Cationized ferritin as a magnetic resonance imaging probe to detect microstructural changes in a rat model of non-alcoholic steatohepatitis

Magnetic Resonance in Medicine

Volumn 70, Issue 6, 2013, Pages 1728-1738

  Beeman, Scott C ^a   Mandarino, Lawrence J ^b,c   Georges, Joseph F ^b   Bennett, Kevin M ^a  

^a Arizona State University   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

^c MAYO CLINIC   (United States)

Author keywords

chronic liver disease; magnetic resonance imaging; molecular imaging; NASH

Indexed keywords

BLOOD; MACROMOLECULES; MAGNETIC RESONANCE IMAGING; MAGNETISM; MOLECULAR IMAGING; PROBES; RESONANCE;

BLOOD PLASMA; CHRONIC LIVER DISEASE; EXTRACELLULAR MATRICES; HEALTHY CONTROLS; HEPATIC FUNCTION; MICROSTRUCTURAL CHANGES; NASH; NON-ALCOHOLIC STEATOHEPATITIS;

RATS;

CATIONIZED FERRITIN; FERRITIN; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; UNCLASSIFIED DRUG; CATION; CONTRAST MEDIUM; MOLECULAR PROBE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; EX VIVO STUDY; EXTRACELLULAR MATRIX; FLAME PHOTOMETRY; IMAGE ANALYSIS; IMMUNOFLUORESCENCE; IN VIVO STUDY; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; RAT; TISSUE STRUCTURE; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; GENETIC PROCEDURES; IMAGE ENHANCEMENT; LIVER; MOLECULAR PROBE; PATHOLOGY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT;

ANIMALS; CATIONS; CONTRAST MEDIA; EXTRACELLULAR MATRIX; FERRITINS; IMAGE ENHANCEMENT; LIVER; MAGNETIC RESONANCE IMAGING; MALE; MOLECULAR PROBE TECHNIQUES; MOLECULAR PROBES; NON-ALCOHOLIC FATTY LIVER DISEASE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84887994978     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.24619     Document Type: Article

References (35)

