Peroxisome proliferator-activated receptor-γ stimulates the synthesis of monounsaturated fatty acids in dairy goat mammary epithelial cells via the control of stearoyl-coenzyme A desaturase

Journal of Dairy Science

Volumn 96, Issue 12, 2013, Pages 7844-7853

  Shi, H B ^a   Luo, J ^a   Yao, D W ^a   Zhu, J J ^a   Xu, H F ^a   Shi, H P ^a   Loor, J J ^b  

^a NORTHWEST A F UNIVERSITY   (China)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Desaturation; Lactation; Metabolism; Nutrition

Indexed keywords

BOVIDAE; CAPRA HIRCUS; RODENTIA;

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACYL COENZYME A DESATURASE; FATTY ACID; MONOUNSATURATED FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE;

ANIMAL; CELL CULTURE; CYTOLOGY; EPITHELIUM CELL; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GOAT; LACTATION; LIPID METABOLISM; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; UDDER;

ANIMALS; CELLS, CULTURED; EPITHELIAL CELLS; FATTY ACIDS; FATTY ACIDS, MONOUNSATURATED; FEMALE; GENE EXPRESSION REGULATION; GOATS; LACTATION; LIPID METABOLISM; MAMMARY GLANDS, ANIMAL; PPAR GAMMA; REAL-TIME POLYMERASE CHAIN REACTION; STEAROYL-COA DESATURASE; THIAZOLIDINEDIONES;

EID: 84888023638     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2013-7105     Document Type: Article

References (46)

