메뉴 건너뛰기




Volumn 100, Issue 1, 2011, Pages 76-85

Final results of the randomized phase III CHARTWEL-trial (ARO 97-1) comparing hyperfractionated-accelerated versus conventionally fractionated radiotherapy in non-small cell lung cancer (NSCLC)

Author keywords

Accelerated radiotherapy; Non small cell lung cancer; Randomized trial; Time factor

Indexed keywords

ARTICLE; CANCER CONTROL; CANCER RADIOTHERAPY; CONTINUOUS HYPERFRACTIONATED ACCELERATED RADIOTHERAPY; DISTANT METASTASIS; DYSPHAGIA; EXTERNAL BEAM RADIOTHERAPY; FEMALE; HUMAN; INTERMETHOD COMPARISON; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OVERALL SURVIVAL; PRIORITY JOURNAL; RADIATION DOSE; RADIATION PNEUMONIA; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

EID: 80051781895     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.06.031     Document Type: Article
Times cited : (135)

References (43)
  • 1
    • 0023894783 scopus 로고
    • The hazard of accelerated tumor clonogen repopulation during radiotherapy
    • H.R. Withers, J.M. Taylor, and B. Maciejewski The hazard of accelerated tumor clonogen repopulation during radiotherapy Acta Oncol. 27 1988 131 146
    • (1988) Acta Oncol. , vol.27 , pp. 131-146
    • Withers, H.R.1    Taylor, J.M.2    MacIejewski, B.3
  • 2
    • 0025719447 scopus 로고
    • Rapid repopulation in radiotherapy: A debate on mechanism. The phantom of tumor treatment-continually rapid proliferation unmasked
    • J.F. Fowler Rapid repopulation in radiotherapy: a debate on mechanism. The phantom of tumor treatment-continually rapid proliferation unmasked Radiother Oncol 22 1991 156 158
    • (1991) Radiother Oncol , vol.22 , pp. 156-158
    • Fowler, J.F.1
  • 3
    • 45849089879 scopus 로고    scopus 로고
    • Exploring the role of cancer stem cells in radioresistance
    • DOI 10.1038/nrc2419, PII NRC2419
    • M. Baumann, M. Krause, and R. Hill Exploring the role of cancer stem cells in radioresistance Nat Rev Cancer 8 2008 545 554 (Pubitemid 351881850)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.7 , pp. 545-554
    • Baumann, M.1    Krause, M.2    Hill, R.3
  • 6
    • 12344337748 scopus 로고    scopus 로고
    • Differentiation status of human squamous cell carcinoma xenografts does not appear to correlate with the repopulation capacity of clonogenic tumour cells during fractionated irradiation
    • DOI 10.1080/095530003400017812
    • F. Hessel, M. Krause, and A. Helm Differentiation status of human squamous cell carcinoma xenografts does not appear to correlate with the repopulation capacity of clonogenic tumour cells during fractionated irradiation Int J Radiat Biol 80 2004 719 727 (Pubitemid 40126088)
    • (2004) International Journal of Radiation Biology , vol.80 , Issue.10 , pp. 719-727
    • Hessel, F.1    Krause, M.2    Helm, A.3    Petersen, C.4    Grenman, R.5    Thames, H.D.6    Baumann, M.7
  • 8
    • 10744228638 scopus 로고    scopus 로고
    • Repopulation during fractionated radiotherapy: Much has been learned, even more is open
    • DOI 10.1080/0955300031000160259
    • M. Baumann, W. Dorr, C. Petersen, and M. Krause Repopulation during fractionated radiotherapy: much has been learned, even more is open Int J Radiat Biol 79 2003 465 467 (Pubitemid 37311050)
    • (2003) International Journal of Radiation Biology , vol.79 , Issue.7 , pp. 465-467
    • Baumann, M.1    Dorr, W.2    Petersen, C.3    Krause, M.4
  • 9
    • 14644414177 scopus 로고    scopus 로고
    • Die verlängerung der wartezeit oder der gesamtbehandlungszeit durch ungeplante bestrahlungspausen. Klinische bedeutung der kompensation
    • DOI 10.1007/s00066-005-1331-9
    • T. Herrmann, and M. Baumann Prolongation of latency or overall treatment time by unplanned radiation pauses. The clinical importance of compensation Strahlenther Onkol 181 2005 65 76 (Pubitemid 40310798)
    • (2005) Strahlentherapie und Onkologie , vol.181 , Issue.2 , pp. 65-76
    • Herrmann, T.1    Baumann, M.2