1. National Center for Health Statistics. Highlights and Detailed Tables-deaths: final Data for 2009. NVSR 2011; 60: 1-90.
2. Erickson SK,. Nonalcoholic fatty liver disease. J Lipid Res 2008; 50 (Suppl): S412-S416.
3. Bataller R,. Liver fibrosis. J Clin Invest 2005; 115: 209-218.
4. Lough J, Rosenthall L, Arzoumanian A, Goresky CA,. Kupffer cell depletion associated with capillarization of liver sinusoids in carbon tetrachloride-induced rat liver cirrhosis. J Hepatol 1987; 5: 190-198.
5. Martinez-Hernandez A, Amenta P,. The extracellular matrix in hepatic regeneration. FASEB J 1995; 9: 1401-1410.
6. Friedman SL,. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000; 275: 2247-2250.
7. Iredale JP,. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest 2007; 117: 539-548.
8. Farrell GC, Teoh NC, Mccuskey RS,. Hepatic microcirculation in fatty liver disease. Anat Rec (Hoboken) 2008; 291: 684-692.
9. Wisse E,. An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids. J Ultrastruct Res 1970; 31: 125-150.
10. Bedossa P, Paradis V,. Liver extracellular matrix in health and disease. J Pathol 2003; 200: 504-515.
11. Teramoto K, Bowers J, Khettry U, Palombo JD, Clouse ME,. A rat fatty liver-transplant model. Transplantation 1993; 55: 737-741.
12. George J, Perra N, Phung N, Leclercq I, Hou JY, Farrell G,. Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis. J Hepatol 2003; 39: 756-764.
13. Rinella ME, Elias MS, Smolak RR, Fu T, Borensztajn J, Green RM,. Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet. J Lipid Res 2008; 49: 1068-1076.
14. McCuskey RS, Ito Y, Robertson GR, McCuskey MK, Perry M, Farrell GC,. Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice. Hepatology 2004; 40: 386-393.
15. Siddique I, El-Naga HA, Madda JP, Memon A, Hassan F,. Sampling variability on percutaneous liver biopsy in patients with chronic hepatitis C virus infection. Scand J Gastroenterol 2003; 38: 427-432.
16. Bedossa P, Dargère D, Paradis V,. Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology 2003; 38: 1449-1457.
17. Thampanitchawong P, Piratvisuth T,. Liver biopsy: complications and risk factors. World J Gastroenterol 1999; 5: 301-304.
18. Ophir J, Céspedes I, Ponnekanti H, Yazdi Y, Li X,. Elastography: a quantitative method for imaging the elasticity of biological tissues. Ultrason Imaging 1991; 13: 111-134.
19. Yeh WC, Li PC, Jeng YM, Hsu HC, Kuo PO, Li ML, Yang PM, Lee PH,. Elastic modulus measurements of human liver and correlation with pathology. Ultrasound Med Biol 2002; 28: 467-474.
20. Sandrin L, Fourquet B, Hasquenoph JM, et al. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol 2003; 29: 1705-1713.
21. Muthupillai R, Lomas DJ, Rossman PJ, Greenleaf JF, Manduca A, Ehman RL,. Magnetic resonance elastography by direct visualization of propagating acoustic strain waves. Science 1995; 269: 1854-1857.
22. Manduca A, Oliphant TE, Dresner MA, Maholwald JL, Kruse SA, Amromin E, Felmlee JF, Ehman RL,. Magnetic resonance elastography: non-invasive mapping of tissue elasticity. Med Image Anal 2001; 5: 237-254.
23. Huwart L, Peeters F, Sinkus R, Annet L, Salameh N, ter Beek LC, Horsmans Y, Van Beers BE,. Liver fibrosis: non-invasive assessment with MR elastography. NMR Biomed 2006; 19: 173-179.
24. Zhang S, Merritt M, Woessner D, Lenkinski RE, Sherry DA,. PARACEST agents: Modulating MRI contrast via water proton exchange. Acc Chem Res 2003; 36: 783-790.
25. Geninatti Crich S, Barge A, Battistini E, Cabella C, Coluccia S, Longo D, Mainero V, Tarone G, Aime S,. Magnetic resonance imaging visualization of targeted cells by the internalization of supramolecular adducts formed between avidin and biotinylated Gd3+ chelates. J Biol Inorg Chem 2005; 10: 78-86.
26. Cormode DP, Jarzyna PA, Mulder WJM, Fayad ZA,. Modified natural nanoparticles as contrast agents for medical imaging. Adv Drug Deliv Rev 2010; 62: 329-338.
27. Bulte JWM, Douglas T, Mann S, Vymazal J, Laughlin PG, Frank JA,. Initial assessment of magnetoferritin biokinetics and proton relaxation enhancement in rats. Acad Radiol 1995; 2: 871-878.
28. Bennett KM, Shapiro EM, Sotak CH, Koretsky AP,. Controlled aggregation of ferritin to modulate MRI relaxivity. Biophys J 2008; 95: 342-351.
29. Uchida M, Terashima M, Cunningham CH, et al. A human ferritin iron oxide nano-composite magnetic resonance contrast agent. Magn Reson Med 2008; 60: 1073-1081.
30. Clavijo Jordan V, Caplan MR, Bennett KM,. Simplified synthesis and relaxometry of magnetoferritin for magnetic resonance imaging. Magn Reson Med 2010; 64: 260-1266.
31. Bennett KM, Zhou H, Sumner JP, Dodd SJ, Bouraoud N, Doi K, Star RA, Koretsky AP,. MRI of the basement membrane using charged nanoparticles as contrast agents. Magn Reson Med 2008; 60: 564-574.
32. Beeman SC, Zhang M, Gubhaju L, Wu T, Bertram JF, Frakes DH, Cherry BR, Bennett KM,. Measuring glomerular number and size in perfused kidneys using MRI. Am J Physiol Renal Physiol 2011; 300: 1454-1457.
33. Heilmann M, Neudecker S, Wolf I, Gubhaju L, Sticht C, Schock-Kusch D, Kriz W, Bertram JF, Schad LR, Gretz N,. Quantification of glomerular number and size distribution in normal rat kidneys using magnetic resonance imaging. Nephrol Dial Transplant 2012; 27: 100-107.
34. Danon D, Goldstein L, Marikovsky Y, Skutelsky E,. Use of cationized ferritin as a label of negative charges on cell surfaces. J Ultrastruct Res 1972; 38: 500-510.
35. Beeman SC, Georges JF, Bennett KM,. Toxicity, biodistribution, and ex vivo MRI detection of intravenously injected cationized ferritin. Magn Reson Med 2013; 69: 853-861.