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Volumn 223, Issue 3, 2013, Pages 280-286

Endocrine effects of chemicals: Aspects of hazard identification and human health risk assessment

Author keywords

Endocrine disruptors; Hazard assessment; Non monotonous dose response; Risk assessment

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 4,4' ISOPROPYLIDENEDIPHENOL; DAIDZEIN; ENDOCRINE DISRUPTOR; EQUOL; FOOD ADDITIVE; GENISTEIN; HORMONE RECEPTOR; INDUSTRIAL CHEMICAL; PHTHALIC ACID;

EID: 84888058512     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.03.022     Document Type: Article
Times cited : (26)

References (77)
  • 1
    • 0346504215 scopus 로고    scopus 로고
    • Endocrine disruption occurring at doses lower than those predicted by classical chemical toxicity evaluations: The case bisphenol A
    • Ashby J. Endocrine disruption occurring at doses lower than those predicted by classical chemical toxicity evaluations: The case bisphenol A. Pure and Applied Chemistry 2003, 75:2167-2179.
    • (2003) Pure and Applied Chemistry , vol.75 , pp. 2167-2179
    • Ashby, J.1
  • 2
    • 0038493955 scopus 로고    scopus 로고
    • The effect on sperm production in adult Sprague-Dawley rats exposed by gavage to bisphenol A between postnatal days 91-97
    • Ashby J., Tinwell H., Lefevre P.A., Joiner R., Haseman J. The effect on sperm production in adult Sprague-Dawley rats exposed by gavage to bisphenol A between postnatal days 91-97. Toxicological Sciences 2003, 74:129-138.
    • (2003) Toxicological Sciences , vol.74 , pp. 129-138
    • Ashby, J.1    Tinwell, H.2    Lefevre, P.A.3    Joiner, R.4    Haseman, J.5
  • 3
    • 33646385579 scopus 로고    scopus 로고
    • Threshold of toxicological concern (TTC) - A tool for assessing substances of unknown toxicity present at low levels in the diet
    • Barlow S. Threshold of toxicological concern (TTC) - A tool for assessing substances of unknown toxicity present at low levels in the diet. ILSI Europe Concise Monographs Series 2005, 1-31.
    • (2005) ILSI Europe Concise Monographs Series , pp. 1-31
    • Barlow, S.1
  • 5
    • 84978167906 scopus 로고    scopus 로고
    • Regulatory definition of an endocrine disrupter in relation to potential threat to human health
    • BfR, Joint DE. - UK position paper. Bundesinstitut für Risikobewertun. Available at: (last accessed 12.11.2012).
    • BfR, 2011. Joint DE. - UK position paper. Regulatory definition of an endocrine disrupter in relation to potential threat to human health. Bundesinstitut für Risikobewertun. Available at: (last accessed 12.11.2012). http://wwwbfrbundde/cm/349/regulatory_definition_of_an_endocrine_disrupter_in_relation_to_potential_threat_to_human_healthpdf.
    • (2011)
  • 7
    • 0034463175 scopus 로고    scopus 로고
    • Comparative assessment of endocrine modulators with oestrogenic activity: I. Definition of a hygiene-based margin of safety (HBMOS) for xeno-oestrogens against the background of European developments
    • Bolt H.M., Janning P., Michna H., Degen G.H. Comparative assessment of endocrine modulators with oestrogenic activity: I. Definition of a hygiene-based margin of safety (HBMOS) for xeno-oestrogens against the background of European developments. Archives of Toxicology 2001, 74:649-662.
    • (2001) Archives of Toxicology , vol.74 , pp. 649-662
    • Bolt, H.M.1    Janning, P.2    Michna, H.3    Degen, G.H.4
  • 10
    • 77958495547 scopus 로고    scopus 로고
    • Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran
    • Budinsky R.A., LeCluyse E.L., Ferguson S.S., Rowlands J.C., Simon T. Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran. Toxicological Sciences 2010, 118:224-235.
    • (2010) Toxicological Sciences , vol.118 , pp. 224-235
    • Budinsky, R.A.1    LeCluyse, E.L.2    Ferguson, S.S.3    Rowlands, J.C.4    Simon, T.5
  • 12
    • 3142755432 scopus 로고    scopus 로고
    • Isoflavones in soy infant formula: a review of evidence for endocrine and other activity in infants
    • Chen A., Rogan W.J. Isoflavones in soy infant formula: a review of evidence for endocrine and other activity in infants. Annual Review of Nutrition 2004, 24:33-54.