  • 10
    • 0028967649 scopus 로고
    • The effect of the overall treatment time of fractionated irradiation on the tumor control probability of a human soft tissue sarcoma xenograft in nude mice
    • A. Allam, L.A. Perez, and P. Huang The effect of the overall treatment time of fractionated irradiation on the tumor control probability of a human soft tissue sarcoma xenograft in nude mice Int J Radiat Oncol Biol Phys 32 1995 105 111
    • (1995) Int J Radiat Oncol Biol Phys , vol.32 , pp. 105-111
    • Allam, A.1    Perez, L.A.2    Huang, P.3
  • 11
    • 77953962354 scopus 로고    scopus 로고
    • The role of overall treatment time in the outcome of radiotherapy of prostate cancer: An analysis of biochemical failure in 4839 men treated between 1987 and 1995
    • H.D. Thames, D. Kuban, and L.B. Levy The role of overall treatment time in the outcome of radiotherapy of prostate cancer: an analysis of biochemical failure in 4839 men treated between 1987 and 1995 Radiother Oncol 96 2010 6 12
    • (2010) Radiother Oncol , vol.96 , pp. 6-12
    • Thames, H.D.1    Kuban, D.2    Levy, L.B.3
  • 12
    • 34249320540 scopus 로고    scopus 로고
    • Effects of prolongation of overall treatment time due to unplanned interruptions during radiotherapy of different tumor sites and practical methods for compensation
    • DOI 10.1016/j.ijrobp.2007.03.010, PII S0360301607005044
    • N.S. Bese, J. Hendry, and B. Jeremic Effects of prolongation of overall treatment time due to unplanned interruptions during radiotherapy of different tumor sites and practical methods for compensation Int J Radiat Oncol Biol Phys 68 2007 654 661 (Pubitemid 46818766)
    • (2007) International Journal of Radiation Oncology Biology Physics , vol.68 , Issue.3 , pp. 654-661
    • Bese, N.S.1    Hendry, J.2    Jeremic, B.3
  • 13
    • 0030737527 scopus 로고    scopus 로고
    • Continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small-cell lung cancer: A randomised multicentre trial
    • DOI 10.1016/S0140-6736(97)06305-8
    • M. Saunders, S. Dische, A. Barrett, A. Harvey, D. Gibson, and M. Parmar Continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small-cell lung cancer: a randomised multicentre trial. CHART Steering Committee Lancet 350 1997 161 165 (Pubitemid 27303621)
    • (1997) Lancet , vol.350 , Issue.9072 , pp. 161-165
    • Saunders, M.1    Dische, S.2    Barrett, A.3    Harvey, A.4    Gibson, D.5    Parmar, M.6
  • 14
    • 0033179899 scopus 로고    scopus 로고
    • Continuous, hyperfractionated, accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer: Mature data from the randomised multicentre trial
    • DOI 10.1016/S0167-8140(99)00087-0, PII S0167814099000870
    • M. Saunders, S. Dische, A. Barrett, A. Harvey, G. Griffiths, and M. Palmar Continuous, hyperfractionated, accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer: mature data from the randomised multicentre trial. CHART Steering committee See comments Radiother Oncol 52 1999 137 148 (Pubitemid 29461081)
    • (1999) Radiotherapy and Oncology , vol.52 , Issue.2 , pp. 137-148
    • Saunders, M.1    Dische, S.2    Barrett, A.3    Harvey, A.4    Griffiths, G.5    Parmar, M.6
  • 16
    • 78651511514 scopus 로고    scopus 로고
    • Effectiveness of surgery and individualized high-dose hyperfractionated accelerated radiotherapy on survival in clinical stage i non-small cell lung cancer. A propensity score matched analysis
    • M.F. Jimenez, A. van Baardwijk, and H.J. Aerts Effectiveness of surgery and individualized high-dose hyperfractionated accelerated radiotherapy on survival in clinical stage I non-small cell lung cancer. A propensity score matched analysis Radiother Oncol 97 2010 413 417
    • (2010) Radiother Oncol , vol.97 , pp. 413-417
    • Jimenez, M.F.1    Van Baardwijk, A.2    Aerts, H.J.3
  • 17
    • 0034819569 scopus 로고    scopus 로고
    • Dose and fractionation concepts in the primary radiotherapy of non-small cell lung cancer
