Efficient search of chemical space: Navigating from fragments to structurally diverse chemotypes

Journal of Medicinal Chemistry

Volumn 56, Issue 21, 2013, Pages 8879-8891

  Wassermann, Anne Mai ^a   Kutchukian, Peter S ^a,c   Lounkine, Eugen ^a   Luethi, Tiffany ^b   Hamon, Jacques ^b   Bocker, Michael T ^a   Malik, Hasnain A ^a   Cowan Jacob, Sandra W ^b   Glick, Meir ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 CHLORO 3 [(4 METHYLPHENYL)AMINO] 1,4 NAPHTHOQUINONE; 3 BENZO 6 CHLORO 7 (2,4 DIOXOPENTAN 3 YL) 1 BENZOFURAN 4,5 DIONE; ADENYLYLTRANSFERASE; BENZOFURAN DERIVATIVE; FOCAL ADHESION KINASE 1; HISTONE DEACETYLASE; HISTONE DEACETYLASE 4 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; HISTONE DEMETHYLASE; HISTONE METHYLTRANSFERASE; IMMUNOGLOBULIN; OXIDOREDUCTASE; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE 1; PROTEIN SERINE THREONINE KINASE 2; PROTEIN SERINE THREONINE KINASE 3; PROTEIN SERINE THREONINE KINASE 4; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE 1; SERINE PROTEINASE; TRANSFERASE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CHEMICAL PARAMETERS; CHEMICAL SPACE; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING FLUORIMETRY; DRUG STRUCTURE; FLUORESCENCE ANALYSIS; FRAGMENT BASED SCREEN; LIQUID CHROMATOGRAPHY; LUMINESCENCE; MASS SPECTROMETRY; MOBILITY SHIFT ASSAY; NUCLEAR MAGNETIC RESONANCE; SURFACE PLASMON RESONANCE; TIME RESOLVED FLUORESCENCE RESONANCE ENERGY TRANSFER;

DRUG DISCOVERY; ENZYME INHIBITORS; ENZYMES; HIGH-THROUGHPUT SCREENING ASSAYS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84887982114     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401309q     Document Type: Article

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