ANIMALS; ANTITUSSIVE AGENTS; CATS; CODEINE; COUGH; DISEASE MODELS, ANIMAL; ELECTROMYOGRAPHY; FEMALE; MEDULLA OBLONGATA; MICROINJECTIONS; RESPIRATORY MUSCLES;

EID: 77950553257     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00783.2009     Document Type: Article

References (65)

1. Adcock JJ, Schneider C, Smith TW. Effects of codeine, morphine and a novel opioid pentapeptide BW443C, on cough, nociception and ventilation in the unanaesthetized guinea-pig. Br J Pharmacol 93: 93-100, 1988.
2. 2. Baekey DM, Morris KF, Gestreau C, Li Z, Lindsey BG, Shannon R. Medullary respiratory neurones and control of laryngeal motoneurones during fictive eupnoea and cough in the cat. J Physiol. 534: 565-581, 2001. (Pubitemid 32677750)
3. Basmajian JV, Stecko G. The role of muscles in arch support of the foot. J Bone Joint Surg Am 45: 1184-1190, 1963.
4. Bianchi AL, Denavit-Saubie M, Champagnat J. Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters. Physiol Rev 75: 1-45, 1995.
5. Boiser DC, DeGennaro FC. Effect of codeine on the inspiratory and expiratory burst pattern during fictive cough in cats. Brain Res 662: 25-30, 1994.
6. Boiser DC, DeGennaro FC, Chapman RW, Hey JA. Central and peripheral sites of action of antitussive drugs in the cat. In: Ventral Brainstem Mechanisms and Control of Respiration and Blood Pressure, edited by Trouth CO, Millis RM. New York: Marcel Dekker, 1995, p. 95-102.
7. Boiser DC, Hey JA, Chapman RW. Influence of central antitussive drugs on the cough motor pattern. J Appl Physiol 86: 1017-1024, 1999.
8. Boiser DC, Reier PJ, Davenport PW. Responses of the anterolateral abdominal muscles during cough and expiratory threshold loading in the cat. J Appl Physiol 88: 1207-1214, 2000.
9. Boiser DC, Davenport PW. Functional organization of the central cough generation mechanism. Pulm Pharmacol Ther 15: 221-225, 2002.
10. 10. Boiser DC, Poliacek I, Jakus J, Fuller DD, Davenport PW. Neurogenesis of cough, other airway defensive behaviors and breathing: a holarchical system? Respir Physiol Neurobiol 152: 255-265, 2006. (Pubitemid 44037506)
11. 11. Boiser DC. Current and future centrally acting antitussives. Respir Physiol Neurobiol 152: 349-355, 2006. (Pubitemid 44037507)
12. 12. Bongianni F, Corda M, Fontana GA, Pantaleo T. Chemical activation of caudal medullary expiratory neurones alters the pattern of breathing in the cat. J Physiol 474: 497-507, 1994. (Pubitemid 24060782)
13. 13. Bongianni F, Mutolo D, Nardone F, Pantaleo T. Ionotropic glutamate receptors mediate excitatory drive to caudal medullary expiratory neurons in the rabbit. Brain Res 1056: 145-157, 2005. (Pubitemid 41557702)
14. 14. Chau TT, Harris LS. Comparative studies of the pharmacological effects of D- and L-isomers of codeine. J Pharmacol Exp Ther 215: 668-672, 1980. (Pubitemid 11210374)
15. Chau TT, Carter FE, Harris LS. Antitussive effect of the optical Isomers of μ, κ and σ opiate agonists/antagonists in the cat. J Pharmacol Exp Ther 226: 108-113, 1983.
16. Chau TT, Harris LS. Antitussive potencies of L- and D-opiates and their inhibition of codeine binding. NIDA Res Monogr 49: 77-84, 1984.
17. Chou DT, Wang SC. Studies on the localization of central cough mechanism; site of action of antitussive drugs. J Pharmacol Exp Ther 194: 499-505, 1975.
18. Chung KF. Pathophysiology and therapy of chronic cough. Minerva Med 96: 29-40, 2005.
19. Eccles R. Codeine, cough and upper respiratory infection. Pulm Pharmacol 9: 293-297, 1996.
20. Eddy NB, Friebel H, Hahn KJ, Halbach H. Codeine and its alternates for pain and cough relief. 3. The antitussive action of codeine-mechanism, methodology and evaluation. Bull Wld Hlth Org 40: 425-454, 1969.
21. Engelhorn R, Weller E. [Central representation of cough effecting afferent impulses in the medulla oblongata in the cat]. Pflügers Arch 284: 224-239, 1965.