    • M. Baumann, S. Appold, C. Petersen, D. Zips, and T. Herrmann Dose and fractionation concepts in the primary radiotherapy of non-small cell lung cancer Lung cancer 33 2001 S35 S45
    • (2001) Lung Cancer , vol.33
    • Baumann, M.1    Appold, S.2    Petersen, C.3    Zips, D.4    Herrmann, T.5
  • 19
    • 0031431622 scopus 로고    scopus 로고
    • Chartwel-bronchus (ARO 97-1): Eine randomisiert multizentrische studie zum vergleich einer konventionell fraktionierten strahlentherapie mit CHARTWEL-bestrahlung bei inoperablen nichtkleinzelligen bronchialkarzinomen
    • M. Baumann, T. Herrmann, W. Matthiessen, R. Koch, K. Strelocke, and U. Paul CHARTWEL-Bronchus (ARO 97-1): a randomized multicenter trial to compare conventional fractionated radiotherapy with CHARTWEL radiotherapy in inoperable non-small-call bronchial carcinoma Strahlenther Onkol 173 1997 663 667 (Pubitemid 28082043)
    • (1997) Strahlentherapie und Onkologie , vol.173 , Issue.12 , pp. 663-667
    • Baumann, M.1    Herrmann, Th.2    Matthiessen, W.3    Koch, R.4    Strelocke, K.5    Paul, U.6
  • 21
    • 0036785983 scopus 로고    scopus 로고
    • From CHART to CHARTWEL in non-small cell lung cancer: Clinical radiobiological modelling of the expected change in outcome
    • S.M. Bentzen, M.I. Saunders, and S. Dische From CHART to CHARTWEL in non-small cell lung cancer: clinical radiobiological modelling of the expected change in outcome Clin Oncol (R Coll Radiol) 14 2002 372 381
    • (2002) Clin Oncol (R Coll Radiol) , vol.14 , pp. 372-381
    • Bentzen, S.M.1    Saunders, M.I.2    Dische, S.3
  • 23
    • 85136397130 scopus 로고    scopus 로고
    • Dose-response relationships in radiotherapy
    • M. Joiner, A.J. van der Kogel, Edward Arnold London
    • S.M. Bentzen Dose-response relationships in radiotherapy M. Joiner, A.J. van der Kogel, Basic Clinical Radiobiology 2009 Edward Arnold London 56 67
    • (2009) Basic Clinical Radiobiology , pp. 56-67
    • Bentzen, S.M.1
  • 24
    • 0036785960 scopus 로고    scopus 로고
    • Dose-escalation with CHARTWEL (continuous hyperfractionated accelerated radiotherapy week-end less) combined with neo-adjuvant chemotherapy in the treatment of locally advanced non-small cell lung cancer
    • M.I. Saunders, A. Rojas, B.E. Lyn, E. Wilson, and H. Phillips Dose-escalation with CHARTWEL (continuous hyperfractionated accelerated radiotherapy week-end less) combined with neo-adjuvant chemotherapy in the treatment of locally advanced non-small cell lung cancer Clin Oncol (R Coll Radiol) 14 2002 352 360
    • (2002) Clin Oncol (R Coll Radiol) , vol.14 , pp. 352-360
    • Saunders, M.I.1    Rojas, A.2    Lyn, B.E.3    Wilson, E.4    Phillips, H.5
  • 25
    • 33749006218 scopus 로고    scopus 로고
    • Toxicity and outcome of a phase II trial of taxane-based neoadjuvant chemotherapy and 3-dimensional, conformal, accelerated radiotherapy in locally advanced nonsmall cell lung cancer
    • DOI 10.1002/cncr.22123
    • A.M. Rojas, B.E. Lyn, and E.M. Wilson Toxicity and outcome of a phase II trial of taxane-based neoadjuvant chemotherapy and 3-dimensional, conformal, accelerated radiotherapy in locally advanced nonsmall cell lung cancer Cancer 107 2006 1321 1330 (Pubitemid 44452782)
    • (2006) Cancer , vol.107 , Issue.6 , pp. 1321-1330
    • Rojas, A.M.1    Lyn, B.E.2    Wilson, E.M.3    Williams, F.J.4    Shah, N.5    Dickson, J.6    Saunders, M.I.7
  • 26
    • 70449657771 scopus 로고    scopus 로고
    • A phase II trial of induction chemotherapy followed by continuous hyperfractionated accelerated radiotherapy in locally advanced non-small-cell lung cancer
    • P. Jenkins, S. Anderson, S. Wronski, and A. Ashton A phase II trial of induction chemotherapy followed by continuous hyperfractionated accelerated radiotherapy in locally advanced non-small-cell lung cancer Radiother Oncol 93 2009 396 401
    • (2009) Radiother Oncol , vol.93 , pp. 396-401