1. Bauman D.E., Ingle D.L., Mellenberger R.W., Davis C.L. Factors affecting in vitro lipogenesis by bovine mammary tissue slices. J. Dairy Sci 1973, 56:1520-1525.
2. Bernard L., Rouel J., Leroux C., Ferlay A., Faulconnier Y., Legrand P., Chilliard Y. Mammary lipid metabolism and milk fatty acid secretion in alpine goats fed vegetable lipids. J. Dairy Sci 2005, 88:1478-1489.
3. Bionaz M., Chen S., Khan M.J., Loor J.J. Functional role of PPARs in ruminants: Potential targets for fine-tuning metabolism during growth and lactation. PPAR Res 2013, 2013:684159.
4. Bionaz M., Loor J.J. Gene networks driving bovine milk fat synthesis during the lactation cycle. BMC Genomics 2008, 9:366.
5. Bugge A., Grøntved L., Aagaard M.M., Borup R., Mandrup S. The PPARγ2 A/B-domain plays a gene-specific role in transactivation and cofactor recruitment. Mol. Endocrinol 2009, 23:794-808.
6. Conte G., Mele M., Chessa S., Castiglioni B., Serra A., Pagnacco G., Secchiari P. Diacylglycerol acyltransferase 1, stearoyl-CoA desaturase 1, and sterol regulatory element binding protein 1 gene polymorphisms and milk fatty acid composition in Italian Brown cattle. J. Dairy Sci 2010, 93:753-763.
7. Demeter R.M., Schopen G.C.B., Oude Lansink A.G.J.M., Meuwissen M.P.M., Arendonk J.A.M. Effects of milk fat composition, DGAT1, and SCD1 on fertility traits in Dutch Holstein cattle. J. Dairy Sci 2009, 92:5720-5729.
8. Elbrecht A., Chen Y., Cullinan C.A., Hayes N., Leibowitz M., Moller D.E., Berger J. Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2. Biochem. Biophys. Res. Commun 1996, 224:431-437.
9. Gou D., Weng T., Wang Y., Wang Z., Zhang H., Gao L., Chen Z., Wang P., Liu L. A novel approach for the construction of multiple shRNA expression vectors. J. Gene Med 2007, 9:751-763.
10. Haenlein G.F.W. Goat milk in human nutrition. Small Rumin. Res 2004, 51:155-163.
11. Horton J.D., Goldstein J.L., Brown M.S. SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest 2002, 109:1125-1131.
12. Jacobs A.A.A., Dijkstra J., Hendriks W.H., van Baal J., van Vuuren A.M. Comparison between stearoyl-CoA desaturase expression in milk somatic cells and in mammary tissue of lactating dairy cows. J. Anim. Physiol. Anim. Nutr. (Berl.) 2013, 97:353-362.
13. Jones B.H., Standridge M.K., Claycombe K.J., Smith P.J., Moustaïd-Moussa N. Glucose induces expression of stearoyl-CoA desaturase in 3T3-L1 adipocytes. Biochem. J 1998, 335:405-408.
14. Kadegowda A.K.G., Bionaz M., Piperova L.S., Erdman R.A., Loor J.J. Peroxisome proliferator-activated receptor-γ activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents. J. Dairy Sci 2009, 92:4276-4289.
15. Kgwatalala P.M., Ibeagha-Awemu E.M., Mustafa A.F., Zhao X. Stearoyl-CoA desaturase 1 genotype and stage of lactation influences milk fatty acid composition of Canadian Holstein cows. Anim. Genet 2009, 40:609-615.
16. Kolak M., Yki-Järvinen H., Kannisto K., Tiikkainen M., Hamsten A., Eriksson P., Fisher R.M. Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes. J. Clin. Endocrinol. Metab 2007, 92:720-724.
17. Lin X., Luo J., Zhang L., Wang W., Shi H., Zhu J. miR-27a suppresses triglyceride accumulation and affects gene mRNA expression associated with fat metabolism in dairy goat mammary gland epithelial cells. Gene 2013, 521:15-23.
18. Loor J.J., Herbein J.H. Reduced fatty acid synthesis and desaturation due to exogenous trans10,cis12-CLA in cows fed oleic or linoleic Oil. J. Dairy Sci 2003, 86:1354-1369.
19. Luo J., Deng Z.-L., Luo X., Tang N., Song W.-X., Chen J., Sharff K.A., Luu H.H., Haydon R.C., Kinzler K.W., Vogelstein B., He T.-C. A protocol for rapid generation of recombinant adenoviruses using the AdEasy system. Nat. Protoc 2007, 2:1236-1247.
20. Mele M., Conte G., Castiglioni B., Chessa S., Macciotta N.P.P., Serra A., Buccioni A., Pagnacco G., Secchiari P. Stearoyl-coenzyme A desaturase gene polymorphism and milk fatty acid composition in Italian Holsteins. J. Dairy Sci 2007, 90:4458-4465.
21. Mele M., Dal Zotto R., Cassandro M., Conte G., Serra A., Buccioni A., Bittante G., Secchiari P. Genetic parameters for conjugated linoleic acid, selected milk fatty acids, and milk fatty acid unsaturation of Italian Holstein-Friesian cows. J. Dairy Sci 2009, 92:392-400.
22. Miyazaki M., Ntambi J.M. Role of stearoyl-coenzyme A desaturase in lipid metabolism. Prostaglandins Leukot. Essent. Fatty Acids 2003, 68:113-121.
23. Moioli B., Contarini G., Avalli A., Catillo G., Orrù L., De Matteis G., Masoero G., Napolitano F. Short communication: Effect of stearoyl-coenzyme A desaturase polymorphism on fatty acid composition of milk. J. Dairy Sci 2007, 90:3553-3558.