    • (2004) Annual Review of Nutrition , vol.24 , pp. 33-54
    • Chen, A.1    Rogan, W.J.2
  • 13
    • 33646255248 scopus 로고    scopus 로고
    • Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR
    • Connor K.T., Aylward L.L. Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR. Journal of Toxicology and Environmental Health. Part B, Critical Reviews 2006, 9:147-171.
    • (2006) Journal of Toxicology and Environmental Health. Part B, Critical Reviews , vol.9 , pp. 147-171
    • Connor, K.T.1    Aylward, L.L.2
  • 14
    • 84888034032 scopus 로고    scopus 로고
    • Regulatory definition of endocrine disruptors
    • COT, Available at: (last accessed 12.11.2012).
    • COT, 2012. Regulatory definition of endocrine disruptors. Committee on Toxicity. Available at: (last accessed 12.11.2012). http://cotfoodgovuk/pdfs/tox201015pdf.
    • (2012) Committee on Toxicity
  • 15
    • 0029061206 scopus 로고
    • Principles underlying dose selection for, and extrapolation from, the carcinogen bioassay: dose influences mechanism
    • Counts J.L., Goodman J.I. Principles underlying dose selection for, and extrapolation from, the carcinogen bioassay: dose influences mechanism. Regulatory Toxicology and Pharmacology 1995, 21:418-421.
    • (1995) Regulatory Toxicology and Pharmacology , vol.21 , pp. 418-421
    • Counts, J.L.1    Goodman, J.I.2
  • 16
    • 44349163013 scopus 로고    scopus 로고
    • Exposure assessment of prepubertal children to steroid endocrine disruptors. 2. Determination of steroid hormones in milk, egg, and meat samples
    • Courant F., Antignac J.P., Laille J., Monteau F., Andre F., Le Bizec B. Exposure assessment of prepubertal children to steroid endocrine disruptors. 2. Determination of steroid hormones in milk, egg, and meat samples. Journal of Agricultural and Food Chemistry 2008, 56:3176-3184.
    • (2008) Journal of Agricultural and Food Chemistry , vol.56 , pp. 3176-3184
    • Courant, F.1    Antignac, J.P.2    Laille, J.3    Monteau, F.4    Andre, F.5    Le Bizec, B.6
  • 19
    • 0030709470 scopus 로고    scopus 로고
    • Anti-thyroid isoflavones from soybean: isolation, characterization, and mechanisms of action
    • Divi R.L., Chang H.C., Doerge D.R. Anti-thyroid isoflavones from soybean: isolation, characterization, and mechanisms of action. Biochemical Pharmacology 1997, 54:1087-1096.
    • (1997) Biochemical Pharmacology , vol.54 , pp. 1087-1096
    • Divi, R.L.1    Chang, H.C.2    Doerge, D.R.3
  • 20
    • 48649105267 scopus 로고    scopus 로고
    • Risk assessment of dietary exposures to compounds that are genotoxic and carcinogenic - an overview
    • Dybing E., O'Brien J., Renwick A.G., Sanner T. Risk assessment of dietary exposures to compounds that are genotoxic and carcinogenic - an overview. Toxicology Letters 2008, 180:110-117.
    • (2008) Toxicology Letters , vol.180 , pp. 110-117
    • Dybing, E.1    O'Brien, J.2    Renwick, A.G.3    Sanner, T.4
  • 21
    • 84888026039 scopus 로고    scopus 로고
    • European workshop on the impact of endocrine disrupters on human health and wildlife
    • EC-Weybridge, Report of Proceedings, Weybridge, United Kingdom, 2-4 December.
    • EC-Weybridge, 1996. European workshop on the impact of endocrine disrupters on human health and wildlife. Report of Proceedings, Weybridge, United Kingdom, 2-4 December.
    • (1996)
  • 22
    • 84888018019 scopus 로고    scopus 로고
    • EDSTAC, Endocrine Disruptor Screening and Testing Advisory Committee Final Report 1998. Available at: (last accessed 12.11.2012).
