메뉴 건너뛰기




Volumn 66, Issue 5, 2008, Pages 660-666

Pharmacokinetic interaction of flecainide and paroxetine in relation to the CYP2D6*10 allele in healthy Korean subjects

Author keywords

CYP2D6; Drug interaction; Flecainide; Paroxetine; Pharmacokinetics

Indexed keywords

CYTOCHROME P450 2D6; FLECAINIDE; PAROXETINE;

EID: 55149095948     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2008.03267.x     Document Type: Article
Times cited : (39)

References (25)
  • 1
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome p450 2d6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • Sachse C, Brockmoller J, Bauer S, Root I. Cytochrome p450 2d6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet 1997 60 : 284 95.
    • (1997) Am J Hum Genet , vol.60 , pp. 284-295
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3    Root, I.4
  • 2
    • 0742286803 scopus 로고    scopus 로고
    • Cytochrome P450 2D6: Overview and update on pharmacology, genetics, biochemistry
    • Zanger UM, Raimundo S, Eichelbaum M. Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry. Naunyn Schmiedebergs Arch Pharmacol 2004 369 : 23 37.
    • (2004) Naunyn Schmiedebergs Arch Pharmacol , vol.369 , pp. 23-37
    • Zanger, U.M.1    Raimundo, S.2    Eichelbaum, M.3
  • 5
    • 34548532227 scopus 로고    scopus 로고
    • Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer
    • Lim HS, Ju Lee H, Seok Lee K, Sook Lee E, Jang IJ, Ro J. Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer. J Clin Oncol 2007 25 : 3837 45.
    • (2007) J Clin Oncol , vol.25 , pp. 3837-3845
    • Lim, H.S.1    Ju Lee, H.2    Seok Lee, K.3    Sook Lee, E.4    Jang, I.J.5    Ro, J.6
  • 7
    • 55149100551 scopus 로고    scopus 로고
    • 3M Pharmaceuticals. Available at. (last accessed: 25 September 2007).
    • 3M Pharmaceuticals. 3M product information: Tambocor™. Available at http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?id=1423&type= display (last accessed: 25 September 2007).
    • 3M Product Information: Tambocor™
  • 8
    • 0021345989 scopus 로고
    • Flecainide: Its proarrhythmic effect and expected changes on the surface electrocardiogram
    • Morganroth J, Horowitz LN. Flecainide: its proarrhythmic effect and expected changes on the surface electrocardiogram. Am J Cardiol 1984 53 : 89B 94B.
    • (1984) Am J Cardiol , vol.53
    • Morganroth, J.1    Horowitz, L.N.2
  • 9
    • 0028236315 scopus 로고
    • Variable disposition kinetics and electrocardiographic effects of flecainide during repeated dosing in humans: Contribution of genetic factors, dose-dependent clearance, and interaction with amiodarone
    • Funck-Brentano C, Becquemont L, Kroemer HK, Buhl K, Knebel NG, Eichelbaum M, Jaillon P. Variable disposition kinetics and electrocardiographic effects of flecainide during repeated dosing in humans: contribution of genetic factors, dose-dependent clearance, and interaction with amiodarone. Clin Pharmacol Ther 1994 55 : 256 69.
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 256-269
    • Funck-Brentano, C.1    Becquemont, L.2    Kroemer, H.K.3    Buhl, K.4    Knebel, N.G.5    Eichelbaum, M.6    Jaillon, P.7
  • 10
    • 0026739663 scopus 로고
    • The effect of a low dose of quinidine on the disposition of flecainide in healthy volunteers
    • Munafo A, Buclin T, Tuto D, Biollaz J. The effect of a low dose of quinidine on the disposition of flecainide in healthy volunteers. Eur J Clin Pharmacol 1992 43 : 441 3.
    • (1992) Eur J Clin Pharmacol , vol.43 , pp. 441-443
    • Munafo, A.1    Buclin, T.2    Tuto, D.3    Biollaz, J.4
  • 11
    • 0026573814 scopus 로고
    • Stereoselective genetically-determined interaction between chronic flecainide and quinidine in patients with arrhythmias
    • Birgersdotter UM, Wong W, Turgeon J, Roden DM. Stereoselective genetically-determined interaction between chronic flecainide and quinidine in patients with arrhythmias. Br J Clin Pharmacol 1992 33 : 275 80.
