Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics

Journal of Medicinal Chemistry

Volumn 56, Issue 21, 2013, Pages 8948-8952

  Von Wantoch Rekowski, Margarete ^a   Kumar, Vijay ^b   Zhou, Zongmin ^c,d   Moschner, Johann ^a   Marazioti, Antonia ^c   Bantzi, Marina ^a   Spyroulias, Georgios A ^c   Van Den Akker, Focco ^b   Giannis, Athanassios ^a   Papapetropoulos, Andreas ^c  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PATRAS   (Greece)

^d UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 5 CYCLOPROPYL 2 [1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL]PYRIMIDINE; ATACIGUAT; CINACIGUAT; GUANYLATE CYCLASE ACTIVATOR; HEME; LIFICIGUAT; NITRIC OXIDE;

ALPHA HELIX; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTALLIZATION; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME CONFORMATION; NONHUMAN; NOSTOC; PROTEIN DOMAIN;

BENZOATES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME ACTIVATION; GUANYLATE CYCLASE; HEME; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NITRIC OXIDE; NOSTOC; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84887960499     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400539d     Document Type: Article

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