    • EDSTAC, 1998. Endocrine Disruptor Screening and Testing Advisory Committee Final Report 1998. Available at: (last accessed 12.11.2012). http://wwwepagov/endo/pubs/edspoverview/finalrpthtm.
    • (1998)
  • 23
    • 68149135446 scopus 로고    scopus 로고
    • Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Bis(2-ethylhexyl)phthalate (DEHP) for use in food contact materials.
    • EFSA
    • EFSA, 2005. Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Bis(2-ethylhexyl)phthalate (DEHP) for use in food contact materials.
    • (2005)
  • 24
    • 79955015246 scopus 로고    scopus 로고
    • Scientific opinion on bisphenol A: evaluation of a study investigating its neurodevelopmental toxicity, review of recent scientific literature on its toxicity and advice on the Danish risk assessment of bisphenol A of the EFSA Panel on Food contact materials, enzymes, flavourings and processing aids (CEF) on request from the European Commission, Questions No EFSA-Q-2009-00864
    • 1929, EFSA, EFSA-Q-2010-01023 and EFSA-Q-2010-00709, adopted on 23rd September 2010
    • EFSA, 2010. Scientific opinion on bisphenol A: evaluation of a study investigating its neurodevelopmental toxicity, review of recent scientific literature on its toxicity and advice on the Danish risk assessment of bisphenol A of the EFSA Panel on Food contact materials, enzymes, flavourings and processing aids (CEF) on request from the European Commission, Questions No EFSA-Q-2009-00864, EFSA-Q-2010-01023 and EFSA-Q-2010-00709, adopted on 23rd September 2010. EFSA Journal 8(9):1929, 1-116.
    • (2010) EFSA Journal , vol.8 , Issue.9 , pp. 1-116
  • 25
    • 84888023617 scopus 로고    scopus 로고
    • European Medicines Agency-CHMP Guideline on the Limits of Genotoxic Impurities
    • EMA, Available at: (last accessed 23.11.2012).
    • EMA, 2006. European Medicines Agency-CHMP Guideline on the Limits of Genotoxic Impurities. Available at: (last accessed 23.11.2012). http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500002903.pdf.
    • (2006)
  • 26
    • 84888047490 scopus 로고    scopus 로고
    • EU, European Union Risk Assessment Report. Bisphenol A, CAS No: 80-05-7, Addendum 2008. Institute for Health and Consumer Protection, European Chemicals Bureau, European Commission Joint Research Centre, 3rd Priority List, Luxembourg: Office for Official Publications of the European Communities.
    • EU, 2008. European Union Risk Assessment Report. Bisphenol A, CAS No: 80-05-7, Addendum 2008. Institute for Health and Consumer Protection, European Chemicals Bureau, European Commission Joint Research Centre, 3rd Priority List, Luxembourg: Office for Official Publications of the European Communities.
    • (2008)
  • 27
    • 84888039421 scopus 로고    scopus 로고
    • EU-SCCNFP, Opinion of the Scientific Committee on Cosmetic and non-food products intended for consumers concerning 4-Methylbenzylidene Camphor Colipa n°S60 adopted during the 28th plenary meeting of 25 May 2004.
    • EU-SCCNFP, 2004. Opinion of the Scientific Committee on Cosmetic and non-food products intended for consumers concerning 4-Methylbenzylidene Camphor Colipa n°S60 adopted during the 28th plenary meeting of 25 May 2004.
    • (2004)
  • 28
    • 84888060479 scopus 로고    scopus 로고
    • FDA, Redbook 2000 - Guidance for industry and other stakeholders, toxicological principles for the safety assessment of food ingredients US Department of Health and Human Services, Food and Drug Administration Center for Food Safety and Applied Nutrition, July 2000; Updated July 2007.
    • FDA, 2007. Redbook 2000 - Guidance for industry and other stakeholders, toxicological principles for the safety assessment of food ingredients US Department of Health and Human Services, Food and Drug Administration Center for Food Safety and Applied Nutrition, July 2000; Updated July 2007.
    • (2007)
  • 30
    • 77955349920 scopus 로고    scopus 로고
    • Guidance for industry: Genotoxic and carcinogenic impurities in drug substances and products - recommended approaches. US Food and Drug Administration
    • FDA, Available at: (last accessed 23.11.2012).
