Fucoidan induces caspase-dependent apoptosis in MC3 human mucoepidermoid carcinoma cells

Experimental and Therapeutic Medicine

Volumn 7, Issue 1, 2013, Pages 228-232

  Lee, Hang Eun ^a   Choi, Eun Sun ^a   Shin, Ji Ae ^a   Lee, Syng Ook ^b   Park, Ki Soo ^c   Cho, Nam Pyo ^a   Cho, Sung Dae ^a  

^a Chonbuk National University   (South Korea)

^b TEXAS A AND M UNIVERSITY   (United States)

^c Korea Health Industry Development Institute   (South Korea)

Author keywords

Apoptosis; Extracellular signal regulated kinase 1 2; Fucoidan; Mucoepidermoid carcinoma; Myeloid cell leukemia 1

Indexed keywords

4', 6 DIAMIDINO 2 PHENYLINDOLE; CASPASE 3; FUCOIDIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN MCL 1; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ADENOSQUAMOUS CARCINOMA; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; STAINING; TUMOR CELL LINE; WESTERN BLOTTING;

EID: 84887972462     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.1368     Document Type: Article

References (31)

1. Zhang Z, Teruya K, Yoshida T, Eto H and Shirahata S: Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in MDA-MB-231 and MCF-7 breast cancer cells. Mar Drugs 11: 81-98, 2013.
2. Cumashi A, Ushakova NA, Preobrazhenskaya ME, et al: A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. Glycobiology 17: 541-552, 2007.
3. Ye J, Li Y, Teruya K, et al: Enzyme-digested fucoidan extracts derived from seaweed Mozuku of Cladosiphon novae-caledoniae kylin inhibit invasion and angiogenesis of tumor cells. Cytotechnology 47: 117-126, 2005.
4. Wang J, Zhang Q, Zhang Z and Li Z: Antioxidant activity of sulfated polysaccharide fractions extracted from Laminariajaponica. Int J Biol Macromol 42: 127-132, 2008.
5. Alekseyenko TV, Zhanayeva SY, Venediktova AA, et al: Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk Sea Fucus evanescens brown alga. Bull Exp Biol Med 143: 730-732, 2007.
6. Maruyama H, Tamauchi H, Iizuka M and Nakano T: The role of NK cells in antitumor activity of dietary fucoidan from Undariapinnatifida sporophylls (Mekabu). Planta Med 72: 1415-1417, 2006.
7. Zhang Z, Teruya K, Eto H and Shirahata S: Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ROS-dependent JNK activation and mitochondria-mediated pathways. PLoS One 6: e27441, 2011.
8. Koyanagi S, Tanigawa N, Nakagawa H, Soeda S and ShimenoH: Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities. Biochem Pharmacol 65: 173-179, 2003.
9. Aisa Y, Miyakawa Y, Nakazato T, et al: Fucoidan induces apoptosis of human HS-sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways. Am J Hematol 78: 7-14, 2005.
10. Chang L and Karin M: Mammalian MAP kinase signalling cascades. Nature 410: 37-40, 2001.
11. Xia Z, Dickens M, Raingeaud J, Davis RJ and GreenbergME: Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331, 1995.
12. Schroeter H, Boyd CS, Ahmed R, et al: c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis. Biochem J 372: 359-369, 2003.
13. Aoki H, Kang PM, Hampe J, et al: Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes. J Biol Chem 277: 10244-10250, 2002.
14. Sun NK, Huang SL, Chang TC and Chao CC: Sorafenib induces endometrial carcinoma apoptosis by inhibiting Elk-1-dependent Mcl-1 transcription and inducing Akt/GSK3β-dependent protein degradation. J Cell Biochem 114: 1819-1831, 2013.
15. Yang-Yen HF: Mcl-1: a highly regulated cell death and survival controller. J Biomed Sci 13: 201-204, 2006.
16. Wagner EF and Nebreda AR: Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 9: 537-549, 2009.
17. Cagnol S and Chambard JC: ERK and cell death: mechanisms of ERK-induced cell death-apoptosis, autophagy and senescence. FEBS J 277: 2-21, 2010.
18. Aquilano K, Baldelli S, Rotilio G and Ciriolo MR: trans-Resveratrol inhibits H2O2-induced adenocarcinoma gastric cells proliferation via inactivation of MEK1/2-ERK1/2-c-Jun signalling axis. Biochem Pharmacol 77: 337-347, 2009.
19. Rahman MS, Yamasaki A, Yang J, Shan L, Halayko AJ and Gounni AS: IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells: role of MAPK (Erk1/2, JNK, and p38) pathways. J Immunol 177: 4064-4071, 2006.
20. Sawatzky DA, Willoughby DA, Colville-Nash PR and Rossi AG: The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo. Am J Pathol 168: 33-41, 2006.
21. Sun HL, Tsai AC, Pan SL, et al: EPOX inhibits angiogenesis by degradation of Mcl-1 through ERK inactivation. Clin Cancer Res15: 4904-4914, 2009.
22. Philchenkov A, Zavelevich M, Imbs T, Zvyagintseva T and Zaporozhets T: Sensitization of human malignant lymphoid cells to etoposide by fucoidan, a brown seaweed polysaccharide. Exp Oncol 29: 181-185, 2007.
23. Párrizas M, Saltiel AR and LeRoith D: Insulin-like growth factor1 inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways. J Biol Chem 272: 154-161, 1997.
24. Anderson P: Kinase cascades regulating entry into apoptosis. Microbiol Mol Biol Rev 61: 33-46, 1997.
25. Jin JO, Song MG, Kim YN, Park JI and Kwak JY: The mechanism of fucoidan-induced apoptosis in leukemic cells: involvement of ERK1/2, JNK, glutathione, and nitric oxide. Mol Carcinog 49: 771-782, 2010.
26. Hyun JH, Kim SC, Kang JI, et al: Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells. Biol Pharm Bull 32: 1760-1764, 2009.
27. Boo HJ, Hyun JH, Kim SC, et al: Fucoidan from Undariapinnatifida induces apoptosis in A549 human lung carcinoma cells. Phytother Res 25: 1082-1086, 2011.
28. Boucher MJ, Morisset J, Vachon PH, Reed JC, Lainé J and Rivard N: MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. J Cell Biochem 79: 355-369, 2000.
29. Balmanno K and Cook SJ: Tumour cell survival signalling by the ERK1/2 pathway. Cell Death Differ 16: 368-377, 2009.
30. Akgul C: Mcl-1 is a potential therapeutic target in multiple types of cancer. Cell Mol Life Sci 66: 1326-1336, 2009.
31. Domina AM, Vrana JA, Gregory MA, Hann SR and Craig RW: MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. Oncogene 23: 5301-5315, 2004.