Impact of genetic polymorphism on drug-drug interactions mediated by cytochromes: A general approach

AAPS Journal

Volumn 15, Issue 4, 2013, Pages 1242-1252

  Tod, Michel ^a,b,c   Nkoud Mongo, Christina ^c   Gueyffier, François ^a,d  

^a UNIVERSITÉ LYON 1   (France)

^b UNIVERSITÉ CLAUDE BERNARD LYON 1   (France)

^c CROIX ROUSSE HOSPITAL   (France)

^d LABORATOIRE DE BIOMÉTRIE ET BIOLOGIE EVOLUTIVE   (France)

Author keywords

cytochromes; drug interactions; genetic polymorphism; quantitative prediction

Indexed keywords

AMIODARONE; AMITRIPTYLINE; ARIPIPRAZOLE; CIMETIDINE; CYTOCHROME; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; DIAZEPAM; DILTIAZEM; DIPHENHYDRAMINE; DRONEDARONE; FLECAINIDE; FLUCONAZOLE; FLUOXETINE; FLURBIPROFEN; FLUVOXAMINE; GLICLAZIDE; HALOPERIDOL; ITRACONAZOLE; LANSOPRAZOLE; LOSARTAN; METOPROLOL; MIRTAZAPINE; PAROXETINE; PHENYTOIN; QUINIDINE; RIFAMPICIN; UNINDEXED DRUG; VORICONAZOLE;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG EXPOSURE; DRUG POTENCY; GENE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; IN VIVO STUDY; METABOLIC REGULATION; PHARMACOGENETICS; QUANTITATIVE ANALYSIS; VALIDATION STUDY;

CYTOCHROME P-450 CYP3A; DRUG INTERACTIONS; FORECASTING; HUMANS; POLYMORPHISM, GENETIC;

EID: 84888001421     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-013-9530-2     Document Type: Article

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