    • Jenkins, P.1    Anderson, S.2    Wronski, S.3    Ashton, A.4
  • 27
    • 20544435485 scopus 로고    scopus 로고
    • Phase III study of the Eastern Cooperative Oncology Group (ECOG 2597): Induction chemotherapy followed by either standard thoracic radiotherapy or hyperfractionated accelerated radiotherapy for patients with unresectable stage IIIA and B non-small-cell lung cancer
    • C.P. Belani, W. Wang, and D.H. Johnson Phase III study of the Eastern Cooperative Oncology Group (ECOG 2597): induction chemotherapy followed by either standard thoracic radiotherapy or hyperfractionated accelerated radiotherapy for patients with unresectable stage IIIA and B non-small-cell lung cancer J Clin Oncol 23 2005 3760 3767
    • (2005) J Clin Oncol , vol.23 , pp. 3760-3767
    • Belani, C.P.1    Wang, W.2    Johnson, D.H.3
  • 28
    • 0033179880 scopus 로고    scopus 로고
    • A randomised phase III study of accelerated or standard fraction radiotherapy with or without concurrent carboplatin in inoperable non-small cell lung cancer: Final report of an Australian multi-centre trial
    • DOI 10.1016/S0167-8140(99)00093-6, PII S0167814099000936
    • D. Ball, J. Bishop, and J. Smith A randomised phase III study of accelerated or standard fraction radiotherapy with or without concurrent carboplatin in inoperable non- small cell lung cancer: final report of an Australian multi-centre trial [see comments] Radiother Oncol 52 1999 129 136 (Pubitemid 29461080)
    • (1999) Radiotherapy and Oncology , vol.52 , Issue.2 , pp. 129-136
    • Ball, D.1    Bishop, J.2    Smith, J.3    O'Brien, P.4    Davis, S.5    Ryan, G.6    Olver, I.7    Toner, G.8    Walker, Q.9    Joseph, D.10
  • 29
    • 33645304581 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of randomised, controlled trials of the timing of chest radiotherapy in patients with limited-stage, small-cell lung cancer
    • D. De Ruysscher, M. Pijls-Johannesma, J. Vansteenkiste, A. Kester, I. Rutten, and P. Lambin Systematic review and meta-analysis of randomised, controlled trials of the timing of chest radiotherapy in patients with limited-stage, small-cell lung cancer Ann Oncol 17 2006 543 552
    • (2006) Ann Oncol , vol.17 , pp. 543-552
    • De Ruysscher, D.1    Pijls-Johannesma, M.2    Vansteenkiste, J.3    Kester, A.4    Rutten, I.5    Lambin, P.6
  • 30
    • 33644986064 scopus 로고    scopus 로고
    • Scheduling of radiation and chemotherapy for limited-stage small-cell lung cancer: Repopulation as a cause of treatment failure?
    • DOI 10.1200/JCO.2005.04.9676
    • A.M. Brade, and I.F. Tannock Scheduling of radiation and chemotherapy for limited-stage small-cell lung cancer: repopulation as a cause of treatment failure? J Clin Oncol 24 2006 1020 1022 (Pubitemid 46638794)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.7 , pp. 1020-1022
    • Brade, A.M.1    Tannock, I.F.2
  • 31
    • 0028278628 scopus 로고
    • Dynamics of tumor cell clonogen repopulation in a murine sarcoma treated with cyclophosphamide
    • DOI 10.1016/0167-8140(94)90465-0
    • L. Milas, T. Nakayama, and N. Hunter Dynamics of tumor cell clonogen repopulation in a murine sarcoma treated with cyclophosphamide Radiother Oncol 30 1994 247 253 (Pubitemid 24107519)
    • (1994) Radiotherapy and Oncology , vol.30 , Issue.3 , pp. 247-253
    • Milas, L.1
  • 33
    • 77952298828 scopus 로고    scopus 로고
    • Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer
    • A. Auperin, C. Le Pechoux, and E. Rolland Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer J Clin Oncol 28 2010 2181 2190
    • (2010) J Clin Oncol , vol.28 , pp. 2181-2190
    • Auperin, A.1    Le Pechoux, C.2    Rolland, E.3
  • 34
  • 35
    • 65749092105 scopus 로고    scopus 로고
    • Radiotherapy of lung cancer: Technology meets biology meets multidisciplinarity
    • M. Baumann, D. Zips, and S. Appold Radiotherapy of lung cancer: technology meets biology meets multidisciplinarity Radiother Oncol 91 2009 279 281
