MAST2 and NOTCH1 translocations in breast carcinoma and associated pre-invasive lesions

Human Pathology

Volumn 44, Issue 12, 2013, Pages 2837-2844

  Clay, Michael R ^a   Varma, Sushama ^a   West, Robert B ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast; FISH; MAST; NOTCH; Pre invasive

Indexed keywords

ARTICLE; BREAST CARCINOMA; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; GENE TRANSLOCATION; HUMAN; HUMAN TISSUE; INTRADUCTAL CARCINOMA; INVASIVE CARCINOMA; MAJOR CLINICAL STUDY; NOTCH1 RECEPTOR GENE; PROTEIN SERINE THREONINE KINASE 2 GENE; TISSUE MICROARRAY; TUMOR GENE;

BREAST; FISH; MAST; NOTCH; PRE-INVASIVE;

ADULT; BREAST; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, INTRADUCTAL, NONINFILTRATING; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR, NOTCH1; TRANSLOCATION, GENETIC;

EID: 84888055912     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.08.001     Document Type: Article

References (21)

1. C. Curtis, S.P. Shah, and S.F. Chin The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups Nature 486 2012 346 352
2. C.M. Perou, T. Serlie, and M.B. Eisen Molecular portraits of human breast tumors Nature 406 2000 747
3. S.P. Shah, A. Roth, and R. Goya The clonal and mutational evolution spectrum of primary triple-negative breast cancers Nature 486 2012 395 399
4. H. Buerger, F. Otterbach, and R. Simon Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways J Pathol 187 1999 396 402
5. J.A. Freudenberg, Q. Wang, and M. Katsumata The role of HER2 in early breast cancer metastasis and the origins of resistance to HER2-targeted therapies Exp Molec Pathol 87 2009 1 11
6. J. Han, M.J. Hendzel, and J. Allalunis-Turner Notch signaling as a therapeutic target for breast cancer treatment? Breast Cancer Res 13 2011 210
7. D.C. Allred, S.K. Mohsin, and S.A.W. Fuqua Histological and biological evolution of human premalignant breast disease Endocr Relat Cancer 8 2001 47 61
8. D.R. Robinson, S. Kalyana-Sundaram, and Y.M. Wu Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer Nat Med 17 2011 1646 1651
9. Miyamoto S, Nakanishi M, Rosenberg DW. Suppression of colon carcinogenesis by targeting Notch signaling. Carcinogenesis 2013, 10.1093/carcin/bgt191[In Press].
10. P. Rizzo, C. Osipo, and K. Foreman Rational targeting of Notch signaling in cancer Oncogene 27 2008 5124 5131
11. X. Wang, Z.S. Fredericksen, and R.A. Vierkant Association of genetic variation in mitotic kinases with breast cancer risk Breast Cancer Res Treat 119 2010 453 462
12. C.P. Giacomini, S. Sun, and S. Varma Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types PLoS Genet 2013 9
13. P.P. Rosen Rosen's breast pathology 2008 Lippincott Williams & Wilkins Philadelphia
14. D.E. Newburger, D. Kashef-Haghighi, and Z. Weng Genome evolution during progression to breast cancer Genome Res 23 2013 1097 1108
15. F. Moinfar, Y.G. Man, and G.L. Bratthauer Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type ("clinging ductal carcinoma in situ"): a simulator of normal mammary epithelium Cancer 88 2000 2072 2081
16. P.T. Simpson, T. Gale, and J.S. Reis-Filho Columnar cell lesions of the breast: the missing link in breast cancer progression? A morphological and molecular analysis Am J Surg Pathol 29 2005 734 746
17. M.L. Troxell, A.L. Brunner, and T. Neff Phosphatidylinositol-3-kinase pathway mutations are common in breast columnar cell lesions Modern Pathol 25 2012 930 937
18. R. Xu, M.A. Perle, and G. Inghirami Amplification of Her-2/neu gene in Her-2/neu-overexpressing and -nonexpressing breast carcinomas and their synchronous benign, premalignant, and metastatic lesions detected by FISH in archival material Modern Pathol 15 2002 116 124
19. K. Heselmeyer-Haddad, L.Y. Berroa Garcia, and A. Bradley Single-cell genetic analysis of ductal carcinoma in situ and invasive breast cancer reveals enormous tumor heterogeneity yet conserved genomic imbalances and gain of MYC during progression Am J Pathol 181 2012 1807 1822
20. P. van der Groep, P.J. van Diest, and Y.H. Smolders HIF-1alpha overexpression in ductal carcinoma in situ of the breast in BRCA1 and BRCA2 mutation carriers PLoS One 8 2013 e56055
21. A.P. Subhawong, T. Subhawong, and H. Nassar Most basal-like breast carcinomas demonstrate the same Rb-/p16+ immunophenotype as the HPV-related poorly differentiated squamous cell carcinomas which they resemble morphologically Am J Surg Pathol 33 2009 163 175