24. Ntambi J.M. The regulation of stearoyl-COA desaturase (SCD). Prog. Lipid Res 1995, 34:139-150.
25. Ostapchuk P., Hearing P. Control of adenovirus packaging. J. Cell. Biochem 2005, 96:25-35.
26. Peterson D.G., Matitashvili E.A., Bauman D.E. The inhibitory effect of trans-10, cis-12 CLA on lipid synthesis in bovine mammary epithelial cells involves reduced proteolytic activation of the transcription factor SREBP-1. J. Nutr 2004, 134:2523-2527.
27. Pieniak-Lendzion K., Niedziółka R. The importance of goat milk in human nutrition. Wiadomości Zootechniczne 2004, 42:39-44.
28. Reh W.A., Maga E.A., Collette N.M.B., Moyer A., Conrad-Brink J.S., Taylor S.J., DePeters E.J., Oppenheim S., Rowe J.D., BonDurant R.H., Anderson G.B., Murray J.D. Hot topic: Using a stearoyl-CoA desaturase transgene to alter milk fatty acid composition. J. Dairy Sci 2004, 87:3510-3514.
29. Ren D., Collingwood T.N., Rebar E.J., Wolffe A.P., Camp H.S. PPARγ knockdown by engineered transcription factors: Exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis. Genes Dev 2002, 16:27-32.
30. Risérus U., Tan G.D., Fielding B.A., Neville M.J., Currie J., Savage D.B., Chatterjee V.K., Frayn K.N., O'Rahilly S., Karpe F. Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: Link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-γ. Diabetes 2005, 54:1379-1384.
31. Rosen E.D., Spiegelman B.M. PPARgamma: A nuclear regulator of metabolism, differentiation, and cell growth. J. Biol. Chem 2001, 276:37731-37734.
32. Schennink A., Stoop W.M., Visker M.H.P.W., Heck J.M.L., Bovenhuis H., van der Poel J.J., van Valenberg H.J.F., van Arendonk J.A.M. DGAT1 underlies large genetic variation in milk-fat composition of dairy cows. Anim. Genet 2007, 38:467-473.
33. Shi H., Luo J., Zhu Y., Wang Z., Zhao W. Cloning, sequence analysis and over-expression of SCD gene of dairy goat. China Agric. Sci 2012, 45:5091-5101.
34. Shi H., Luo J., Zhu J., Li J., Sun Y., Lin X., Zhang L., Yao D., Shi H. PPARγ regulates genes involved in triacylglycerol synthesis and secretion in mammary gland epithelial cells of dairy goats. PPAR Res 2013, 2013:310948.
35. Shimano H. Sterol regulatory element-binding proteins (SREBPs): Transcriptional regulators of lipid synthetic genes. Prog. Lipid Res 2001, 40:439-452.
36. Singh Ahuja H., Liu S., Crombie D.L., Boehm M., Leibowitz M.D., Heyman R.A., Depre C., Nagy L., Tontonoz P., Davies P.J.A. Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents. Mol. Pharmacol 2001, 59:765-773.
37. Thaller G., Kramer W., Winter A., Kaupe B., Erhardt G., Fries R. Effects of DGAT1 variants on milk production traits in German cattle breeds. J. Anim. Sci 2003, 81:1911.
38. Tontonoz P., Hu E., Graves R.A., Budavari A.I., Spiegelman B.M. mPPAR gamma 2: Tissue-specific regulator of an adipocyte enhancer. Genes Dev 1994, 8:1224-1234. a.
39. Tontonoz P., Hu E., Spiegelman B.M. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 1994, 79:1147-1156. b.
40. Walkey C.J., Spiegelman B.M. A functional peroxisome proliferator-activated receptor-γ ligand-binding domain is not required for adipogenesis. J. Biol. Chem 2008, 283:24290-24294.
41. Wang W., Luo J., Zhong Y., Lin X., Shi H., Zhu J., Li J., Sun Y., Zhao W. Goat liver X receptor α, molecular cloning, functional characterization and regulating fatty acid synthesis in epithelial cells of goat mammary glands. Gene 2012, 505:114-120.
42. Wang Z., Luo J., Wang W., Zhao W., Lin X. Characterization and culture of isolated primary dairy goat mammary gland epithelial cells. Sheng Wu Gong Cheng Xue Bao 2010, 26:1123-1127.
43. Waters K.M., Ntambi J.M. Polyunsaturated fatty acids inhibit hepatic stearoyl-CoA desaturase-1 gene in diabetic mice. Lipids 1996, 31:S33-S36.
44. Way J.M., Harrington W.W., Brown K.K., Gottschalk W.K., Sundseth S.S., Mansfield T.A., Ramachandran R.K., Willson T.M., Kliewer S.A. Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor γ activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Endocrinology 2001, 142:1269-1277.
45. Yao-Borengasser A., Rassouli N., Varma V., Bodles A.M., Rasouli N., Unal R., Phanavanh B., Ranganathan G., McGehee R.E., Kern P.A. Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-γ responsiveness. J. Clin. Endocrinol. Metab 2008, 93:4431-4439.
46. Yu S., Matsusue K., Kashireddy P., Cao W.-Q., Yeldandi V., Yeldandi A.V., Rao M.S., Gonzalez F.J., Reddy J.K. Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPARγ1) overexpression. J. Biol. Chem 2003, 278:498-505.