    • FDA, 2008. Guidance for industry: Genotoxic and carcinogenic impurities in drug substances and products - recommended approaches. US Food and Drug Administration. Available at: (last accessed 23.11.2012). http://wwwfdagov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm079235pdf.
    • (2008)
  • 31
    • 0029610682 scopus 로고
    • Biologically bounded risk assessment for receptor-mediated nongenotoxic carcinogens
    • Gastel J.A., Sutter T.R. Biologically bounded risk assessment for receptor-mediated nongenotoxic carcinogens. Regulatory Toxicology and Pharmacology 1995, 22:273-282.
    • (1995) Regulatory Toxicology and Pharmacology , vol.22 , pp. 273-282
    • Gastel, J.A.1    Sutter, T.R.2
  • 32
    • 33947271077 scopus 로고    scopus 로고
    • The enhancement of the subacute repeat dose toxicity test OECD TG 407 for the detection of endocrine active chemicals: comparison with toxicity tests of longer duration
    • Gelbke H.P., Hofmann A., Owens J.W., Freyberger A. The enhancement of the subacute repeat dose toxicity test OECD TG 407 for the detection of endocrine active chemicals: comparison with toxicity tests of longer duration. Archives of Toxicology 2007, 81:227-250.
    • (2007) Archives of Toxicology , vol.81 , pp. 227-250
    • Gelbke, H.P.1    Hofmann, A.2    Owens, J.W.3    Freyberger, A.4
  • 33
    • 5344220954 scopus 로고    scopus 로고
    • OECD test strategies and methods for endocrine disruptors
    • Gelbke H.P., Kayser M., Poole A. OECD test strategies and methods for endocrine disruptors. Toxicology 2004, 205:17-25.
    • (2004) Toxicology , vol.205 , pp. 17-25
    • Gelbke, H.P.1    Kayser, M.2    Poole, A.3
  • 37
    • 84860663501 scopus 로고    scopus 로고
    • An overview of values for the threshold of toxicological concern
    • Hennes E.C. An overview of values for the threshold of toxicological concern. Toxicology Letters 2012, 211:296-303.
    • (2012) Toxicology Letters , vol.211 , pp. 296-303
    • Hennes, E.C.1
  • 38
    • 84866622862 scopus 로고    scopus 로고
    • Of mice and men (and rats): phthalate-induced fetal testis endocrine disruption is species-dependent
    • Johnson K.J., Heger N.E., Boekelheide K. Of mice and men (and rats): phthalate-induced fetal testis endocrine disruption is species-dependent. Toxicological Sciences 2012, 129:235-248.
    • (2012) Toxicological Sciences , vol.129 , pp. 235-248
    • Johnson, K.J.1    Heger, N.E.2    Boekelheide, K.3
  • 41
    • 0031080387 scopus 로고    scopus 로고
    • A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data
    • Klimisch H.J., Andreae M., Tillmann U. A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data. Regulatory Toxicology and Pharmacology 1997, 25:1-5.
    • (1997) Regulatory Toxicology and Pharmacology , vol.25 , pp. 1-5
    • Klimisch, H.J.1    Andreae, M.2    Tillmann, U.3
  • 42
    • 84862189991 scopus 로고    scopus 로고
    • State of the art assessment of endocrine disrupters
    • Final Report. Available at: (last accessed 16.11.2012).
    • Kortenkamp, A., Martin, O., Faust, M., Evans, R., McKinlay, R., Orton, F., Rosivatz, E., 2011. State of the art assessment of endocrine disrupters. Final Report. Available at: (last accessed 16.11.2012). http://eceuropaeu/environment/endocrine/documents/4_SOTAEDCFinalReportV36Feb12pdf.
    • (2011)
    • Kortenkamp, A.1    Martin, O.2    Faust, M.3    Evans, R.4    McKinlay, R.5    Orton, F.6    Rosivatz, E.7
  • 43
    • 0037186896 scopus 로고    scopus 로고
    • Threshold of toxicological concern (TTC) in food safety assessment
    • Kroes R., Kozianowski G. Threshold of toxicological concern (TTC) in food safety assessment. Toxicology Letters 2002, 127:43-46.