    • (2009) Radiother Oncol , vol.91 , pp. 279-281
    • Baumann, M.1    Zips, D.2    Appold, S.3
  • 36
    • 65749120006 scopus 로고    scopus 로고
    • Increased (18)F-deoxyglucose uptake in the lung during the first weeks of radiotherapy is correlated with subsequent Radiation-Induced Lung Toxicity (RILT): A prospective pilot study
    • D. De Ruysscher, A. Houben, and H.J. Aerts Increased (18)F-deoxyglucose uptake in the lung during the first weeks of radiotherapy is correlated with subsequent Radiation-Induced Lung Toxicity (RILT): a prospective pilot study Radiother Oncol 91 2009 415 420
    • (2009) Radiother Oncol , vol.91 , pp. 415-420
    • De Ruysscher, D.1    Houben, A.2    Aerts, H.J.3
  • 37
    • 65649140133 scopus 로고    scopus 로고
    • Identification of residual metabolic-active areas within individual NSCLC tumours using a pre-radiotherapy (18)fluorodeoxyglucose-PET-CT scan
    • H.J. Aerts, A.A. van Baardwijk, and S.F. Petit Identification of residual metabolic-active areas within individual NSCLC tumours using a pre-radiotherapy (18)fluorodeoxyglucose-PET-CT scan Radiother Oncol 91 2009 386 392
    • (2009) Radiother Oncol , vol.91 , pp. 386-392
    • Aerts, H.J.1    Van Baardwijk, A.A.2    Petit, S.F.3
  • 38
    • 65649142624 scopus 로고    scopus 로고
    • Is pre-therapeutical FDG-PET/CT capable to detect high risk tumor subvolumes responsible for local failure in non-small cell lung cancer?
    • A. Abramyuk, S. Tokalov, and K. Zophel Is pre-therapeutical FDG-PET/CT capable to detect high risk tumor subvolumes responsible for local failure in non-small cell lung cancer? Radiother Oncol 91 2009 399 404
    • (2009) Radiother Oncol , vol.91 , pp. 399-404
    • Abramyuk, A.1    Tokalov, S.2    Zophel, K.3
  • 39
    • 62549156647 scopus 로고    scopus 로고
    • Use of PET and PET/CT for radiation therapy planning: IAEA expert report 2006-2007
    • M. MacManus, U. Nestle, and K.E. Rosenzweig Use of PET and PET/CT for radiation therapy planning: IAEA expert report 2006-2007 Radiother Oncol 91 2009 85 94
    • (2009) Radiother Oncol , vol.91 , pp. 85-94
    • MacManus, M.1    Nestle, U.2    Rosenzweig, K.E.3
  • 40
    • 0032761213 scopus 로고    scopus 로고
    • Repair halftimes estimated from observations of treatment-related morbidity after CHART or conventional radiotherapy in head and neck cancer
    • S.M. Bentzen, M.I. Saunders, and S. Dische Repair halftimes estimated from observations of treatment-related morbidity after CHART or conventional radiotherapy in head and neck cancer Radiother Oncol 53 1999 219 226
    • (1999) Radiother Oncol , vol.53 , pp. 219-226
    • Bentzen, S.M.1    Saunders, M.I.2    Dische, S.3
  • 42
    • 77956628128 scopus 로고    scopus 로고
    • Elective nodal irradiation (ENI) vs. involved field radiotherapy (IFRT) for locally advanced non-small cell lung cancer (NSCLC): A comparative analysis of toxicities and clinical outcomes
    • A.T. Fernandes, J. Shen, and J. Finlay Elective nodal irradiation (ENI) vs. involved field radiotherapy (IFRT) for locally advanced non-small cell lung cancer (NSCLC): a comparative analysis of toxicities and clinical outcomes Radiother Oncol 95 2010 178 184
    • (2010) Radiother Oncol , vol.95 , pp. 178-184
    • Fernandes, A.T.1    Shen, J.2    Finlay, J.3
  • 43
    • 65749083552 scopus 로고    scopus 로고
    • Relation between elective nodal failure and irradiated volume in non-small-cell lung cancer (NSCLC) treated with radiotherapy using conventional fields and doses
    • N. Sanuki-Fujimoto, M. Sumi, and Y. Ito Relation between elective nodal failure and irradiated volume in non-small-cell lung cancer (NSCLC) treated with radiotherapy using conventional fields and doses Radiother Oncol 91 2009 433 437
    • (2009) Radiother Oncol , vol.91 , pp. 433-437
    • Sanuki-Fujimoto, N.1    Sumi, M.2    Ito, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.