An Endogenous Retrovirus Derived from Human Melanoma Cells

Cancer Research

Volumn 63, Issue 24, 2003, Pages 8735-8741

  Muster, Thomas ^a   Waltenberger, Andrea ^a   Grassauer, Andreas ^a   Hirschl, Sonja ^a   Caucig, Peri ^a   Romirer, Ingrid ^a   Födinger, Dagmar ^a   Seppele, Heide ^a   Schanab, Oliver ^a   Magin Lachmann, Christine ^b   Löwer, Roswitha ^b   Jansen, Burkhard ^a   Pehamberger, Hubert ^a   Wolff, Klaus ^a  

^a Universitatsklinik fur Dermatologie   (Austria)

^b PAUL EHRLICH INSTITUT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; POL PROTEIN; REC PROTEIN; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; VIRUS PROTEIN;

ARTICLE; BIOSYNTHESIS; CANCER GROWTH; CONTROLLED STUDY; DNA PACKAGING; ENZYME ACTIVITY; GENE EXPRESSION; GENETICS; HUMAN; HUMAN CELL; HUMAN ENDOGENOUS RETROVIRUS K; ISOLATION AND PURIFICATION; LYMPH NODE; LYMPH NODE METASTASIS; MALIGNANT TRANSFORMATION; MELANOCYTE; MELANOMA; MELANOMA CELL; METABOLISM; METASTASIS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTO ONCOGENE; RETROVIRUS; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SKIN TUMOR; STRUCTURAL GENE; VIROLOGY; VIRUS ACTIVATION; VIRUS GENE; VIRUS PARTICLE; VIRUS STRAIN;

BASE SEQUENCE; ENDOGENOUS RETROVIRUSES; GENE PRODUCTS, ENV; GENE PRODUCTS, GAG; GENE PRODUCTS, POL; HUMANS; LYMPHATIC METASTASIS; MELANOMA; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, NUCLEIC ACID; SKIN NEOPLASMS;

