Involvement of phosphatidylinositol 3-Kinase/Akt signaling pathway in β1 integrin-mediated internalization of Staphylococcus aureus by alveolar epithelial cells

Journal of Microbiology

Volumn 51, Issue 5, 2013, Pages 644-650

  Wang, Jia He ^a   Zhang, Ke ^a   Wang, Nan ^a   Qiu, Xiao Min ^a   Wang, Yi Bing ^a   He, Ping ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

1 integrin; alveolar epithelial cells; internalization; phosphatidylinositol 3 kinase; Staphylococcus aureus

Indexed keywords

RATTUS; STAPHYLOCOCCUS AUREUS;

BETA1 INTEGRIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL; ARTICLE; CELL CULTURE; ENDOCYTOSIS; EPITHELIUM CELL; GENE EXPRESSION PROFILING; GENE SILENCING; HUMAN; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTIGENS, CD29; CELLS, CULTURED; ENDOCYTOSIS; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; GENE KNOCKDOWN TECHNIQUES; HUMANS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS;

EID: 84888006452     PISSN: 12258873     EISSN: 19763794     Source Type: Journal    
DOI: 10.1007/s12275-013-3040-x     Document Type: Article

References (26)

1. Agerer, F., Michel, A., Ohlsen, K., and Hauck, C. R. 2003. Integrin-mediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases. J. Biol. Chem. 278, 42524-42531.
2. Almeida, R. A., Matthews, K. R., Cifrian, E., Guidry, A. J., and Oliver, S. P. 1996. Staphylococcus aureus invasion of bovine mammary epithelial cells. J. Dairy Sci. 79, 1021-1026.
3. Bayles, K. W., Wesson, C. A., Liou, L. E., Fox, L. K., Bohach, G. A., and Trumble, W. R. 1998. Intracellular Staphylococcus aureus escapes the endosome and induces apoptosis in epithelial cells. Infect. Immun. 66, 336-342.
4. Beekhuizen, H., van de Gevel, J. S., Olsson, B., van Benten, I. J., and van Furth, R. 1997. Infection of human vascular endothelial cells with Staphylococcus aureus induces hyperadhesiveness for human monocytes and granulocytes. J. Immunol. 158, 774-782.
5. Dziewanowska, K., Patti, J. M., Deobald, C. F., Bayles, K. W., Trumble, W. R., and Bohach, G. A. 1999. Fibronectin binding protein and host cell tyrosine kinase are required for internalization of Staphylococcus aureus by epithelial cells. Infect. Immun. 67, 4673-4678.
6. Feng, Y., Chen, C. J., Su, L. H., Hu, S., Yu, J., and Chiu, C. H. 2008. Evolution and pathogenesis of Staphylococcus aureus: Lessons learned from genotyping and comparative genomics. FEMS Microbiol. Rev. 32, 23-37.
7. Foster, T. J. and Hook, M. 1998. Surface protein adhesins of Staphylococcus aureus. Trends Microbiol. 6, 484-488.
8. Fowler, T., Wann, E. R., Joh, D., Johansson, S., Foster, T. J., and Hook, M. 2000. Cellular invasion by Staphylococcus aureus in volves a fibronectin bridge between the bacterial fibronectin-binding MSCRAMMs and host cell beta1 integrins. Eur. J. Cell Biol. 79, 672-679.
9. Fowler, T. J., Wary, K. K., and Höök, M. 2003. Src kinase has a central role in in vitro cellular internalization of Staphylococcus aureus. Cell. Microbiol. 5, 417-426.
10. Genestier, A. L., Michallet, M. C., Prevost, G., Bellot, G., Chalabreysse, L., Peyrol, S., Thivolet, F., Etienne, J., Lina, G., Vallette, F. M., andet al. 2005. Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils. J. Clin. Invest. 115, 3117-3127.
11. Giancotti, F. G. and Ruoslahti, E. 1999. Integrin signaling. Science285, 1028-1032.
12. Gustavsson, A., Armulik, A., Brakebusch, C., Fassler, R., Johansson, S., and Fallman, M. 2002. Role of the β1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia. J. Cell. Sci. 115, 2669-2678.
13. Hamill, R. J., Vann, J. M., and Proctor, R. A. 1986. Phagocytosis of Staphylococcus aureus by cultured bovine aortic endothelial cells: Model for post adherence events in endovascular infections. Infect. Immun. 54, 833-836.
14. Hudson, M. C., Ramp, W. K., Nicholson, N. C., Williams, A. S., and Nousiainen, M. T. 1995. Internalization of Staphylococcus aureus by cultured osteoblasts. Microb. Pathog. 19, 409-419.
15. Joh, D., Wann, E. R., Kreikemeyer, B., Speziale, P., and Hook, M. 1999. Role of fibronectin-binding MSCRAMMs in bacterial adherence and entry into mammalian cells. Matrix Biol. 18, 211-223.
16. Liang, X. and Ji, Y. 2006. Alpha-toxin interferes with integrin-mediated adhesion and internalization of Staphylococcus aureus by epithelial cells. Cell. Microbiol. 8, 1656-1668.
17. Lowy, F. D. 1998. Staphylococcus aureus infections. N. Engl. J. Med. 339, 520-532.
18. Mairbaurl, H., Mayer, K., Kim, K. J., Borok, Z., Bartsch, P., and Crandall, E. D. 2002. Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers. Am. J. Physiol. Lung Cell Mol. Physiol. 282, 659-665.
19. Mairbaurl, H., Wodopia, R., Eckes, S., Schulz, S., and Bartsch, P. 1997. Impairment of cation transport in A549 cells and rat alveolar epithelial cells by hypoxia. Am. J. Physiol. 273, 797-806.
20. McElroy, M. C., Cain, D. J., Tyrrell, C., Foster, T. J., and Haslett, C. 2002. Increased virulence of a fibronectin-binding protein mutant of Staphylococcus aureus in a rat model of pneumonia. Infect. Immun. 70, 3865-3873.
21. McElroy, M. C., Harty, H. R., Hosford, G. E., Boylan, G. M., Pittet, J. F., and Foster, T. J. 1999. Alpha-toxin damages the air-blood barrier of the lung in a rat model of Staphylococcus aureus-induced pneumonia. Infect. Immun. 67, 5541-5544.
22. Oviedo-Boyso, J., Cortés-Vieyra, R., Huante-Mendoza, A., Yu, H. B., Valdez-Alarcón, J. J., Bravo-Patiño, A., Cajero-Juárez, M., Finlay, B. B., and Baizabal-Aguirre, V. M. 2011. The hosphoinositide-3-kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells. Infect. Immun. 79, 4569-4577.
23. Patti, J. M., Allen, B. L., McGavin, M. J., and Hook, M. 1994. MSCRAMM-mediated adherence of microorganisms to host tissues. Annu. Rev. Microbiol. 48, 585-617.
24. Peacock, S. J., Foster, T. J., Cameron, B. J., and Berendt, A. R. 1999. Bacterial fibronectin-binding proteins and endothelial cell surface fibronectin mediate adherence of Staphylococcus aureus to resting human endothelial cells. Microbiology145, 3477-3486.
25. 1. Cell. Microbiol. 1, 101-117.
26. Wong, K. W. and Isberg, R. R. 2005. Emerging views on integrin signaling via Rac1 during invasin-promoted bacterial uptake. Curr. Opin. Microbiol. 8, 4-9.