"Virtual fragment linking": An approach to identify potent binders from low affinity fragment hits

Journal of Medicinal Chemistry

Volumn 51, Issue 8, 2008, Pages 2481-2491

  Crisman, Thomas J ^a   Bender, Andreas ^a   Milik, Mariusz ^a   Jenkins, Jeremy L ^a   Scheiber, Josef ^a   Sukuru, Sai Chelan K ^a   Fejzo, Jasna ^a   Hommel, Ulrich ^b   Davies, John W ^a   Glick, Meir ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BINDING AFFINITY; DATA BASE; DRUG TARGETING; FRAGMENTATION REACTION; HIGH THROUGHPUT SCREENING; IC 50; MOLECULAR LIBRARY; MOLECULAR WEIGHT; STATISTICAL ANALYSIS; VIRTUAL FRAGMENT LINKING;

DATABASE MANAGEMENT SYSTEMS; DRUG EVALUATION, PRECLINICAL; MOLECULAR WEIGHT;

EID: 43049111044     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701314u     Document Type: Article

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