In silico and biochemical analyses identify quinone reductase 2 as a target of piceatannol

Current Medicinal Chemistry

Volumn 20, Issue 33, 2013, Pages 4195-4202

  Hsieh, Tze Chen ^a   Bennett, Dylan John ^a   Lee, Yong Syu ^a   Wu, Erxi ^b   Wu, Joseph M ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

Biotransformation; Chemoprevention; CWR22Rv1 prostate cancer cells; Cytochrome P450 CYP1B1; In silico analysis; NQO2; NQO2 knockdown; Piceatannol; Resveratrol

Indexed keywords

CYTOCHROME P450 1B1; PICEATANNOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) 2; RESVERATROL; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BIOTRANSFORMATION; CELL CYCLE PHASE; CELL GROWTH; CELL PROLIFERATION; CHEMICAL ANALYSIS; CLONOGENESIS; COMPUTER MODEL; CONTROLLED STUDY; DRUG BINDING SITE; DRUG BIOAVAILABILITY; DRUG PROTEIN BINDING; DRUG TARGETING; DRUG TRANSFORMATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; PROTEIN EXPRESSION; PROTEIN TARGETING;

APOPTOSIS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MOLECULAR DOCKING SIMULATION; NAD(P)H DEHYDROGENASE (QUINONE); PROTEIN STRUCTURE, TERTIARY; QUINONE REDUCTASES; RNA INTERFERENCE; RNA, SMALL INTERFERING; STILBENES;

EID: 84887975302     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/09298673113209990252     Document Type: Article

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