Toxicity, biodistribution, and ex vivo MRI detection of intravenously injected cationized ferritin

Magnetic Resonance in Medicine

Volumn 69, Issue 3, 2013, Pages 853-861

  Beeman, Scott C ^a   Georges, Joseph F ^b   Bennett, Kevin M ^a  

^a Arizona State University   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

Author keywords

biodistribution; cationic ferritin; cationized ferritin; kidney; MRI; nanoparticle; toxicology

Indexed keywords

ENDOTHELIAL CELLS; MAGNETIC RESONANCE IMAGING; NANOPARTICLES;

BIODISTRIBUTIONS; CATIONIC FERRITIN; CATIONIZED; KIDNEY; TOXICOLOGY;

TOXICITY;

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CALCIUM; CATIONIZED FERRITIN; CREATININE; FERRITIN; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BIODEGRADATION; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; ENDOTHELIUM CELL; EX VIVO STUDY; EXTRACELLULAR MATRIX; GLYCOCALYX; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; KIDNEY; LEUKOCYTE COUNT; LIVER; LIVER CELL; LIVER SINUSOID; LIVER TOXICITY; MACROPHAGE; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; SPLEEN; TISSUE DISTRIBUTION; UREA NITROGEN BLOOD LEVEL;

EID: 84874345516     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.24301     Document Type: Article

References (34)