22. 22. Ezure K. Synaptic connections between medullary respiratory neurons and considerations on the genesis of respiratory rhythm. Prog Neurobiol 35: 429-450, 1990. (Pubitemid 20335020)
23. Freestone C, Eccles R. Assessment of the antitussive efficacy of codeine in cough associated with common cold. J Pharm Pharmacol 49: 1045-1049, 1997.
24. 24. Gestreau C, Bianchi Al Grelot L. Differential brainstem Fos-like immunoreactivity after laryngeal-induced coughing and its reduction by codeine. J Neurosci 17: 9340-9352, 1997. (Pubitemid 27498460)
25. 25. Gestreau C, Grelot L, Bianchi AL. Activity of respiratory laryngeal motoneurons during fictive coughing and swallowing. Exp Brain Res 130: 27-34, 2000. (Pubitemid 30088239)
26. 26. Hosokawa T, Kamei J, Misawa M, Yanaura S, Hukuhara T. Effects of antitussive drugs on the central respiratory mechanisms during the cough reflex. Nippon Yakurigaku Zasshi 80: 367-374, 1982. (Pubitemid 13169114)
27. Iscoe S. Control of abdominal muscles. Prog Neurobiol 56: 433-506, 1998.
28. Jakus J, Tomori Z, Stransky A. Activity of bulbar respiratory neurones during cough and other respiratory tract reflexes in cats. Physiol Bohemoslov 34: 127-136, 1985.
29. Jakus J, Tomori Z, Stransky A. Neuronal Determinants of Breathing, Coughing and Related Motor Behaviours. Martin, Slovak Republic: Wist, 2004.
30. 30. Jakus J, Poliacek I, Halasova E, Murin P, Knocikova J, Tomori Z, Boiser DC. Brainstem circuitry of tracheal-bronchial cough: c-fos study in anesthetized cats. Respir Physiol. Neurobiol 160: 289-300, 2008. (Pubitemid 351754803)
31. 31. Kalia M, Mesulam MM. Brain stem projections of sensory and motor components of the vagus complex in cat. II. Laryngeal, tracheobronchial, pulmonary, cardiac, and gastrointestinal branches. J Comp Neurol 193: 467-508, 1980. (Pubitemid 11233763)
32. 32. Kamei J, Hosokawa T, Yanaura S, Hukuhara T. Involvement of central serotonergic mechanisms in the cough reflex. Jpn J Pharmacol 42: 531-538, 1986. (Pubitemid 17213850)
33. 2- channel antagonists. Eur J Pharmacol 212: 61-66, 1992.
34. 34. Kamei J. Role of opioidergic and serotonergic mechanisms in cough and antitussives. Pulm Pharmacol 9: 349-356, 1996. (Pubitemid 27277765)
35. Kase Y. Pharmacological studies on cough reflex. Part 3. "Coughing dog" and its application. Jap J Pharmacol 4: 130-135, 1955.
36. Kase Y. Antitussive agents and their sites of action. Trends Pharmacol Sci 1: 237-239, 1980.
37. 37. Kito G, Kase Y, Miyata T, Takahama K. Neural mechanism for production of spasmodic expiratory response like cough induced by amygdala stimulation in the cat. I. Pathways from the amygdala to the lower brain stem. Arch Int Pharmacodyn Ther 229: 116-128, 1977. (Pubitemid 8210912)
38. Korpas J, Tomori Z. Cough and Other Respiratory Reflexes. New York: Karger, 1979.
39. 39. Krolo M, Stuth EA, Tonkovic-Capin M, Dogas Z, Hopp FA, McCrimmon DR, Zuperku EJ. Differential roles of ionotropic glutamate receptors in canine medullary inspiratory neurons of the ventral respiratory group. J Neurophysiol 82: 60-68, 1999. (Pubitemid 29330061)
40. 40. Kubin L, Alheid GF, Zuperku EJ, McCrimmon DR. Central pathways of pulmonary and lower airway vagal afferents. J Appl Physiol 101: 618-627, 2006. (Pubitemid 44162373)
41. 41. Lindsey BG, Segers LS, Shannon R. Functional associations among simultaneously monitored lateral medullary respiratory neurons in the cat. II. Evidence for inhibitory actions of expiratory neurons. J Neurophysiol 57: 1101-1117, 1987. (Pubitemid 17059749)
42. Lipski J, Bellingham MC, West MJ, Pilowski P. Limitations of the technique of pressure microinjection of excitatory amino acids for evoking responses from localized regions of the CNS. J Neurosci Methods 26: 169-179, 1988.
43. 43. Madison JM, Irwin RS. Chronic cough in adults with interstitial lung disease. Curr Opin Pulm Med 11: 412-416, 2005. (Pubitemid 41291085)
44. Mori M, Sakai Y. Effects of antitussive drugs on the activity of the recurrent laryngeal nerve in cats. Jpn J Pharmacol 25: 671-680, 1975.