    • (2002) Toxicology Letters , vol.127 , pp. 43-46
    • Kroes, R.1    Kozianowski, G.2
  • 51
    • 48649102067 scopus 로고    scopus 로고
    • The Threshold of Toxicological Concern (TTC) in risk assessment
    • Munro I.C., Renwick A.G., Danielewska-Nikiel B. The Threshold of Toxicological Concern (TTC) in risk assessment. Toxicology Letters 2008, 180:151-156.
    • (2008) Toxicology Letters , vol.180 , pp. 151-156
    • Munro, I.C.1    Renwick, A.G.2    Danielewska-Nikiel, B.3
  • 52
    • 84884930699 scopus 로고    scopus 로고
    • Endocrine disruptors. National Resources Defence Council
    • NRDC, Available at: (last accessed 12.11.2012).
    • NRDC, 1998. Endocrine disruptors. National Resources Defence Council. Available at: (last accessed 12.11.2012). http://wwwnrdcorg/health/effects/qendocasp.
    • (1998)
  • 53
    • 84977988601 scopus 로고    scopus 로고
    • Conceptual framework for the testing and assessment of endocrine disrupting chemicals
    • OECD, Organisation for Economic Co-operation and Development. Available at: (last accessed 12.11.2012).
    • OECD, 2002. Conceptual framework for the testing and assessment of endocrine disrupting chemicals. Organisation for Economic Co-operation and Development. Available at: (last accessed 12.11.2012). http://wwwoecdorg/document/58/0,3343,en_2649_34377_2348794_1_1_1_1,00html.
    • (2002)
  • 54
    • 84881096817 scopus 로고    scopus 로고
    • Guideline for the Testing of Chemicals - TG 407
    • OECD, Organisation for Economic Co-operation and Development. Available at: (last accessed 25.02.2013).
    • OECD, 2008. Guideline for the Testing of Chemicals - TG 407. Organisation for Economic Co-operation and Development. Available at: (last accessed 25.02.2013). http://wwwoecdorg/env/ehs/testing/oecdguidelinesforthetestingofchemicalshtm.
    • (2008)
  • 55
    • 84884924284 scopus 로고    scopus 로고
    • Draft guidance document 116 on the design and conduct of chronic toxicity and carcinogenicity studies, supporting TG 451, 452 and 453
    • OECD, Organisation for Economic Co-operation and Development. Available at: (last accessed 23.11.2012).
    • OECD, 2010. Draft guidance document 116 on the design and conduct of chronic toxicity and carcinogenicity studies, supporting TG 451, 452 and 453. Organisation for Economic Co-operation and Development. Available at: (last accessed 23.11.2012). http://wwwoecdorg/chemicalsafety/testingofchemicals/46766792pdf.
    • (2010)
  • 56
    • 84878372851 scopus 로고    scopus 로고
    • Guidance document on the assessment of chemicals for endocrine disruption
    • OECD, version 9. Organisation for Economic Co-operation and Development. Available at: (last accessed 23.11.2012).
    • OECD, 2010. Guidance document on the assessment of chemicals for endocrine disruption, version 9. Organisation for Economic Co-operation and Development. Available at: (last accessed 23.11.2012). http://wwwoecdorg/chemicalsafety/testingofchemicals/46436593pdf.
    • (2010)
  • 58
    • 0030861599 scopus 로고    scopus 로고
    • Reflections on risk assessment of receptor-acting xenobiotics
    • Poland A. Reflections on risk assessment of receptor-acting xenobiotics. Regulatory Toxicology and Pharmacology 1997, 26:41-43.
    • (1997) Regulatory Toxicology and Pharmacology , vol.26 , pp. 41-43
    • Poland, A.1
  • 60
    • 84864029430 scopus 로고    scopus 로고
    • Low-dose effects and nonmonotonic dose-responses of endocrine disrupting chemicals: has the case been made?
    • Rhomberg L.R., Goodman J.E. Low-dose effects and nonmonotonic dose-responses of endocrine disrupting chemicals: has the case been made?. Regulatory Toxicology and Pharmacology 2012, 64:130-133.
    • (2012) Regulatory Toxicology and Pharmacology , vol.64 , pp. 130-133
    • Rhomberg, L.R.1    Goodman, J.E.2
  • 61
    • 0029045537 scopus 로고
    • Environmental and dietary estrogens and human health: is there a problem?
    • Safe S.H. Environmental and dietary estrogens and human health: is there a problem?. Environmental Health Perspectives 1995, 103:346-351.