1. Adams JC, Watt FM,. Regulation of development and differentiation by the extracellular matrix. Development 1993; 117: 1183-1198.
2. Boudreau N, Werb Z, Bissell MJ,. Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle. Proc Natl Acad Sci USA 1996; 93: 3509-3513.
3. Rana B, Mischoulon D, Xie Y, Bucher N, Farmer SR,. Cell-extracellular matrix interactions can regulate the switch between growth and differentiation in rat hepatocytes: reciprocal expression of C/EBP alpha and immediate-early growth response transcription factors. Mol Cell Biol 1994; 14: 5858-5869.
4. Sanes JR,. Extracellular matrix molecules that influence neural development. Ann Rev Neurosci 1989; 12: 491-516.
5. Sanes JR,. Roles of extracellular matrix in neural development. Ann Rev Physiol 1983; 45: 581-600.
6. Schindler M, Nur-E-Kamal A, Ahmed I, Kamal J, Liu HY, Amor N, Ponery AS, Crockett DP, Grafe TH, Chung HY,. Living in three dimensions. Cell Biochem Biophys 2006; 45: 215-227.
7. Bulte JW, Douglas T, Mann S, Frankel RB, Moskowitz BM, Brooks RA, Baumgarner CD, Vymazal J, Frank JA,. Magnetoferritin. Biomineralization as a novel molecular approach in the design of iron-oxide-based magnetic resonance contrast agents. Invest Radiol 1994; 29 (Suppl. 2): S214-S216.
8. Bulte JW, Douglas T, Mann S, Frankel RB, Moskowitz BM, Brooks RA, Baumgarner CD, Vymazal J, Strub MP, Frank JA,. Magnetoferritin: characterization of a novel superparamagnetic MR contrast agent. J Magn Reson Imaging 1994; 4: 497-505.
9. Clavijo Jordan V, Caplan MR, Bennett KM,. Simplified synthesis and relaxometry of magnetoferritin for magnetic resonance imaging. Magn Reson Med 2010; 64: 1260-1266.
10. Meldrum FC, Heywood BR, Mann S,. Magnetoferritin: in vitro synthesis of a novel magnetic protein. Science 1992; 257: 522-523.
11. Danon D, Goldstein L, Marikovsky Y, Skutelsky E,. Use of cationized ferritin as a label of negative charges on cell surfaces. J Ultrastruct Res 1972; 38: 500-510.
12. Bennett KM, Zhou H, Sumner JP, Dodd SJ, Bouraoud N, Doi K, Star RA, Koretsky AP,. MRI of the basement membrane using charged nanoparticles as contrast agents. Magn Reson Med 2008; 60: 564-574.
13. Beeman SC, Zhang M, Gubhaju L, Wu T, Bertram JF, Frakes DH, Cherry BR, Bennett KM,. Measuring glomerular number and size in perfused kidneys using MRI. Am J Physiol Renal Physiol 2011; 300: F1454-F1457.
14. Heilmann M, Neudecker S, Wolf I, Gubhaju L, Sticht C, Schock-Kusch D, Kriz W, Bertram JF, Schad LR, Gretz N,. Quantification of glomerular number and size distribution in normal rat kidneys using magnetic resonance imaging. Nephrol Dial Transplant 2012; 27: 100-107.
15. Brenner BM, Garcia DL, Anderson S,. Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens 1988; 1: 335-347.
16. Hoy WE, Bertram JF, Denton RD, Zimanyi M, Samuel T, Hughson MD,. Nephron number, glomerular volume, renal disease and hypertension. Curr Opin Nephrol Hypertens 2008; 17: 258-265.
17. Beeman SC, Mandarino L, Rakela J, Bennett KM,. MRI-based detection of the extracellular matrix surrounding the hepatic sinusoid. In Proceedings of the 19th Annual Meeting of ISMRM, Montreal, Canada, 2011; p. 397.
18. Beeman SC, Georges JF, Mandarino L, Rakela J, Bennett KM,. MRI-based detection of extracellular changes in the hepatic sinusoid in a rat model of non-alcoholic steatohepatitis. In Proceedings of the 20th Annual Meeting of ISMRM, Melbourne, Australia, 2012, p. 4042.
19. Bulte JWM, Douglas T, Mann S, Vymazal J, Laughlin PG, Frank JA,. Initial assessment of magnetoferritin biokinetics and proton relaxation enhancement in rats. Acad Radiol 1995; 2: 871-878.
20. Jain TK, Reddy MK, Morales MA, Leslie-Pelecky DL, Labhasetwar V,. Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats. Mol Pharmacol 2008; 5: 316-327.
21. Harendza S, Schneider A, Helmchen U, Stahl RA,. Extracellular matrix deposition and cell proliferation in a model of chronic glomerulonephritis in the rat. Nephrol Dial Transplant 1999; 14: 2873-2879.
22. Bedossa P, Paradis V,. Liver extracellular matrix in health and disease. J Pathol 2003; 200: 504-515.
23. Voelz K, Kondziella D, von Rautenfeld DB, Brinker T, Ludemann W,. A ferritin tracer study of compensatory spinal CSF outflow pathways in kaolin-induced hydrocephalus. Acta Neuropathol 2007; 113: 569-575.
24. Brody JS, Vaccaro CA, Hill NS, Rounds S,. Binding of charged ferritin to alveolar wall components and charge selectivity of macromolecular transport in permeability pulmonary edema in rats. Circ Res 1984; 55: 155-167.
25. Dermietzel R, Thurauf N, Kalweit P,. Surface charges associated with fenestrated brain capillaries. II. In vivo studies on the role of molecular charge in endothelial permeability. J Ultrastruct Res 1983; 84: 111-119.
26. Peress NS, Tompkins D,. Effect of molecular charge on choroid-plexus permeability: tracer studies with cationized ferritins. Cell Tissue Res 1981; 219: 425-431.
27. Schmidley JW, Wissig SL,. Anionic sites on the luminal surface of fenestrated and continuous capillaries of the CNS. Brain Res 1986; 363: 265-271.
28. Barrowcliffe M, Jones JG,. Solute permeability of the alveolar capillary barrier. Thorax 1987; 42: 1-10.
29. Simionescu N, Simionescu M, Palade GE,. Differentiated microdomains on the luminal surface of the capillary endothelium. I. Preferential distribution of anionic sites. J Cell Biol 1981; 90: 605-613.
30. Iskandar SS, Zhang J, Rodriguez E,. Nephropathy induced in a nephritis resistant inbred mouse strain with the use of a cationic antigen. Am J Pathol 1986; 123: 67-72.
31. Santambrogio P, Levi S, Cozzi A, Rovida E, Albertini A, Arosio P,. Production and characterization of recombinant heteropolymers of human ferritin H and L chains. J Biol Chem 1993; 268: 12744-12748.
32. Uchida M, Terashima M, Cunningham CH, Suzuki Y, Willits DA, Willis AF, Yang PC, Tsao S, McConnell MV, Young MJ, Douglas T,. A human ferritin iron oxide nano-composite magnetic resonance contrast agent. Magn Res Med 2008; 60: 1073-1081.
33. Uchida M, Flenniken ML, Allen M, Willits DA, Crowley BE, Brumfield S, Willis AF, Jackiw L, Jutila M, Young MJ, Douglas T,. Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles. J Am Chem Soc 2006; 128: 16626-16633.
34. Batsford SR, Sasaki M, Takamiya H, Vogt A,. Cationic macromolecule- induced nephrotic syndrome in rabbits. Lack of immune complex involvement. Lab Invest 1983; 49: 260-269.