45. Mutolo D, Bongianni F, Cinelli E, Fontana GA, Pantaleo T. Modulation of the cough reflex by antitussive agents within the caudal aspect of the nucleus tractus solitarii in the rabbit. Am J Physiol Regul Integr Comp Physiol. 295: R243-R251, 2008.
46. Nersesian LB, Baklavadzhian OG, Oleinik GN, Sarukhanian RV. [Reactions of the neurons of the bulbar respiratory center area to microiontophoretic application of opiate substances and serotonin], Fiziol Zh 70: 130-137, 1984.
47. 47. Nicholson C. Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity. Brain Res 333: 325-329, 1985. (Pubitemid 15093590)
48. 48. Nicholson C, Chen KC, Hrabetova S, Tao L. Diffusion of molecules in brain extracellular space: theory and experiment. In: Progress In Brain Research, edited by Agnati LF, Fuxe K, Nicholson C, Sykova E. Amsterdam.: Elsevier, 2000, vol.125, p. 129-154. (Pubitemid 35460795)
49. Nosalova G. [Actions of drugs affecting the cough reflex], Bratisl Lek Listy 99: 531-535, 1998.
50. 50. Ohi Y, Yamazaki H, Takeda R, Haji A. Functional and morphological organization of the nucleus tractus solitarius in the fictive cough reflex of guinea pigs. Neurosci Res 53: 201-209, 2005. (Pubitemid 41219537)
51. Oldendorf WH, Hyman S, Braun L, Oldendorf SZ. Blood-brain barrier: penetration of morphine, codeine, heroin, and methadone after carotid injection. Science 178: 984-986, 1972.
52. Pert CB, Snyder SH. Opiate receptor: demonstration in nervous tissue. Science 179: 1011-1014, 1973.
53. 53. Poliacek I, Stransky A, Jakus J, Barani H, Tomori Z, Halasova E. Activity of the laryngeal abductor and adductor muscles during cough, expiration and aspiration reflexes in cats. Physiol Res 52: 749-762, 2003. (Pubitemid 38090104)
54. 54. Poliacek I, Corrie LW, Wang C, Rose MJ, Boiser DC. Microinjection of DLH into the region of the caudal ventral respiratory column in the cat: evidence for an endogenous cough-suppressant mechanism. J Appl Physiol 102: 1014-1021, 2007. (Pubitemid 46377026)
55. Poliacek I, Rose MJ, Corrie LWC, Wang C, Jakus J, Barani H, Stransky A, Polacek H, Halasova E, Boiser DC. Short reflex expirations (expiration reflexes) induced by mechanical stimulation of the trachea in anesthetized cats. Cough 4: 1, 2008.
56. Sevelius H, McCoy JF, Colmore JP. Dose response to codeine in patients with chronic cough. Clin Pharmacol Ther 12: 449-455, 1971.
57. 57. Shannon R, Baekey DM, Morris KF, Lindsey BG. Ventrolateral medullary respiratory network and a model of cough motor pattern generation. J Appl Physiol 84: 2020-2035, 1998. (Pubitemid 28255964)
58. 58. Shannon R, Baekey DM, Morris KF, Nuding SC, Segers LS, Lindsey BG. Production of reflex cough by brainstem respiratory networks. Pulm Pharmacol Ther 17: 369-376, 2004. (Pubitemid 39572478)
59. 59. Shiba K, Satoh I, Kobayashi N, Hayashi F. Multifunctional laryngeal motoneurons: an intracellular study in the cat. J Neurosci 19: 2717-2727, 1999. (Pubitemid 29162419)
60. Smith JC, Morrison DE, Ellenberger HH, Otto MR, Feldman JL. Brainstem projections to the major respiratory neuron populations in the medulla of the cat. J Comp Neurol 281: 69-96, 1989.
61. Smith J, Owen E, Earis J, Woodcock A. Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease. J Allergy Clin Immunol 117: 831-835, 2006.
62. Szekely SM, Vickers MD. A comparison of the effects of codeine and tramadol on laryngeal reactivity. Eur J Anaesthesiol 9: 111-120, 1992.
63. 63. Xie R, Hammarlund-Udenaes M. Blood-brain barrier equilibration of codeine in rats studied with microdialysis. Pharm Res 15: 570-575, 1998. (Pubitemid 28214950)
64. 64. Yamakura T, Sakimura K, Shimoji K. Direct inhibition of the Nmethyl-D-aspartate receptor channel by high concentrations of opioids. Anesthesiology 91: 1053-1063, 1999. (Pubitemid 29466541)
65. 65. Yanaura S, Kitagawa H, Hosokawa T, Misawa M. Difference in the effects of antitussive drugs on respiration and cough reflex. Nippon Yakurigaku Zasshi 82: 213-222, 1983. (Pubitemid 14231802)