    • (1995) Environmental Health Perspectives , vol.103 , pp. 346-351
    • Safe, S.H.1
  • 62
    • 0033939186 scopus 로고    scopus 로고
    • Endocrine disruptors and human health - is there a problem? An update
    • Safe S.H. Endocrine disruptors and human health - is there a problem? An update. Environmental Health Perspectives 2000, 108:487-493.
    • (2000) Environmental Health Perspectives , vol.108 , pp. 487-493
    • Safe, S.H.1
  • 63
    • 77950895735 scopus 로고    scopus 로고
    • Is it time to end concerns over the estrogenic effects of bisphenol A?
    • Sharpe R.M. Is it time to end concerns over the estrogenic effects of bisphenol A?. Toxicological Sciences 2010, 114:1-4.
    • (2010) Toxicological Sciences , vol.114 , pp. 1-4
    • Sharpe, R.M.1
  • 65
    • 70349929491 scopus 로고    scopus 로고
    • The presence (or not) of effects from low oral doses of BPA
    • Tyl R.W. The presence (or not) of effects from low oral doses of BPA. Journal of Toxicological Sciences 2009, 34:587-588.
    • (2009) Journal of Toxicological Sciences , vol.34 , pp. 587-588
    • Tyl, R.W.1
  • 68
    • 60549106214 scopus 로고    scopus 로고
    • Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption
    • Vandenberg L.N., Maffini M.V., Sonnenschein C., Rubin B.S., Soto A.M. Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption. Endocrine Reviews 2009, 30:75-95.
    • (2009) Endocrine Reviews , vol.30 , pp. 75-95
    • Vandenberg, L.N.1    Maffini, M.V.2    Sonnenschein, C.3    Rubin, B.S.4    Soto, A.M.5
  • 72
    • 0004094150 scopus 로고    scopus 로고
    • Global assessment of the state-of-the-science of endocrine disruptors
    • WHO/IPCS, WHO/PCS/EDC/02.2, World Health Organisation, Geneva
    • WHO/IPCS, 2002. Global assessment of the state-of-the-science of endocrine disruptors. WHO/PCS/EDC/02.2, World Health Organisation, Geneva, pp. 180.
    • (2002) , pp. 180
  • 73
    • 84884931314 scopus 로고    scopus 로고
    • WHO/IPCS, Available at: (last accessed 12.11.2012).
    • WHO/IPCS, 2004. Exposure assessment and risk assessment terminology. Available at: (last accessed 12.11.2012). http://wwwwhoint/ipcs/methods/harmonization/areas/terminology/en/indexhtml.
    • (2004) Exposure assessment and risk assessment terminology
  • 74
    • 0033985347 scopus 로고    scopus 로고
    • U.S. Environmental Protection Agency's revised guidelines for carcinogen risk assessment: evaluating a postulated mode of carcinogenic action in guiding dose-response extrapolation
    • Wiltse J.A., Dellarco V.L. U.S. Environmental Protection Agency's revised guidelines for carcinogen risk assessment: evaluating a postulated mode of carcinogenic action in guiding dose-response extrapolation. Mutation Research 2000, 464:105-115.
    • (2000) Mutation Research , vol.464 , pp. 105-115
    • Wiltse, J.A.1    Dellarco, V.L.2
  • 75
    • 0036973956 scopus 로고    scopus 로고
    • Endocrine disruptors: can biological effects and environmental risks be predicted?
    • Witorsch R.J. Endocrine disruptors: can biological effects and environmental risks be predicted?. Regulatory Toxicology and Pharmacology 2002, 36:118-130.
    • (2002) Regulatory Toxicology and Pharmacology , vol.36 , pp. 118-130
    • Witorsch, R.J.1
  • 76
    • 0036210287 scopus 로고    scopus 로고
    • Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the Enhanced OECD Test Guideline no. 407
    • Yamasaki K., Sawaki M., Noda S., Imatanaka N., Takatsuki M. Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the Enhanced OECD Test Guideline no. 407. Archives of Toxicology 2002, 76:65-74.
    • (2002) Archives of Toxicology , vol.76 , pp. 65-74
    • Yamasaki, K.1    Sawaki, M.2    Noda, S.3    Imatanaka, N.4    Takatsuki, M.5


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