Effect of weight loss on the rate of muscle protein synthesis during fasted and fed conditions in obese older adults

Obesity

Volumn 20, Issue 9, 2012, Pages 1780-1786

  Villareal, Dennis T ^a,b   Smith, Gordon I ^a   Shah, Krupa ^a,c   Mittendorfer, Bettina ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOISOCAPROIC ACID; GLUCOSE; INSULIN; LEUCINE; MUSCLE PROTEIN;

AGED; AMINO ACID BLOOD LEVEL; ARTICLE; BODY MASS; CALORIC RESTRICTION; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY BALANCE; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INTERVENTION STUDY; MALE; NEGATIVE FEEDBACK; OBESITY; OUTCOME ASSESSMENT; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; THERAPY EFFECT; TREATMENT DURATION; WEIGHT CHANGE; WEIGHT REDUCTION;

AGED; AGED, 80 AND OVER; AGING; BLOOD GLUCOSE; ENERGY INTAKE; ENERGY METABOLISM; FASTING; FEMALE; HUMANS; INSULIN; LEUCINE; MALE; MUSCLE PROTEINS; MUSCLE STRENGTH; MUSCLE, SKELETAL; OBESITY; PROTEIN BIOSYNTHESIS; WEIGHT LOSS;

EID: 84865662231     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2011.280     Document Type: Article

References (28)

1. Van Baak MA, Visscher TL. Public health success in recent decades may be in danger if lifestyles of the elderly are neglected. Am J Clin Nutr 2006;84:1257-1258. (Pubitemid 44912805)
2. Villareal DT, Apovian CM, Kushner RF, Klein S; American Society for Nutrition; NAASO, The Obesity Society. Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Obes Res 2005;13:1849-1863.
3. Kennedy RL, Chokkalingham K, Srinivasan R. Obesity in the elderly: who should we be treating, and why, and how? Curr Opin Clin Nutr Metab Care 2004;7:3-9.
4. Dunn MA, Houtz SK, Hartsook EW. Effects of fasting on muscle protein turnover, the composition of weight loss, and energy balance of obese and nonobese Zucker rats. J Nutr 1982;112:1862-1875. (Pubitemid 13212893)
5. Goodman MN, McElaney MA, Ruderman NB. Adaptation to prolonged starvation in the rat: curtailment of skeletal muscle proteolysis. Am J Physiol 1981;241:E321-E327.
6. Clark AS, Mitch WE. Comparison of protein synthesis and degradation in incubated and perfused muscle. Biochem J 1983;212:649-653. (Pubitemid 13056888)
7. Campbell WW, Haub MD, Wolfe RR et al. Resistance training preserves fat-free mass without impacting changes in protein metabolism after weight loss in older women. Obesity (Silver Spring) 2009;17:1332-1339.
8. Villareal DT, Holloszy JO, Kohrt WM. Effects of DHEA replacement on bone mineral density and body composition in elderly women and men. Clin Endocrinol (Oxf) 2000;53:561-568.
9. Heymsfield SB, Smith R, Aulet M et al. Appendicular skeletal muscle mass: measurement by dual-photon absorptiometry. Am J Clin Nutr 1990;52:214-218.
10. Villareal DT, Smith GI, Sinacore DR, Shah K, Mittendorfer B. Regular multicomponent exercise increases physical fitness and muscle protein anabolism in frail, obese, older adults. Obesity (Silver Spring) 2011;19:312-318.
11. Smith GI, Atherton P, Reeds DN et al. Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial. Am J Clin Nutr 2011;93:402-412.
12. Patterson BW, Zhang XJ, Chen Y, Klein S, Wolfe RR. Measurement of very low stable isotope enrichments by gas chromatography/mass spectrometry: application to measurement of muscle protein synthesis. Metab Clin Exp 1997;46:943-948. (Pubitemid 27339921)
13. Langenbeck U, Luthe H, Schaper G. Keto acids in tissues and biological fluids: O-t-butyldimethylsilyl quinoxalinols as derivatives for sensitive gas chromatographic/mass spectrometric determination. Biomed Mass Spectrom 1985;12:507-509. (Pubitemid 15237241)
14. Wolfe RR. Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis. 1992; Wiley-Liss: New York.
15. Matthews DR, Hosker JP, Rudenski AS et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419. (Pubitemid 15018832)
16. Fabbrini E, Klein S. Fundamentals of cardiometabolic risk factor reduction: achieving and maintaining weight loss with pharmacotherapy or bariatric surgery. Clin Cornerstone 2008;9:41-8; discussion 49.
17. Aronne LJ, Isoldi KK. Overweight and obesity: key components of cardiometabolic risk. Clin Cornerstone 2007;8:29-37. (Pubitemid 351597782)
18. Rolland Y, Kim MJ, Gammack JK et al. Office management of weight loss in older persons. Am J Med 2006;119:1019-1026. (Pubitemid 44826936)
19. Cuthbertson D, Smith K, Babraj J et al. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J 2005;19:422-424. (Pubitemid 40316537)
20. Guillet C, Prod'homme M, Balage M et al. Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans. FASEB J 2004;18:1586-1587. (Pubitemid 39561641)
21. Rasmussen BB, Fujita S, Wolfe RR et al. Insulin resistance of muscle protein metabolism in aging. FASEB J 2006;20:768-769. (Pubitemid 46671209)
22. Bohé J, Low A, Wolfe RR, Rennie MJ. Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a doseresponse study. J Physiol (Lond) 2003;552:315-324. (Pubitemid 37265489)
23. Moore DR, Robinson MJ, Fry JL et al. Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. Am J Clin Nutr 2009;89:161-168.
24. Dillon EL, Sheffield-Moore M, Paddon-Jones D et al. Amino acid supplementation increases lean body mass, basal muscle protein synthesis, and insulin-like growth factor-I expression in older women. J Clin Endocrinol Metab 2009;94:1630-1637.
25. Kanaley JA, Haymond MW, Jensen MD. Effects of exercise and weight loss on leucine turnover in different types of obesity. Am J Physiol 1993;264:E687-E692. (Pubitemid 23156739)
26. Welle S, Statt M, Barnard R, Amatruda J. Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women. Metab Clin Exp 1994;43:441-445. (Pubitemid 24113163)
27. Henderson GC, Nadeau D, Horton ES, Nair KS. Effects of adiposity and 30 days of caloric restriction upon protein metabolism in moderately vs. severely obese women. Obesity (Silver Spring) 2010;18:1135-1142.
28. Nair KS, Halliday D, Griggs RC. Leucine incorporation into mixed skeletal muscle protein in humans. Am J Physiol 1988;254:E208-E213.