EID: 9144273204     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Löwer, R., Löwer, J., and Kurth, R. The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences. Proc. Natl. Acad. Sci. USA, 93: 5177-5184, 1996.
2. Mayer, J., Sauter, M., Racz, A., Scherer, D., Mueller-Lantzsch, N., and Meese, E. An almost-intact human endogenous retrovirus K on human chromosome 7. Nat. Genet., 21: 257-258, 1999.
3. Magin, C., Löwer, R., and Löwer, J. cORF and RcRE, the Rev/Rex and RRE/RxRE homologues of the human endogenous retrovirus family HTDV/HERV-K. J. Virol., 73: 9496-9507, 1999.
4. Yang, J., Bogerd, H. P., Peng, S., Wiegand, H., Truant, R., and Cullen, B. R. An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein. Proc. Natl. Acad. Sci. USA, 96: 13404-13408, 1999.
5. Löwer, R., Boller, K., Hasenmaier, B., Korbmacher, C., Müller-Lantzsch, N., Löwer, J., and Kurth, R. Identification of human endogenous retroviruses with complex mRNA expression and particle formation. Proc. Natl. Acad. Sci. USA. 90: 4480-4484, 1993.
6. Löwer, R., Tönjes, R., Boller, K., Denner, J., Kaiser, B., Phelps, R. C., Löwer, J., Kurth, R., Badenhoop, K., Donner, H., Henning Usadel, K., Miethke, T., Lapatschek, M., and Wagner, H. Development of insulin-dependent diabetes mellitus does not depend on specific expression of the human endogenous retrovirus HERV-K. Cell. 95: 11-14, 1998.
7. Löwer, R. The pathogenic potential of endogenous retroviruses: facts and fantasies. Trends Microbiol., 7: 350-356, 1999.
8. Patience, C., Takeuchi, Y., and Weiss, R. A. Infection of human cells by an endogenous retrovirus of pigs. Nat. Med., 3: 282-286, 1997.
9. Tönjes, R., Czauderna, F., and Kurth, R. Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K. J. Virol., 73: 9187-9195, 1999.
10. Dennis, L. K. Analysis of the melanoma epidemic, both apparent and real. Arch. Dermatol., 135: 275-280, 1999.
11. Langley, R. G. B., Barnhill, R. L., Mihm, M. C., Fitzpatrick, T. B., and Sober, A. J. Neoplasms: cutaneous melanoma. In: I. M. Freedberg, A. Z. Eisen, and K. Wolff, (eds.), Fitzpatrick's Dermatology in General Medicine, Ed. 5, pp. 1080-1116. New York: McGraw-Hill, 1999.
12. Li, M., Xu, F., Muller, J., Hearing, V. J., and Gorelik, E. Ecotropic C-type retrovirus of B16 melanoma and malignant transformation of normal melanocytes. Int. J. Cancer, 76: 430-436, 1998.
13. Li, M., Huang, X., Zhu, Z., and Gorelik, E. Sequence and insertion sites of murine melanoma-associated retrovirus. J. Virol., 73: 9178-9186, 1999.
14. Balda, B. R., Hehlmann, R., Cho, J. R., and Spiegelmann, S. Oncoma-like particles in human skin cancers. Proc. Natl. Acad. Sci. USA, 72: 3697-3700, 1975.
15. Birkmayer, G. D., Balda, B-R., Miller, F., and Braun-Falco, O. Virus-like particles in metastases of human malignant melanoma. Naturwissenschaften, 8: 369-370, 1972.
16. Birkmayer, G. D., Balda, B-R., and Miller, F. Oncorna-viral information in human melanoma. Eur. J. Cancer, 10: 419-424, 1974.
17. Schiavetti, F., Thonnard, J., Colau, D., Boon, T., and Coulie, P. G. A human endogenous retroviral sequence encoding an antigen recognized on melanoma by cytolytic T lymphocytes. Cancer Res., 62: 5510-5516, 2002.
18. Löwer, R., Tönjes, R. R., Korbmacher, C., Kurth, R., and Löwer, J. Identification of a rev-related protein by analysis of spliced transcripts of the human endogenous retroviruses HDTV/HERV-K. J. Virol., 69: 141-149, 1995.
19. Jansen, B., Schlagbauer-Wadl, H., Eichler, H-G., Wolff, K., van Elsas, A., Schrier, P. I., and Pehamberger, H. Activated N-ras contributes to the chemoresistance of human melanoma in severe combined immunodeficiency (SCID) mice by blocking apoptosis. Cancer Res., 57: 362-365, 1997.
20. Moller-Larsen, A., and Christensen, T. Isolation of a retrovirus from multiple sclerosis patients in self-generated lodixanol gradients. J. Virol. Methods, 73: 151-161, 1998.
21. Arnold, B. A., Hepler, R. W., and Keller, P. M. One-step fluorescent probe product-enhanced reverse transcriptase assay. Biotechniques, 25: 98-106, 1998.
22. McLean, I. W., and Nakane, P. K. Periodate-lysine-paraformaldehyde fixative. A new fixative for immunoelectron microscopy. J. Histochem. Cytochem., 22: 1077-1083, 1974.
23. Mueller-Lantzsch, N., Sauter, M., Weiskircher, A., Kramer, K., Best, B., Buck, M., and Grässer, F. Human endogenous retroviral element K10 (HERV-K10) encodes a full-length gag homologous 73-kDa protein and a functional protease. AIDS Res. Hum. Retroviruses, 9: 343-350, 1993.
24. Bosserhof, A-K., Moser, M., Hein, R., Landthaler, M., and Buettner, R. In situ expression patterns of melanoma-inhibiting activity (MIA) in melanomas and breast cancer. J. Pathol., 187: 446-454, 1999.
25. Barbulescu, M., Turner, G., Seaman, M. I., Deinard, A. S., Kidd, K. K., and Lenz, J. Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans. Curr. Biol., 9: 861-868, 1999.
26. Turner, G., Barbulescu, M., Su, M., Jensen-Seaman, M., Kidd, K. K., and Lenz, J. Insertional polymorphisms of full-length endogenous retroviruses in humans. Curr. Biol., 11: 1531-1535, 2001.
27. Zavorotinskaya, T., and Albritton, L. M. Failure to cleave murine leukemia virus envelope protein does not preclude its incorporation in virions and productive virus-receptor interaction. J. Virol., 73: 5621-5629, 1999.
28. Kazazian, H. H., Wong, C., Youssoufian, R., Scott, A. F., Phillips, D. G., and Antonarakis, S. E. Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man. Nature (Lond.), 332: 164-166, 1988.
29. Kazazian, H. H., Jr. Mobile elements and disease. Curr. Opin. Genet. Dev., 3: 343-350, 1998.
30. Morse, B., Rothberg, P., South, V., Spandorfer, J., and Astrin, S. Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma. Nature (Lond.), 333: 87-90, 1988.
31. Miki, Y., Nishisho, I., Horii, A., Miyoshi, Y., Utsunomiya, J., Kinzler, K. W., Vogelstein, B., and Nakamura, Y. Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. Cancer Res., 52: 643-645, 1992.
32. Kowalski, P. E., Freeman, J. D., and Mager, D. L. Intergenic splicing between a HERV-H endogenous retrovirus and two adjacent human genes. Genomics, 57: 371-379, 1999.