    • (1992) Br J Clin Pharmacol , vol.33 , pp. 275-280
    • Birgersdotter, U.M.1    Wong, W.2    Turgeon, J.3    Roden, D.M.4
  • 12
    • 33750439114 scopus 로고    scopus 로고
    • Effect of CYP2D6 genotype on flecainide pharmacokinetics in Japanese patients with supraventricular tachyarrhythmia
    • Doki K, Homma M, Kuga K, Kusano K, Watanabe S, Yamaguchi I, Kohda Y. Effect of CYP2D6 genotype on flecainide pharmacokinetics in Japanese patients with supraventricular tachyarrhythmia. Eur J Clin Pharmacol 2006 62 : 919 26.
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 919-926
    • Doki, K.1    Homma, M.2    Kuga, K.3    Kusano, K.4    Watanabe, S.5    Yamaguchi, I.6    Kohda, Y.7
  • 13
    • 18844426008 scopus 로고    scopus 로고
    • In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine: Prediction of nonstationary pharmacokinetics and drug interaction magnitude
    • Venkatakrishnan K, Obach RS. In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine: prediction of nonstationary pharmacokinetics and drug interaction magnitude. Drug Metab Dispos 2005 33 : 845 52.
    • (2005) Drug Metab Dispos , vol.33 , pp. 845-852
    • Venkatakrishnan, K.1    Obach, R.S.2
  • 14
    • 33645109079 scopus 로고    scopus 로고
    • CYP2D6*36 gene arrangements within the CYP2D6 locus: Association of CYP2D6*36 with poor metabolizer status
    • Gaedigk A, Bradford LD, Alander SW, Leeder JS. CYP2D6*36 gene arrangements within the CYP2D6 locus: association of CYP2D6*36 with poor metabolizer status. Drug Metab Dispos 2006 34 : 563 9.
    • (2006) Drug Metab Dispos , vol.34 , pp. 563-569
    • Gaedigk, A.1    Bradford, L.D.2    Alander, S.W.3    Leeder, J.S.4
  • 15
    • 0033461165 scopus 로고    scopus 로고
    • Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data
    • Gaedigk A, Gotschall RR, Forbes NS, Simon SD, Kearns GL, Leeder JS. Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data. Pharmacogenetics 1999 9 : 669 82.
    • (1999) Pharmacogenetics , vol.9 , pp. 669-682
    • Gaedigk, A.1    Gotschall, R.R.2    Forbes, N.S.3    Simon, S.D.4    Kearns, G.L.5    Leeder, J.S.6
  • 18
    • 0029053644 scopus 로고
    • Genetic analysis of the CYP2D6 locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects
    • Dahl ML, Yue QY, Roh HK, Johansson I, Sawe J, Sjovist F, Bertilsson L. Genetic analysis of the CYP2D6 locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects. Pharmacogenetics 1995 5 : 159 64.
    • (1995) Pharmacogenetics , vol.5 , pp. 159-164
    • Dahl, M.L.1    Yue, Q.Y.2    Roh, H.K.3    Johansson, I.4    Sawe, J.5    Sjovist, F.6    Bertilsson, L.7
  • 20
    • 0036694258 scopus 로고    scopus 로고
    • Pharmacokinetics and electrocardiographic effects of a new controlled-release form of flecainide acetate: Comparison with the standard form and influence of the CYP2D6 polymorphism
    • Tenneze L, Tarral E, Ducloux N, Funck-Brentano C. Pharmacokinetics and electrocardiographic effects of a new controlled-release form of flecainide acetate: comparison with the standard form and influence of the CYP2D6 polymorphism. Clin Pharmacol Ther 2002 72 : 112 22.
    • (2002) Clin Pharmacol Ther , vol.72 , pp. 112-122
    • Tenneze, L.1    Tarral, E.2    Ducloux, N.3    Funck-Brentano, C.4
  • 21
    • 0026361512 scopus 로고
    • Concordance of P450 2D6 (debrisoquine hydroxylase) phenotype and genotype: Inability of dextromethorphan metabolic ratio to discriminate reliably heterozygous and homozygous extensive metabolizers
    • Evans WE, Relling MV. Concordance of P450 2D6 (debrisoquine hydroxylase) phenotype and genotype: inability of dextromethorphan metabolic ratio to discriminate reliably heterozygous and homozygous extensive metabolizers. Pharmacogenetics 1991 1 : 143 8.
    • (1991) Pharmacogenetics , vol.1 , pp. 143-148
    • Evans, W.E.1    Relling, M.V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.